Publications
375 | Shimizu, N., Asatsuma-Okumura, T., Yamamoto, J., Yamaguchi, Y., Hiroshi
Handa, H. and Ito, T. PLZF and its fusion proteins are pomalidomide-dependent
CRBN neosubstrates. Commun. Biol., 4, 1277, 2021. DOI: 10.1038/s42003-021-02801-y |
374 | Kabe, Y., Koike, I., Yamamoto, T., Hirai, M., Kanai, A., Furuhata, R., Tsugawa, H., Harada, E., Sugase, K., Hanadate, K., Yoshikawa, N., Hayashi, H., Noda, M., Uchiyama, S., Yamazaki, H., Tanaka, H., Kobayashi, T., Handa, H. and Suematsu, M. Glycyrrhizin derivatives suppress cancer chemoresistance by inhibiting progesterone receptor membrane component 1. Cancers, 13, 3265, 2021. DOI:10.3390/cancers13133265 |
373 | Miyahara, K., Takano, N., Yamada, Y., Kazama, H., Tokuhisa, M., Hirotsugu
Hino, H., Koji Fujita, K., Barroga, E., Hiramoto, M., Handa, H., Kuroda,
M., Ishikawa, T. and Miyazawa, K. BRCA1 degradation in response to mitochondrial
damage in breast cancer cells. Sci. Rep., 11, 8735, 2021. DOI: 10.1038/s41598-021-87698-7 |
372 | Ishibashi, M., Yamamoto, J., Ito, T., Handa, H., Sunakawa, M., Inokuchi,
K, Morita, R. and Tamura, H. Durvalumab combined with immunomodulatory
drugs (IMiD) overcomes suppression of antitumor responses due to IMiD-induced
PD-L1 upregulation on myeloma cells. Mol. Cancer Ther., 2021. DOI: 10.1158/1535-7163.MCT-20-0246 |
371 | Hirano, M., Imai, Y., Kaito, Y., Murayama, T., Sato, K., Ishida, T., Yamamoto, J., Ito, T., Futami, M., Ri, M., Yasui, H., Denda, T., Tanaka, Y., Ota, Y., Nojima, M., Kamikubo, Y., Gotoh, N., Iida, S., Handa, H. and Tojo, A. Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma. J. Exp. Clin. Cancer Res., 40, 110, 2021. DOI: 10.1186/s13046-021-01909-7 |
370 | Tsukahara, T., Sahara, Y., Ribeiro, N., Tsukahara, R., Gotoh, M., Sakamoto, S., Handa, H. and Murakami-Murofushi, K. Adenine nucleotide translocase 2, a putative target protein for 2-carba cyclic phosphatidic acid in microglial cells. Cell. Signal., 82, 109951, 2021. DOI: 10.1016/j.cellsig.2021.109951 |
369 | Hirose, Y., Kitazono, T., Sezaki, M., Abe, M., Sakimura, K., Funato, H., Handa, H., Vogt, K. E. and Yanagisawa, M. Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway. Proc. Natl. Acad. Sci. USA, 117, 23106-23112, 2020. DOI: 10.1073/pnas.1917701117 |
368 | Cho, J., Horikawa, Y., Enya, M., Takeda, J., Imai, Y., Imai, Y., Handa, H. and Imai, T. L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells. Commun. Biol., 3, 497, 2020. DOI: 10.1038/s42003-020-01226-3 |
367 | Yamamoto, J., Suwa, T., Murase, Y., Tateno, S., Mizutome, H., Asatsuma-Okumura, T., Shimizu, N., Kishi, T., Momose, S., Kizaki, M., Ito, T., Yamaguchi, Y. and Handa, H. ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells. Nat. Chem. Biol., 16, 1208-1217, 2020. DOI: 10.1038/s41589-020-0645-3 |
366 | Cho, J., Hiramoto, M., Masaike, Y., Sakamoto, S., Imai, Y., Imai, Y., Handa, H. and Imai, T. UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner. Biochem. Biophys. Res. Commun., 527, 668-675, 2020. DOI: 10.1016/j.bbrc.2020.04.158 |
365 | Yokose, T., Kabe, Y., Matsuda, A., Kitago, M., Matsuda, S., Hirai, M., Nakagawa, T., Masugi, Y., Hishiki, T., Nakamura, Y., Shinoda, M., Yagi, H., Abe, Y., Oshima, G., Hori, S., Nakano, Y., Honda, K., Kashiro, A., Morizane, C., Nara, S., Kikuchi, S., Shibahara, T., Itonaga, M., Ono, M., Minegishi, N., Koshiba, S., Yamamoto, M., Kuno, A., Handa, H., Sakamoto, M., Suematsu, M. and Kitagawa, Y. O-Glycan-altered extracellular vesicles: a specific serum marker elevated in pancreatic cance. Cancers, 12, 2469, 2020. DOI: 10.3390/cancers12092469 |
364 | Tsugawa, H., Kabe, Y., Kanai, A., Sugiura, Y., Hida, S., Taniguchi, S., Takahashi, T., Matsui, H., Yasukawa, Z., Itou, H., Takubo, K., Suzuki, H., Honda, K., Handa, H. and Suematsu, M. Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection. PLoS Biol., 18, e3000813, 2020. DOI: 10.1371/journal.pbio.3000813 |
363 | Saika, K., Kato, M., Sanada, H., Matsushita, S., Matsui, M., Handa, H. and Kawano, M. Induction of adaptive immune responses against antigens incorporated within the capsid of simian virus 40. J. Gen. Virol., 101, 853-862, 2020. DOI: 10.1099/jgv.0.001445 |
362 | Tochigi, T., Miyamoto, T., Hatakeyama, K., Sakoda, T., Ishihara, D., Irifune, H., Shima, T., Kato, K., Maeda, T., Ito, T., Handa, H., Akashi, K. and Kikushige, Y. Aromatase is a novel neosubstrate of cereblon responsible for immunomodulatory drugs-induced thrombocytopenia. Blood, 135, 2146-2158, 2020. DOI: 10.1182/blood.2019003749 |
361 | Tateno, S., Iida, M., Fujii, S., Suwa, T., Katayama, M., Tokuyama, H.,
Yamamoto, J., Ito, T., Sakamoto, S., Handa, H. and Yamaguchi, Y. Genome-wide
screening reveals a role for subcellular localization of CRBN in the anti-myeloma
activity of pomalidomide. Sci. Rep., 10, 4012, 2020. DOI: 10.1038/s41598-020-61027-w |
360 | Asakawa, K., Handa, H. and Kawakami, K. Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons. Nat. Commun., 11, 1004, 2020. DOI: 10.1038/s41467-020-14815-x |
359 | Kabe, Y., Takemoto, D., Kanai, A., Hirai, M., Ono, Y., Akazawa, S., Horikawa, M., Kitagawa, Y., Handa, H., Rogi, T., Shibata, H. and Suematsu, M. Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites. NPJ Sci. Food, 4, 4, 2020. DOI: 10.1038/s41538-020-0064-6 |
358 | Sekino, M., Kuwahata, A., Yoshibe, A., Imai, K., Kaneko, M., Chikaki, S., Saito, I., Tsuruma, A., Sakamoto, S., Handa, H., Matsuda, S. and Kusakabe, M. Development of an automatic magnetic immunostaining system for rapid intraoperative diagnosis of cancer metastasis. AIP Adv., 10, 015106, 2020. DOI:10.1063/1.5130478 |
357 | Asatsuma-Okumura, T., Ando, H., Simone, M. D., Yamamoto, J., Sato, T., Shimizu, N., Asakawa, K., Yamaguchi, Y., Ito, T., Guerrini, L. and Handa, H. p63 is a cereblon substrate involved in thalidomide teratogenicity. Nat. Chem. Biol., 15, 1077-1084, 2019. DOI: 10.1038/s41589-019-0366-7 |
356 | Tsugawa, Y., Natori, M., Handa, H. and Imai, T. Estradiol accelerates liver regeneration through estrogen receptor α. Clin. Exp. Gastroenterol., 12, 331–336, 2019. DOI: 10.2147/CEG.S214196 |
355 | Tsugawa, Y., Handa, H. and Imai, T. Arginine induces IGF-1 secretion from the endoplasmic reticulum. Biochem. Biophys. Res. Commun., 514, 1128-1132, 2019. DOI: 10.1016/j.bbrc.2019.05.044 |
354 | Ando, H., Sato, T., Ito, T., Yamamoto, J., Sakamoto, S., Nitta, N., Asatsuma-Okumura, T., Shimizu, N., Mizushima, R., Aoki, I., Imai, T., Yamaguchi, Y., Berk, A. J. and Handa, H. Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation. iScience, 15, 95-108, 2019. DOI: 10.1016/j.isci.2019.04.007 |
353 | Onishi, T., Matsuda, S., Nakamura, Y., Kuramoto, J., Tsuruma, A., Sakamoto, S., Suzuki, S., Fuchimoto, D., Onishi, A., Chikaki, S., Kaneko, M., Kuwahata, A., Sekino, M., Yasuno, H., Hanyu, N., Kurita, T., Takei, H., Sakatani, T., Taruno, K., Nakamura, S., Hayashida, T., Jinno, H., Kusakabe, M., Handa, H., Kameyama, K. and Kitagawa, Y. Magnetically promoted rapid immunofluorescence staining for frozen tissue sections. J. Histochem. Cytochem., 67, 575-587, 2019. DOI: 10.1369/0022155419841023 |
352 | Sharma, J., Ono, T., Yukino, R., Miyashita, H., Hanyu, N., Handa, H. and
Sandhu, A. Smartphone based platform for real-time sharing of medical diagnostics
information by optical detection of functionalized fluorescent magnetic
nanoparticles. Biomed. Phys. Eng. Express, 5, 035014, 2019. DOI: 10.1016/j.sbsr.2020.100347 |
351 | Kabe, Y., Suematsu, M., Sakamoto, S., Hirai, M., Koike, I., Hishiki, T., Matsuda, A., Hasegawa, Y., Tsujita, K., Ono, M., Minegishi, N., Hozawa, A., Murakami, Y., Kubo, M., Itonaga, M. and Handa, H. Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera. Clin. Chem., 64, 1463-1473, 2018. DOI: 10.1373/clinchem.2018.291963 |
350 | Kimura, A., Kitajima, M., Nishida, K., Serada, S., Fujimoto, M., Naka,
T., Fujii-Kuriyama, Y., Sakamato, S., Ito, T., Handa, H., Tanaka, T., Yoshimura,
A. and Suzuki, H. NQO1 inhibits the TLR-dependent production of selective
cytokines by promoting IκB-ζ degradation. J. Exp. Med., 215, 2197-2209, 2018. DOI: 10.1084/jem.20172024 |
349 | Mori, T., Ito, T., Liu, S., Ando, H., Sakamoto, S., Yamaguchi, Y., Tokunaga,
E., Shibata, N., Handa, H. and Hakoshima, T. Structural basis of thalidomide
enantiomer binding to cereblon. Sci. Rep., 8, 1294, 2018. DOI: 10.1038/s41598-018-19202-7 |
348 | Boccitto, M., Lee, N., Sakamoto, S., Spruce, L., Handa, H., Clardy, J., Seeholzer, S. and Kalb, R. The neuroprotective marine compound psammaplysene A binds the RNA- binding protein HNRNPK. Mar. Drugs, 15, 246, 2017. DOI: 10.3390/md15080246 |
347 | Sharma, J., Ishizawa, S., Yukino, R., Takamura, T., Hanyu, N., Yasuno, H., Handa, H. and Sandhu, A. Fast and sensitive medical diagnostic protocol based on integrating circular current lines for magnetic washing and optical detection of fluorescent magnetic nanobeads. Sens. Bio-Sensing Res., 9, 7-12, 2016. DOI: 10.1016/j.sbsr.2016.05.002 |
346 | Matyskiela, M. E., Lu, G., Ito, T., Pagarigan, B., Lu, C-C., Miller, K., Fang, W., Wang, N-Y., Nguyen, D., Houston, J., Carmel, G., Tran, T., Riley, M., Nosaka, L., Lander, G. C., Gaidarova, S., Xu, S., Ruchelman, A. L., Handa, H., Carmichael, J., Daniel, T. O., Cathers, B. E., Lopez-Girona, A. and Chamberlain, P. P. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature, 535, 252-257, 2016. DOI: 10.1038/nature18611 |
345 | Nguyen, T. V., Lee, J. E., Sweredoski, M. J., Yang, S. J., Jeon, S. J., Harrison, J. S., Yim, J. H., Lee, S. G., Handa, H., Kuhlman, B., Jeong, J. S., Reitsma, J. M., Park, C. S., Hess, S. and Deshaies, R. J. Glutamine triggers acetylation-dependent degradation of glutamine synthetase via the thalidomide receptor cereblon. Mol. Cell, 61, 809-820, 2016. DOI: 10.1016/j.molcel.2016.02.032 |
344 | Klaeger, S., Gohlke, B., Perrin, J., Gupta, V., Heinzlmeir, S., Helm, D.,
Qiao, H., Bergamini, G., Handa, H., Savitski, M. M., Bantscheff, M., Medard,
G., Preissner, R. and Kuster, B. Chemical proteomics reveals ferrochelatase
as a common off-target of kinase inhibitors. ACS Chem. Biol., 11, 1245-1254, 2016. DOI: 10.1021/acschembio.5b01063 |
343 | Kabe, Y., Nakane, T., Koike, I., Yamamoto, T., Sugiura, Y., Harada, E., Sugase, K., Shimamura, T., Ohmura, M., Muraoka, K., Yamamoto, A., Uchida, T., Iwata, S., Yamaguchi, Y., Krayukhina, E., Noda, M., Handa, H., Ishimori, K., Uchiyama, S., Kobayashi, T. and Suematsu, M. Haem-dependent dimerization of PGRMC1/sigma-2 receptor facilitates cancer proliferation and chemoresistance. Nat. Commun., 7, 11030, 2016. DOI: 10.1038/ncomms11030 |
342 | Mukai, S., Moriya, S., Hiramoto, M., Kazama, H., Kokuba, H., Che, X-F., Yokoyama, T., Sakamoto, S., Sugawara, A., Sunazuka, T., Ōmura, S., Handa, H., Itoi, T. and Miyazawa, K. Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines. Int. J. Oncol., 48, 45-54, 2015. DOI: 10.3892/ijo.2015.3237 |
341 | Laitem, C., Zaborowska, J., Tellier, M., Yamaguchi, Y., Qingfu, C., Egloff,
S., Handa, H. and Murphy, S. CTCF regulates NELF, DSIF and P-TEFb recruitment
during transcription. Transcription, 6, 79-90, 2015. DOI: 10.1080/21541264.2015.1095269 |
340 | Cao, Q-F., Yamamoto, J., Isobe, T., Tateno, S., Murase, Y., Chen, Y., Handa, H. and Yamaguchi, Y. Characterization of the human transcription elongation factor Rtf1: evidence for nonoverlapping functions of Rtf1 and the Paf1 complex. Mol. Cell. Biol., 35, 3459-3470, 2015. DOI: 10.1128/MCB.00601-15 |
339 | Ito, T. and Handa, H. Another action of a thalidomide derivative.(News and Views) Nature, 523, 167-168, 2015. DOI: 10.1038/nature14628 |
338 | Kawano, M., Doi, K., Fukuda, H., Kita, Y., Imai, K., Inoue, T., Enomoto, T., Matsui, M., Hatakeyama, M., Yamaguchi, Y. and Handa, H. SV40 VP1 major capsid protein in its self-assembled form allows VP1 pentamers to coat various types of artificial beads in vitro regardless of their sizes and shapes. Biotechnol. Rep., 5, 105-111, 2015. DOI: 10.1016/j.btre.2014.12.008 |
337 | Chamberlain, P. P., Lopez-Girona, A., Miller, K., Carmel, G., Pagarigan, B., Chie-Leon, B., Rychak, E., Corral, L. G., Ren, Y. J., Wang, M., Riley, M., Delker, S. L., Ito, T., Ando, H., Mori, T., Hirano, Y., Handa, H., Hakoshima, T., Daniel, T. O. and Cathers, B. E. Structure of the human cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nat. Struct. Mol. Biol., 21, 803-809, 2014. DOI: 10.1038/nsmb.2874 |
336 | Pérez-Perarnau, A., Preciado, S., Palmeri, C. M., Moncunill-Massaguer, C., Iglesias-Serret, D., González-Gironès, D. M., Miguel, M., Karasawa, S., Sakamoto, S., Cosialls, A. M., Rubio-Patiño, C., Saura-Esteller, J., Ramón, R., Caja, L., Fabregat, I., Pons, G., Handa, H., Albericio, F., Gil, J. and Lavilla, R. A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins. Angew. Chem. Int. Ed., 53, 10150-10154, 2014. DOI: 10.1002/anie.201405758 |
