Selected Publications    著書・和文総説

 原著論文・英文総説

■ 2016年
409  Ito, T. and Handa, H. Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs. Int.J.Hematol., 2016.
408 Sharma, J., Ishizawa, S., Yukino, R., Takamura, T., Hanyu, N., Yasuno, H., Handa, H. and Sandhu, A. Fast and sensitive medical diagnostic protocol based on integrating circular current lines for magnetic washing anyyd optical detection of fluorescent magnetic nanobeads. Sens. Bio-Sensing Res., 9, 7-12, 2016.
407 Matyskiela, M. E., Lu, G., Ito, T., Pagarigan, B., Lu, C-C., Miller, K., Fang, W., Wang, N-Y., Nguyen, D., Houston, J., Carmel, G., Tran, T., Riley, M., Nosaka, L., Lander, G. C., Gaidarova, S., Xu, S., Ruchelman, A. L., Handa, H., Carmichael, J., Daniel, T. O., Cathers, B. E., Lopez-Girona, A., and Chamberlain, P. P. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature, 535, 252-257, 2016.
406 Thang Van Nguyen, J. Eugene Lee, Michael J. Sweredoski, Seung-Joo Yang, Seung-Je Jeon, Joseph S. Harrison, Jung-Hyuk Yim, Sang Ghil Lee, Handa H., Brian Kuhlman, Ji-Seon Jeong, Justin M. Reitsma, Chul-Seung Park, Sonja Hess, and Raymond J. Deshaies. Glutamine triggers acetylation-dependent degradation of glutamine synthetase via the thalidomide receptor cereblon. Mol.Cell, 61, 6, 809-820, 2016.
405 Klaeger, S., Gohlke, B., Perrin, J., Gupta, V., Heinzlmeir, S., Helm, D., Qiao, H., Bergamini, G., Handa, H., Savitski, M, M., Bantscheff, M., Medard, G., Preissner, R. and Kuster, B. Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem.Biol., 2016. in press.
404 Kabe, Y., Nakane, T., Koike, I., Yamamoto, T., Sugiura, Y., Harada, E., Sugase, K., Shimamura, T., Ohmura, M., Muraoka, K., Yamamoto, A., Uchida, T., Iwata, S., Yamaguchi,Y., Krayukhina, E., Noda, M., Handa, H., Ishimori, K., Uchiyama, S., Kobayashi, T. and Suematsu, M. Haem-dependent dimerization of PGRMC1/sigma-2 receptor facilitates cancer proliferation and chemoresistance. Nat.Commun., 2016. in press.
■ 2015年
403  Mukai, S., Moriya, S., Hiramoto, M., Kazama, H., Kokuba, H., Sunazuka, T., Ōmura, S., Handa, H., Itoi, T. and Miyazawa, K. Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines. Int. J. Oncol. 48, 45-54, 2015.
402  Laitem, C., Zaborowska, J., Tellier, M., Yamaguchi, Y., Qingfu, C., Egloff, S., Handa, H. and Murphy, S. CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription. Transcription, 6, 79-90, 2015.
401
 Cao, Q. F., C., Yamamoto, J., Isobe, T., Tateno, S., Murase, Y., Chen, Y., Handa, H. and Yamaguchi, Y. Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Non-overlapping Functions of Rtf1 and the Paf1 Complex. Mol. Cell. Biol., 35, 3459-3470, 2015.
400  Ito, T. and Handa, H. Another action of a thalidomide derivative.Nature (News and Views), 523, 167-168, 2015
399  Kawano, M., Doi, K., Fukuda, H., Kita, Y., Imai, K., Inoue, T., Enomoto, T., Matsui, M., Hatakeyama, M., Yamaguchi, Y. and Handa, H. SV40 VP1 major capsid protein in its self-assembled form allows VP1 pentamers to coat various types of artificial beads in vitro regardless of their sizes and shapes. Biotechnology Reports, 5, 105-111, 2015.
■ 2014年
 398  Chamberlain, P., Lopez-Girona, A., Miller, K., Carmel, G., Pagarigan, B., Chie-Leon, B., Rychak, E., Corral, L., Ren, Y., Wang, M., Riley, M., Delker, S., Ito, T., Ando, H., Mori, T., Hirano, Y., Handa, H., Hakoshima, T., Daniel, T. and Cathers, B. Structure of the human cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nat. Struct. Mol. Biol. , 21, 803-809, 2014.
 397 Pérez-Perarnau, A., Preciado, S., Palmeri, CM., Moncunill-Massaguer, C., Iglesias-Serret, D., González-Gironès, DM., Miguel, M., Karasawa, S., Sakamoto, S., Cosialls, AM., Rubio-Patiño, C., Saura-Esteller, J., Ramón, R., Caja, L., Fabregat, I., Pons, G., Handa, H., Albericio, F., Gil, J. and Lavilla, R. Novel trifluorinated thiazoline scaffold leading to proapoptotic agents targeting prohibitins. Angew. Chem. Int. Ed., 53, 10150-10154, 2014.
 396 Yamamoto, J., Hagiwara, Y., Chiba, K., Isobe, T., Narita, T., Handa, H., and Yamaguchi, Y. DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes. Nat. Commun., in press.
395 Sakamoto, S., Omagari, K., Kita, Y., Mochizuki, Y., Naito, Y., Kawata, S., Matsuda, S., Itano, O., Jinno, H., Takeuchi, H., Yamaguchi, Y., Kitagawa, Y. and Handa, H. Magnetically Promoted Rapid Immunoreactions Using Functionalized Fluorescent Magnetic Beads:  A Proof of Principle. Clinical Chemistry, 60,610-620, 2014.
394 Gandhi, A. K., Kang, J., Havens, C. G., Conklin, T., Ning, Y., Wu, L., Ito, T., Ando, H., Waldman, M. F., Thankurta, A., Klippel, A., Handa, H., Daniel, T. O., Schafer, P. H. and Chopra, R. Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN. Br. J. Haematol., 164, 811-821, 2014.
393 Takemoto, M., Kawamura, Y., Hirohama, M., Yamaguchi, Y., Handa, H., Saitoh, H., Nakao, Y., Kawada, M., Khalid, K., Koshino, H., Kimura, K., Ito, A., and Yoshida, M. Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata. J.Antibio., 67, 335-338, 2014.
392 Kawano, M., Matsui, M., and Handa, H. SV40 virus-like particles as an effective delivery system and a vaccine platform. (review) Future Medicine, 86-100,2014.
391 Kawano, M., Morikawa, K., Suda, T., Ohno, N., Matsushita, S., Akatsuka, T., Handa, H. and Matsui, M. Chimeric SV40 virus-like particles induce specific cytotoxicity and protective immunity against influenza A virus without the need of adjuvants. Virology, 448, 159-167, 2014.
390 Nakagomi, M., Shudo, K., Sakamoto, S., Handa, H., Iwamoto, T. and Matsuura, T.  A Novel Aromatic Carboxylic Acid Inhibits Luciferase Enzymatic Activity in Mammalian Cells by Acylation of an Active Regulatory Lysine Residue. (progress) Biophys. J. 106, 264a, 2014.
389 Terada, K., Tanaka, T., Hanyu, N., Honda, T. and Handa, H. Rapid and sensitive detection of alpha-fetoprotein by a magnetically promoted shake-free immunoassay employing fluorescent magnetic nanobeads Int. J. Anal. Bio-Sci., 2, 101-107. 2014.
■ 2013年
388 Ohno,K.,Sawada,J.,Takiya,S.,Kimoto,M.,Matsumoto,A.,Tsubota,T.,Uchino,T.,Hui,C-C.,Sezutsu,H.,Handa,H.and Suzuki,Y.Silk Gland Factor-2(SGF-2) Involved in Fibroin Gene Transcription Consists of LIM-homeodomain,LIM-interacting,and Single-Stranded DNA-Binding Proteins.J.Biol.Chem.,288,31581-31591,2013. 
387  Gupta,V.,Liu,S.Ando,H.Ishii,R.,Tateno,S.,Kaneko,Y.,Yugami,M.,Sakamoto,S.,Yamaguchi,Y.,Nureki,O.and Handa,H. Salicycle acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesisi activity. Mol.Pharmacol.,84,824-833,2013.
386 Miyazaki, H., Higashomoto,K., Yada, Y., Endo, T. A., Sharif, J., Komori, T., Matsuda, M., Koseki, Y.,Nakayama, M., Soejima, H., Handa, H., Koseki, H., Hirose, S. and Nishioka, K. Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract Polycomf silencing. Plos Genetics, 9, e1003897, 2013.
 385 Iida, S., Imai, K., Matsuda, S., Itano, O., Hatakeyama, M., Sakamoto, S., Kokuryo, D., Okabayashi, K., Endo, T., Ishii, Y., Hasegawa, H., Aoki, I., Handa, H. and Kitagawa, Y. In vivo identification of sentinel lymph nodes using MRI and size-controlled and monodispersed magnetite nanoparticles. J. Magn. Reson. Imaging, 38,1346-1355,2013.
384  Enomoto, T., Kawano, M., Fukuda, H., Sawada, W., Inoue, T., Haw, K. C., Kita, Y., Sakamoto, S., Yamaguchi, Y., Imai, T., Hatakeyama, M., Saito, S., Sandhu, A., Matsui, M., Aoki, I. and Handa, H. Viral protein-coating of magnetic nanoparticles using simian virus 40 VP1. J. Biotechnol., 167, 8-15, 2013.
383  Kang, J., Shen, Z., Lim, J-M., Handa, H., Wells, L. and Tantin, D. Regulation of Oct1 transcription activity by O-GlcNAc modification. FASEB J., 27, 2807-2817, 2013.
382  Hotta, K., Nashimoto, A., Yasumura, E., Suzuki, M., Azuma, M., Iizumi, Y., Shima, D., Nabeshima, R., Hiramoto, M., Okada, A., Sakata-Sogawa, K., Tokunaga, M., Ito, T., Ando, H., Sakamoto, S., Kabe, Y., Aizawa, S., Imai, T., Yamaguchi, Y., Watanabe, H. and Handa, H. Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein. Mol. Pharmacol., 83, 930-938, 2013.
381  Kawano, M., Matsui, M. and Handa, H. SV40 virus-like particles as an effective delivery system and its application to a vaccine carrier. Expert Rev. Vaccines, 12, 199-210, 2013.
380  Jeff Kershaw, Christoph Leuze, Aoki, I., Obata, T., Kanno, I., Ito, H., Yamaguchi, Y., and Handa, H. Systematic changes to the apparent diffusion tensor of in vivo rat brain measured with an oscillating-gradient spin-echo sequence. Neuroimage, 70, 10-20. 2013.
 379 Karasawa, S., Azuma, M., Kasama, T., Sakamoto, S., Kabe, Y., Imai, T., Yamaguchi, Y., Miyazawa, K. and Handa, H. Vitamin K2 covalently binds to Bak and induces Bak-mediated apoptosis. Mol. Pharmacol. 83, 613-620. 2013.
378 Yamaguchi, Y., Shibata H. and Handa, H. Transcription elongation factors DSIF and NELF: Promoter-proximal pausing and beyond. (review) Biochim. Biophs. Acta, 1829, 98-104, 2013.
377  Uebi, T., Umeda, M., Maekawa, N., Karasawa, S., Handa, H. and Imai, T. Prohibitins, novel vitamin K2 target factors in osteoblast. J. Biosci. Med., 1, 1-4, 2013
376 Umeda, M., Uebi, T., Maekawa, N., Masaike, Y., Handa, H. and Imai, T. Effective cofactor complex purification using nanobeads. J. Biosci. Med., 1, 5-10, 2013
■ 2012年
 375  Ito, Y., Ito, T., Karasawa, S., Enomoto, T., Nashimoto, A., Hase, Y., Sakamoto, S., Mimori, T., Matsumoto, Y., Yamaguchi, Y. and Handa, H. Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of Bisphenol A. Plos ONE, 7.e50481.2012.