335 | Yamamoto, J., Hagiwara, Y., Chiba, K., Isobe, T., Narita, T., Handa, H. and Yamaguchi, Y. DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes. Nat. Commun., 5, 4263, 2014. DOI: 10.1038/ncomms5263 |
334 | Sakamoto, S., Omagari, K., Kita, Y., Mochizuki, Y., Naito, Y., Kawata, S., Matsuda, S., Itano, O., Jinno, H., Takeuchi, H., Yamaguchi, Y., Kitagawa, Y. and Handa, H. Magnetically promoted rapid immunoreactions using functionalized fluorescent magnetic beads: a proof of principle. Clin. Chem., 60, 610-620, 2014. DOI: 10.1373/clinchem.2013.211433 |
333 | Gandhi, A. K., Kang, J., Havens, C. G., Conklin, T., Ning, Y., Wu, L., Ito, T., Ando, H., Waldman, M. F., Thankurta, A., Klippel, A., Handa, H., Daniel, T. O., Schafer, P. H. and Chopra, R. Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN. Br. J. Haematol., 164, 811-821, 2014. DOI: 10.1111/bjh.12708 |
332 | Takemoto, M., Kawamura, Y., Hirohama, M., Yamaguchi, Y., Handa, H., Saitoh, H., Nakao, Y., Kawada, M., Khalid, K., Koshino, H., Kimura, K., Ito, A. and Yoshida, M. Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata. J. Antibiot., 67, 335-338, 2014. DOI: 10.1038/ja.2013.142 |
331 | Kawano, M., Morikawa, K., Suda, T., Ohno, N., Matsushita, S., Akatsuka, T., Handa, H. and Matsui, M. Chimeric SV40 virus-like particles induce specific cytotoxicity and protective immunity against influenza A virus without the need of adjuvants. Virology, 448, 159-167, 2014. DOI: 10.1016/j.virol.2013.10.010 |
330 | Terada, K., Tanaka, T., Hanyu, N., Honda, T. and Handa, H. Rapid and sensitive detection of alpha-fetoprotein by a magnetically promoted shake-free immunoassay employing fluorescent magnetic nanobeads. Int. J. Anal. Bio-Sci., 2, 101-107. 2014. Pdf : https://plaza.umin.ac.jp/~e-jabs/2/2.101.pdf |
329 | Ohno, K., Sawada, J., Takiya, S., Kimoto, M., Matsumoto, A., Tsubota, T., Uchimo, K., Hui, C., Sezutsu, H., Handa, H. and Suzuki, Y. Silk gland factor-2, involved in fibroin gene transcription, consists of LIM homeodomain, LIM-interacting, and single-stranded DNA-binding proteins. J. Biol. Chem., 288, 31581-31591, 2013. DOI: 10.1074/jbc.M113.514471 |
328 | Gupta, V., Liu, S., Ando, H., Ishii, R., Tateno, S., Kaneko, Y., Yugami, M., Sakamoto, S., Yamaguchi, Y., Nureki, O. and Handa, H. Salicycle acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesisi activity. Mol. Pharmacol., 84, 824-833, 2013. DOI: 10.1124/mol.113.087940 |
327 | Miyazaki, H., Higashimoto, K., Yada, Y., Endo, T. A., Sharif, J., Komori, T., Matsuda, M., Koseki, Y., Nakayama, M., Soejima, H., Handa, H., Koseki, H., Hirose, S. and Nishioka, K. Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract Polycomb silencing. PLoS Genet., 9, e1003897, 2013. DOI: 10.1371/journal.pgen.1003897 |
326 | Iida, S., Imai, K., Matsuda, S., Itano, O., Hatakeyama, M., Sakamoto, S., Kokuryo, D., Okabayashi, K., Endo, T., Ishii, Y., Hasegawa, H., Aoki, I., Handa, H. and Kitagawa, Y. In Vivo identification of sentinel lymph nodes using MRI and size-controlled and monodispersed magnetite nanoparticles. J. Magn. Reson. Imaging, 38, 1346-1355,2013. DOI: 10.1002/jmri.24108 |
325 | Enomoto, T., Kawano, M., Fukuda, H., Sawada, W., Inoue, T., Haw, K. C., Kita, Y., Sakamoto, S., Yamaguchi, Y., Imai, T., Hatakeyama, M., Saito, S., Sandhu, A., Matsui, M., Aoki, I. and Handa, H. Viral protein-coating of magnetic nanoparticles using simian virus 40 VP1. J. Biotechnol., 167, 8-15, 2013. DOI: 10.1016/j.jbiotec.2013.06.005 |
324 | Kang, J., Shen, Z., Lim, J-M., Handa, H., Wells, L. and Tantin, D. Regulation of Oct1/Pou2f1 transcription activity by O-GlcNAcylation. FASEB J., 27, 2807-2817, 2013. DOI: 10.1096/fj.12-220897 |
323 | Hotta, K., Nashimoto, A., Yasumura, E., Suzuki, M., Azuma, M., Iizumi, Y., Shima, D., Nabeshima, R., Hiramoto, M., Okada, A., Sakata-Sogawa, K., Tokunaga, M., Ito, T., Ando, H., Sakamoto, S., Kabe, Y., Aizawa, S., Imai, T., Yamaguchi, Y., Watanabe, H. and Handa, H. Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein. Mol. Pharmacol., 83, 930-938, 2013. DOI: 10.1124/mol.112.081935 |
322 | Kershaw, J., Leuze, C., Aoki, I., Obata, T., Kanno, I., Ito, H., Yamaguchi, Y. and Handa, H. Systematic changes to the apparent diffusion tensor of in vivo rat brain measured with an oscillating-gradient spin-echo sequence. NeuroImage, 70, 10-20. 2013. DOI: 10.1016/j.neuroimage.2012.12.036 |
321 | Karasawa, S., Azuma, M., Kasama, T., Sakamoto, S., Kabe, Y., Imai, T., Yamaguchi, Y., Miyazawa, K. and Handa, H. Vitamin K2 covalently binds to Bak and induces Bak-mediated apoptosis. Mol. Pharmacol., 83, 613-620. 2013. DOI: 10.1124/mol.112.082602 |
320 | Uebi, T., Umeda, M., Maekawa, N., Karasawa, S., Handa, H. and Imai, T. Prohibitins, novel vitamin K2 target factors in osteoblast. J. Biosci. Med., 1, 1-4, 2013. DOI: 10.4236/jbm.2013.13001 |
319 | Umeda, M., Uebi, T., Maekawa, N., Masaike, Y., Handa, H. and Imai, T. Effective cofactor complex purification using nanobeads. J. Biosci. Med., 1, 5-10, 2013. DOI: 10.4236/jbm.2013.13002 |
318 | Ito, Y., Ito, T., Karasawa, S., Enomoto, T., Nashimoto, A., Hase, Y., Sakamoto, S., Mimori, T., Matsumoto, Y., Yamaguchi, Y. and Handa, H. Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of Bisphenol A. PLOS One, 7.e50481, 2012. DOI: 10.1371/journal.pone.0050481 |
317 | Diamant, G., Amir-Zilberstein, L., Yamaguchi, Y., Handa, H. and Dikstein, R. DSIF restricts NF-kB signaling by coordinating elongation with mRNA Processing of negative feedback genes. Cell Rep., 2, 722-731, 2012. DOI: 10.1016/j.celrep.2012.08.041 |
316 | Wada,T., Hara, M., Taneda, T., Qingfu, C., Takata, R., Moro, K., Takeda, K., Kishimoto, T. and Handa, H. Antisense morpholino targeting just upstream from a poly(A) tail junction of maternal mRNA removes the tail and inhibits translation. Nucleic Acids Res., 40, e173, 2012. DOI: 10.1093/nar/gks765 |
315 | Lopez-Girona, A., Mendy, D., Ito, T., Miller, K., Gandhi, A. K., Kang, J., Karasawa, S., Carmel, G., Jackson, P., Abbasian, M., Mahmoudi, A., Cathers, B., Rychak, E., Gaidarova, S., Chen, R., Schafer, P. H., Handa, H., Daniel, T. O., Evans, J. F. and Chopra, R. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia, 26, 2326-2335, 2012. DOI: 10.1038/leu.2012.119 |
314 | Okuda-Ashitaka, E., Minami, T., Tsubouchi, S., Kiyonari, H., Iwamatsu, A., Noda, T., Handa, H. and Ito, S. Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission. J. Biol. Chem., 287, 10403-10413, 2012. DOI: 10.1074/jbc.M111.271866 |
313 | Kawano, A., Hayashi, Y., Noguchi, S., Handa, H., Horikoshi, M. and Yamaguchi,
Y. Global analysis for functional residues of histone variant Htz1 using
the comprehensive point mutant library. Genes Cells, 16, 590-607, 2011. DOI: 10.1111/j.1365-2443.2011.01512.x |
312 | Enomoto, T., Kukimoto, I., Kawano, M., Yamaguchi, Y., Berk, A. J. and Handa, H. In vitro reconstitution of SV40 particles that are composed of VP1/2/3 capsid proteins and nucleosomal DNA and direct efficient gene transfer. Virology, 420, 1-9, 2011. DOI: 10.1016/j.virol.2011.08.014 |
311 | Kitai, Y., Fukuda, H., Enomoto, T., Asakawa, Y., Suzuki, T., Inouye, S. and Handa, H. Cell selective targeting of a simian virus 40 virus-like particle conjugated to epidermal growth factor. J. Biotechnol., 155, 251-256, 2011. DOI: 10.1016/j.jbiotec.2011.06.030 |
310 | Yasuma, A., Ochiai, T., Azuma, M., Nishiyama, H., Kikuchi, K., Kondo, M. and Handa, H. Exogenous coproporphyrin III production by Corynebacterium aurimucosum and Microbacterium oxydans in erythrasma lesions. J. Med. Microbiol., 60, 1038-1042, 2011. DOI: 10.1099/jmm.0.027276-0 |
309 | Hatakeyama, M., Kishi, H., Kita, Y., Imai, K., Nishio, K., Karasawa, S., Masaike, Y., Sakamoto, S., Sandhu, A., Tanimoto, A., Gomi, T., Kohda, E., Abe, M. and Handa, H. A two-step ligand exchange reaction generates highly water-dispersed magnetic nanoparticles for biomedical applications. J. Mater. Chem., 21, 5959-5966, 2011. DOI: 10.1039/C0JM04381H |
308 | Aizawa, M., Abe, Y., Ito, T., Handa, H. and Nawa, H. mRNA distribution of the thalidomide binding protein cereblon in adult mouse brain. Neurosci. Res., 69, 343-347, 2011. DOI: 10.1016/j.neures.2010.12.019 |
307 | Taneda, T., Zhu, W., Cao, Q., Watanabe, H., Yamaguchi, Y., Handa, H. and Wada, T. Erythropoiesis is regulated by the transcription elongation factor Foggy/Spt5 through gata1 gene regulation. Genes Cells, 16, 231-242, 2011. DOI: 10.1111/j.1365-2443.2010.01481.x |
306 | Maekawa, N., Hiramoto, M., Sakamoto, S., Azuma, M., Ito, T., Ikeda, M., Naitou, M., Acharya, H. P., Kobayashi, Y., Suematsu, M., Handa, H. and Imai, T. High-performance affinity purification for identification of 15-deoxy-Δ12,14-PGJ2 interacting factors using magnetic nanobeads. Biomed. Chromatogr., 25, 466-471, 2011. ODI: 10.1002/bmc.1469 |
305 | Morimoto, Y., Takamura, T., Park, S. Y., Sakamoto, S., Kawata, S., Handa, H. and Sandhu, A. Detection of 8 nm diameter superparamagnetic beads by magnetically-induced manipulation of micrometer-sized magnetic beads: A novel protocol for magnetically-labeled biosensing. Jpn. J. Appl. Phys., 49, 04DL07, 2010. DOI: 10.1143/JJAP.49.04DL07 |
304 | Kim, S., Yamamoto, J., Chen, Y., Aida, M., Wada, T., Handa, H. and Yamaguchi,
Y. Evidence that cleavage factor Im is a heterotetrameric protein complex
controlling alternative polyadenylation. Genes Cells, 15, 1003-1013, 2010. DOI: 10.1111/j.1365-2443.2010.01436.x |
303 | Park, S. Y., Ko, P. J., Handa, H. and Sandhu, A. Exploring magneto-optical properties of biofunctionalized magnetic chains for developing label-free immunoassays. J. Appl. Phys., 107, 09B324, 2010. DOI: 10.1063/1.3355896 |
302 | Kume, K., Iizumi, Y., Shimada, M., Ito, Y., Kishi, T., Yamaguchi, Y. and Handa, H. Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. Genes Cells, 15, 339-349, 2010. DOI: 10.1111/j.1365-2443.2010.01385.x |
301 | Ito, T., Ando, H., Suzuki, T., Ogura, T., Hotta, K., Imamura, Y., Yamaguchi, Y. and Handa, H. Identification of a primary target of thalidomide teratogenicity. Science, 327, 1345-1350, 2010. DOI: 10.1126/science.1177319 |
300 | Park, S. Y., Handa, H. and Sandhu, A. Magneto-optical biosensing platform based on light scattering from self-assembled chains of functionalized rotating magnetic beads. Nano Lett.,10, 446-451, 2010. DOI: 10.1021/nl9030488 |
299 | Tominaga, A., Sugawara, H., Futagawa, T., Inoue, K., Sasaki, K., Minamino, N., Hatakeyama, M., Handa, H. and Miyata, A. Characterization of the testis-specific promoter region in the human pituitary adenylate cyclase-activating polypeptide (PACAP) gene. Genes Cells, 15, 595-606, 2010. DOI: 10.1111/j.1365-2443.2010.01403.x |
298 | Masaike, Y., Takagi, T., Hirota, M., Yamada, J., Ishihara, S., Yung, T. M. C., Inoue, T., Sawa, C., Sagara, H., Sakamoto, S., Kabe, Y., Takahashi, Y., Yamaguchi, Y. and Handa, H. Identification of dynamin-2-mediated endocytosis as a new target of osteoporosis drugs, bisphosphonates. Mol. Pharmacol., 77, 262-269, 2010. DOI: 10.1124/mol.109.059006 |
297 | Hiramoto, M., Maekawa, N., Kuge, T., Ayabe, F., Watanabe, A., Masaike,
Y., Hatakeyama, M., Handa, H. and Imai, T. High-performance affinity chromatography
method for identification of L-arginine interacting factors using magnetic
nanobeads. Biomed. Chromatogr., 24, 606-612, 2010. DOI: 10.1002/bmc.1334 |
296 | Park, S. Y., Handa, H. and Sandhu, A. Determination of Inter-Molecular
Forces by Magneto-Optical Transmittance of Molecule-Covered Superparamagnetic
Particles in Solution. IEEE Trans. Magn., 46, 1409-1411, 2010. DOI: 10.1109/TMAG.2010.2048747 |
295 | Oda, T., Lee, J. S., Sato, Y., Kabe, Y., Sakamoto, S., Handa, H., Mangindaan, R.E.P. and Namikoshi, M. Inhibitory effect of N,N-didesmethylgrossularine-1 on inflammatory cytokine production in lipopolysaccharide-stimulated RAW 264.7 cells. Mar. Drugs, 7, 589-599, 2009. DOI: 10.3390/md7040589 |
294 | Chen, H., Contreras, X., Yamaguchi, Y., Handa, H., Peterlin, B. M., and
Guo, S. Repression of RNA polymerase II elongation in vivo is critically
dependent on the C-terminus of Spt5. Plos ONE, 4, e6918, 2009. DOI: 10.1371/journal.pone.0006918 |
293 | Kawano, M., Xing, L., Tsukamoto, H., Inoue, T., Hand, H. and Cheng, R.
H. Calcium bridge triggers capsid disassembly in the cell entry process
of simian virus 40. J. Biol. Chem., 284, 34703-34712, 2009. DOI: 10.1074/jbc.M109.015107 |
292 | Chen, Y., Yamaguichi, Y., Tsugeno, Y., Yamamoto, J., Yamada, T., Nakamura, M., Hisatake, K. and Handa, H. DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation. Genes Dev., 23, 2765-2777, 2009. DOI: 10.1101/gad.1834709 |
291 | Tanaka, T., Shimazu, R., Nagai, H., Tada, M., Nakagawa, T., Sandhu, A.,
Handa, H. and Abe, M. Preparation of spherical and uniform-sized ferrite
nanoparticles with diameters between 50 and 150 nm for biomedical applications.