374  Diamant, G., Amir-Zilberstein, L., Yamaguchi, Y., Handa, H. and Dikstein, R. DSIF restricts NF-kB signaling by coordinating elongation with mRNA Processing of negative feedback genes. Cell Reports, 2, 1-10, 2012.
373  Wada,T., Hara, M., Taneda, T., Qingfu, C., Takara, R., Moro, K., Takeda, K., Kishimoto, T. and Handa, H. Antisense morpholino targeting just upstream from a poly(A) tail junction of maternal mRNA removes the tail and inhibits translation. Nucleic Acids Research, 40, e173, 2012.
372  Lopez-Girona, A., Mendy, D., Ito, T., Miller, K., Gandhi, A. K., Kang, J., Karasawa, S., Carmel, G., Jackson, P., Abbasian, M., Mahmoudi, A., Cathers, B., Rychak, E., Gaidarova, S., Chen, R., Schafer, P. H., Handa, H., Daniel, T. O., Evans, J. F. and Chopra, R. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia, 26, 2326-2335, 2012.
371  Ito, T. and Handa, H. Deciphering the mystery of thalidomide teratogenicity. (review) Congenital Anomalies, 52, 1-7, 2012.
370  Okuda-Ashitaka, E., Minami, T., Tsubouchi, S., Kiyonari, H., Iwamatsu, A., Noda, T., Handa, H. and Ito, S. Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission. J. Biol. Chem., 287, 10403-10413, 2012.
369  Sakamoto, S., Hatakeyama, M., Ito, T. and Handa, H. Tools and methodologies capable of isolating and identifying a target molecule for a bioactive compound. (review) Bioorg. Med. Chem., 20, 1990-2001, 2012.
368 Kallumadil, M., Abe, M., Ueda, T. and Handa, H. Optimisation of Flux Concentrator-Coil Design for Application in Magnetic Hyperthermia. J. Phys.: Conf. Ser., 352, 012034, 2012.
367 Abe, M., Ueda, T., Masaki, T., Kitamoto, Y ., Matsushita, N. and Handa, H.  Detecting Ferrite Nanobeads for Sentinel Lymph Node Mapping with a Highly Sensitive Hall Differential Magnetic Field Sensor. J. Phys.: Conf. Ser., 352, 012015, 2012.
■ 2011年
366  Kawano, A., Hayashi, Y., Noguchi, S., Handa, H., Horikoshi, M., and Yamaguchi, Y. Global analysis for functional residues of histone variant Htz1 using the comprehensive point mutant library. Genes Cells, 16, 590-607, 2011.
365  Enomoto, T., Kukimoto I., Kawano, M., Yamaguchi, Y., Berk, A. J. and Handa, H. In vitro reconstitution of SV40 particles that are composed of VP1/2/3 capsid proteins and nucleosomal DNA and direct efficient gene transfer. Virology, 420, 1-9, 2011.
364  Kitai, Y., Fukuda, H., Enomoto, T., Asakawa, Y., Suzuki, T., Inouye, S. and Handa, H. Cell selective targeting of a simian virus 40 virus-like particle conjugated to epidermal growth factor. J. Biotechnol., 155, 251-256, 2011.
363  Yasuma, A., Ochiai, T., Azuma, M., Nishiyama, H., Kikuchi, K., Kondo, M. and Handa, H. Exogenous coproporphyrin III production by Corynebacterium aurimucosum and Microbacterium oxydans in erythrasma lesions. J. Med. Microbiol., 60, 1038-1042, 2011.
362  Hatakeyama, M., Kishi, H., Kita, Y., Imai, K., Nishio, K., Karasawa, S., Masaike, Y., Akamoto, S., Sandhu, A., Tanimoto, A., Gomi, T., Kohda, E., Abe, M. and Handa, H. A two-step ligand exchange reaction generates highly water-dispersed magnetic nanoparticles for biomedical applications. J. Mater. Chem., 21, 5959-5966, 2011.
361  Ito, T., Ando, H. and Handa, H. Teratogenic effects of thalidomide: molecular mechanisms. (review) Cell. Mol. Life Sci., 68,1569-1579, 2011.
360  Aizawa, M., Abe, Y., Ito, T., Handa, H. and Nawa, H. mRNA distribution of the thalidomide binding protein cereblon in adult mouse brain. Neurosci Res., 69, 343-347, 2011.
359  Taneda, T., Zhu, W., Cao, Q., Watanabe, H., Yamaguchi, Y., Handa, H. and Wada, T. Erythropoiesis is refulated by the transcription elongation factor Foggy/Spt5 through gata1 gene regulation. Genes Cells, 16, 231-242, 2011.
358 Maekawa, N., Hiramoto, M., Sakamoto, S., Azuma, M., Ito, T., Ikeda, M., Naitou, M., Acharya, H. P., Kobayashi, Y., Suematsu, M., Handa, H. and Imai, T. High-performance affinity purification for identification of 15-deoxy-Δ12,14-PGJ2 interacting factors using magnetic nanobeads. Biomed. Biomedical Chromatogr.,25, 466-471,2011
357 Kawano, M., Xing, L., Lam, K.S., Handa, H., Miyamura, T., Barnett, S., Srivastava, I.K. and Cheng, R.H. Design Platforms of Nanocapsules for Human Therapeutics or Vaccines. In Development of Vaccines: From Discovery to Clinical Testing. (eds. Singh, M. and Srivastava, I.K.) (Book) John Wiley & Sons, Inc., New Jersey, 125-140, 2011.
■ 2010年
356 Morimoto, Y., Takamura, T., Park, S. Y., Sakamoto, S., Kawata, S., Handa, H. and Sandhu, A. Detection of 8nm Diameter Superparamagnetic Beads by Magnetically-Induced Manipulation of Micrometer-Sized Magnetid Beads: A Novel Protocol for Magnetically-Labeled Biosensing. Jpn. J. Appl. Phys., 49, 04DL07, 2010.
355  Chiba, K., Yamamoto, J., Yamaguchi, Y. and Handa, H. Promoter-proximal pausing and its release molecular mechanisms and physiological functions. (review) Exp. Cell Res., 316, 2723-2730, 2010.
354  Sandhu, A., Handa, H. and Abe, M. Synthesis and applications of magnetic nanoparticles for biorecognition and point of care medical diagnostics. (review) Nanotechnology, 21, 442001-442022, 2010.
353  Kim, S., Yamamoto, J., Chen, Y., Aida, M., Wada, T., Handa, H. and Yamaguchi, Y. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. Genes Cells, 15, 1003-1013, 2010.
352  Park, S. Y., Ko, J. K., Handa, H. and Sandhu, A. Exploring magneto-optical properties of biofunctionalized magnetic chains for developing label-free immunoassays. J. Appl. Phys., 107, 09B324, 2010.
351  Kume, K., Iizumi, Y., Shimada, M., Ito, Y., Kishi T., Yamaguchi, Y. and Handa, H. Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. Genes Cells, 15, 339-349, 2010.
350  Ito, T., Ando, H., Suzuki, T., Ogura, T., Hotta, K., Imamura, Y., Yamaguchi, Y. and Handa, H. Identification of a primary target of thalidomide teratogenicity. Science, 327, 1345-1350, 2010.
349  Park, S. Y., Handa, H. and Sandhu, A. Magneto-optical biosensing platform based on light scattering from self-assembled chains of functionalized rotating magnetic beads. Nano Lett., 10, 446-451, 2010.
348  Tominaga, A., Sugawara, H., Futagawa, T., Inoue, K., Sasaki, K., Minamino, N., Hatakeyama, M., Handa, H. and Miyata, A. Characterization of the testis-specific promoter region in the human pituitary adenylate cyclase-activating polypeptide (PACAP) gene. Genes Cells, 15, 595-606, 2010.
347  Masaike, Y., Takagi, T., Hirota, M., Yamada, J., Ishihara, S., Yung, T.M.C., Inoue, T., Sawa, C.,Sagara, H., Sakamoto, S., Kabe, Y., Takahashi, Y., Yamaguchi, Y. and Handa, H. Identification of dynamin-2-mediated endocytosis as a new target of osteoporosis drugs, bisphosphonates. Mol. Pharmacol., 77, 262-269, 2010.
346  Hiramoto, M., Maekawa, N., Kuge, T., Ayabe, F., Watanabe, A., Masaike, Y., Hatakeyama, M., Handa, H. and Imai, T. High-performance affinity chromatography method for identification of L-arginine interacting factors using magnetic nanobeads. Biomed. Chromatogr., 24, 606-612, 2010.
345 Abe, M.and Handa, H. Preparation and Biomedical Application of Ferrite Nanobeads. In Biocompatible Nanomaterials:: Synthesis, Characterization and Applications(Nanotechnology Science and Technology). (eds. Kumar, S.A., Thiagarajans, S.and Wang, S.F.)(Book)Nova Science Pub Inc., New York, 225-241,2010.
344 Park, S. Y., Handa, H. and Sandhu, A. Determination of InterMolecular Forces by Magneto-Optical Transmittance of Molecule-Covered Superparamagnetic Particles in Solution. IEEE Trans. Magn., 46, 1409-1411, 2010.
■ 2009年
343 Oda, T., Lee, JS., Sato, Y., Kabe, Y., Sakamoto, S., Handa, H., Mangindaan, RE. and Namikoshi, M. Inhibitory effect of N,N-didesmethylgrossularine-1 on inflammatory cytokine production in lipopolysaccharide-stimulated RAW 264.7 cells. Mar. Drugs, 7, 589-599, 2009.
342  Chen, H., Contreras, X., Yamaguchi, Y., Handa, H., Peterlin, B. M., and Guo, S. Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5. PLoS ONE, 4, e6918, 2009.
341  Kawano, M-A., Xing, L., Tsukamoto, H., Inoue, T., Hand, H. and Cheng, R. H. Calcium- bridge triggers capsid disassembly in the cell entry process of simian virus 40. J. Biol. Chem., 284, 34703-34712, 2009.
340  Chen, Y., Yamaguichi, Y., Tsugeno, Y., Yamamoto, J., Yamada, t., Nakamura, M., Hisatake, K. and Handa,H. DSIF, the Paf1 complex, and Tat-SF1 have non-redundant, cooperative roles in RNA polymerase II elongation. Genes Dev., 23, 2765-2777, 2009.
339  Kabe, Y., Hatakeyama, M., Sakamoto, S. Nishio, K and Handa, H. Novel applications of affinity beads. In Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications. (ed. Oasda, H) John Wiley & Sons, Inc, New Jersey, 39-56, 2009.
338   Tanaka, T., Shimazu, R., Nagai, H., Tada, M., Nakagawa, T., Sandhu, A., Handa, H. and Abe, M. Preparation of spherical and uniform-sized ferrite nanoparticles with diameters between 50-150 nm for biomedical applications. J. Magn. Magn. Mater., 321, 1417-1420, 2009.
337  Suzuki, E., Ogura, H., Kato, K., Takei, I., Kabe, Y., Handa, H. and Umezawa, K. Preparation of conophylline affinity nano-beads and identification of a target preotein. Bioorg. Med. Chem., 17, 6188-6195, 2009.
336  Kamiya, H., Suzuki, A., Yamaguchi, Y., Handa, H. and Harashima, H. Incorporation of 8-hydroxyguanosine 5’-triphosphate (8-oxo-7,8-dihydroguanosine 5’-triphosphate) by bacterial and human RNA polymerases. Free. Radic. Biol. Med., 46, 1703-1707, 2009.
335  Yung, T.M.C., Narita, T., Komori, T., Yamaguchi, Y. and Handa, H. Cellular dynamics of the negative transcription elongation factor NELF. Exp. Cell Res., 315, 1693-1705, 2009.
334  Abe, M., Nishio, K., Hatakeyama. M., Hanyu, N., Tanaka, T., Nakagawa, T., Sandhu, A. and Handa, H. Preparation and medical application of magnetic beads conjugated with bioactive molecules. J. Magn. Magn. Mater., 321, 645-649, 2009.
333  Hanyu, N., Nishio, K., Hatakeyama, M., Yasuno, H., Tanaka, T., Tada, M., Nakagawa, T., Sandhu, A., abe, M. and Handa, H. High-throughput bioscreening system utilizing high-performance affinity magnetic carriers exhibiting minimal non-specific protein binding. J. Magn. Magn. Mater., 321, 1625-1627, 2009.
332  Tada, M., Kanemaru, T., Hara, T., Nakagawa, T., Handa, H. and Abe, M. Synthesis of hollow ferrite nanospheres for biomedical applications. J. Magn. Magn. Mater., 321, 1414-1416, 2009.
331  Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T., Soga, T., Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanabe, H., Kataoka, K., Suematsu, M. and Handa, H. Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis. Toxicological Sciences, 109, 143-151, 2009.
330  Zou, G-M., Karikari, C., Kabe, Y., Handa, H. Anders, R. A. and Maitra, A. The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: Therapeutic implications in tumor angiogenesis. J. Cell. Physiol., 219, 209-218, 2009.
329  Park, S.Y., Handa, H. and Sandhu, A. High speed magneto-optical valve: Rapid control of the optical transmittance of aqueous solutions by magnetically induced self-assembly of superparamagnetic particle chains. J. Appl. Phys., 105, 07B526, 2009.
328  Bando, M., Ohashi, T., Dede, M., Akram, R., Oral, A., Park, S.Y., Shibasaki, I., Handa, H. and Sandhu, A. High sensitivity and multifunctional micro-Hall sensors fabricated using InAlSb/InAsSb/InAlSb heterostructures. J. Appl. Phys., 105, 07E909, 2009.
327  Morimoto, Y., Abe, M., Hatakeyama, M., Handa, H. and Sandhu, A. Detection of Magnetic Nanobeads by Self-Assembly of Superparamagnetic Microbeads for Biosensing. IEEE Transactions on Magnetics., 45, 2871-2874, 2009.
326  Sakamoto, S., Kabe, Y., Hatakeyama, M., Yamaguchi, Y. and Handa, H. Development and application of high-performance affinity beads: toward chemical biology and drug discovery (review). Chem. Rec., 9, 66-85, 2009.
 325  Kuramori, C., Azuma, M., Kume, K., Kaneko, Y., Inoue, A., Yamaguchi, Y., Kabe, Y., Hosoya, T., Kizaki, M., Suematsu, M. and Handa, H., Capsaicin binds to prohibitin 2 and displacesit from the mitochondria to the nuclus. Biochem. Biophys. Res. Commun., 379, 519-525, 2009.
 324  Hatakeyama, M., Mochizuki, Y., Kita, H., Kishi, K., Nishio, S., Sakamoto, M., Abe, M. and Handa, H. Characteization of a magnetic carrier encapsulating europium and ferrite nanoparticles for biomolecular recognition and imaging., J. Magn. Magn. Mater., 321, 1364-1367, 2009.
323  Komori, K., Inukai, N., Yamada, T., Yamaguchi, Y. and Handa, H., The role of human transcription elongation factor DSIF in the suppression of senescence and apoptosis. Genes Cells., 14, 343-354, 2009.
322  Nagasaki, S., Suzuki, T., Miki, Y., Akahira, J-I., Kitada, K., Ishida, T., Handa, H., Ohuchi, N. and Sasano, H. 17β-hydroxysteeroid dehydrogenase type 12 in human breast carcinoma: a prognostic factor via potential regulation of fatty acids synthesis. Cancer Res., 69, 1392-1399, 2009.
321  Kang, J., Gemberling, M., Nakamura, M., Whitby, F. G., Handa, H., Fairbrother, W. and Tantin, D. A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Genes Dev., 23, 208-222, 2009.
320 Tanaka, T., Nagai, H., Tada, M., Nakagawa, T., Sandhu, A., Tamaura, Y., Handa, H. and  Abe, M. Wide range (20-200 nm) size control of spherical ferrite particles grown on seed crystals in aqueous solution added with sucrose. J. Mater. Res., 24, 2051-2055, 2009.
■ 2008年
319   Kawano, M., Handa, H. and Cheng, R, H. DNA tumor virus, In Structure-Based Study of Viral Replication. (eds. Cheng, R. H. and Miyamura, T.) World Scientific Publishing Co, Pte. Ltd. Singapore, 609-630, 2008.
318  Nakanishi, A., Chapellie, B., Maekawa, N., Hiramoto, M., Kuge, T., Takahashi, R-H. Handa, H. and Imai, T. SV40 vectors carrying minimal sequence of viral origin with exchangeable capsids. Virology., 379, 110-117, 2008.
317  Takahashi, R-H., Kanesashi, S-N., Inoue, T., Enomoto, T., Kawano, M-A., Tsukamoto, H., Takeshita, F., Imai, T., Ochiya, T., Kataoka, K., Yamaguchi, Y. and Handa, H. Presentation of functional foreign peptides on the surface of SV40 virus-like particles. J. Biotechnol., 135, 385-392, 2008.
316  Azuma, M., Kabe, Y., Kuramori, C., kondo, M., Yamaguchi, Y. and Handa, H. Adenine nucleotide translocator transports haem precursors into mitochondria. Plos ONE., 3, e3070, 2008.
315  Shimizu, N., Yoshikawa, N., Wada, T., Handa, H., Sano, M., Fukuda, K., Suematsu, M., Sawai, T., Morimoto, C. and Tanaka, H. Tissu- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by HEXIM1. Mol. Endocrinol., 22, 2609-2623, 2008.
314   Ando, K., Hirao, S., Kabe, Y., Ogura, Y., Sato, I., Yamaguchi, Y., Wada, T. and Handa, H. A new APE1/Ref-1-dependent pathway leading to reduction of NF-kB and AP-1, and activation of their DNA-binding activity. Nucleic Acid Res., 36, 4327-4336, 2008.
313  Hase, Y., Tatsuno, M., Nishi, T., Kataoka, K., Kabe, Y., Yamaguchi, Y., Ozawa, N., Natori, M., Handa, H. and Watanabe, H. Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm. Biochem. Biophys. Res. Commun., 366, 66-72, 2008.
312  Suzuki, M., Furukawa, S., Kuramori, C., Sawa, C., Kabe, Y., Nakamura, M., Sawada, J., Yamaguchi, Y., Sakamoto, S., Inoue, S. and Handa, H. Development of a chemical screening system using aqueorin-fused protein. Biochem. Biophys. Res. Commun., 368, 600-605, 2008.
311  Nishio, K., Masaike, Y., Ikeda, M., Narimatsu, H., Gokon, N., Tsubouchi, S., Hatakeyama, M., Sakamoto, S., Hanyu, N., Sandhu, A., Kawaguchi, H., Abe, M. and Handa, H. Development of novel magnetic nano-carriers for high-performance affinity purification. Colloids and Surfaces B: Biointerfaces, 64, 162-169, 2008.
310  Yoshida, M., Kabe, Y., Wada, T., Asai, A. and Handa,H. A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Mol. Pharmacol., 73, 987-994, 2008.
309  Inoue. T., Kawano, M., Takahashi, R., Tsukamoto, H., Enomoto, T., Imai, T., Kataoka, K. and Handa, H. Engineering of SV40-based nano-capsules for delivery of heterologous proteins as fusions with minor capsid proteins VP2/3. J. Biotechnol., 134, 181-192, 2008.
308  Kuraoka, I., Ito, S., Wada, T., Hayashida, M., Lee, L., Saijo, M., Nakatsu, Y., Matsumoto, M.., Matsunaga, T., Handa, H., Qin, J., Nakatani, Y. and Tanaka, K. Isolation of XAB2 complex involved in pre-mRNA splicing, transcription and transcription-coupled repair. J. Biol. Chem.,283,940-950, 2008.
307 Kumagai, Y., Imai, Y., Abe,M.,toshi Sakamoto,S.,roshi Handa, H. and Sandhu, A. Sensitivity dependence of Hall biosensor arrays with the position of superparamagnetic beads on their active regions. J. Appl. Phys., 103, 07A309-07A309-3. 2008.
306 Matsushita, N., Nakagawa, K., Taniguchi, T., Handa. H., Tada, M., Abe, M. and Yoshimura, M. Hundred-nanometer sized biomagnetic beads with large magnetization using ferrite nanoparticles grown by hydrothermal process. J. Appl. Phys., 103, 07A317, 2008.
305 Nishio, K., Kita, Y., Kishi, H., Masaike, Y., Mochizuki, Y., Imai, K., Sakamoto, S.,  Hatakeyama, M., Izumi, Y.,  Abe, M. and Handa, H. Observation of Binding Mode of a Sulfur-Containing Compound with Ferrite Nanoparticles. Photon Factory Activity Report 2007 #25 Part B, 56, 2008.
 ■  2007年
 304   Saito, Y., Imazeki, H., Miura, S., Yoshimura, T., Okutsu, H., Harada, Y., Ohwaki, T., Nagao, O., Kamiya, S., Hayashi, R., Kodama, H., Handa, H., Yoshida, T. and Fukai, F. A peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4. J. Biol. Chem., 282, 34929-34937, 2007.
 303   Agawa, Y., Sarhan, M., Kageyama, Y., Akagi, K., Takai, M., Hashiyama, K., Wada, T., Handa, H., Iwamatsu, A., Hirose, S. and Ueda, S. Drosophila Blimp-1 is a transient transcriptional respressor that controls timing of the ecdysone-induced developmenatal pathway. Mol. Cell. Biol., 27, 8739-8747, 2007.
 302   Iizumi, Y., Sagara, H., Kabe, Y., Azuma, M., Kume, K., Ogawa, M., Nagai, T., Gillespie, P. G., Sasakawa, C. and Handa, H. The Enteropathogenic E.coli effector EspB facilitates microvillus effacing and antiphagocytosis by inhibiting myosin function. Cell Host & Microbe, 2, 383-392, 2007.
301   Tsukamoto, H., Kawano, M., Inoue, T., Enomoto, T., Takahashi, R., Yokoyama, N., Yamamoto, N., Imai, T., Kataoka, K., Yamaguchi, Y. and Handa, H. Evidence that SV40 VP1-DNA interactions contribute to the assembly of 40-nm spherical viral particles. Genes Cells, 12, 1267-1279, 2007.
300  Yamaguchi, Y., Mura, T., Chanarat, S., Okamoto, S. and Handa, H. Hepatitis delta antigen binds to the clamp of RNA polymerase II and affects transcriptional fidelity. Genes Cells, 12, 863-875, 2007.
299  Zhu, W., Wada, T., Okabe, S., Taneda, T., Yamaguchi, Y. and Handa, H. DSIF contributes to transcriptional activation by DNA-binding activators by preventing pausing during transcription elongation. Nucleic Acids Res, 35, 4064-4075, 2007.
298  Amir-Zilberstein L, Ainbinder E, Toube L, Yamaguchi Y, Handa H, Dikstein R. Differential regulation of NF-kappaB by elongation factors is determined by core promoter type. Mol Cell Biol, 27, 5246-5259, 2007.
297   Kuraoka I, Suzuki K, Ito S, Hayashida M, Kwei JS, Ikegami T, Handa H, Nakabeppu Y, Tanaka K. RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS. DNA Repair, 6, 841-851, 2007.
296   Narita, T., Yung, T. M. C., Yamamoto, J., Tsuboi, Y., Tanabe, H., Tanaka, K., Yamaguchi, Y. and Handa, H. NELF interacts with CBC and participates in 3’-end processing of replication-dependent histone mRNAs. Mol Cell, 26, 349-365, 2007..
295   Sandhu, A., Kumagai, Y., Lapicki, A., Sakamoto, S., Abe, A. and Handa, H. High efficiency Hall effect micro-biosensor platform for detection of magnetically labeled biomolecules,  Biosensors and Bioelectronics, 22, 2115-2120, 2007.
294   Yokoyama, N., Kawano, M., Tsukamoto, H., Enomoto, T., Inoue, T., Takahashi, R., Nakanishi, A., Imai, T., Wada, T. and Handa, H. Mutational analysis of the carboxyl-terminal region of the SV40 major capsid protein VP1. J. Biochem., 141, 279-286, 2007.