J. Magn. Magn. Mater., 321, 1417-1420, 2009. DOI: 10.1016/j.jmmm.2009.02.054 |
290 | Suzuki, E., Ogura, H., Kato, K., Takei, I., Kabe, Y., Handa, H. and Umezawa,
K. Preparation of conophylline affinity nano-beads and identification of
a target preotein. Bioorg. Med. Chem., 17, 6188-6195, 2009. DOI: 10.1016/j.bmc.2009.07.062 |
289 | Kamiya, H., Suzuki, A., Yamaguchi, Y., Handa, H. and Harashima, H. Incorporation
of 8-hydroxyguanosine 5’-triphosphate (8-oxo-7,8-dihydroguanosine) 5’-triphosphate
by bacterial and human RNA polymerases. Free. Radic. Biol. Med., 46, 1703-1707, 2009. DOI: 10.1016/j.freeradbiomed.2009.04.005 |
288 | Yung, T.M.C., Narita, T., Komori, T., Yamaguchi, Y. and Handa, H. Cellular dynamics of the negative transcription elongation factor NELF. Exp. Cell Res., 315, 1693-1705, 2009. DOI: 10.1016/j.yexcr.2009.02.013 |
287 | Abe, M., Nishio, N., Hatakeyama. M., Hanyu, N., Tanaka, T., Tada, M., Nakagawa, T., Sandhu, A. and Handa, H. Preparation and medical application of magnetic beads conjugated with bioactive molecules. J. Magn. Magn. Mater., 321, 645-649, 2009. DOI: 10.1016/j.jmmm.2008.11.086 |
286 | Hanyu, N., Nishio, K., Hatakeyama, M., Yasuno, H., Tanaka, T., Tada, M., Nakagawa, T., Sandhu, A., abe, M. and Handa, H. High-throughput bioscreening system utilizing high-performance affinity magnetic carriers exhibiting minimal non-specific protein binding. J. Magn. Magn. Mater., 321, 1625-1627, 2009. DOI: 10.1016/j.jmmm.2009.02.100 |
285 | Tada, M., Kanemaru, T., Hara, T., Nakagawa, T., Handa, H. and Abe, M. Synthesis of hollow ferrite nanospheres for biomedical applications. J. Magn. Magn. Mater., 321, 1414-1416, 2009. DOI: 10.1016/j.jmmm.2009.02.053 |
284 | Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T., Soga, T., Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanabe, H., Kataoka, K., Suematsu, M. and Handa, H. Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis. Toxicological Sciences, 109, 143-151, 2009. DOI: 10.1093/toxsci/kfp041 |
283 | Zou, G-M., Karikari, C., Kabe, Y., Handa, H. Anders, R. A. and Maitra, A. The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: Therapeutic implications in tumor angiogenesis. J. Cell. Physiol., 219, 209-218, 2009. DOI: 10.1002/jcp.21666 |
282 | Park, S.Y., Handa, H. and Sandhu, A. High speed magneto-optical valve: Rapid control of the optical transmittance of aqueous solutions by magnetically induced self-assembly of superparamagnetic particle chains. J. Appl. Phys., 105, 07B526, 2009. DOI: 10.1063/1.3072762 |
281 | Bando, M., Ohashi, T., Dede, M., Akram, R., Oral, A., Park, S.Y., Shibasaki, I., Handa, H. and Sandhu, A. High sensitivity and multifunctional micro-Hall sensors fabricated using InAlSb/InAsSb/InAlSb heterostructures. J. Appl. Phys., 105, 07E909, 2009. DOI: 10.1063/1.3074513 |
280 | Morimoto, Y., Abe, M., Hatakeyama, M., Handa, H. and Sandhu, A. Detection
of Magnetic Nanobeads by Self-Assembly of Superparamagnetic Microbeads
for Biosensing. IEEE Trans. Magn., 45, 2871-2874, 2009. DOI: 10.1109/TMAG.2009.2018861 |
279 | Kuramori, C., Azuma, M., Kume, K., Kaneko, Y., Inoue, A., Yamaguchi, Y., Kabe, Y., Hosoya, T., Kizaki, M., Suematsu, M. and Handa, H., Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nuclus. Biochem. Biophys. Res. Commun., 379, 519-525, 2009. DOI: 10.1016/j.bbrc.2008.12.103 |
278 | Hatakeyama, M., Mochizuki, Y., Kita, Y., Kishi, H., Nishio, K., Sakamoto, S., Abe, M. and Handa, H. Characterization of a magnetic carrier encapsulating europium and ferrite nanoparticles for biomolecular recognition and imaging. J. Magn. Magn. Mater., 321, 1364-1367, 2009. DOI: 10.1016/j.jmmm.2009.02.039 |
277 | Komori, T., Inukai, N., Yamada, T., Yamaguchi, Y. and Handa, H., Role of human transcription elongation factor DSIF in the suppression of senescence and apoptosis. Genes Cells., 14, 343-354, 2009. DOI: 10.1111/j.1365-2443.2008.01273.x |
276 | Nagasaki, S., Suzuki, T., Miki, Y., Akahira, J-I., Kitada, K., Ishida,
T., Handa, H., Ohuchi, N. and Sasano, H. 17β-hydroxysteeroid dehydrogenase
type 12 in human breast carcinoma: a prognostic factor via potential regulation
of fatty acids synthesis. Cancer Res., 69, 1392-1399, 2009. DOI: 10.1158/0008-5472.CAN-08-0821 |
275 | Kang, J., Gemberling, M., Nakamura, M., Whitby, F. G., Handa, H., Fairbrother, W. G. and Tantin, D. A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Genes Dev., 23, 208-222, 2009. DOI: 10.1101/gad.1750709 |
274 | Tanaka, T., Nagai, H., Tada, M., Nakagawa, T., Sandhu, A., Tamaura, Y., Handa, H. and Abe, M. Wide range (20-200 nm) size control of spherical ferrite particles grown on seed crystals in aqueous solution added with sucrose. J. Mater. Res., 24, 2051-2055, 2009. DOI: 10.1557/jmr.2009.0253 |
273 | Nakanishi, A., Chapellie, B., Maekawa, N., Hiramoto, M., Kuge, T., Takahashi, R. Handa, H. and Imai, T. SV40 vectors carrying minimal sequence of viral origin with exchangeable capsids. Virology., 379, 110-117, 2008. DOI: 10.1016/j.virol.2008.06.032 |
272 | Takahashi, R., Kanesashi, S., Inoue, T., Enomoto, T., Kawano, M., Tsukamoto, H., Takeshita, F., Imai, T., Ochiya, T., Kataoka, K., Yamaguchi, Y. and Handa, H. Presentation of functional foreign peptides on the surface of SV40 virus-like particles. J. Biotechnol., 135, 385-392, 2008. DOI: 10.1016/j.jbiotec.2008.05.012 |
271 | Azuma, M., Kabe, Y., Kuramori, C., Kondo, M., Yamaguchi, Y. and Handa, H. Adenine nucleotide translocator transports haem precursors into mitochondria. Plos ONE, 3, e3070, 2008. DOI: 10.1371/journal.pone.0003070 |
270 | Shimizu, N., Yoshikawa, N., Wada, T., Handa, H., Sano, M., Fukuda, K., Suematsu, M., Sawai, T., Morimoto, C. and Tanaka, H. Tissu- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by Hexamethylene Bisacetamide-Inducible Protein 1. Mol. Endocrinol., 22, 2609-2623, 2008. DOI: 10.1210/me.2008-0101 |
269 | Ando, K., Hirao, S., Kabe, Y., Ogura, Y., Sato, I., Yamaguchi, Y., Wada, T. and Handa, H. A new APE1/Ref-1-dependent pathway leading to reduction of NF-κB and AP-1, and activation of their DNA-binding activity. Nucleic Acids Res., 36, 4327-4336, 2008. DOI: 10.1093/nar/gkn416 |
268 | Hase, Y., Tatsuno, M., Nishi, T., Kataoka, K., Kabe, Y., Yamaguchi, Y., Ozawa, N., Natori, M., Handa, H. and Watanabe, H. Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm. Biochem. Biophys. Res. Commun., 366, 66-72, 2008. DOI: 10.1016/j.bbrc.2007.11.107 |
267 | Suzuki, M., Furukawa, S., Kuramori, C., Sawa, C., Kabe, Y., Nakamura, M., Sawada, J., Yamaguchi, Y., Sakamoto, S., Inoue, S. and Handa, H. Development of a chemical screening system using aqueorin-fused protein. Biochem. Biophys. Res. Commun., 368, 600-605, 2008. DOI: 10.1016/j.bbrc.2008.01.107 |
266 | Nishio, K., Masaike, Y., Ikeda, M., Narimatsu, H., Gokon, N., Tsubouchi, S., Hatakeyama, M., Sakamoto, S., Hanyu, N., Sandhu, A., Kawaguchi, H., Abe, M. and Handa, H. Development of novel magnetic nano-carriers for high-performance affinity purification. Colloids Surf. B, 64, 162-169, 2008. DOI: 10.1016/j.colsurfb.2008.01.013 |
265 | Yoshida, M., Kabe, Y., Wada, T., Asai, A. and Handa, H. A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Mol. Pharmacol., 73, 987-994, 2008. DOI: 10.1124/mol.107.043307 |
264 | Inoue, T., Kawano, M., Takahashi, R., Tsukamoto, H., Enomoto, T., Imai, T., Kataoka, K. and Handa, H. Engineering of SV40-based nano-capsules for delivery of heterologous proteins as fusions with minor capsid proteins VP2/3. J. Biotechnol., 134, 181-192, 2008. DOI: 10.1016/j.jbiotec.2007.12.006 |
263 | Kuraoka, I., Ito, S., Wada, T., Hayashida, M., Lee, L., Saijo, M., Nakatsu, Y., Matsumoto, M.., Matsunaga, T., Handa, H., Qin, J., Nakatani, Y. and Tanaka, K. Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair. J. Biol. Chem., 283, 940-950, 2008. DOI: 10.1074/jbc.M706647200 |
262 | Kumagai, Y., Imai, Y., Abe, M., Sakamoto, S., Handa, H. and Sandhu, A. Sensitivity dependence of Hall biosensor arrays with the position of superparamagnetic beads on their active regions. J. Appl. Phys., 103, 07A309, 2008. DOI: 10.1063/1.2833306 |
261 | Matsushita, N., Nakagawa, K., Taniguchi, T., Handa. H., Tada, M., Abe, M. and Yoshimura, M. Hundred-nanometer sized biomagnetic beads with large magnetization using ferrite nanoparticles grown by hydrothermal process. J. Appl. Phys., 103, 07A317, 2008. DOI: 10.1063/1.2838015 |
260 | Saito, Y., Imazeki, H., Miura, S., Yoshimura, T., Okutsu, H., Harada, Y., Ohwaki, T., Nagao, O., Kamiya, S., Hayashi, R., Kodama, H., Handa, H., Yoshida, T. and Fukai, F. A peptide derived from tenascin-C induces β1 integrin activation through syndecan-4. J. Biol. Chem., 282, 34929-34937, 2007. DOI: 10.1074/jbc.M705608200 |
259 | Agawa, Y., Sarhan, M., Kageyama, Y., Akagi, K., Takai, M., Hashiyama, K., Wada, T., Handa, H., Iwamatsu, A., Hirose, S. and Ueda, H. Drosophila Blimp-1 is a transient transcriptional respressor that controls timing of the ecdysone-induced developmenatal pathway. Mol. Cell. Biol., 27, 8739-8747, 2007. DOI: 10.1128/MCB.01304-07 |
258 | Iizumi, Y., Sagara, H., Kabe, Y., Azuma, M., Kume, K., Ogawa, M., Nagai, T., Gillespie, P. G., Sasakawa, C. and Handa, H. The Enteropathogenic E.coli effector EspB facilitates microvillus effacing and antiphagocytosis by inhibiting myosin function. Cell Host Microbe, 2, 383-392, 2007. DOI: 10.1016/j.chom.2007.09.012 |
257 | Tsukamoto, H., Kawano, M., Inoue, T., Enomoto, T., Takahashi, R., Yokoyama, N., Yamamoto, N., Imai, T., Kataoka, K., Yamaguchi, Y. and Handa, H. Evidence that SV40 VP1-DNA interactions contribute to the assembly of 40-nm spherical viral particles. Genes Cells, 12, 1267-1279, 2007. DOI: 10.1111/j.1365-2443.2007.01134.x |
256 | Yamaguchi, Y., Mura, T., Chanarat, S., Okamoto, S. and Handa, H. Hepatitis delta antigen binds to the clamp of RNA polymerase II and affects transcriptional fidelity. Genes Cells, 12,863-875,2007. DOI: 10.1111/j.1365-2443.2007.01094.x |
255 | Zhu, W., Wada, T., Okabe, S., Taneda, T., Yamaguchi, Y. and Handa, H. DSIF contributes to transcriptional activation by DNA-binding activators by preventing pausing during transcription elongation. Nucleic Acids Res., 35, 4064-4075, 2007. DOI: 10.1093/nar/gkm430 |
254 | Amir-Zilberstein, L., Ainbinder, E., Toube, L., Yamaguchi, Y., Handa, H. and Dikstein, R. Differential regulation of NF-κB by elongation factors is determined by core promoter type. Mol. Cell. Biol., 27, 5246-5259, 2007. DOI: 10.1128/MCB.00586-07 |
253 | Kuraoka, I., Suzuki, K., Ito, S., Hayashida, M., Kwei, J.S.M., Ikegami, T., Handa, H., Nakabeppu, Y. and Tanaka, K. RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS. DNA Repair, 6, 841-851, 2007.DOI: 10.1016/j.dnarep.2007.01.014 |
252 | Narita, T., Yung, T. M. C., Yamamoto, J., Tsuboi, Y., Tanabe, H., Tanaka, K., Yamaguchi, Y. and Handa, H. NELF interacts with CBC and participates in 3’end processing of replication-dependent histone mRNAs. Mol. Cell, 26, 349-365, 2007. DOI: 10.1016/j.molcel.2007.04.011 |
251 | Sandhu, A., Kumagai, Y., Lapicki, A., Sakamoto, S., Abe, M. and Handa, H. High efficiency Hall effect micro-biosensor platform for detection of magnetically labeled biomolecules. Biosens. Bioelectron., 22, 2115-2120, 2007. DOI: 10.1016/j.bios.2006.09.021 |
250 | Yokoyama, N., Kawano, M., Tsukamoto, H., Enomoto, T., Inoue, T., Takahashi, R., Nakanishi, A., Imai, T., Wada, T. and Handa, H. Mutational analysis of the carboxyl-terminal region of the SV40 major capsid protein VP1. J. Biochem., 141, 279-286, 2007. DOI: 10.1093/jb/mvm038 |
249 | Nakanishi, A., Itoh, N., Li, P. P., Handa, H., Liddington, R. C. and Kasamatsu, H. Minor capsid proteins of Simian Virus 40 are dispensable for nucleocapsid assembly and cell entry but are required for nuclear entry of the viral genome. J. Virol., 81, 3778-3785, 2007. DOI: 10.1128/JVI.02664-06 |
248 | Nishio, K., Ikeda, M., Gokon, N., Tsubouchi, S., Narimatsu, H., Mochizuki, Y., Sakamoto, S., Snadhu, A., Abe, M. and Handa, H. Preparation of size controlled (30-100 nm) magnetite nanoparticles for biomedical applications. J. Magn. Magn. Mater., 310, 2408-2410, 2007. DOI: 10.1016/j.jmmm.2006.10.795 |
247 | Nishio, K., Gokon, N., Hasegawa, M., Ogura, Y., Ikeda, M., Narimatsu, H., Tada, M., Yamaguchi, Y., Sakamoto, S., Abe, M. and Handa, H. Identification of a chemical substructure that is immobilized to ferrite nanoparticles (FP). Colloids Surf. B, 54, 249-253, 2007. DOI: 10.1016/j.colsurfb.2006.10.039 |
246 | Yamamoto, N., Suzuki, M., Kawano, M., Inoue, T., Takahashi, R., Tsukamoto, H., Enomoto, T., Yamaguchi, Y., Wada, T. and Handa, H. Adeno-associated virus site-specific integration is regulated by TRP-185. J. Virol., 81, 1990-2001, 2007. DOI: 10.1128/JVI.02014-06 |
245 | Yugami, M., Kabe, Y., Yamaguchi, Y., Wada, T. and Handa, H. hnRNP-U enhances the expression of specific genes by stabilizing mRNA. FEBS Lett., 581, 1-7, 2007. DOI: 10.1016/j.febslet.2006.11.062 |