293  Nakanishi, A., Itoh, N., Li, P. P., Handa, H., Liddington, R. C. and Kasamatsu, H. Minor capsid proteins of SV40 are dispensable for nucleocapsid assembly and cell entry, but are required for nuclear entry of the viral genome. J. Virol., 81, 3778-3785, 2007.
292   Nishio, K., Ikeda, M., Gokon, N., Tsubouchi, S., Narimatsu, H., Mochizuki, Y., Sakamoto, S., Snadhu, A., Abe, M. and Handa, H. Preparation of size controlled (30-100 nm) magnetite nanoparticles for biomedical applications. J. Magn. Magn. Mater., 310, 2408-2410, 2007.
291  Nishio, K., Gokon, N., Hasegawa, M., Ogura, Y., Ikeda, M., Narimatsu, H., Tada, M., Yamaguchi, Y., Sakamoto, S., Abe, M. and Handa, H. Identification of a chemical substance that is immobilized to ferrite nanoparticles (FP). Colloids and Surfaces B: Biointerfaces, 54, 249-253, 2007.
290   Yamamoto, N., Suzuki, M., Kawano, M., Inoue, T., Takahashi, R., Tsukamoto, H., Enomoto, T., Yamaguchi, Y., Wada, T. and Handa, H. Adeno-associated virus site-specific integration is regulated by TRP-185. J. Virol., 81, 1990-2001, 2007.
289   Yugami, M., Kabe, Y., Yamaguchi, Y., Wada, T. and Handa, H. hnRNP-U enhances the expression of specific genes by stabilizing mRNA. FEBS Lett., 581, 1-7, 2007.
 ■  2006年
288   Kusunoki, N., Ito, T., Sakurai, N., Handa, H. and Kawai S.  A Celecoxib Derivative Potently Inhibits Proliferation of Colon Adenocarcinoma Cells by Induction of Apoptosis. Anticancer Res. 26: 3229-3236, 2006.
287   Kubo, T., Wada, T., Yamaguchi, Y., Shimizu, A. and Handa, H. Knock-down of 25-kDa subunit of cleavage factor Im in HeLa cells alters alternative polyadenylation within 3’ UTRs. Nucleic Acids Res., 34, 6264-6271, 2006.
286  Uga, H., Kuramori, C., Ohta, A., Tsuboi, Y., Tanaka, H., Hatakeyama, M., Yamaguchi, Y., Takahashi, T., Kizaki, M. and Handa, H. A new mechanism of methotrxate action revealed by target screening with affinity beads. Mol. Pharmacol., 70, 1832-1839, 2006.
285  Kabe, Y., Ohmori, M., Shinouchi, K., Tsuboi, Y., Hirano, S., Azuma, M., Watanabe, H., Okura, I. and Handa, H. Porphyrins accumulate in mitochondria via 2-oxoglutarate carrier. J. Biol. Chem., 281, 31729-31735, 2006.
284   Nishio, K., Gokon, N., Tsubouchi, S., Ikeda, M., Narimatsu, H., Sakamoto, S., Izumi, Y., Abe, M. and Handa, H. Direct Detection of Redox Reactions of Sulfur-containing Compounds on Ferrite Nanoparticle (FP) Surface. Chem. Lett., 35, 974-975, 2006.
283   Aida, M., Chen, Y., Nakajima, K., Yamaguchi, Y., Wada, T. and Handa, H. Dual role DSIF-and NELF-mediated transcriptional pausing in regulating immediate-early ezpression of junB gene. Mol. Cell. Biol., 16, 6094-6104, 2006.
282   Handa, H. and Yamaguchi, Y. (eds). Hepatitsi Delta Virus. Landes Bioscience and Springer Science + Business Media, Inc, 2006.
281   Sakurai, N., Miki, Y., Suzuki, T, Watanabe, K., Narita, T., Ando, K., Young, T.C.Y., Aoki, D., Sasano, H. and Handa, H. Systemic Distribution and Tissue Localizations of Human 17beta-Hydroxysteroid Dehydrogenase Type 12. J. Steroid Biochem. Mol. Biol., 99, 174-181, 2006.
280   Kawano, M., Inoue, T., Tsukamoto, H., Takaya, T., Enomoto, T., Takahashi, R. U., Yokoyama, N., Yamamoto, N., Nakanishi, A., Imai, T., Wada, T., Kataoka, K. and Handa, H. The VP2/VP3 minor capsid protein of SV40 promotes the in vitro assembly of the major capsid protein VP1 into particles. J. Biol. Chem., 281, 10164-10173, 2006.
279   Okawa, K., Sekine, M., Maeda, M., Tada, M., Abe, M., Matsushita, N., Nishio, K. and Handa, H. Heating ability of magnetite nanobeads with various sizes for magnetic hyperthermia at120kHz, a noninvasive frequency. J. Appl. Phys., 99, 08H102, 2006.
278  Maeda, M., Kuroda, S., Shimura, T., Tada, M., Abe, M., Yamamuro, S., Sumiyama, K. and Handa, H. Magnetic carriers of iron nanoparticles coated with a functional polymer for high thoughput bio-screening. J. Appl. Phys., 99, 08H103, 2006.
277  Ogura, Y., Azuma, M., Tsuboi, Y., Kabe, Y., Yamaguchi, Y., Wada, T., Watanabe, H. and Handa, H. TFII-I douwnregulates asubset of estrogen-responsive genes through its interaction with an initiator element and estrogen receptor alpha. Genes Cells. 11, 373-381, 2006.
276   Yamada, T., Yamaguchi, Y., Inukai, N., Kamijo, S., Mura, T. and Handa, H. P-TEFb-mediated phosphorylation of the hSpt5 C-terminal repeats is critical to processive transcription elongation. Mol. Cell, 21, 227-237, 2006.
275   Togawa, K., Sanbonsugi, H., Sandhu, A., Narimatsu, H., Nishio, K. and Handa, H. Detection of magnetically labeled DNA using pseudomorphic AlGaAs/InGaAs/GaAs heterostructure micro-Hall biosensor. J. Appl. Phys., 99, 08P103, 2006.
274 Yamagata, M., Abe, M., Handa, H. and Kawaguchi, H. Magnetite/Polymer Composite Particles Prepared by Molecular Assembling Followed by In‐Situ Magnetite Formation. Macromol. Symp., 245-246, 363-370, 2006.
273 Kuroda, C. S., Shimura, T., Maeda, M., Tada, M., Handa, H., Sandhu, A. and  Abe, M.   “Ferrite Route” Preparation of Iron Nanoparticles and Their Encapsulation in Styrene-GMA Co-Polymer for Biomedical Applications. IEEE Trans. Magn., 42, 3569-3571, 2006. 
 ■  2005年
272  Shimazu, R., Tada, M., Matsushita, N., Handa, H. and Masanori Abe. Expediting Magnetic Separation Using Ni Wires, Applicable for Robot-Manipulated Bio-Screening Systems, IEEE Trans. Magn., 41, 4143-4145, 2005. 
271   Kuroda, C. S., Maeda, M., Nishibiraki, H., Matsushita, N., Handa, H. and Abe, M. Styrener-coated iron nanobeads for medical use. IEEE Trans. Magn., 41, 4117-4119, 2005.
270  Abe, M., Matsushita, N., Tada, M., Gokon, N., Nishio, K. and Handa, H. Novel Medical Ferrite Nanobeads with Bioactive Molecules Immobilized Strongly onto the Surfaces, Mater. Res. Soc. Symp. Proc., (Conference Papaer)Warrendale, PA, 1-12, 2005.
269  Funabashi, H., Tanaka, Y., Imamura, Y., Mie. M., Manabe, T., Tanaka, H., Takahashi, Takashi., Handa, H., Aizawa, M. and Kobatake, E. Glucose oxidase assisted homogeneous electrochemical receptor binding assay for drug screening. Biosens Bioelectron., 21, 1675-1683, 2005.
268  Sandhu, A. and Handa. H., Practical Hall Sensors for Biomedical Instrumentation. IEEE Trans. Magn., 41, 4123-4127, 2005. .
267 Lapicki. A., Sanbonsugi. H., Yamamura. T., Matsuhita. N., Abe. M., Narimatsu. H., Handa. H., and Sandhu, A. Functionalization of Micro-Hall Effect Sensors for Biomedical Applications Utilizing Superparamagnetic Beads. IEEE Trans. Magn., 41, 4134-4136, 2005.
266   Togawa. K., Sanbonsugi. H., Lapicki. A., Abe. M., Handa. H., and Sandhu, A., High Sensitivity InSb Thin Film Micro-Hall Sensor Arrays for Simultaneous Multiple Detection of Magnetic Beads for Biomedical Applications, IEEE Trans. Magn., 41, 3661-3663, 2005.
265   Hasegawa, M., Ohno, H., Tanaka, H., Hatakeyama, M., Kawaguchi, H., Takahashi, T. and Handa, H. Affinity Identification of δ Opioid Receptors Using Latex Nanoparticles, Bioorg. Med. Chem. Lett., 16, 158-161, 2005.
264   Azuma, N., Tadokora, K., Asaka, A., Yamada, M., Yamaguchi, Y., Handa, H., Matsushima, S., Watanabe, T., Kida, Y., Ogura, T., Shimamura, K. and Nakafuku, M. Transdifferntiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcription factor. Hum. Mol. Genet., 14, 1059-1068, 2005.
263   Urano, A., Endoh, M., Wada, T., Morikawa, Y., Itoh, M., Kataoka, Y., Taki, T., Akazawa, H., Nakajima, H., Komuro, I., Yoshida, N., Hayashi, Y., Handa, H., Kitamura, T. and Nosaka, T. Infertility with defective spermiogenesis in mice lacking AF5q31, the target of  chromosomal translocation in human infant leukemia. Mol. Cell. Biol., 25, 6834-6845, 2005.
262  Kusunoki, N., Ito, T., Sakurai, N., Suguro, T., Handa, H. and Kawai, S. A novel celecoxib derivative potently induces apoptosis of human synovial fibroblasts. J Pharmcol. Exp. Ther., 314, 796-803, 2005.
261   Azuma, N., Tadokoro, K., Asaka, A., Yamada, M., Yamaguchi,Y., Handa, H., Matsushima, S., Watanabe, T., Kohsaka, S., Kida, Y., Shiraishi, T., Ogura, T., Shimamura, K. and Nakafuku, M. The Pax6 isoform bearing an alternative spliced exon promotes the development of the neural retinal structure. Hum. Mol. Genet., 14, 735-745, 2005.
260   Delehouzee, S., Yoshikawa, T., Sawa, C., Sawada, J-I., Ito, T., Omori, M., Wada, T, Yamaguchi, Y., Kabe, Y. and Handa, H. GABP, HCF-1 and YY1 are involved in Rb gene expression during myogenesis. Genes Cells, 10, 717-731, 2005.
259   Shimizu, N., Ouchida, R., Yoshikawa, N., Hisada, T., Watanabe, H., Okamoto, K., Kusuhara, M., Handa, H., Morimoto, C and Tanaka, H. HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b. Proc. Natl. Acad. Sci. USA, 102, 8555-8560, 2005.
258   Oba, S., Hatakeyama, M., Handa, H and Kawaguchi, H. Development of polymer latex particles for selctive cleavage of mismatched DNA and their application for DNA diagnosis. Bioconjugate Chemistry, 16, 551-558, 2005.
257   Wu, C-H., Lee, C., Fan, R., Smith, J.M., Yamaguchi, Y., Handa, H. and Gilmour, D.S. Molecular characterization of Drosophila NELF. Nucleic Acids Res., 33, 1-11, 2005.
256  Wang, G., Balamotis, M.A., Stevens, J.L., Yamaguchi, Y., Handa, H. and Berk, A. J. Mediator requirement for both recruitment and postrecruitment steps in transcription initiation.Mol. Cell, 5, 683-694, 2005.
255   Parent M.,Young, T.C.Y., Rancourt, A., Ho, E.L.Y., Parent, M., Vispe, S., Suzuki-Matsuda, F., Uehara, A., Wada, T., Handa, H. and Sato, M. Poly(ADP-ribose)polymerase-1 is a negative regulator of HIV-1 expression through competitive binding to TAR RNA. J. Biol. Chem., 280, 448-457, 2005.
254   Ohtsu, Y., Ohba, R., Imamura, Y., Kobayashi, M., Hatori, H., Zenkoh, T., Hatakeyama, M., Manabe, T., Hino, M., Yamaguchi, Y., Kataoka, K., Kawaguchi, H., Watanabe, H. and Handa, H. Selective ligand purification using high-performance affinity beads. Anal. Biochem., 338, 245-252, 2005.
253   Kabe, Y., Yamada, J., Uga, H., Yamaguchi, Y., Wada, T. and Handa, H. NF-Y is essential for the recruitment of RNA polymerase II and synergistically acts the induced transcription on CCAAT box containing promoters. Mol. Cell. Biol., 25, 512-522, 2005.
252   Kabe, Y., Hirao, S., Ando, K. and Handa, H. Redox Regulation of NF-kappa B activation-the distinct redox regulation between the cytoplasm and the nucleus. Antioxid. Redox. Signal., 7, 393-403, 2005.
251  Sandhu, A. and Handa, H. Practical Hall effect sensors for biomedical instrumentation - 'horses for courses'. (Conference Paper) Magnetics Conference, 2005. INTERMAG Asia 2005. Digests of the IEEE International, 523-524, 2005.

250  Nishibiraki, H., Kuroda, C. S., Maeda, M., Matsushita, N., Abe, M. and Handa, H.   Preparation of medical magnetic nanobeads with ferrite particles encapsulated in a polyglycidyl methacrylate (GMA) for bioscreening. J. Appl. Phys., 97, 10Q919.1-10Q919.3, 2005.
249  Togawa, K., Sanbonsugi, H., Sandhu, A., Abe, M., Narimatsu, H., Nishio, K. and Handa, H.  High Sensitivity InSb Hall Effect Biosensor Platform for DNA Detection and Biomolecular Recognition Using Functionalized Magnetic Nanobeads. Jpn. J. Appl. Phys., 44, 46-49, 2005.
 ■  2004年
248  Tsubouchi, S., Nishio, K., Ikeda, M., Narimatsu, H., Gokon, N., Handa, H. and Abe, M. Polymer coating of ferrite nanoparticles by using “connecter” chemical compounds. Proceedings of the Ninth International Conference on Ferrites (ICF-9), San Francisco, pp.499-454,2004.
247  Watanabe, H., Suzuki, A., Goto, M., Ohsako, S., Tohyoma, C., Handa, H. and Iguchi, T. Comparative uterine gene expression analisis after dioxin and estradiol administration, J. Mol. Endocr., 33, 763-771, 2004.
246  Jennings, B.H., Shah, S., Yamaguchi, Y., Seki, M., Phillips, R.G., Handa, H. and Ish-Horowicz, D. Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila. Curr. Biol., 14, 1680-1684, 2004.
245   Imamura, Y., Ohtsu, Y., Tanaka, H., Hatakeyama, M., Manabe, T., Kawaguchi, H., Handa, H. and Takahashi, T. Synthesis of affinity nanoparticles coupled to FR901464 derivatives. Heterocycles, 64, 51-56, 2004.
244   Hiramoto, M., Kawakami, Y., Nabeshima, R., Shima, D., Handa, H. and Aizawa, S. Identification of differentiation-inducing activity produced by human bone marrow stromal cell line LP101. Int. J. Mol. Med., 14, 867-872, 2004.
243  Kwei, J.S.M., Kuraoka, I., Horibata, K., Ubukata, M., Kobatake, E., Iwai, S., Handa, H and Tanaka, K. Blockage of RNA polymerase II at a cyclobutane pyrimidine dimmer and 6-4 photoproduct. Biochem. Biophys. Res. Commun., 320, 1133-1138, 2004.
242   Nishio, K., Hasegawa, M., Ikeda, M., Narimatsu, H., Hase, Y., Ogura., Y, Gokon, N., Tsubouchi, S., Hatakeyama, M., Abe, M. and Handa, H. Synthesis of monodisperse ferrite nanoparticles coated with polyacrylic acid (PAA). Trans. Mater. Res. Soc. Jpn., 29, 1659-1662, 2004.
241
  Aiyar, S.E., Sun, J-L., Blair, L.A., Moskaluk, A.C., Lv, Y., Ye, O-N., Yamaguchi, Y., Mukherjee, A., Re, D-M., Handa, H. and Li, R. Attenuation of estrogen receptor α-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev., 18, 2134-2146, 2004.
240  Hatori, H., Zenkoh, T., Kobayashi, M., Ohtsu, Y., Shigematsu, N., Setoi, H., Hino, M. and  Handa, H. FR-225659-binding proteins: identification as serine/threonine protein phosphatase PP1 and PP2A using high-performance affinity beads. J. Antibiotics, 57, 456-461, 2004.
239   Zenkoh, T., Hatori, H., Tanaka, H., Hasegawa, M., Hatakeyama, M., Kabe, Y., Setoi, H., Kawaguchi, H., Handa, H. and Takahashi, T. Design and synthesis of a solid-supported FR225659 derivative for its receptor screening. Organic Letters., 6, 2477-2480, 2004.
238   Sandhu, A., Sanbonsugi, H., Shibasaki, I., Abe, M. and Handa, H. High sensitivity InSb ultra-thin film micro-Hall sensors for bioscreening applications. Jpn. J. Appl. Phys., 43, 868-870, 2004.
237   Oshima.S., Nakamura.T., Namiki.S., Okada.E., Tsuchiya.K., Okamaoto.R., Yamazaki.M., Yokota.T., Aida.M., Yamaguchi.Y., Kanai.T., Handa, H. and Watanabe, M. Interferon Regulatory Factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol. Cell. Biol., 24, 6298-6310, 2004.
236   Watanabe, H., Suzuki, M., Goto, M., Lubahn, D. B., Handa, H. and Iguchi, T. Tissue-specific estrogenic and non-estrogenic effects of axenoestrogen, nonylphenol. J. Mol. Endocr., 33, 243-252, 2004.
235   Sawa, C., Nedea, E., Krogan, N., Wada, T., Handa, H., Greenblatt, J. and Buratowski, S. Bromodomai factor 1 (Bdf1) is phosphorylated by protein kinase CK2. Mol. Cell. Biol., 24, 4734-4742, 2004. 
234   Mandal. S.S, Chu, C., Wada, T., Handa, H., Shatkin, J.A. and Reinberg, D. Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate transcription during promoter escape. Proc. Natl. Acad. Sci. USA., 101, 7572-7577, 2004.
233   Endoh, M., Zhu, W., Hasegawa, J., Watanabe, H., Kim, D-K., Aida, M., Inukai, N., Yamada, T., Furuya, A., Sato, H., Yamaguchi, Y., Mandal, S.S., Reinberg, D., Wada, T. and Handa, H. Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. Mol. Cell. Biol., 24, 3324-3336, 2004.
232  Ainbinder, E., Amir-Zilberstein, L., Yamaguchi, Y., Handa, H. and Dikstein, R. Elongation inhibition by DSIF is regulated by the A20 promoter via a novel negative element and NF-kB. Mol. Cell. Biol., 24, 2444-2454, 2004.
231   Inukai, N., Yamaguchi, Y., Kuramori, I., Yamada, T., Kamijo, S., Kato, J., Tanaka, K. and Handa, H. A novel hydrogen peroxide-induced phosphorylation and ubiqutination pathway leading to RNA polymerase II proteolysis. J. Biol. Chem., 279, 8190-8195, 2004.
230   Han, S-I., Kawano, M., Ishizu, K-I., Watanabe, H., Hasegawa, M., Kanesashi, S-N., Kim, Y-S., Nakanishi, A., Kataoka, K. and Handa, H. Rep68 protein of adeno-associated virus type 2 interacts with 14-3-3 proteins depending on phosphorylation at serine 535. Virology, 320, 144-155, 2004.
229   Miyazawa, S., Suzuki, A., Katsu, Y., Kobayashi, M., Goto, M., Handa, H., Watanabe, H. and Iguchi, T. Persistent gene expression in mouse vagina exposed neonatally to diethylstilbesterol. J. Mol. Endocr., 32, 663-677, 2004.
228   Nakadai, T., Shimada, M., Shima, D., Handa, H. and Tamura, T. Specific interaction with TFIIA and localization of the mammalian TBP-like protein (TLP/TRF2/TLF). J. Biol. Chem., 279, 7477-7455, 2004.

 2003年
227   Nedialkov, YA., Gong, XQ., Yamaguchi, Y., Handa, H. and Burton, ZF. Assay of transient state kinetics of RNA polymerase II elongation. Methods Enzymol., 371, 252-264, 2003.
226    Shirai, T., Maehara, A., Kititooshi, N., Matsuzaki, F., Handa, H. and Nakagoshi, H. Differential requirement of EGFR signaling for the expression of defective proventriculus gene in the Drosophila endoderm and ectoderm. Biochem. Biophy. Res. Commun., 311, 473-477, 2003.
225    Watanabe, H., Suzuki, A., Kobayashi, M,, Lubahn, D.B., Handa, H. and Iguchi, T. Similarities and differences in uterine gene expression patterns caused by treatment with physiological and non-physiological estrogens. J. Mol. Endocrinol., 31, 347-358, 2003.
224    Hatanaka, S., Matsushita, N., Abe, M., Nishimura, K., Hasegawa, M. and Handa, H. Direct immobilization of fluorescent dyes onto ferrite nannoparticles during their synthesis aqueous solution. J. Appl. Phys., 91, 7569-7570, 2003.
 223   Kataoka, K., Shioda, S., Ando, K., Handa, H. and Yasuda, K. Differentially expressed Maf family transcription factors, c-Maf and Maf-A, activate glucagons and insulin gene expression in pamcreatic islet α- and β-cells. J. Mol. Endocrinol., 32, 9-20, 2003.
 222   Ando, K., Shioda, S., Handa, H. and Kataoka, K. Isolation and characterization of an alternatively spliced variant of transcription factor Islet-1. J. Mol. Endocrinol., 31, 419-425, 2003.
221    Handa, H. New approach to chemical biology for drug development: construction of new affinity beads and their application. (Conference Paper) Arthritis Research & Therapy, 3rd World Congress of the Global Arthritis Research Network (GARN): Internal Arthritis Summit, 5, S27, 2003.
 220   Imaki, H., Nakayama, K., Delehouzee, S., Handa, H., Kitagawa, M., Kamura, T. and Nakayama, K.I. Cell Cycle-dependent regulation of the Skp2 promoter by GA-binding protein. Cancer Res., 63, 4607-4613, 2003.
 219   Shimojima, T., Okada, M., Nakayama, T., Ueda, H., Okawa, K., Iwamatsu, A., Handa, H. and Hirose, H. Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor. Genes Dev., 17, 1605-1616, 2003.   
218   Wu, C-H., Yamaguchi, Y., Benjamin, L., Horvat-Gordon, M., Washinski, J., Enerly, E., Lambertsson, A., Handa, H. and Gilmour, D. NELF and DSIF are implicated in causing promoter proximal pausing on the hsp70 promoter in Drosophila. Genes Dev., 17, 1402-1414, 2003.
217   Nedialkov, Y.A., Gong, X.Q., Hovde, S.L., Yamaguchi, Y., Handa, H., Geiger, J.H., Yan, H. and Burton, Z.F. NTP-driven translocation by human RNA polymerase II. J. Biol. Chem., 278, 18303-18312, 2003.
216  Azuma, N., Yamaguchi, Y., Handa, H., Tadokoro, K., Asuka, A. and Yamada, M. Mutations of the PAX6 gene detected in patients with a variety of optic nerve malformations. Am. J. Hum. Genet., 72, 1565-1570, 2003.