244 | Kusunoki, N., Ito, T., Sakurai, N., Handa, H. and Kawai S. A Celecoxib Derivative Potently Inhibits Proliferation of Colon Adenocarcinoma Cells by Induction of Apoptosis. Anticancer Res., 26: 3229-3236, 2006. PDF: http://ar.iiarjournals.org/content/26/5A/3229.long (DOI不明) |
243 | Kubo, T., Wada, T., Yamaguchi, Y., Shimizu, A. and Handa, H. Knock-down of 25-kDa subunit of cleavage factor Im in HeLa cells alters alternative polyadenylation within 3’ -UTRs. Nucleic Acids Res.,34, 6264-6271, 2006. DOI: 10.1093/nar/gkl794 |
242 | Uga, H., Kuramori, C., Ohta, A., Tsuboi, Y., Tanaka, H., Hatakeyama, M., Yamaguchi, Y., Takahashi, T., Kizaki, M. and Handa, H. A new mechanism of methotrxate action revealed by target screening with affinity beads. Mol. Pharmacol., 70, 1832-1839, 2006. DOI: 10.1124/mol.106.025866 |
241 | Kabe, Y., Ohmori, M., Shinouchi, K., Tsuboi, Y., Hirano, S., Azuma, M., Watanabe, H., Okura, I. and Handa, H. Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier. J. Biol. Chem., 281, 31729-31735, 2006. DOI: 10.1074/jbc.M604729200 |
240 | Nishio, K., Gokon, N., Tsubouchi, S., Ikeda, M., Narimatsu, H., Sakamoto, S., Izumi, Y., Abe, M. and Handa, H. Direct Detection of Redox Reactions of Sulfur-containing Compounds on Ferrite Nanoparticle (FP) Surface. Chem. Lett., 35, 974-975, 2006. DOI: /10.1246/cl.2006.974 |
239 | Aida, M., Chen, Y., Nakajima, K., Yamaguchi, Y., Wada, T. and Handa, H. Transcriptional Pausing Caused by NELF Plays a Dual Role in Regulating Immediate-Early Expression of the junB Gene. Mol. Cell. Biol., 26, 6094-6104, 2006. DOI: 10.1128/MCB.02366-05 |
238 | Sakurai, N., Miki, Y., Suzuki, T, Watanabe, K., Narita, T., Ando, K., Young, T.M.C., Aoki, D., Sasano, H. and Handa, H. Systemic distribution and tissue localizations of human 17beta-hydroxysteroid dehydrogenase type 12. J. Steroid Biochem. Mol. Biol., 99, 174-181, 2006. DOI: 10.1016/j.jsbmb.2006.01.010 |
237 | Kawano, M., Inoue, T., Tsukamoto, H., Takaya, T., Enomoto, T., Takahashi, R., Yokoyama, N., Yamamoto, N., Nakanishi, A., Imai, T., Wada, T., Kataoka, K. and Handa, H. The VP2/VP3 minor capsid protein of Simian Virus 40 promotes the in vitro assembly of the major capsid protein VP1 into particles. J. Biol. Chem., 281, 10164-10173, 2006. DOI: 10.1074/jbc.M511261200 |
236 | Okawa, K., Sekine, M., Maeda, M., Tada, M., Abe, M., Matsushita, N., Nishio, K. and Handa, H. Heating ability of magnetite nanobeads with various sizes for magnetic hyperthermia at 120kHz, a noninvasive frequency. J. Appl. Phys., 99, 08H102, 2006. DOI:10.1063/1.2173208 |
235 | Maeda, M., Kuroda, C.S., Shimura, T., Tada, M., Abe, M., Yamamuro, S., Sumiyama, K. and Handa, H. Magnetic carriers of iron nanoparticles coated with a functional polymer for high thoughput bio-screening. J. Appl. Phys., 99, 08H103, 2006. DOI: 10.1063/1.2165127 |
234 | Ogura, Y., Azuma, M., Tsuboi, Y., Kabe, Y., Yamaguchi, Y., Wada, T., Watanabe, H. and Handa, H. TFII-I douwnregulates a subset of estrogen-responsive genes through its interaction with an initiator element and estrogen receptor α. Genes Cells. 11, 373-381, 2006. DOI: 10.1111/j.1365-2443.2006.00952.x |
233 | Yamada, T., Yamaguchi, Y., Inukai, N., Okamoto, S., Mura, T. and Handa, H. P-TEFb-mediated phosphorylation of the hSpt5 C-terminal repeats is critical for processive transcription elongation. Mol. Cell, 21, 227-237, 2006. DOI: 10.1016/j.molcel.2005.11.024 |
232 | Togawa, K., Sanbonsugi, H., Sandhu, A., Abe, M., Narimatsu, H., Nishio, K. and Handa, H. Detection of magnetically labeled DNA using pseudomorphic AlGaAs/InGaAs/GaAs heterostructure micro-Hall biosensors. J. Appl. Phys., 99, 08P103, 2006. DOI: 10.1063/1.2162041 |
231 | Yamagata, M., Abe, M., Handa, H. and Kawaguchi, H. Magnetite/Polymer Composite Particles Prepared by Molecular Assembling Followed by In-Situ Magnetite Formation. Macromol. Symp., 245-246, 363-370, 2006. DOI: 10.1002/masy.200651350 |
230 | Kuroda, C. S., Shimura, T., Maeda, M., Tada, M., Handa, H., Sandhu, A. and Abe, M. “Ferrite Route” Preparation of Iron Nanoparticles and Their Encapsulation in Styrene-GMA Co-Polymer for Biomedical Applications. IEEE Trans. Magn., 42, 3569-3571, 2006. DOI: 10.1109/TMAG.2006.879622 |
229 | Shimazu, R., Tada, M., Matsushita, N., Handa, H. and Abe, M. Expediting Magnetic Separation Using Ni Wires, Applicable for Robot-Manipulated Bio-Screening Systems. IEEE Trans. Magn., 41, 4143-4145, 2005. DOI: 10.1109/TMAG.2005.855342 |
228 | Funabashi, H., Tanaka, Y., Imamura, Y., Mie, M., Manabe, T., Tanaka, H., Takahashi, T., Handa, H., Aizawa, M. and Kobatake, E. Glucose oxidase assisted homogeneous electrochemical receptor binding assay for drug screening. Biosens. Bioelectron., 21, 1675-1683, 2005. DOI: 10.1016/j.bios.2005.08.002 |
227 | Lapicki, A., Sanbonsugi, H., Yamamura, T., Matsuhita, N., Abe, M., Narimatsu, H., Handa, H., and Sandhu, A. Functionalization of micro-Hall effect sensors for biomedical applications utilizing superparamagnetic beads. IEEE Trans. Magn., 41, 4134-4136, 2005. DOI: 10.1109/TMAG.2005.855341 |
226 | Sandhu, A. and Handa, H. Practical Hall sensors for biomedical instrumentation. IEEE Trans. Magn., 41, 4123-4127, 2005. DOI: 10.1109/TMAG.2005.855339 |
225 | Kuroda, C. S., Maeda, M., Nishibiraki, H., Matsushita, N., Handa, H. and Abe, M. Styrene-coated iron nanobeads for medical use. IEEE Trans. Magn., 41, 4117-4119, 2005. DOI: 10.1109/TMAG.2005.855336 |
224 | Togawa, K., Sanbonsugi, H., Lapicki, A., Abe, M., Handa, H., and Sandhu, A. High sensitivity InSb thin-film micro-Hall sensor arrays for simultaneous multiple detection of magnetic beads for biomedical applications. IEEE Trans. Magn., 41, 3661-3663, 2005. DOI: 10.1109/TMAG.2005.854789 |
223 | Hasegawa, M., Ohno, H., Tanaka, H., Hatakeyama, M., Kawaguchi, H., Takahashi, T. and Handa, H. Affinity Identification of δ-Opioid Receptors Using Latex Nanoparticles. Bioorg. Med. Chem. Lett., 16, 158-161, 2005. DOI: 10.1016/j.bmcl.2005.09.028 |
222 | Azuma, N., Tadokoro, K., Asaka, A., Yamada, M., Yamaguchi, Y., Handa, H., Matsushima, S., Watanabe, T., Kida, Y., Ogura, T., Torii, M., Shimamura, K. and Nakafuku, M. Transdifferntiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor. Hum. Mol. Genet., 14, 1059-1068, 2005. DOI: 10.1093/hmg/ddi098 |
221 | Urano, A., Endoh, M., Wada, T., Morikawa, Y., Itoh, M., Kataoka, Y., Taki, T., Akazawa, H., Nakajima, H., Komuro, I., Yoshida, N., Hayashi, Y., Handa, H., Kitamura, T. and Nosaka, T. Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia. Mol. Cell. Biol., 25, 6834-6845, 2005. DOI: 10.1128/MCB.25.15.6834-6845.2005 |
220 | Kusunoki, N., Ito, T., Sakurai, N., Suguro, T., Handa, H. and Kawai, S. A novel celecoxib derivative potently induces apoptosis of human synovial fibroblasts. J. Pharmcol. Exp. Ther., 314, 796-803, 2005. DOI: 10.1124/jpet.105.086116 |
219 | Azuma, N., Tadokoro, K., Asaka, A., Yamada, M., Yamaguchi,Y., Handa, H., Matsushima, S., Watanabe, T., Kohsaka, S., Kida, Y., Shiraishi, T., Ogura, T., Shimamura, K. and Nakafuku, M. The Pax6 isoform bearing an alternative spliced exon promotes the development of the neural retinal structure. Hum. Mol. Genet., 14, 735-745, 2005. DOI: 10.1093/hmg/ddi069 |
218 | Delehouzee, S., Yoshikawa, T., Sawa, C., Sawada, J., Ito, T., Omori, M., Wada, T, Yamaguchi, Y., Kabe, Y. and Handa, H. GABP, HCF-1 and YY1 are involved in Rb gene expression during myogenesis. Genes Cells, 10, 717-731, 2005. DOI: 10.1111/j.1365-2443.2005.00873.x |
217 | Shimizu, N., Ouchida, R., Yoshikawa, N., Hisada, T., Watanabe, H., Okamoto, K., Kusuhara, M., Handa, H., Morimoto, C and Tanaka, H. HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b. Proc. Natl. Acad. Sci. USA, 102, 8555-8560, 2005. DOI: 10.1073/pnas.0409863102 |
216 | Oba, S., Hatakeyama, M., Handa, H. and Kawaguchi, H. Development of polymer latex particles for selctive cleavage of mismatched DNA and their application for DNA diagnosis. Bioconjugate Chemistry, 16, 551-558, 2005. DOI: 10.1021/bc049728l |
215 | Wu, C-H., Lee, C., Fan, R., Smith, M. J., Yamaguchi, Y., Handa, H. and Gilmour, D.S. Molecular characterization of Drosophila NELF. Nucleic Acids Res., 33, 1269-1279, 2005. DOI: 10.1093/nar/gki274 |
214 | Wang, G., Balamotis, M.A., Stevens, J.L., Yamaguchi, Y., Handa, H. and Berk, A.J. Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Mol. Cell, 5, 683-694, 2005. DOI: 10.1016/j.molcel.2005.02.010 |
213 | Parent, M., Young, T.M.C., Rancourt, A., Ho, E.L.Y., Vispe, S., Suzuki-Matsuda, F., Uehara, A., Wada, T., Handa, H. and Satoh, M. Poly(ADP-ribose) polymerase-1 is a negative regulator of HIV-1 transcription through competitive binding to TAR RNA with Tat·Positive transcription elongation factor b (p-TEFb) complex. J. Biol. Chem., 280, 448-457, 2005. DOI: 10.1074/jbc.M408435200 |
212 | Ohtsu, Y., Ohba, R., Imamura, Y., Kobayashi, M., Hatori, H., Zenkoh, T., Hatakeyama, M., Manabe, T., Hino, M., Yamaguchi, Y., Kataoka, K., Kawaguchi, H., Watanabe, H. and Handa, H. Selective ligand purification using high-performance affinity beads. Anal. Biochem., 338, 245-252, 2005. DOI: 10.1016/j.ab.2004.10.006 |
211 | Kabe, Y., Yamada, J., Uga, H., Yamaguchi, Y., Wada, T. and Handa, H. NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes. Mol. Cell. Biol., 25, 512-522, 2005. DOI: 10.1128/MCB.25.1.512-522.2005 |
210 | Kabe, Y., Ando, K. Hirao, S., Yoshida, M., and Handa, H. Redox Regulation of NF-κB activation : distinct redox regulation between the cytoplasm and the nucleus. Antioxid. Redox. Signal., 7, 393-403, 2005. DOI: 10.1089/ars.2005.7.395 |
209 | Nishibiraki, H., Kuroda, C.S., Maeda, M., Matsushita, N., Abe, M. and Handa, H. Preparation of medical magnetic nanobeads with ferrite particles encapsulated in a polyglycidyl methacrylate (GMA) for bioscreening. J. Appl. Phys., 97, 10Q919, 2005. DOI: 10.1063/1.1861272 |
208 | Togawa, K., Sanbonsugi, H., Sandhu, A., Abe, M., Narimatsu, H., Nishio, K. and Handa, H. High Sensitivity InSb Hall Effect Biosensor Platform for DNA Detection and Biomolecular Recognition Using Functionalized Magnetic Nanobeads. Jpn. J. Appl. Phys., 44, 46-49, 2005. DOI:10.1143/JJAP.44.L1494 |
207 | Watanabe, H., Suzuki, A., Goto, M., Ohsako, S., Tohyoma, C., Handa, H. and Iguchi, T. Comparative uterine gene expression analisis after dioxin and estradiol administration. J. Mol. Endocr., 33, 763-771, 2004. DOI: 10.1677/jme.1.01529 |
206 | Jennings, B.H., Shah, S., Yamaguchi, Y., Seki, M., Phillips, R.G., Handa, H. and Ish-Horowicz, D. Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila. Curr. Biol., 14, 1680-1684, 2004. DOI: 10.1016/j.cub.2004.08.066 |
205 | Imamura, Y., Ohtsu, Y., Tanaka, H., Hatakeyama, M., Manabe, T., Kawaguchi, H., Handa, H. and Takahashi, T. Synthesis of affinity nanoparticles coupled to FR901464 derivatives. Heterocycles, 64, 51-56, 2004. https://iss.ndl.go.jp/books/R000000004-I7224795-00 (DOI不明)別刷り有 |
204 | Hiramoto, M., Kawakami, Y., Nabeshima, R., Shima, D., Handa, H. and Aizawa, S. Identification of differentiation-inducing activity produced by human bone marrow stromal cell line LP101. Int. J. Mol. Med., 14, 867-872, 2004. DOI:10.3892/ijmm.14.5.867 |
203 | Kwei, J.S.M., Kuraoka, I., Horibata, K., Ubukata, M., Kobatake, E., Iwai, S., Handa, H and Tanaka, K. Blockage of RNA polymerase II at a cyclobutane pyrimidine dimer and 6-4 photoproduct. Biochem. Biophys. Res. Commun., 320, 1133-1138, 2004. DOI: 10.1016/j.bbrc.2004.06.066 |
202 | Nishio, K., Hasegawa, M., Ikeda, M., Narimatsu, H., Hase, Y., Ogura, Y., Gokon, N.,Tsubouchi, S., Hatakeyama, M., Abe, M. and Handa, H. Synthesis of monodisperse ferrite nanoparticles coated with polyacrylic acid (PAA). Trans. Mater. Res. Soc. Jpn., 29, 1659-1662, 2004. 別刷り有 |
201 | Aiyar, S.E., Sun, J-L., Blair, A.L., Moskaluk, C.A., Lu, Y.Z., Ye, Q-N., Yamaguchi, Y., Mukherjee, A., Ren, D-M., Handa, H. and Li, R. Attenuation of estrogen receptor α-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev., 18, 2134-2146, 2004. DOI: 10.1101/gad.1214104 |
200 | Hatori, H., Zenkoh, T., Kobayashi, M., Ohtsu, Y., Shigematsu, N., Setoi, H., Hino, M. and Handa, H. FR-225659-binding proteins: identification as serine/threonine protein phosphatase PP1 and PP2A using high-performance affinity beads. J. Antibiotics, 57, 456-461, 2004. DOI: 10.7164/antibiotics.57.456 |
199 | Zenkoh, T., Hatori, H., Tanaka, H., Hasegawa, M., Hatakeyama, M., Kabe, Y., Setoi, H., Kawaguchi, H., Handa, H. and Takahashi, T. Design and synthesis of a solid-supported FR225659 derivative for its receptor screening. Org. Lett., 6, 2477-2480, 2004. DOI:10.1021/ol049100q |
198 | Sandhu, A., Sanbonsugi, H., Shibasaki, I., Abe, M. and Handa, H. High sensitivity InSb ultra-thin film micro-Hall sensors for bioscreening applications. Jpn. J. Appl. Phys., 43, 868-870, 2004. DOI:10.1143/JJAP.43.L868 |