215   Kanesashi, S., Ishizu, K., Kawano, M., Han, S-I., Tomita, S., Watanabe, H., Kataoka, K. and Handa, H. Simian virus 40 VP1 capsid protein forms polymorphic assembles in vitro. J. Gen. Virol., 84, 1899-1905, 2003.
214    Watanabe, H., Suzuki, A., Kobayashi, M., Takahashi, E., Itamoto, M., Lubahn, D.B., Handa, H. and Iguchi, T. Analysisi of temporal changes in the expression of estrogen regulated genes in the uterus. J. Mol. Endocrinol., 30, 347-358, 2003.
213   Li, P.P., Nakanishi, A., Tran, M.A., Ishizu, K-I., Kawano, M., Phillips, M., Handa, H., Liddington, R.C. and Kasamatsu, H. Important of Vp1 calucium-binding residues in assembly, cell entry, and nuclear entry of Simian Virus 40. J. Virol., 77, 7527-7538, 2003.
212   Narita, T., Yamaguchi, Y., Yano, K., Sugimoto, S., Wada, T., Kim, D-K., Hasegawa, J., Omori, M., Inukai, N., Endou, M., Yamada, T., and Handa, H. Human transcription elongation factor NELF: Identification of novel subunits and reconstitution of the functionally active complex. Mol. Cell. Biol., 23, 1863-1873, 2003.
211  Kim, D-K., Inukai, N., Yamada, T., Furuya, A., Sato, H., Yamaguchi, Y., Wada, T. and Handa, H. Structure–function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex. Genes Cells, 8, 371-378, 2003.
210   Shima, D., Yugami, M., Tatsuno, M., Wada, T., Yamaguchi, Y. and Handa, H. Mechanism of H-8 inhibition of Cyclin-dependent kinase 9: study using inhibitor-immobilized matrices. Genes Cells, 8, 215-223, 2003.
209   Ouchida, R., Kusuhara, M., Shimizu, N., Hisada, T., Makino, Y., Morimoto, C., Handa, H., Ohsuzu, F. and Tanaka, H. Suppression of NF-B-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells. Genes Cells, 8, 95-107, 2003.
208    Hasegawa, J., Endou, M., Narita, T., Yamada, T., Yamaguchi, Y., Wada, T. and Handa, H. A rapid purification method for human RNA polymerase II by two-step affinity chromatography. J. Biochem., 133, 133-138, 2003.
207   Kuraoka, I., Endou, M., Yamaguchi, Y., Wada, T., Handa, H. and Tanaka, K. Effects of endogeneous DNA base lesions on transcription elongation by mammalian RNA polymerase II: implications for transcription-coupled DNA repair and transcriptional mutagenesis. J. Biol. Chem., 278, 7294-7299, 2003.
206    Bando, M., Hasegawa, M., Tsuboi, Y., Miyake, Y., Shiina, M., Ito, M., Handa, H., Nagai, K. and Kataoka, T. The mycotoxin penicillic acid inhibits Fas-ligand-induced apotosis by blocking self-processing of caspase-8 in death-inducing signaling complex. J. Biol. Chem., 278, 5786-5793, 2003.
205   Oda, T., So, Y., Sato, Y., Shimizu, N., Handa, H., Yasukochi, Y. and Kasahara, T. Inhibition by (+/-)-indenesterol A of interferon gamma-stimulated nitric oxide formation in murine macrophage RAW 264.7 cells. Mutat Res., 534, 187-195, 2003.
204   Hasegawa, M., Uga, H., Ohba, R., Tsuboi, Y., Sato, I., Tang, J., Kabe, Y. and Handa, H. Development of affinity-purification technology for identification of drug receptors. Recent Res. Develp. Biophys. Biochem., 3, 445-456, 2003.
 2002年
203    Kataoka, K., Han, S-I., Shioda, S., Hirai, M., Nishizawa, M. and Handa, H. MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J. Biol. Chem., 277, 49903-49910, 2002.
202   Nishi, T., Shimizu, N., Hiramoto, M., Sato. I., Yamaguchi, Y., Hasegawa, M., Aizawa, S., Tanaka, H., Kataoka, K., Watanabe, H. and Handa, H. Spatial redox regulation of a critical cysteine residue of NF-B in vivo. J. Biol. Chem., 277, 44548-44556, 2002.
201   Watanabe, H., Suzuki, A., Mizutani, H., Handa, H. and Iguchi, T. Large-scale gene expression analysis for evaluation of endocrine disruptors. In Toxicogenomics, inoue, T. and Pennie, W. D. (eds.),(Book) Springer, 129-134, 2002.
200   Oda, T., Ueda, A., Shimizu, N., Handa, H. and Kasahara, T. Suppression of monocyte chemoattractant protein 1, but not IL-8, by alprazolam: effect of alprazolam on c-Rel/p65 and c-Rel/p50 binding to the monocyte chemoattractant protein 1 promoter region. J. Immunol., 169, 3329-3335, 2002.
199  Yamaguchi, Y., Delehouzee, S. and Handa, H. HIV and hepatitis delta virus: evolution takes different paths to relieve blocks in transcriptional elongation (review). Microbes Infect., 4, 1169-1175, 2002.
 198  Sawa, C., Yoshikawa, T., Matsuda-Suzuki, F., Delehouzee, S., Goto, M., Watanabe, H., Sawada, J., Kataoka, K., and Handa, H. YEAF1/RYBP and YAF-2 are functionally distinct members of a confactor family for the YY1 and E4TF1/hGABP transcription factors. J. Biol. Chem., 277, 22484-22490, 2002.
 197  Tomohiro, T., Sawada, J., Sawa, C., Nakura, H., Yoshida, S., Kodaka, M., Hatakeyama, M., Kawaguchi, H., Handa, H. and Okuno, H. Total analysis and purification of cellular proteins brinding to cisplatin-damaged DNA using submicron beads. Bioconjug. Chem., 13, 163-166, 2002.
196   Nishimura, K., Hasegawa. M., Ogura, Y., Nishi, T., Kataoka, K., Handa, H. and Abe, M. 4℃ preparation of ferrite nanoparticles having protein molecules immobilized on their surfaces. J. Appl. Phys., 91, 8555-8556, 2002.
195  Hiramoto, M., Shimizu, N., Nishi, T., Shima, D., Aizawa, S., Tanaka, H., Hatakeyama, M., Kawaguchi, H. and Handa, H. High-performance affinity beads for identifying anti-NF-κB drug receptors. Methods Enzymol., 353, 81-88, 2002.
194   Watanabe, H., Suzuki, A., Mizutani, T., Khono, S., Lubahn, B.D., Handa, H. and Iguchi, T. Genome-wide analysis of changes in early gene expression induced by oestrogen. Genes Cells, 7, 497-507, 2002.
 ■
 2001年
193   Yamaguchi, Y., Inukai, N., Narita, T., Wada, T. and Handa, H. Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. Mol. Cell Biol., 22, 2918-2927, 2002.
192   Yoshimatsu, T., Saitoh, A., Ryu, J.N., Shima, D., Handa, H., Hiramoto, M., Kawakami, Y., and Aizawa, S. Characterization of immortalized human chondrocytes originated from osteoarthritis cartilage. Int. J. Mol. Med., 8, 345-351, 2001.
191   Renner, D.B., Yamaguchi, Y., Wada, T., Handa, H. and Price, D.H. A highly purified RNA polymerase II elongation control system. J. Biol. Chem., 276, 42601-42609, 2001.
190   Lavoie, S.B., Albert, A.L., Handa, H., Vincent, M. and Bensaude, O. The Peptidyl-prolyl isomerase Pin 1 interacts with hSpt5 phosphorylated by Cdk9. J. Mol Biol., 312, 675-685, 2001.
189   Kataoka, K., Shioda, S., Yoshitomo-Nakagawa, K., Handa, H. and Nishizawa, M.. Maf and Jun nuclear oncoproteins share downstream target genes for inducing cell transformation J.Biol. Chem., 276, 36849-36856, 2001.
188   Kataoka, K., Handa, H., and Nishizawa, M. Induction of cellular antioxidative stress genes through heterodimeric transcription factor Nrf2/small Maf by antirheumatic gold(I) compounds. J. Biol. Chem., 276, 34074-34081, 2001.
187   Sakai, M., Matsushita, N., Kitamoto, Y., Kawaguchi, H., Handa, H. and Abe, M. Ferrite plating of styrene-glycidyl methacrylate latex particles for bioseparaton and DNA diagnosis. Ferrites: Proceedings of the Eighth International Conference on Ferrites (ICF a8), Kyoto and Tokyo, pp.111-113, 2001
186   Kim, D-K., Yamaguchi, Y., Wada, T. and Handa, H. The regulation of elongation by eukaryotic RNA polymerase II: A recent view (review). Mol. Cells., 11, 267-274, 2001.
185   Yamaguchi, Y., Filipovska, J., Yano, K., Furuya, A., Inukai, N., Narita, T., Wada, T., Sugimoto, S., Konarska, M.M. and Handa, H. Stimulation of RNA polymerase II elongation by hepatitis delta antigen. Science, 293, 124-127, 2001.
184   Morii, E., Ogihara, H., Oboki, K., Sawa, C., Sakuma, T., Nomura, S., Esko, J.D., Handa, H. and Kitamura, Y. Inhibitory effect of the mi transcription factor encoded by the mutant mi allele on GA binding protein-mediated transcript expression in mouse mast cells. Blood, 15, 3032-3039, 2001.
183   Yamaguchi, Y., Narita, T., Inukai, N., Wada, T. and Handa, H. SPT genes: key players in the regulation of transcription, chromatin structure and other cellular processes (review). J. Biochem., 129, 185-191, 2001.
182   Shiba, K., Hamaguchi, T., Kataoka, K., Yamaguchi, Y., Handa, H. and Adachi, K. Cloning of the hamster androgen receptor gene. J. Dermatol. Sci., 26, 163-168, 2001.
181   Ishizu, K-I., Watanabe, H., Han, S-I., Kanesashi, S-N., Hoque, M., Yajima, H., Kataoka, K. and Handa, H. Roles of disulfide linkage and calcium ion-mediated interactions in assembly and disassembly by virus-like particles composed of simian virus 40 VP1 capsid protein. J.Virol., 75, 61-72, 2001.
180   Guo, S., Yamaguchi, Y., Schilbach, S., Wada, T., Lee, J., Goddard, A., French, D., Handa, H. and Rosenthal, A. A regulator of transcriptional elongation controls vertebrate neuronal development. Nature, 408, 366-369, 2001. 
 ■  2000年
179  Yoshida, N., Yoshida, S., Araie, M., Handa, H. and Nabeshima,  Y-I. Ets family transcriptionfactor ESE-1 is expressed in corneal epithelial cells and is involved in their differentiation. Mech. Dev., 97 , 27-34 , 2000.
178   Aizawa, S., Hiramoto, M., Hoshi, H., Shima, D., Handa, H. and Toyama, K. Induction of apoptotic change of hematopoienic cells by cloned stromal cells from MDS patient via direct cellular interactions. Exp.Hematol., 28, 122, 2000.
177   Handa, H. Studies of the network of regulatory circuits formed by a family of transcription factors. The Waksman Foundation of Japan Inc. (Research Report.) 174-175, The Waksman Foundation of Japan Inc., 2000.
176  Aizawa, S., Shimizu, N., Handa, H., Hiramoto, M., Hoshi, H., Nagasu, M., Kanno, H., Nagasu, Y. and Imanishi, Y. Effects of cyclic polylactate (CPL) on the growth of cloned leukemic cells in vitro. Hematol. Oncol., 18, 51-60, 2000.
175  Tomohiro, T., Sawa, C., Sawada, J., Nakura, H., Yoshida, S., Kodaka, M., Handa, H. and Okuno, H. Affinity purification of cisplatin-damaged DNA binding proteins. Abstr. Pap. Amer. Chem. Soc., 219, 202-BIOT, 2000.