197 | Oshima. S., Nakamura. T., Namiki. S., Okada. E., Tsuchiya. K., Okamaoto. R., Yamazaki. M., Yokota. T., Aida. M., Yamaguchi. Y., Kanai. T., Handa, H. and Watanabe, M. Interferon Regulatory Factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol. Cell. Biol., 24, 6298-6310, 2004. DOI: 10.1128/MCB.24.14.6298-6310.2004 |
196 | Watanabe, H., Suzuki, M., Goto, M., Lubahn, D. B., Handa, H. and Iguchi, T. Tissue-specific estrogenic and non-estrogenic effects of a xenoestrogen, nonylphenol. J. Mol. Endocr., 33, 243-252, 2004. DOI: 10.1677/jme.0.0330243 |
195 | Sawa, C., Nedea, E., Krogan, N., Wada, T., Handa, H., Greenblatt, J. and Buratowski, S. Bromodomai factor 1 (Bdf1) is phosphorylated by protein kinase CK2. Mol. Cell. Biol., 24, 4734-4742, 2004. DOI: 10.1128/MCB.24.11.4734-4742.2004 |
194 | Mandal. S.S, Chu, C., Wada, T., Handa, H., Shatkin, A.J. and Reinberg, D. Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II. Proc. Natl. Acad. Sci. USA, 101, 7572-7577, 2004. DOI: 10.1073/pnas.0401493101 |
193 | Endo, M., Zhu, W., Hasegawa, J., Watanabe, H., Kim, D-K., Aida, M., Inukai, N., Narita, T., Yamada, T., Furuya, A., Sato, H., Yamaguchi, Y., Mandal, S.S., Reinberg, D., Wada, T. and Handa, H. Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. Mol. Cell. Biol., 24, 3324-3336, 2004. DOI: 10.1128/MCB.24.8.3324-3336.2004 |
192 | Ainbinder, E., Amir-Zilberstein, L., Yamaguchi, Y., Handa, H. and Dikstein, R. Elongation inhibition by DRB sensitivity-inducing factor is regulated by the A20 promoter via a novel negative element and NF-κB. Mol. Cell. Biol., 24, 2444-2454, 2004. DOI: 10.1128/mcb.24.6.2444-2454.2004 |
191 | Inukai, N., Yamaguchi, Y., Kuraoka, I., Yamada, T., Kamijo, S., Kato, J., Tanaka, K. and Handa, H. A novel hydrogen peroxide-induced phosphorylation and ubiqutination pathway leading to RNA polymerase II proteolysis. J. Biol. Chem., 279, 8190-8195, 2004. DOI: 10.1074/jbc.M311412200 |
190 | Han, S-I., Kawano, M., Ishizu, K-I., Watanabe, H., Hasegawa, M., Kanesashi, S-N., Kim, Y-S., Nakanishi, A., Kataoka, K. and Handa, H. Rep68 protein of adeno-associated virus type 2 interacts with 14-3-3 proteins depending on phosphorylation at serine 535. Virology, 320, 144-155, 2004. DOI: 10.1016/j.virol.2003.11.024 |
189 | Miyazawa, S., Suzuki, A., Katsu, Y., Kobayashi, M., Goto, M., Handa, H., Watanabe, H. and Iguchi, T. Persistent gene expression in mouse vagina exposed neonatally to diethylstilbesterol. J. Mol. Endocrinol., 32, 663-677, 2004. DOI: 10.1677/jme.0.0320663 |
188 | Nakadai, T., Shimada, M., Shima, D., Handa, H. and Tamura, T. Specific interaction with transcription factor IIA and localization of the mammalian TATA-binding protein-like protein (TLP/TRF2/TLF). J. Biol. Chem., 279, 7477-7455, 2004. DOI: 10.1074/jbc.M305412200 |
187 | Kataoka, K., Shioda, S., Ando, K., Sakagami, K., Handa, H. and Yasuda, K. Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet α- and β-cells. J. Mol. Endocrinol., 32, 9-20, 2004. DOI: 10.1677/jme.0.0320009 |
186 | Nedialkov, Y.A., Gong, X.Q., Yamaguchi, Y., Handa, H. and Burton, Z.F. Assay of transient state kinetics of RNA polymerase II elongation. Methods Enzymol., 371, 252-264, 2003. DOI: 10.1016/S0076-6879(03)71018-0 |
185 | Shirai, T., Maehara, A., Kiritooshi, N., Matsuzaki, F., Handa, H. and Nakagoshi, H. Differential requirement of EGFR signaling for the expression of defective proventriculus gene in the Drosophila endoderm and ectoderm. Biochem. Biophy. Res. Commun., 311, 473-477, 2003. DOI: 10.1016/j.bbrc.2003.10.017 |
184 | Watanabe, H., Suzuki, A., Kobayashi, M,, Lubahn, D.B., Handa, H. and Iguchi, T. Similarities and differences in uterine gene expression patterns caused by treatment with physiological and non-physiological estrogens. J. Mol. Endocrinol., 31, 487-497, 2003. DOI: 10.1677/jme.0.0310487 |
183 | Hatanaka, S., Matsushita, N., Abe, M., Nishimura, K., Hasegawa, M. and Handa, H. Direct immobilization of fluorescent dyes onto ferrite nanoparticles during their synthesis from aqueous solution. J. Appl. Phys., 93, 7569, 2003. DOI: 10.1063/1.1558677 |
182 | Ando, K., Shioda, S., Handa, H. and Kataoka, K. Isolation and characterization of an alternatively spliced variant of transcription factor Islet-1. J. Mol. Endocrinol., 31, 419-425, 2003. DOI: 10.1677/jme.0.0310419 |
181 | Imaki, H., Nakayama, K., Delehouzee, S., Handa, H., Kitagawa, M., Kamura, T. and Nakayama, K.I. Cell Cycle-dependent regulation of the Skp2 promoter by GA-binding protein. Cancer Res., 63, 4607-4613, 2003. Pubmed:12907639 (DOI不明) |
180 | Shimojima, T., Okada, M., Nakayama, T., Ueda, H., Okawa, K., Iwamatsu, A., Handa, H. and Hirose, S. Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor. Genes Dev., 17, 1605-1616, 2003. DOI: 10.1101/gad.1086803 |
179 | Wu, C-H., Yamaguchi, Y., Benjamin, L.R., Horvat-Gordon, M., Washinski, J., Enerly, E., Larsson, J., Lambertsson, A., Handa, H. and Gilmour, D. NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. Genes Dev., 17, 1402-1414, 2003. DOI: 10.1101/gad.1091403 |
178 | Nedialkov, Y.A., Gong, X.Q., Hovde, S.L., Yamaguchi, Y., Handa, H., Geiger, J.H., Yan, H. and Burton, Z.F. NTP-driven translocation by human RNA polymerase II. J. Biol. Chem., 278, 18303-18312, 2003. DOI: 10.1074/jbc.M301103200 |
177 | Azuma, N., Yamaguchi, Y., Handa, H., Tadokoro, K., Asuka, A., Kawase, E., and Yamada, M. Mutations of the PAX6 gene detected in patients with a variety of optic-nerve malformations. Am. J. Hum. Genet., 72, 1565-1570, 2003. DOI: 10.1086/375555 |
176 | Kanesashi, S., Ishizu, K., Kawano, M., Han, S-I., Tomita, S., Watanabe, H., Kataoka, K. and Handa, H. Simian virus 40 VP1 capsid protein forms polymorphic assembles in vitro. J. Gen. Virol., 84, 1899-1905, 2003. DOI: 10.1099/vir.0.19067-0 |
175 | Watanabe, H., Suzuki, A., Kobayashi, M., Takahashi, E., Itamoto, M., Lubahn, D.B., Handa, H. and Iguchi, T. Analysisi of temporal changes in the expression of estrogen-regulated genes in the uterus. J. Mol. Endocrinol., 30, 347-358, 2003. DOI: 10.1677/jme.0.0300347 |
174 | Li, P.P., Nakanishi, A., Tran, M.A., Ishizu, K-I., Kawano, M., Phillips, M., Handa, H., Liddington, R.C. and Kasamatsu, H. Important of Vp1 calucium-binding residues in assembly, cell entry, and nuclear entry of Simian Virus 40. J. Virol., 77, 7527-7538, 2003. DOI: 10.1128/jvi.77.13.7527-7538.2003 |
173 | Narita, T., Yamaguchi, Y., Yano, K., Sugimoto, S., Chanarat, S.,Wada, T., Kim, D-K., Hasegawa, J., Omori, M., Inukai, N., Endoh, M., Yamada, T., and Handa, H. Human transcription elongation factor NELF: Identification of novel subunits and reconstitution of the functionally active complex. Mol. Cell. Biol., 23, 1863-1873, 2003. DOI: 10.1128/MCB.23.6.1863-1873.2003 |
172 | Kim, D-K., Inukai, N., Yamada, T., Furuya, A., Sato, H., Yamaguchi, Y., Wada, T. and Handa, H. Structure–function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex. Genes Cells, 8, 371-378, 2003. DOI: 10.1046/j.1365-2443.2003.00638.x |
171 | Shima, D., Yugami, M., Tatsuno, M., Wada, T., Yamaguchi, Y. and Handa, H. Mechanism of H-8 inhibition of Cyclin-dependent kinase 9: study using inhibitor-immobilized matrices. Genes Cells, 8, 215-223, 2003. DOI: 10.1046/j.1365-2443.2003.00627.x |
170 | Ouchida, R., Kusuhara, M., Shimizu, N., Hisada, T., Makino, Y., Morimoto, C., Handa, H., Ohsuzu, F. and Tanaka, H. Suppression of NF-κB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells. Genes Cells, 8, 95-107, 2003. DOI: 10.1046/j.1365-2443.2003.00618.x |
169 | Hasegawa, J., Endou, M., Narita, T., Yamada, T., Yamaguchi, Y., Wada, T. and Handa, H. A rapid purification method for human RNA polymerase II by two-step affinity chromatography. J. Biochem., 133, 133-138, 2003. DOI: 10.1093/jb/mvg013 |
168 | Kuraoka, I., Endou, M., Yamaguchi, Y., Wada, T., Handa, H. and Tanaka, K. Effects of endogeneous DNA base lesions on transcription elongation by mammalian RNA polymerase II: implications for transcription-coupled DNA repair and transcriptional mutagenesis. J. Biol. Chem., 278, 7294-7299, 2003. DOI: 10.1074/jbc.M208102200 |
167 | Bando, M., Hasegawa, M., Tsuboi, Y., Miyake, Y., Shiina, M., Ito, M., Handa, H., Nagai, K. and Kataoka, T. The mycotoxin penicillic acid inhibits Fas ligand-induced apotosis by blocking self-processing of caspase-8 in death-inducing signaling complex. J. Biol. Chem., 278, 5786-5793, 2003. DOI: 10.1074/jbc.M204178200 |
166 | Oda, T., So, Y., Sato, Y., Shimizu, N., Handa, H., Yasukochi, Y. and Kasahara, T. Inhibition by (+/-)-indenesterol A of interferon gamma-stimulated nitric oxide formation in murine macrophage RAW 264.7 cells. Mutat Res., 534, 187-195, 2003. DOI: 10.1016/s1383-5718(02)00275-9 |
165 | Hasegawa, M., Uga, H., Ohba, R., Tsuboi, Y., Sato, I., Tang, J., Kabe, Y. and Handa, H. Development of affinity-purification technology for identification of drug receptors. Recent Res. Devel. Biophys. Biochem., 3, 445-456, 2003. (DOI不明) 別刷り有 |
164 | Kataoka, K., Han, S-I., Shioda, S., Hirai, M., Nishizawa, M. and Handa, H. MafA is a glucose-regulated and pancreatic β-cell-specific transcriptional activator for the insulin gene. J. Biol. Chem., 277, 49903-49910, 2002. DOI: 10.1074/jbc.M206796200 |
163 | Nishi, T., Shimizu, N., Hiramoto, M., Sato. I., Yamaguchi, Y., Hasegawa, M., Aizawa, S., Tanaka, H., Kataoka, K., Watanabe, H. and Handa, H. Spatial redox regulation of a critical cysteine residue of NF-κB in vivo. J. Biol. Chem., 277, 44548-44556, 2002. DOI: 10.1074/jbc.M202970200 |
162 | Oda, T., Ueda, A., Shimizu, N., Handa, H. and Kasahara, T. Suppression of monocyte chemoattractant protein 1, but not IL-8, by alprazolam: effect of alprazolam on c-Rel/p65 and c-Rel/p50 binding to the monocyte chemoattractant protein 1 promoter region. J. Immunol., 169, 3329-3335, 2002. DOI: 10.4049/jimmunol.169.6.3329 |
161 | Sawa, C., Yoshikawa, T., Matsuda-Suzuki, F., Deléhouzée, S., Goto, M., Watanabe, H., Sawada, J., Kataoka, K., and Handa, H. YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors. J. Biol. Chem., 277, 22484-22490, 2002. DOI:10.1074/jbc.M203060200 |
160 | Tomohiro, T., Sawada, J., Sawa, C., Nakura, H., Yoshida, S., Kodaka, M., Hatakeyama, M., Kawaguchi, H., Handa, H. and Okuno, H. Total analysis and purification of cellular proteins brinding to cisplatin-damaged DNA using submicron beads. Bioconjug. Chem., 13, 163-166, 2002. DOI: 10.1021/bc015560h |
159 | Nishimura, K., Hasegawa. M., Ogura, Y., Nishi, T., Kataoka, K., Handa, H. and Abe, M. 4 °C preparation of ferrite nanoparticles having protein molecules immobilized on their surfaces. J. Appl. Phys., 91, 8555-8556, 2002. DOI:10.1063/1.1452207 |
158 | Hiramoto, M., Shimizu, N., Nishi, T., Shima, D., Aizawa, S., Tanaka, H., Hatakeyama, M., Kawaguchi, H. and Handa, H. [8] - High-performance affinity beads for identifying anti-NF-κB drug receptors. Methods Enzymol., 353, 81-88, 2002. DOI: 10.1016/s0076-6879(02)53038-x |
157 | Watanabe, H., Suzuki, A., Mizutani, T., Khono, S., Lubahn, D.B., Handa, H. and Iguchi, T. Genome-wide analysis of changes in early gene expression induced by oestrogen. Genes Cells, 7, 497-507, 2002. DOI: 10.1046/j.1365-2443.2002.00535.x |
156 | Yamaguchi, Y., Inukai, N., Narita, T., Wada, T. and Handa, H. Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. Mol. Cell Biol., 22, 2918-2927, 2002. DOI:10.1128/MCB.22.9.2918-2927.2002 |
155 | Yoshimatsu, T., Saitoh, A., Ryu, J.N.S., Shima, D., Handa, H., Hiramoto, M., Kawakami, Y., and Aizawa, S. Characterization of immortalized human chondrocytes originated from osteoarthritis cartilage. Int. J. Mol. Med., 8, 345-351, 2001. DOI: 10.3892/ijmm.8.4.345 |
154 | Renner, D.B., Yamaguchi, Y., Wada, T., Handa, H. and Price, D.H. A highly purified RNA polymerase II elongation control system. J. Biol. Chem., 276, 42601-42609, 2001. DOI: 10.1074/jbc.M104967200 |
153 | Lavoie, S.B., Albert, A.L., Handa, H., Vincent, M. and Bensaude, O. The Peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9. J. Mol Biol., 312, 675-685, 2001. DOI: 10.1006/jmbi.2001.4991 |
152 | Kataoka, K., Shioda, S., Yoshitomo-Nakagawa, K., Handa, H. and Nishizawa, M.. Maf and Jun nuclear oncoproteins share downstream target genes for inducing cell transformation. J. Biol. Chem., 276, 36849-36856, 2001. DOI: 10.1074/jbc.M102234200 |
151 | Kataoka, K., Handa, H., and Nishizawa, M. Induction of cellular antioxidative stress genes through heterodimeric transcription factor Nrf2/small Maf by antirheumatic gold(I) compounds. J. Biol. Chem., 276, 34074-34081, 2001. DOI: 10.1074/jbc.M105383200 |
150 | Yamaguchi, Y., Filipovska, J., Yano, K., Furuya, A., Inukai, N., Narita, T., Wada, T., Sugimoto, S., Konarska, M.M. and Handa, H. Stimulation of RNA polymerase II elongation by hepatitis delta antigen. Science, 293, 124-127, 2001. DOI: 10.1126/science.1057925 |
149 | Morii, E., Ogihara, H., Oboki, K., Sawa, C., Sakuma, T., Nomura, S., Esko, J.D., Handa, H. and Kitamura, Y. Inhibitory effect of the mi transcription factor encoded by the mutant mi allele on GA binding protein-mediated transcript expression in mouse mast cells. Blood, 97, 3032-3039, 2001. DOI: 10.1182/blood.v97.10.3032 |
148 | Shiba, K., Hamaguchi, T., Kataoka, K., Yamaguchi, Y., Handa, H. and Adachi, K. Cloning of the hamster androgen receptor gene. J. Dermatol. Sci., 26, 163-168, 2001. DOI: 10.1016/s0923-1811(00)00172-9 |
147 | Ishizu, K-I., Watanabe, H., Han, S-I., Kanesashi, S-N., Hoque, M., Yajima, H., Kataoka, K. and Handa, H. Roles of disulfide linkage and calcium ion-mediated interactions in assembly and disassembly by virus-like particles composed of simian virus 40 VP1 capsid protein. J. Virol., 75, 61-72, 2001. DOI: 10.1128/JVI.75.1.61-72.2001 |
146 | Guo, S., Yamaguchi, Y., Schilbach, S., Wada, T., Lee, J., Goddard, A., French, D., Handa, H. and Rosenthal, A. A regulator of transcriptional elongation controls vertebrate neuronal development. Nature, 408, 366-369, 2000. DOI: 10.1038/35042590 |
145 | Yoshida, N., Yoshida, S., Araie, M., Handa, H. and Nabeshima, Y-I. Ets family transcription factor ESE-1 is expressed in corneal epithelial cells and is involved in their differentiation. Mech. Dev., 97, 27-34, 2000. DOI: 10.1016/s0925-4773(00)00419-6 |
144 | Aizawa, S., Hiramoto, M., Hoshi, H., Shima, D., Handa, H. and Toyama, K. Induction of apoptotic change of hematopoietic cells by cloned stromal cells from MDS patient via direct cellular interactions. Exp. Hematol., 28, 69, 2000. DOI: 10.1016/S0301-472X(00)00304-0 |
143 | Aizawa, S., Shimizu, N., Handa, H., Hiramoto, M., Hoshi, H., Nagasu, M., Kanno, H., Nagasu, Y. and Imanishi, Y. Effects of cyclic polylactate (CPL) on the growth of cloned leukemic cells in vitro. Hematol. Oncol., 18, 51-60, 2000. DOI: 10.1002/1099-1069(200006)18:2<51::aid-hon656>3.0.co;2-p |
142 | Shimizu, N., Sugimoto, K., Tang, J., Nishi, T., Sato, I., Hiramoto, M., Aizawa, S., Hatakeyama, M., Ohba, R., Hatori, H., Yoshikawa, T., Suzuki, F., Oomori, A., Tanaka, H., Kawaguchi, H., Watanabe, H. and Handa, H. High-performance affinity beads for identifying drug receptors. Nature. Biotechnol., 18, 877-881, 2000. DOI: 10.1038/78496 |
141 | Wada, T., Orphanides, G., Hasegawa, J., Kim, D-K., Shima, D., Yamaguchi, Y., Fukuda, A., Hisatake, K., Oh, S., Reinberg, D. and Handa, H. FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. Mol. Cell, 5, 1067-1072, 2000. DOI: 10.1016/s1097-2765(00)80272-5 |
140 | Satoh, S., Hirota, M., Noguchi, T., Hijikata, M., Handa, H. and Shimotohno, K. Cleavage of hepatitis C virus nonstructural protein 5A by a caspase-like protease(s) in mammalian cells. Virology, 270, 476-487, 2000. DOI: 10.1006/viro.2000.0287 |
139 | Araki-Sasaki, K., Aizawa, S., Hiramoto, M., Nakamura, M., Iwase, O., Nakata, K., Sasaki, Y., Mano, T., Handa, H. and Tano, Y. Substance P-induced cadherin expression and its signal transduction in a cloned human corneal epithelial cell line. J. Cell Physiol., 182, 189-195, 2000. DOI: 10.1002/(SICI)1097-4652(200002)182:2<189::AID-JCP7>3.0.CO;2-9 |
138 | Aizawa, S., Hiramoto, M., Hoshi, H., Toyama., K., Shima, D. and Handa, H. Establishment of stromal cell line from an MDS RA patient which induced an apoptopic change in hematopoietic and leukemic cells in vitro. Exp. Hematol., 28, 148-155, 2000. DOI: 10.1016/s0301-472x(99)00142-3 |
137 | Takayama, M., Kim, E., Kidokoro, M., Shimamura, K., Shiroki, K., Yajima, H., Kosukegawa, A., Handa, H. and Inokuchi, S. Transfer of SV40 temperature-sensitive early gene into human epidermal keratinocytes by the recombinant adenovirus vector. In Vitro Cell. Dev. Biol., 36, 110-116, 2000. DOI: 10.1290/1071-2690(2000)036<0110:tostse>2.0.co;2 |
136 | Mishima, M., Ozaki, J., Ikegami, T., Kabe, Y., Goto, M., Ueda, H., Hirose, S., Handa, H. and Shirakawa, M. Resonance assignments, secondary structure and 15N relaxation data of the human transcriptional coactivator hMBF1(57-148). J. Biomol. NMR., 14, 373-376, 1999. DOI: 10.1023/a:1008347729176 |
135 | Hoque, M., Shimizu, N., Ishizu, K-I., Yajima, H., Arisaka, F., Suzuki, K., Watanabe, H., and Handa, H. Chimeric virus-like particle formation of adeno-associated virus. Biochem. Biophys. Res. Commun., 266, 371-376, 1999. DOI: 10.1006/bbrc.1999.1831 |
134 | Kabe, Y., Goto, M., Shima, D., Imai, T., Wada, T., Morohashi, K-I., Shirakawa, M., Hirose, S. and Handa, H. The role of human MBF1 as a transcriptional coactivator. J. Biol. Chem., 274, 34196-34202, 1999. DOI: 10.1074/jbc.274.48.34196 |
133 | Sawada, J-I., Shimizu, N., Suzuki, F., Sawa, C., Goto, M., Hasegawa, M., Imai, T., Watanabe, H. and Handa, H. Synergistic transcriptional activation of hGABP and select members of the activation transcription Factor/cAMP response element-binding protein family. J. Biol. Chem., 274, 35475-35482, 1999. DOI: 10.1074/jbc.274.50.35475 |
132 | Tsutsui, H., Geltinger, C., Murata, T., Itakura, K., Wada, T., Handa, H. and Yokoyama, K.K. The DNA-binding and transcriptional activities of MAZ, a myc-associated zinc finger protein, are regulated by casein kinase II. Biochem. Biophys. Res. Commun., 262, 198-205, 1999. DOI: 10.1006/bbrc.1999.1130 |
131 | Kim, J.B., Yamaguchi, Y., Wada, T., Handa, H. and Sharp, P.A. Tat-SF1 Protein associates with RAP30 and Human SPT5 Proteins. Mol. Cell. Biol., 19, 5960-5968, 1999. DOI: 10.1128/mcb.19.9.5960 |
130 | Hoque, M., Ishizu, K-I., Matsumoto, A., Han, S-I., Arisaka, F., Takayama, M., Suzuki, K., Kato, K., Kanda, T., Watanabe, H. and Handa, H. Nuclear transport of the major capsid protein is essential for Adeno-Associated Virus Capsid Formation. J. Virol., 73, 7912-7915, 1999. DOI:10.1128/JVI.73.9.7912-7915.1999 |
129 | Aizawa, S., Nakano, M., Iwase, O., Yaguchi, M., Hiramoto, M., Hoshi. H., Nabeshima, R., Shima, D., Handa, H. and Toyama, K. Bone marrow stroma from refractory anemia of myelodysplastic syndrome is defective in its ability to support normal CD34-positive cell proliferation and differentiation in vitro. Leuk. Res., 23, 239-246, 1999. DOI: 10.1016/s0145-2126(98)00163-5 |
128 | Ozaki, J., Takemaru, K-I., Ikegami, T., Mishima, M., Ueda, H., Hirose, S., Kabe, Y., Handa, H., and Shirakawa, M. Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1. Genes Cells, 4, 415-424, 1999. DOI: 10.1046/j.1365-2443.1999.00267.x |
127 | Azuma, N., Yamaguchi, Y., Handa, H. Hayakawa, M., Kanai, A. and Yamada, M. Missense mutation in the alternative splice region of the PAX6 gene in eye anomalies. Am. J. Hum. Genet., 65, 656-663, 1999. DOI:10.1086/302529 |
126 | Hashimoto, M., Chayama, K., Kobayashi, M., Tsubota, A., Arase, Y., Saitoh, S., Suzuki, Y., Ikeda, K., Matsuda, M., Koike, H., Kobayashi, M., Handa, H. and Kumada, H. Fluctuations of hepatitis C virus load are not related to amino acid substitutions in hypervariable region 1 and interferon sensitivity determining region. J. Med. Virol., 58, 247-255, 1999. DOI: 10.1002/(sici)1096-9071(199907)58:3<247::aid-jmv10>3.0.co;2-3 |
125 | Satoh, S., Hijikata, M., Handa, H. and Shimotohno, K. Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha. Biochem. J., 342, 65-70, 1999. PMID: 10432301 (DOI不明) |
124 | Nishina, S., Kohsaka, S., Yamaguchi, Y., Handa, H., Kawakami, A., Fujisawa, H. and Azuma, N. PAX6 expression in the developing human eye. Br. J. Ophthal., 83, 723-727, 1999. DOI: 10.1136/bjo.83.6.723 |
123 | Sanda, F., Kamatani, J., Handa, H. and Endo, T. Radical polymerization behavior of a proline-substituted acrylamide. Effect of s-cis-s-trans isomerization on the polymerization. Macromolecules, 32, 2490-2494, 1999. DOI:10.1021/ma9814090 |
122 | Yamaguchi, Y., Wada, T., Watanabe, D., Takagi, T., Hasegawa, J. and Handa, H. Structure and function of the human transcription elongation factor DSIF. J. Biol. Chem., 274, 8085-8092, 1999. DOI: 10.1074/jbc.274.12.8085 |
121 | Yamaguchi, Y., Takagi, T., Wada, T., Yano, K., Furuya, A., Sugimoto, S., Hasegawa, J. and Handa, H. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA plymerase II elongation. Cell, 97, 41-51, 1999. DOI: 10.1016/s0092-8674(00)80713-8 |
120 | Aizawa, S., Nakano, M., Iwase, O., Yaguchi, M., Hiramoto, M., Hoshi, H., Nabeshima, R., Shima, D., Handa, H. and Toyama, K. Bone marrow stroma from refractory anemia of myelodysplastic syndrome is defective in its ability to support normal CD34-positive cell proliferation and differentiation in vitro. Leuk. Res., 23, 239-246, 1999. DOI: 10.1016/s0145-2126(98)00163-5 |
119 | van Dijk, T.B., Baltus, B., Caldenhoven, E., Handa, H., Raaijmakers, J.A.M., Lammers, J-W.J., Koenderman, L. and de Groot, R.P. Cloning and characterization of the human interleukin-3 (IL-3)/IL-5/granulocyte-macrophage colony-stimulating factor receptor βc gene: Regulation by Ets family members. Blood, 92, 3636-3646, 1998. DOI: 10.1182/blood.V92.10.3636 |
118 | Toyoda, M., Gotoh, N., Handa, H. and Shibuya, M. Involvement of MAP kinase-independent protein kinase C signaling pathway in the EGF-induced p21(WAF1/Cip1) expression and growth inhibition of A431 cells. Biochem. Biophys. Res. Commun., 250, 430-435,1998. DOI: 10.1006/bbrc.1998.9332 |
117 | Wada, T., Takagi, T., Yamaguchi, Y., Watanabe, D. and Handa, H. Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro. EMBO J., 17, 7395-7403, 1998. DOI: 10.1093/emboj/17.24.7395 |
116 | Suzuki, F., Goto, M., Sawa, C., Ito, S., Watanabe, H., Sawada, J-I. and Handa, H. Functional interactions of transcription factor human GA-binding protein subunits. J. Biol. Chem., 273, 29302-29308, 1998. DOI: 10.1074/jbc.273.45.29302 |
115 | Yamaguchi, Y., Wada, T., Suzuki, F., Takagi, T., Hasegawa, J. and Handa, H. Casein kinase II interacts with the bZIP domains of several transcription factors. Nucleic Acids Res., 26, 3854-3861, 1998. DOI: 10.1093/nar/26.16.3854 |
114 | Hatakeyama, M., Nakamura, K., Iwato, S., Handa, H., Fujimoto, K. and Kawaguchi, H. DNA-carrying latex particles for DNA diagnosis. 2. Distinction of normal and point mutant DNA using S1 nuclease. Colloids Surf. B, 10, 171-178, 1998. DOI:10.1016/S0927-7765(97)00058-1 |
113 | Hatakeyama, M., Iwato, S., Fujimoto, K., Handa, H. and Kawaguchi, H. DNA-carrying latex particles for DNA diagnosis. 1. Separation of normal and point mutant DNAs according to the difference in hybridization efficiency. Colloids Sur. B, 10, 161-169, 1998. DOI:10.1016/S0927-7765(97)00059-3 |
112 | Vassias, I., Hazan, U., Michel, Y., Sawa, C., Handa, H., Gouya, L. and Morinet, F. Regulation of human B19 parvovirus promoter expression by hGABP (E4TF1) transcription factor. J. Biol. Chem., 273, 8287-8293, 1998. DOI: 10.1074/jbc.273.14.8287 |
111 | Hirano, F., Tanaka, H., Hirano, Y., Hiramoto, M., Handa, H., Makino, I. and Scheidereit, C. Functional interference of sp1 and NF-κB through the same DNA binding site. Mol. Cell. Biol., 18, 1266-1274, 1998. DOI: 10.1128/mcb.18.3.1266 |
110 | Hartzog, G.A., Wada, T., Handa, H. and Winston, F. Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae. Genes Dev., 12, 357-369, 1998. DOI: 10.1101/gad.12.3.357 |
109 | Wada, T., Takagi, T., Yamaguchi, Y., Ferdous, A., Imai, T., Hirose, S., Sugimoto, S., Yano, K., Hartzog, G.A., Winston, F., Buratowski, S. and Handa, H. DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. Genes Dev., 12, 343-356, 1998. DOI: 10.1101/gad.12.3.343 |
108 | Hiramoto, M., Aizawa, S., Iwase, O., Nakano, M., Toyama, K., Hoque, M., Nabeshima, R., Kaidow, A., Imai, T., Hoshi, H. and Handa, H. Stimulatory effects of substance P on CD34 positive cell proliferation and differentiation in vitro are mediated by the modulation of stromal cell function. Int. J. Mol. Med., 1, 347- 401, 1998. DOI: 10.3892/ijmm.1.2.347 |
107 | Hiramoto, M., Shimizu, N., Sugimoto, K., Tang, J., Kawakami, Y., Ito, M., Aizawa, S., Tanaka, H. Makino, I. and Handa, H. Nuclear targetted suppression of NF-kB activity by the novel quinone derivative E3330. J. Immunol., 160, 810-819, 1998. PMID: 9551916 (DOI不明) |
106 | Nakade, K., Handa, H. and Nagata, K. Promoter structure of the MxA gene that confers resistance to influenza virus. FEBS Lett., 418, 315-318, 1997. DOI: 10.1016/s0014-5793(97)01372-0 |
105 | Hatakeyama, M., Ogura, Y., Sawada, J., Fujimoto, K., Handa, H. and Kawaguchi, H. Preparation of dimerized polypeptide-carrying microspheres and purification of specific proteins bound to these microspheres. Colloids Surf. B, 10, 41-49, 1997. DOI: 10.1016/S0927-7765(97)00042-8 |
104 | Sowa, Y., Shiio, Y., Fujita, T., Matsumoto, T., Okuyama, Y., Kato, D., Inoue, J-I., Sawada, J-I., Goto, M., Watanabe, H., Handa, H. and Sakai, T. Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1. Cancer Res., 57, 3145-3148, 1997. PubMed: 9242441 (DOI不明) |
103 | Yamaguchi, Y., Sawada, J-I., Yamada, M., Handa, H. and Azuma, N. Autoregulation of Pax6 transcriptional activation by two distinct DNA-binding subdomains of the paired domain. Genes Cells, 2, 255-261, 1997. DOI: 10.1046/j.1365-2443.1997.1170315.x |
102 | Li, F.Q., Takemaru, K-I., Goto, M., Ueda, H., Handa, H. and Hirose, S. Transcriptional activation through interaction of MBF2 with TFIIA. Genes Cells, 2, 143-153, 1997. DOI:10.1046/j.1365-2443.1997.1090306.x |