174  Shimizu, N., Sugimoto, K., Tang, J., Nishi, T., Sato, I., Hiramoto, M., Aizawa, S., Hatakeyama, M., Ohba, R., Hatori, H., Yoshikawa, T., Suzuki, F., Oomori, A., Watanabe, H., Tanaka, H., Kawaguchi, H. and Handa, H. High-performance affinity beads for identifying drug receptors. Nature. Biotechnol., 18, 877-881, 2000.
173   Nagata, K. and Handa, H. (eds). Real-Time Analysis of Biomolecular Interactions: ALi.P.Pcations of BIACORE. Springer-Verlag Tokyo, 2000.
172   Wada, T., Orphanides, G., Hasegawa, J., Kim, D-K., Shima, D., Yamaguchi, Y., Fukuda, A., Hisatake, K., Oh, S., Reinberg, D. and Handa, H. FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. Mol. Cell, 5, 1067-1072, 2000.
171   Satoh, S., Hirota, M., Noguchi, T., Hijikata, M., Handa, H. and Shimotohno, K. Cleavage of hepatitis C virus nonstructural protein 5A by a caspase-like protease(s) in mammalian cells. Virology, 270, 476-487, 2000.
170   Araki-Sasaki, K., Aizawa, S., Hiramoto, M., Nakamura, M., Iwase, O., Nakata, K., Sasaki, Y., Mano, T., Handa, H. and Tano, Y. Substance P-induced cadherin expression and its signal transduction in a cloned human corneal epithelial cell line. J. Cell Physiol., 182, 371-376, 2000.
169   Aizawa, S., Hiramoto, M., Hoshi, H., Toyama., K., Shima, D. and Handa, H. Establishment of stromal cell line from an MDS RA patient which induced an apoptotic change in hematopoietic and leukemic cells in vitro. Exp. Hematol., 28, 148-155, 2000.
168   Takayama, M., Kim, E., Kidokoro, M., Shimamura, K., Shiroki, K., Yajima, H., Kosukegawa, A., Handa, H. and Inokuchi, S. Transfer of SV40 temperature-sensitive early gene into human epidermal keratinocytes by the recombinant adenovirus vector. In Vitro Cell. Dev. Biol., 36, 110-116, 2000.
 1999年
167  Mishima, M., Ozaki, J., Ikegami, T., Kabe, Y., Goto, M., Ueda, M., Hirose, S., Handa, H. and Shirakawa, M. Resonance assignments, secondary structure and15N relaxation data of the human transcriptional coactivator hMBF1(57-148). J. Biomol. NMR., 14, 373-376, 1999.
166   Hoque, M., Shimizu, N., Ishizu, K-I., Yajima, H., Arisaka, F., Suzuki, K., Watanabe, H., and Handa, H. Chimeric virus-like particle formation of adeno-associated virus. Biochem. Biophys. Res. Commun., 266, 371-376, 1999.
165   Kabe, Y., Goto, M., Shima, D., Imai, T., Wada, T., Morohashi, K-I., Shirakawa, M., Hirose, S. and Handa, H. The role of human MBF1 as a transcriptional coactivator. J. Biol. Chem., 274, 34196-34202, 1999.
164   Sawada, J-I., Shimizu, N., Suzuki, F., Sawa, C., Goto, M., Hasegawa, M., Imai, T., Watanabe, H. and Handa, H. Synergistic transcriptional activation of hGABP and select members of the ATF/CREB family. J. Biol. Chem., 274, 35475-35482, 1999.
163   Tsutsui, H., Geltinger, C., Murata, T., Itakura, K., Wada, T., Handa, H. and Yokoyama, K.K. The DNA-binding and transcriptional activities of MAZ, a myc-associated zinc finger protein, are regulated by casein kinase II. Biochem. Biophys. Res. Commun., 262, 198-205, 1999.
162   Kim, J.A., Yamaguchi, Y., Wada, T., Handa, H. and Sharp, P.A. Tat-SF1 Protein associates with RAP30 of TFIIF and hSPT5 Protein. Mol. Cell. Biol., 19, 5960-5968, 1999.
161   Hoque, M., Ishizu, K., Matsumoto, A., Han, S-I., Arisaka, F., Takayama, M., Suzuki, K., Kanda, T., Kato, K., Watanabe, H. and Handa, H. Nuclear transport of the major capsid protein is essential for the capsid formation of adeno-associated virus. J. Virol., 73, 7912-7915, 1999.
160   Aizawa, S., Nakano, M., Iwase, O., Yaguchi, M., Hiramoto, M., Hoshi. H., Nabeshima, R., Shima, D., Handa, H. and Toyama, K. Bone marrow stroma from refractory anemia of myelodysplastic syndromes is defective in its ability to support CD34-positive cell proliferation and differentiation in vitro. Exp.Hematol., 27, 180, 1999.
159   Ozaki, J., Ikegami, T., Mishima, M., Takemaru, K-I., Kabe, Y., Handa, H., Ueda, H., Hirose, S. and Shirakawa, M. Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1. Genes Cells, 4, 415-424, 1999.
158   Azuma, N., Yamaguchi, Y., Handa, H. and Azuma, N. Missense mutation in the alternative splice region of the PAX6 gene in eye anomalies. Am. J. Hum. Genet., 65, 656-663, 1999.
157   Hashimoto, M., Chayama, K., Kobayashi, M., Tsubota, A., Arase, Y., Saitou, S., Suzuki, Y., Ikeda, K., Matsuda, M., Koike, H., Kobayashi, M., Handa, H. and Kumada, H. Fluctuations of hepatitis C virus load are not related to amino acid substitutions in hyper variable region 1 and interferon sensitivity determining region. J. Med. Virol., 58, 247-255, 1999.
156   Satoh, S., Hijikata, M., Handa, H. and Shimotono, S. Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2. Biochem. J., 342, 65-70, 1999.
155   Wada, T., Takagi, T., Yamaguchi, Y., Kawase, H., Hiramoto, M., Ferdous, A., Takayama, M., Lee, K.A.W., Hurst, H.C. and Handa, H. Copurification of casein kinase II with transcription factor ATF/E4TF3. In Alteration of Transcription by  DNA Tumor Virus Proteins. (ed. Handa.H) (Book)Azuma Printing Co.,Ltd. 27-35, 1999.
154   Nishina, S., Kohsaka, S., Yamaguchi, Y., Handa, H., Kawakami, A., Fujisawa, H. and Azuma, N. PAX6 expression in the developing human eye. Br. J. Ophthal., 83, 723-727, 1999.
153   Sanda, F., Kamatani, J., Handa, H. and Endo, T. Radical polymerization behavior of a proline-substituted acrylamide. Effect of s-cis-s-trans isomerization on the polymerization. Macromolecules, 32, 2490-2494, 1999.
152   Yamaguchi, Y., Wada, T., Watanabe, D., Takagi, T., Hasegawa, J. and Handa, H. Structure and function of the human transcription elongation factor DSIF. J. Biol. Chem., 274, 8085-8092, 1999.
151   Handa, H., Yamaguchi, Y. and Wada, T. Purification of DNA binding proteins. In High Resolution Choromatography: A Practical Approach. (ed. Miller.P.A) (Book) Oxford University Press, 283-302, 1999.
150   Yamaguchi, Y., Takagi, T., Wada, T., Yano, K., Furuya, A., Sugimoto, S., Hasegawa, J. and Handa, H. NELF, a multiple complex containing RD, cooperates with DSIF to repress RNA plymerase II elongation. Cell, 97, 41-51, 1999.
149   Aizawa, S., Nakano, M., Iwase, O., Yaguchi, M., Hiramoto, M., Hoshi, H., Nabeshima, R., Shima, D., Handa, H. and Toyama, K. Bone marrow stroma from refractory anemia of myelodysplastic syndrome is defective in its ability to support normal CD34-positive cell proliferation and differentiation in vitro. Leuk.Res., 23, 239-246, 1999.
■   1998年
148  van Dijkm, T.B., Baltus, B., Caldenhoven, E., Handa, H., Raaijmakers, J.A.m., Lammers, J-W.J., Koenderman, L. and de Groot, R.P. Cloning and characterization of the human interleukin-3 (IL-3)/IL-5/granulocyte-macrophage colony-stimulating factor receptor betac gene: Regulation by Ets family members. Blood, 92, 3636-3646, 1998. 
147   Toyoda, M., Gotoh, M., Handa, H. and Shibuya, M. Involvement of MAP kinase-independent protein kinase C signaling pathway in the EGF-induced  p21(WAF1/Cip1) expression and growth inhibition of A431 cells. Biochem. Biophys. Res. Commun., 250, 430-435,1998.
146   Wada, T., Takagi, T., Yamaguchi, Y., Watanabe, D. and Handa, H. Evidence that p-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro. EMBO J., 17, 7395-7403, 1998.
145   Suzuki, F., Goto, M., Sawa, C., Ito, S., Watanabe, H., Sawada, J-I. and Handa, H. Functional interactions of transcription factor hGABP subunits. J. Biol. Chem., 273, 29302-29308, 1998.
144   Yamaguchi, Y., Wada, T., Suzuki, F., Takagi, T., Hasegawa, J. and Handa, H. Casein kinase II interacts with the bZip domains of several transcription factors. Nucleic Acids Res., 26, 3854-3861, 1998.
143   Hatakeyama, M., Nakamura, K., Iwato, S., Handa, H., Fujimoto, K. and Kawaguchi, H. DNA-carrying latex particles for DNA diagnosis. 2. Distinction of normal and point mutant DNA using S1 nuclease. Colloids and Surfaces B: Biointefaces, 10, 171-178, 1998.
142   Hatakeyama, M., Iwato, S., Fujimoto, K., Handa, H. and Kawaguchi, H. DNA-carrying latex particles for DNA diagnosis. 1. Separation of normal and point mutant DNAs according to the difference in hybridization efficiency. Colloids and Surfaces B: Biointerfaces, 10, 161-169, 1998.
141   Vassias, I., Hazan, U., Michel, Y., Sawa, C., Handa, H., Gouya, L. and Morinet, F. Regulation of human B19 parvovirus promoter expression by hGABP (E4TF1) transcription factor. J. Biol. Chem., 273, 8287-8293, 1998.
140   Yamaguchi, Y., Wada, T. and Handa, H. Drawing a new view of DRB: Interplay between positive and negative elongation factors. (review) Genes Cells, 3,9-15, 1998.
139   Hirano, F., Tanaka, H., Hirano, Y., Hiramoto, M., Handa, H., Makino, I. and Scheidereit, C. Functional interference of sp1 and NF-kB through the same DNA binding site. Mol. Cell. Biol., 18, 1266-1274, 1998. 
138   Hartzog, G.A., Wada, T., Handa, H. and Winston, F. Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae. Genes Dev., 12, 357-369, 1998.
137   Wada, T., Takagi, T., Yamaguchi, Y., Ferdous, A., Imai, T., Hirose, S., Sugimoto, S., Yano, K., Hartzog, G.A., Winston, F., Buratowski, S. and Handa, H. DSIF, a novel negative transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. Genes Dev., 12, 343-356, 1998.
136   Hiramoto, M., Aizawa, S., Iwase, O., Nakano, M., Toyama, K., Hoque, M., Nabeshima, R., Kaidow, A., Imai, T., Hoshi, H. and Handa, H. Stimulatory effects of substance P on CD34 positive cell proliferation and differentiation in vitro are mediated by the modulation of stromal cell function. Int. J. Mol. Med., 1, 347- 354, 1998.
135   Hiramoto, M., Nabeshima, R., Shima, D., Handa, H., Hoshi, H. and Aizawa, S. Study for the regulatory mechanism of cytokine production and secretion by flag-fused cytokine expression system. Exp.Hematol., 26, 111, 1998.
134   Hiramoto, M., Shimizu, N., Sugimoto, K., Tang, J., Kawakami, Y., Ito, M., Aizawa, S., Tanaka, H. Makino, I. and Handa, H. Nuclear targetted suppression of NF-kB activity by the novel quinone derivative E3330. J. Immunol., 160, 810-819, 1998.