101 | Aizawa, S., Nakano, M., Yaguchi, M., Kuriyama, Y., Iwase, O., Toyama, K., Tanaka, K., Hoshi, H., Sugimoto, K., Kaido, A., Imai, T., Nabeshima, R. and Handa, H. Possible involvement of bone marrow stromal cells in agranulocytosis caused by vesnarinone treatment. Acta Haematol., 98, 140-146, 1997. DOI: 10.1159/000203608 |
100 | Aoki, H., Seki, T., Sawada, J-I., Handa, H. and Adachi, K. The promoter of the androgen dependent gene in the hamster flank organ. J. Dermatol. Sci., 15, 36-43, 1997. DOI:10.1016/S0923-1811(97)00597-5 |
99 | Komai, T., Ishikawa, Y., Yagi, R., Suzuki-Sugawara, H., Nishigaki, T. and Handa, H. Development of HIV-1 protease expression methods using T7 phage promoter system. Appl. Microbiol. Biotechnol., 47, 241-245, 1997. DOI: 10.1007/s002530050920 |
98 | Komai, T., Yagi, R., Suzuki-Sunagawa, H., Sakurai, M., Higashida, S., Sugano, M., Handa, H., Mohri, H., Yasuoka, A., Oka, S., Yabe, Y., Nishigaki, T., Kimura, S. and Shimada, K. In vitro and ex vivo anti-human immunodeficiency virus(HIV) activities of a new water-soluble HIV protease inhibitor, R-87366, containing (2S,3S)-3-amino-2-hidroxy-4- phenylbutanoic acid. Biol..Pharm.Bull., 20, 175-180, 1997. DOI: 10.1248/bpb.20.175 |
97 | Nabeshima, R., Aizawa, S., Nakano, M., Toyama, K., Sugimoto, K., Kaidow, A., Imai, T. and Handa, H. Effects of vesnarinone on the bone marrow stromal cell-dependent proliferation and differentiation of HL60 cells in vitro. Exp. Hematol., 25, 509-515, 1997. PMID: 9197329 (DOI不明) |
96 | Murakami, M., Sonobe, M.H., Ui, M., Kabuyama, Y., Watanabe, H., Wada, T., Handa, H., and Iba, H. Phosphorylation and high level expression of Fra-2 in v-src transformed cells: a pathway of activation of endogeneous AP-1. Oncogene, 14, 2435-2444, 1997. DOI: 10.1038/sj.onc.1201077 |
95 | Imai, T., Matsuda, K., Shimojima, T., Hashimoto, T., Masuhiro, Y., Kitamoto, T., Sugita, A., Suzuki, K., Matsumoto, H., Masushige, S., Nogi, Y., Muramatsu, M., Handa, H. and Kato, S. ERC-55, a binding protein for the papilloma virus E6 oncoprotein, specifically interacts with vitamin D receptor among nuclear receptors. Biochem. Biophys. Res. Commun., 233, 765-769, 1997. DOI: 10.1006/bbrc.1997.6531 |
94 | Momose, F., Handa, H. and Nagata, K. Identification of host factors that regulate the influenza virus RNA polymerase activity. Biochimie, 78, 1103-1108, 1996. DOI: 10.1016/s0300-9084(97)86736-3 |
93 | Kamura, T., Handa, H., Hamasaki, N. and Kitajima, S. Characterization of the human thrombopoietin gene promoter : A POSSIBLE ROLE OF AN Ets TRANSCRIPTION FACTOR, E4TF1. J. Biol. Chem., 272, 11361-11368, 1997. DOI: 10.1074/jbc.272.17.11361 |
92 | Komai, T., Yagi, R., Suzuki-Sunagawa, H., Ishikawa, Y., Kasuya, A., Miyamoto, S., Handa, H. and Nishigaki, T. Inhibition of HIV-1 protease by oxim derivatives. Biochem. Biophys. Res. Commun., 230, 557-561, 1997. DOI: 10.1006/bbrc.1996.5907 |
91 | Kawase, H., Okuwaki, M., Miyaji, M., Ohba, R., Handa, H., Ishimi, Y., Fujii-Nakata, T., Kikuchi, A. and Nagata, K. NAP-1 is a functional homologue of TAF-1 that is required for replication and transcription of the adenovirus genome in a chromatin-like structure. Genes Cells, 1, 1045-1056, 1996. DOI: 10.1046/j.1365-2443.1996.d01-223.x |
90 | Komai, T., Higashida, S., Sakurai, M., Nitta, T., Kasuya, A., Miyamaoto, S., Yagi, R., Ozawa, Y., Handa, H., Mohri, H., Yasuoka, A., Oka, S., Nishigaki, T., Kimura, S., Shimada, K. and Yabe, Y. Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA-II. Modification of pyrrolidine ring at P1’ prolone. Bioorgan. Med. Chem., 4, 1365-1377, 1996. DOI: 10.1016/0968-0896(96)00130-7 |
89 | Sawa, C., Goto. M., Suzuki, F., Watanabe, H., Sawada. J-I. and Handa, H. Functional domains of transcription factor hGABPβ1/E4TF1-53 required for nuclear localization and transcription activation. Nucleic Acids Res., 24, 4954-4961, 1996. DOI:10.1093/nar/24.24.4954 |
88 | Yajima, H., Kosukegawa, A., Hoque, M.M., Shimojima, T., Ishizu, K-I., Takayama, M., Sasaki, Y., Sakai, H., Otsuka, M., Inokuchi, S. and Handa, H. Construction and characterization of a recombinant adenovirus vector carrying the human preproinsulin gene under the control of the methallothionein gene promoter. Biochem. Biophys. Res. Commun., 229, 778-787, 1996. DOI: 10.1006/bbrc.1996.1880 |
87 | Okazaki, T., Takita, J., Kohno, T., Handa, H. and Yokota, J. Detection of amplified genomic sequences in human small-cell lung carcinoma cells by arbitrarily primed-PCR genomic fingerprinting. Human Genomics, 98, 253-258, 1996. DOI: 10.1007/s004390050203 |
86 | Kosukegawa, A., Arisaka, F., Takayama, M., Yajima, H., Kaidow, A. and Handa, H. Purification and characterization of virus-like particles and pentamers produced by the expression of SV40 capsid proteins in insect cells. Biochim. Biophys. Acta., 1290, 37-45, 1996. DOI:10.1016/0304-4165(95)00184-0 |
85 | Hashimoto, M., Chayama, K., Tsubota, A., Kobayashi M., Saitou, S., Arase, Y., Ikeda, K., Kobayashi, M., Nakano, A., Takagi, K., Koike, H., Okamoto, K., Handa, H. and Kumada, H. Typing six major hepatitis C virus genotypes by polymerase chain reaction using primers derived from nucleotide sequences of the NS5 region. Int. Hepatol. Commun., 4, 263- 267, 1996. DOI:10.1016/0928-4346(96)00257-5 |
84 | Shimada, H., Wada, T., Handa, H., Ohta, H., Mizoguchi, H., Nishimura, K., Masuda, T., Shioi, Y. and Takamiya, K-I. A transcription factor with a leucine-zipper motif involved in light-dependent inhibition of expression of the puf operon in the photosynthetic bacterium Rhodobacter sphaeroides. Plant Cell Physiol., 37, 515-522, 1996. DOI: 10.1093/oxfordjournals.pcp.a028974 |
83 | Shiio, Y., Sawada, J., Handa, H., Yamamoto, T. and Inoue, J. Activation of the retinoblastoma gene expression by Bcl-3: Implication for muscle cell differentiation. Oncogene, 12, 1837-1845, 1996. PMID: 8649843 (DOI不明) |
82 | Wada, T., Takagi, T., Yamaguchi, Y., Kawase, H., Hiramoto, M., Ferdous, A., Takayama, M., Lee, K.A.W., Hurst, H.C. and Handa, H. Copurification of casein kinase II with transcription factor ATF/E4TF3. Nucleic Acids Res., 24, 876-884, 1996. DOI:10.1093/nar/24.5.876 |
81 | Hirano, F., Tanaka, H., Makino, Y., Okamoto, K., Hiramoto, M., Handa, H. and Makino, I. Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids. Carcinogenesis, 17, 427-433, 1996. DOI: 10.1093/carcin/17.3.427 |
80 | Imai, T., Sumi, Y., Hatakeyama M., Fujimoto, K., Kawaguchi, H., Hayashida, N., Shiozaki, K., Terada, K., Yajima, H. and Handa, H. Selective isolation of DNA or RNA using single-stranded DNA affinity latex particles. J. Colloid Interface Sci., 177, 245-249, 1996. DOI: 10.1006/jcis.1996.0027 |
79 | Watanabe, K., Handa, H., Mizumoto, K. and Nagata, K. Mechanism for inhibition of influenza virus RNA polymerase activity by matrix protein. J. Virol., 70, 241-247, 1996. PMID: 8523532 (DOI不明) |
78 | Goto, M., Shimizu, T., Sawada, J-I., Sawa, C., Watanabe, H., Ichikawa, H., Ohira. M., Ohki, M. and Handa, H. Assignment of the E4TF1-60 gene to human chromosome 21q21.2-q21.3. Gene, 166, 337-338, 1995. DOI: 10.1016/0378-1119(95)00575-7 |
77 | Tanaka, H., Makino, Y., Hiramoto, M., Handa, H. and Makino, I. Potentiation of glucocorticoid-mediated gene expression by the novel benzoquinone derivative (2E)-3-[5-(2,3-dimethoxy-o-methyl-1,4-benzoquinoyl)]-2-nonyl-2-propenoic acid (E3330). Eur. J. Pharm. : Molecular Pharmacology, 291, 121-127, 1995. DOI: 10.1016/0922-4106(95)90133-7 |
76 | Hayashida, N., Sumi, Y., Wada, T., Handa, H. and Shinozaki, K. Construction of a cDNA library for a specific region of chromosome using a novel cDNA selection method utilizing latex particles. Gene, 165, 155-161, 1995. DOI: 10.1016/0378-1119(95)00473-j |
75 | Rosmarin, A.G., Caprio D.G., Kirsch, D.G., Handa, H. and Simkevich, C.P. GABP and PU.1 compete for binding, yet cooperate to increase CD18 (β2 leukocyte integrin) transcription. J. Biol. Chem., 270, 23627-23633, 1995. DOI: 10.1074/jbc.270.40.23627 |
74 | Watanabe, K., Momose, F., Handa, H. and Nagata, K. Interaction between influenza virus proteins and pine cone antitumor substance that inhibits the virus multiplication. Biochem. Biophys. Res. Commun., 214, 318-323, 1995. DOI: 10.1006/bbrc.1995.2290 |
73 | Sueyoshi, T., Kobayashi, R., Nishio, K., Aida, K., Moore, R., Wada, T., Handa, H. and Negishi, M. A nuclear factor (NF2d9) that binds to the male-specific P450 (Cyp2d-9) gene in mouse liver. Mol. Cell. Biol., 15, 4158-4166, 1995. DOI: 10.1128/mcb.15.8.4158 |
72 | Inomata, Y., Kasuya, Y., Fujimoto, K., Handa, H. and Kawaguchi, H. Purification of membrane receptors with peptide-carrying affinity latex particles. Colloids and Surfaces B: Biointerfaces, 4, 231-241, 1995. DOI:10.1016/0927-7765(95)01192-L |
71 | Wada, T., Watanabe, H., Kawaguchi, H. and Handa, H. DNA affinity chromatography. Methods Enzymol., 254, 595-604, 1995. DOI: 10.1016/0076-6879(95)54042-3 |
70 | Tashiro, S., Takemoto, Y., Handa H. and Ishii, S. Cell type-specific trans-activation by the B-myb gene product: requirement of the putative cofactor binding to the C-terminal conserved domain. Oncogene, 10, 1699-1707, 1995. PMID: 7753546 (DOI不明) |
69 | Matsumoto, K., Okuwaki, M., Kawase, H., Handa, H., Hanaoka, F. and Nagata, K. Stimulation of DNA transcription by the replication factor from the adenovirus genome in a chromatin-like structure. J. Biol. Chem., 270, 9645-9650, 1995. DOI: 10.1074/jbc.270.16.9645 |
68 | Zhang, Y., Araki-Sasaki, K., Handa, H. and Akhtar, R.A. Effect of carbachol on phospholipase C-mediated phosphatidylinositol 4,5-bisphosphate hydrolysis, and its modulation by isoproterenol in rabbit corneal epithelial cells. Curr. Eye Res., 14, 563-571, 1995. DOI:10.3109/02713689508998403 |
67 | Araki-Sasaki, K., Ohashi, Y., Sasabe, T., Hayashi, K., Watanabe, H., Tano, Y. and Handa, H. An SV40-immortalized human corneal epithelial cell line and its characterization. Invest. Ophthalmol. Vis. Sci., 36, 614-621, 1995. PMID: 7534282 (DOI不明) |
66 | Nagata, K., Kawase, H., Handa, H., Yano, K., Yamasaki, M., Ishimi, Y., Okuda, A., Kikuchi, A. and Matsumoto, K. Replication factor encoded by putative oncogene, set, associated with myeloid leukemogenesis. Proc. Natl. Acad. Sci. USA, 92, 4279-4283, 1995. DOI: 10.1073/pnas.92.10.4279 |
65 | Mach, V., Takiya, S., Ohno, K., Handa, H., Imai, T. and Suzuki, Y. Silk gland factor-1 involved in the regulation of bombyx sericin-1 gene contains fork head motif. J. Biol. Chem., 270, 9340-9346, 1995. DOI: 10.1074/jbc.270.16.9340 |
64 | Inokuchi, S., Handa, H., Imai, T., Makuuchi, H., Kidokoro, M., Tohya, H., Aizawa, S., Shimamura, K., Ueyama, Y., Mitomi, T. and Sawada, Y. Immortalization of human oesophageal epithelial cells by a recombinant SV40 adenovirus vector. Br. J. Cancer., 71, 819-825, 1995. DOI:10.1038/bjc.1995.158 |
63 | Sawada, J-I., Goto, M., Watanabe, H., Handa, H. and Yoshida, M.C. Regional mapping of two subunits of transcription factor E4TF1 to human chromosome. Jpn. J. Can. Res., 86, 10-12, 1995. DOI: 10.1111/j.1349-7006.1995.tb02981.x |
62 | Takemoto, Y., Tashiro, S., Handa, H. and Ishii, S. Multiple nuclear localization signals of the B-myb gene product. FEBS Lett., 350, 55-60, 1994. DOI: 10.1016/0014-5793(94)00733-0 |
61 | Sakurai, M., Higashida, S., Sugano, M., Handa, H., Komai, T., Yagi, R., Nishigaki, T. and Yabe, Y. Studies of human-immunodeficiency-virus type-1(HIV-1) protease inhibitors. Ⅲ. Structure-activity relationship of HIV-1 protease inhibitors containing cyclohexylalanylalanine hydroxyethylene dipeptide isostere. Chem. Pharm. Bull., 42, 534-540, 1994. DOI:10.1248/cpb.42.534 |
60 | Shimizu, K., Handa, H., Nakada, S. and Nagata, K. Regulation of influenza virus RNA polymerase activity by cellular and viral factors. Nucleic Acids Res., 22, 5047-5053, 1994. DOI: 10.1093/nar/22.23.5047 |
59 | Sanda, F., Nakamura, M., Endo, T., Takaka, T. and Handa, H. Synthesis of novel optically active polymethacrylamide having L-leucine structure in the side chain. Macromolecules, 27, 7928-7929, 1994. DOI:10.1021/ma00104a059 |
58 | Hojo, H., Yamaguchi, M., Nagasu, M., Aizawa, S., Nakano, M., Harigaya, K., Handa, H. and Toyama, K. Establishment of a human thymic stromal cell line (R-3-4) and its adhesive capacity with T cells in vitro. Hematol. Path., 8, 177-185, 1994. PMID: 7860435 (DOI不明) |
57 | Savoysky, E., Mizuno, T., Sowa, Y. Watanabe, H., Sawada, J-I., Nomura, H., Ohsugi, Y., Handa, H. and Sakai, T. The retinoblastoma binding factor 1 (RBF-1) site in RB gene promoter binds preferentially E4TF1, a member of the Ets transcription factors family. Oncogene, 9, 1839-1846, 1994. PMID: 8208529 (DOI不明) |
56 | Sawada, J-I., Goto, M., Sawa, C., Watanabe, H. and Handa, H. Transcriptional activation through the tetrameric complex formation of E4TF1 subunits. EMBO J., 13, 1396-1402, 1994. PMID: 8137823 (DOI不明) |
55 | Aizawa, S., Yaguchi, M., Nakano, M., Toyama, K., Inokuchi, S., Imai, T., Yasuda, M., Nabeshima, R. and Handa, H. Hematopoietic supportive function of human bone marrow stromal cell lines established by a recombinant SV40-adenovirus vector. Exp. Hematol., 22, 482-487, 1994. PMID: 8187845 (DOI不明) |
54 | Sumi, Y., Shiroya, T., Fujimoto, K., Wada, T., Handa, H. and Kawaguchi, H. Application of cationic latex particles for protein separation. Colloids and Surfaces B: Biointerfaces, 2, 419-427, 1994. DOI:10.1016/0927-7765(94)80006-5 |
53 | Inomata, Y., Wada, T., Handa, H., Fujimoto, K. and Kawaguchi, H. Preparation of DNA-carrying affinity latex and purtification of transcription factors with the latex. J. Biomater. Sci. Polymer Edn., 5, 293-302, 1994. DOI:10.1163/156856294X00031 |
52 | Ma, D., Watanabe, H., Mermelstein, F., Admon, A., Oguri, K., Sun, X., Wada, T., Imai, T., Shiroya, T., Reinberg, D. and Handa, H. Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription. Genes Dev., 7, 2246-2257, 1993. DOI: 10.1101/gad.7.11.2246 |
51 | Sakurai M., Higashida, S., Sugano, M., Nishi, T., Saito, F., Ohata, Y., Handa, H., Komai, T., Yagi, R., Nishigaki, T. and Yabe, Y. Studies of HIV-1 protease inhibitors. II. Incorporation of four types of hydroxyethylene dipeptide isosteres at the scissile site of substrate sequences. Chem. Pharm. Bull., 41, 1378-1386, 1993. DOI:10.1248/cpb.41.1378 |
50 | Sakurai, M., Sugano, M., Handa, H., Konami, K., Yagi, R., Nishigaki, T. and Yabe, Y. Studies of HIV-1 protease inhibitors. I. Incorporation of a reduced peptide, simple aminoalcohol, and statine analog at the scissile site of substrate sequences. Chem. Pharm. Bull., 41, 1369-1377, 1993. DOI:10.1248/cpb.41.1369 |
49 | Araki, K., Ohashi, Y., Sasabe, T., Kinoshita, S., Hayashi, K., Yang X.Z., Hosaka, Y., Aizawa, S. and Handa, H. Immortalization of rabbit corneal epithelial cells by a recombinant SV40-adenovirus vector. Invest. Ophthalmol. Vis. Sci., 34, 2665-2671, 1993. PMID: 7688358 (DOI不明) |
48 | Tabuchi, H., Handa, H. and Hirose, S. Underwinding of DNA on binding of yeast TFIID to the TATA element. Biochem. Biophys. Res. Commun., 192, 1432-1438, 1993. DOI: 10.1006/bbrc.1993.1576 |
47 | Watanabe, H., Sawada J-I., Yano, K-I., Yamaguchi, K., Goto, M. and Handa, H. cDNA cloning of transcription factor E4TF1 subunits with ets and notch motifs. Mol. Cell. Biol., 13, 1385-1391, 1993. DOI: 10.1128/mcb.13.3.1385 |
46 | Hirose, F., Yamaguchi, M., Handa, H., Inomata, Y. and Matsukage, A. Novel 8-base pair sequence (Drosophila DNA replication-related element) and specific binding factor involved in the expression of Drosophila genes for DNA polymerase α and proliferating cell nuclear antigen. J. Biol. Chem., 268, 2092-2099, 1993. PMID: 8093616 (DOI不明) |
45 | Hashimoto, T., Morohashi, K-I., Takayama, K., Honda., S-I., Wada, T., Handa, H. and Omura, T. Cooperative transcription activation between Ad1, a CRE-like element, and other elements in the CYP11B gene promoter. J. Biochem., 112, 573-575, 1992. DOI:10.1093/oxfordjournals.jbchem.a123941 |
44 | Zu, Y-L., Takamatsu, Y., Zhao, M-J., Maekawa, T., Handa, H. and Ishii, S. Transcriptional regulation by a point mutant of adenovirus-2 E1a product lacking DNA binding activity. J. Biol. Chem., 267, 20181-20187, 1992. PMID: 1356975 (DOI不明) |
43 | Morohashi, K-I., Honda, S-I., Inomata, Y., Handa, H. and Omura, T. A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s. J. Biol. Chem., 267, 17913-17919, 1992. PMID: 1517227 (DOI不明) |
42 | Inomata, Y., Kawaguchi, H., Hiramoto, M., Wada, T. and Handa, H. Direct purification of multiple ATF/E4TF3 polypeptides from HeLa cell crude nuclear extracts using DNA affinity latex particles. Anal. Biochem., 206, 109-114, 1992. DOI:10.1016/S0003-2697(05)80018-1 |
41 | Hosaka, Y., Kitamoto, A., Shimojo, M., Nakajima, K., Imai, Y., Handa, H. and Kohsaka, S. Generation of microglia cell lines by transfection with simian virus 40 large T gene. Neursci. Lett., 141, 139-142, 1992. DOI: 10.1016/0304-3940(92)90880-g |
40 | Inokuchi, S., Hashimoto, K., Mitomi, T., Ueda, M. and Handa, H. Immortalization of human epidermal keratinocytes by the recombinant SV40 adenovirus vector. In Vitro Cell. Dev. Biol., 27, 827-828, 1991. DOI: 10.1007/BF02630980 |
39 | Hibi, T., Fujisawa, T., Kanai, T., Akatsuka, A., Habu, S., Handa, H. and Tsuchiya, M. Establishment of epithelial cell lines from human and mouse thymus immortalized by the 12S adenoviral E1a gene product. Thymus, 18, 155-167, 1991. |
38 | Satoh, M.S., Moriyama, C., Asai, A., Handa, H., Rajewsky, M.F., Kuroki, T. and Huh, N. Monoclonal antibody-mediated solid-phase assay for mammalian O6-alkylguanine DNA alkyltransferase activity. Anal. Biochem., 196, 403-409, 1991. DOI:10.1016/0003-2697(91)90485-C |
37 | Usuda, Y., Kubota, A., Berk, A.J. and Handa, H. Affinity purification of transcription factor IIA from HeLa cell nuclear extracts. EMBO J., 10, 2305-2310, 1991. PMID: 2065666 (DOI不明) |
36 | Aizawa, S., Yaguchi, M., Nakano, M., Inokuchi, S., Handa, H. and Toyama, K. Establishment of a variety of human bone marrow stromal cell lines by the recombinant SV40-adenovirus vector. J. Cell. Physiol., 148, 245-251, 1991. DOI: 10.1002/jcp.1041480209 |
35 | Mizutani, M., Ohta, T., Watanabe, H., Handa, H. and Hirose, S. Negative supercoiling of DNA facilitates an interaction between transcription factor IID and the fibroin gene promoter. Proc. Natl. Acad. Sci. USA, 88, 718-722, 1991. DOI: 10.1073/pnas.88.3.718 |
34 | Wada, T., Watanabe, H., Usuda, Y. and Handa, H. Different biological activities of the hetero- and homodimers formed by the 47- and 43-kilodalton proteins of transcription factor ATF/E4TF3. J. Virol., 65, 557-564, 1991. PMID: 1987369 (DOI不明) |
33 | Imai, T., Kawaguchi, H., Wada, T. and Handa, H. E1A gene products stimulate in vitro transciption from the adenovirus early region 4 promoter by enhancing a stable preinitiation complex. Virus Genes, 5, 47-55, 1991. DOI: 10.1007/BF00571730 |
32 | Wada, T., Nogi, Y., Handa, H. and Fukasawa, T. Strain-specific lethal effect of the adenovirus E1a protein on Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun., 170, 470-476, 1990. DOI: 10.1016/0006-291x(90)92115-g |
31 | Watanabe, H., Wada, T. and Handa, H. Transcription factor E4TF1 contains two subunits with different functions. EMBO J., 9, 841-847, 1990. PMID: 2311585 (DOI不明) |
30 | Kawaguchi, H., Asai, A., Ohtsuka, Y., Watanabe, H., Wada, T. and Handa, H. Purification of DNA-binding transcription factors by their selective adsorption on the affinity latex particles. Nucleic Acids Res., 17, 6229-6240, 1989. DOI: 10.1093/nar/17.15.6229 |
29 | Handa, H., Watanabe, H., Suzuki, Y. and Hirose, S. Effect of DNA supercoiling on in vitro transcription from the adenovirus early region 4. FEBS Lett., 249, 17-20, 1989. DOI: 10.1016/0014-5793(89)80006-7 |
28 | Ooyama, S., Imai, T., Hanaka, S. and Handa, H. Transcription in the reverse orientation at either terminus of the adenovirus type 5 genome. EMBO J., 8, 863-868, 1989. PMID: 2524383 (DOI不明) |
27 | Sogawa, K., Handa, H., Fujisawa-Sehara, A., Hiromasa, T., Yamane, M. and Fujii-Kuriyama, Y. Repression of cytochrome P-450c gene expression by cotransfection with adenovirus E1a DNA. Eur. J. Biochem., 181, 539-544, 1989. DOI: 10.1111/j.1432-1033.1989.tb14757.x |
26 | Akahori, Y., Handa, H., Imai, K., Abe, M., Kameyama, K., Hibiya, M., Yasui, H., Okamura, K., Naito, M., Matsuoka, H. and Kurosawa, Y. Sigma region located between Cμ and Cδ genes of human immunoglobulin heavy chain: possible involvement of tRNA-like structure in RNA splicing. Nucleic Acids Res., 16, 9497-9511, 1988. DOI: 10.1093/nar/16.20.9497 |
25 | Abe, A., Wada, T., Handa, H., Nogi, Y. and Fukasawa, T. Efficient usage of a galactose-inducible expression vector for the production of heterologous protein in yeast. Agric. Biol. Chem., 52, 2035-2041, 1988. DOI:10.1271/bbb1961.52.2035 |
24 | Kohama, T., Handa, H. and Harigaya, K. A burst-promoting activity derived from the human bone marrow stromal cell line KM-102 is identical to the granulocyte-macrophage colony-stimulating factor. Exp. Hematol., 16, 603-608, 1988. PMID: 3134250 (DOI不明) |
23 | Watanabe, H., Imai, T., Sharp, P.A. and Handa, H. Identification of two transcription factors that bind to specific elements in the promoter of the adenovirus early-region 4. Mol. Cell. Biol., 8, 1290-1300, 1988. DOI: 10.1128/mcb.8.3.1290 |
22 | Nishigaki, T., Hanaka, S., Kingston, R. E. and Handa, H. A specific domain of the adenovirus EIV promoter is necessary to maintain susceptibility of the integrated promoter to EIA transactivation. Mol. Cell. Biol., 8, 353-360, 1988. DOI: 10.1128/mcb.8.1.353 |
21 | Handa, H., Toda, T., Tajima, M., Wada, T., Iida, H. and Fukasawa, T. Expression of the human adenovirus E1a product in yeast. Gene, 58, 127-136, 1987. DOI: 10.1016/0378-1119(87)90035-7 |
20 | Hanaka, S., Nishigaki, T., Sharp, P. A. and Handa, H. Regulation of in vitro and in vivo transcription of early-region IV of adenovirus type 5 by multiple cis-acting elements. Mol. Cell. Biol., 7, 2578-2587, 1987. DOI: 10.1128/mcb.7.7.2578 |
19 | Oda, K., Masuda-Murata. M., Shiroki, K. and Handa, H. Mitogenic activity of the adenovirus type 12 E1A gene induced by hormones in rat cells. J. Virol., 58, 125-133, 1986. PMID: 2936902 (DOI不明) |
18 | Harigaya, K. and Handa, H. Generation of functional clonal cell lines from human bone marrow stroma. Proc. Natl. Acad. Sci. USA, 82, 3477-3480, 1985. DOI: 10.1073/pnas.82.10.3477 |
17 | Handa, H., Mizumoto, K., Oda, K., Okamoto, T. and Fukasawa, T. Transcription of the human adenovirus E1a gene in Saccharomyces cerevisiae. Gene, 33, 159-168, 1985. DOI: 10.1016/0378-1119(85)90090-3 |
16 | Handa, H. and Sharp, P. A. Requirement for distal upstream sequences for maximal transcription in vitro of early region IV of adenovirus. Mol. Cell. Biol., 4, 791-798, 1984. DOI: 10.1128/mcb.4.4.791 |
15 | Notake, M., Kurosaki, T., Yamamoto, T., Handa, H., Mishina, M. and Numa, S. Sequence requirement for transcription in vitro of the human corticotropin/β-lipotropin precursor gene. Eur. J. Biochem., 133, 599-605, 1983. DOI:10.1111/j.1432-1033.1983.tb07504.x |
14 | Handa, H., Kingston, R.E. and Sharp, P.A. Inhibition of adenovirus early region IV transcription in vitro by a purified viral DNA binding protein. Nature, 302, 545-547, 1983. DOI:10.1038/302545a0 |
13 | Saito, I., Sato, J-I., Handa, H., Shiroki, K. and Shimojo, H. Mapping of RNAs transcribed from adenovirus type 12 early and VA RNA regions. Virology, 114, 379-398, 1981. DOI:10.1016/0042-6822(81)90219-1 |
12 | Cepko, C.L., Hansen, U., Handa, H. and Sharp, P.A. Sequential transcription-translation of Simian virus 40 by using mammalian cell extracts. Mol. Cell. Biol., 1, 919-931, 1981. DOI: 10.1128/mcb.1.10.919 |
11 | Handa, H., Kaufman, R.J., Manley, J., Gefter, M.L. and Sharp, P.A. Transcription of Simian virus 40 DNA in a HeLa whole cell extracts. J. Biol. Chem., 256, 478-482, 1981. PMID: 6256354 (DOI不明) |
10 | Handa, H. and Sharp, P.A. Expression of early and late Simian virus 40 transcripts in the absence of protein synthesis. J. Virol., 34, 592-597, 1980. PMID: 6247498 (DOI不明) |
9 | Handa, H. and Carter, B.J. Adeno-associated virus DNA replication complexes in herpes simplex virus or adenovirus-infected cells. J. Biol. Chem., 254, 6603-6610, 1979. PMID: 221504 (DOI不明) |
8 | Hashimoto, K., Handa, H., Umehara, K. and Sasaki, S. Germfree mice reared on an “antigen-free” diet. Lab. Anim. Sci., 28, 38-45, 1978. PMID: 633838 (DOI不明) |
7 | Handa, H. and Shimojo, H. Isolation of the viral DNA replication complex from adeno-associated virus type 1-infected cells. J. Virol., 24, 444-450, 1977. PMID: 916024 (DOI不明) |
6 | Shiroki, K., Handa, H., Shimojo, H., Yano, S., Ojima, S. and Fujinaga, K. Establishment and characterization of rat cell lines transformed by restriction endonuclease fragments of adenovirus 12 DNA. Virology, 82, 462-471, 1977. DOI: 10.1016/0042-6822(77)90019-8 |
5 | Handa, H., Shiroki, K. and Shimojo, H. Helper factor(s) for growth of adeno-associated virus in cells transformed by adenovirus 12. Proc. Natl. Acad. Sci. USA, 74, 4508-4510, 1977. DOI:10.1073/pnas.74.10.4508 |
4 | Handa, H., Shiroki, K. and Shimojo, H. Establishment and characterization of KB cell lines latently infected with adeno-associated virus type 1. Virology, 82, 84-92, 1977. DOI: 10.1016/0042-6822(77)90034-4 |
3 | Handa, H. and Shimojo, H. Viral DNA sysnthesis in vitro with nuclei isolated from adeno-associated virus type 1-infected cells. Virology, 77, 424-428, 1977. DOI: 10.1016/0042-6822(77)90441-x |
2 | Handa, H., Shimojo, H. and Yamaguchi, K. Multiplication of adeno-associated virus type 1 in cells coinfected with A temperature-sensitive mutant of human adenovirus type 31. Virology, 74, 1-15, 1976. DOI: 10.1016/0042-6822(76)90123-9 |
1 | Handa, H., Shiroki, K. and Shimojo, H. Complementation of adeno-associated virus growth with temperature-sensitive mutants of human adenovirus types 12 and 5. J. Gen. Virol., 29, 239-242, 1975. DOI: 10.1099/0022-1317-29-2-239 |