 ■
 1997年
133   Hirano, F., Tanaka, H., Hiramoto, M., Handa, H., Makino, I. and Scheidereit, C. Functional interference of sp1 and NF-kB through the same DNA binding site. Faseb.J., 11, 2002, 1997.
132   Nakade, K., Handa, H. and Nagata, K. Promote structure of the MxA gene that confers resistance to influenza virus. FEBS Lett., 418, 315-318, 1997.
131   Kawaguchi, H., Hatakeyama, M., Iwato, S., Fujimoto, K. and Handa, H. Affinity latex for DNA diagnosis. In Advances in Polymer Biomaterials. (eds. Akaike, T., Okano, T., Akashi, M., Terano, M. and Yui, N.) (Book) CMC, 355-362, 1997.
130   Hatakeyama, M., Ogura, Y., Sawada, J-I., Fujimoto, K., Handa, H. and Kawaguchi, H. Preparation of dimerized polypeptide-carrying microspheres and purification of specific proteins bound to these microspheres. Colloids and Surfaces B:Biointerfaces, 10, 41-49, 1997.
129   Sowa, Y., Shiio, Y., Fujita, T., Matsumoto, T., Okuyama, Y., Kato, D., Inoue, J-I., Sawada, J-I., Goto, M., Watanabe, H., Handa, H. and Sakai, T. Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1. Cancer Res., 57, 3145-3148, 1997.
128   Yamaguchi, Y., Sawada, J-I., Yamada, M., Handa, H. and Azuma, N. Autoregulation of Pax6 transcriptional activation by two distinct DNA-binding subdomains of the paired domain. Genes Cells, 2, 255-261, 1997.
127   Li, F.Q., Takemoto, K-I., Goto, M., Ueda, H., Handa, H. and Hirose, S. Molecular cloning of MBF2 reveals its contact with TFIIA that leads to transcriptional activation. Genes Cells, 2, 143-153, 1997.
126   Aizawa, S., Nakano, M., Yaguchi, M., Kuriyama, Y., Iwase, O., Toyama, K., Tanaka, K., Hoshi, H., Sugimoto, K., Kaidoh, A., Imai, T., Nabeshima, R. and Handa, H. Possible involvement of bone marrow stromal cells in agranulocytosis caused by vesnarinone treatment. Acta Hematologica., 98, 140-146, 1997.
125   Iwase, O., Toyama, K., Nabeshima, R., Handa, H., Hoshi, H., Hiramoto, M. and Aizawa, S. Stimulatory effects of substance p on hemopoiesis in vitro. Exp.Hematol., 25, 63-63, 1997.
124   Aoki, H., Seki, T., Sawada, J-I., Handa, H. and Adachi, K. The promoter of the androgen dependent gene in the flank organ of hamsters. J. Dermatol. Sci., 15, 36-43, 1997.
123   Komai, T., Ishikawa, Y., Yagi, R., Suzuki-Sugawara, H., Nishigaki, T. and Handa, H. Development of HIV-1 protease expression methods using T7 phage promoter system. Appl. Microbiol. Biotechnol., 47, 241-245, 1997.
122   Komai, T., Yagi, R., SuzukiSunagawa, H., Sakurai, M., Higashida, S., Sugano, M., Handa, H., Mohri, H., Yasuoka, A., Oka, S., Yabe, Y., Nishigaki, T., Kimura, S. and Shimada, K. In vitro and ex vivo anti-human immunodeficiency virus(HIV) activities of a new water-soluble HIV protease inhibitor, R-87366, containing (2S,3S)-3-amino-2-hidroxy-4- phenyldutanoic acid. Biol..Pharm.Bull., 20, 175-180, 1997.
121   Nabeshima, R., Aizawa, S., Nakano, M., Toyama, K., Sugimoto, K., Kaidoh, A., Imai, T. and Handa, H. Effects of vesnarinone on the bone marrow stromal cell-dependent proliferation and differentiation of HL60 cells in vitro. Exp. Hematol., 25, 509-515, 1997.
120   Murakami, M., Sonobe, M.H., Ui, M., Kabuyama, Y., Watanabe, H., Wada, T., Handa, H., and Iba, H. Phosphorylation and high level expression of Fra-2 in v-src transformed cells: a pathway of activation of endogeneous AP-1. Oncogene, 14, 2435-2444, 1997.
119   Imai, T., Matsuda, K., Shimojima, T., Hashimoto, T., Masuhiro, Y., Kitamoto, T., Sugita, A., Suzuki, K., Matsumoto, H., Masushige, S., Nogi, Y., Muramatsu, M., Handa, H. and Kato, S. ERC-55, a binding protein for the papilloma virus E6 oncoprotein, specifically interacts with vitamin D receptor among nuclear receptors. Biochem. Biophys. Res. Commun., 233, 765-769, 1997.
118   Momose, F., Handa, H. and Nagata, K. Identification of host factors that regulate the influenza virus RNA polymerase activity. Biochimie, 78, 1103-1108, 1997.
117   Kitamura, T., Handa, H., Hamasaki, N. and Kitajima, S. Characterization of the human thrombopoietin gene promoter. J. Biol. Chem., 272, 11361-11368, 1997.
116    Komai, T., Yagi, R., Suzuki-Sunagawa, H., Ishikawa, Y., Kasuya, A., Miyamoto, S., Handa, H. and Nishigaki, T. Inhibition of HIV-1 protease by oxim derivatives. Biochem. Biophys. Res. Commun., 230, 557-561, 1997.
 1996年
115  Kawase, H., Okuwaki, M., Miyaji, M., Ohba, R., Handa, H., Ishimi, Y., Fujii-Nakata, T., Kikuchi, T. and Nagata, K. NAP-1 is a functional homologue of TAF-1 that is required for replication and transcription of the adenovirus genome in chromatin-like structure. Genes Cells, 1, 1045-1056, 1996.
114   Sasaki, Y., Horimoto, M., Nabeshima, R., Wada, S., Ito, T., Kasahara, A., Handa, H. and Hayashi, N. Establishment of rat hepatocyte cell lines by a temperature sensitive or a wild type recombinant SV40-adenovirus vector. Hepatology., 24, 47-47, 1996.
113   Matsumoto, M., Misawa, S., Chiba, N., Hayashi, H. and Handa, H. Construction of the expression system of the active herpes simplex virus type 1 protease and its kinetic analysis with sythetic peptides. Protein.Eng., 9, 18-18, 1996.
112   Komai, T., Higashida, S., Sakurai, M., Nitta, T., Kasuya, A., Miyamaoto, S., Yagi, R., Ozawa, Y., Handa, H., Mohri, H., Yasuoka, A., Oka, S., Nishigaki, T., Kimura, S., Shimada, K. and Yabe, Y. Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA-II. Modification of pyrrolidine ring at P1’ prolone. Bioorgan.Med.Chem., 4, 1365-1377, 1996.
111   Nabeshima, R., Handa, H., Aizawa, S., Hoshi, H. and Toyama, K. Possible involvement of bone marrow stromal cells in agranulocytosis caused by vesnarinone treatment. Exp.Hematol., 24, 490-490, 1996.
110   Sawa, C., Goto. M., Suzuki, F., Watanabe, H., Sawada. J. and Handa, H. Functional domains of transcription factor hGABPβ1/E4TF1-53 required for nuclear localization and transcription activation. Nucleic Acids Res., 24, 4954-4961, 1996.
109   Yajima, H., Kosukegawa, A., Hoque, M.H., Shimojima, T., Takayama, M., Sasaki, Y., Sakai, H., Ohtsuka, M., Inokuchi, S. and Handa, H. Construction and characterization of a recombinant adenovirus vector carrying the human preproinsulin gene under the control of the methallothionein gene promoter. Biochem. Biophys. Res. Commun., 229, 778-787, 1996.
108   Okazaki, T., Takita, J., Kohno, T., Handa, H. and Yokota, J. Detection of amplified genomic sequences in human small-cell lung carcinoma cell lines by arbitrarily primed-PCR genomic fingerprinting. Human Genomics, 98, 253-258, 1996. 
107   Kosukegawa, A., Aisaka, F., Takayama, M., Yajima, H., Kaidow, A. and Handa, H. Purification and characterization of virus-like particles and pentamers produced by the expression of SV40 capsid proteins in insect cells. Biochim. Biophys. Acta., 1290, 37-45, 1996.
106   Hashimoto, M., Chayama, K., Tsubota, A., Kobayashi M., Saitou, S., Arase, Y., Ikeda, K., Kobayashi, M., Nakano, A., Takagi, K., Koike, H., Okamoto, K., Handa, H., Kumada, H. Typing six major hepatitis C virus genotypes by polymerase chain reaction using primers derived from nucleotide sequences of the NS5 region. Int. Hepatol. Commun., 4, 263- 267, 1996.
105   Shimada, H., Wada, T., Handa, H., Ohta, H., Mizuguchi, H., Nishimura, K., Masuda, T., Shioi, Y. and Takamiya, K-I. A transcription factor with a leucine-zipper motif involved in light-dependent inhibition of expression of the puf operon in the photosynthetic bacterium rhodobacter sphaeroides. Plant Cell Physiol., 37, 515-522, 1996.
104   Shiio, Y., Sawada, J-I., Handa, H., Yamamoto, T. and Inoue, J-I. Activation of the retinoblastoma gene expression by Bcl-3: Implication for muscle cell differentiation. Oncogene, 12, 1837-1845, 1996.
103   Wada, T., Takagi, T., Yamaguchi, Y., Kawase, H., Hiramoto, M., Ferdous, A., Takayama, M., Lee, K.A.W., Hurst, H.C. and Handa, H. Copurification of casein kinase II with transcription factor ATF/E4TF3. Nucleic Acids Res., 24, 876-884, 1996.
102   Hirano, F., Tanaka, H., Makino, Y., Okamoto, K., Hiramoto, M., Handa, H. and Makino, I. Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids. Carcinogenesis, 17, 427-433, 1996.
101   Imai, T., Sumi, Y., Hatakeyama M., Fujimoto, K., Kawaguchi, H., Hayashida, N., Shiozaki, K., Yajima, H. and Handa, H. Selective purification of DNA or RNA using single-stranded DNA affinity latex particles. J. Colloid Interface Sci., 177, 245-249, 1996.
100   Watanabe, K., Handa, H., Mizumoto, K. and Nagata, K. Mechanism for inhibition of influenza virus RNA polymerase activity by matrix protein. J. Virol., 70, 241-247, 1996.
 1995年
99   Goto, M., Shimizu, T., Sawada, J-I., Sawa, C., Watanabe, H., Ichikawa, H., Ohira. M., Ohki, M. and Handa, H. Assignment of the E4TF1-60 gene, an Ets-related transcription factor, to human chromosome 21q21.2-q21.3. Gene, 166, 337-338, 1995.
98   Tanaka, H., Makino, Y., Hiramoto, M., Handa, H. and Makino, I. Potentiation of glucocorticoid-mediated gene expression by the novel benzoquinone derivative (2E)-3-[5-(2,3-dimethoxy-o-methyl-1,4-benzoquinoyl)]-2-nonyl-2-propenoicacid (E3330). Eur. J. Pharm., 291, 121-127, 1995.
97   Hayashida, N., Sumi, Y., Wada, T., Handa, H. and Shinozaki, K. Construction of a cDNA library for a specific region of chromosome by a novel cDNA selection method using latex particles. Gene, 165, 155-161, 1995.
96   Rosmarin, A.G., Caprio D.G., Kirsch, D.G., Handa, H. and Simkevich, C.P. GABP and PU.1 compete for binding yet cooperate to increase CD18 (β-2 leukocyte integrin) transcription. J. Biol. Chem., 270, 23627-23633, 1995.
95   Watanabe, K., Momose, F., Handa, H. and Nagata, K. Interaction between influenza virus proteins and pine cone antitumor substance that inhibits the virus  multiplication. Biochem. Biophys. Res. Commun., 214, 318-323, 1995.
94   Sueyoshi, T., Kobayashi, R., Nishio, K., Aida, K., Moore, R., Wada, T., Handa, H. and Negishi, M. A nuclear factor (NF2d9) that binds to the male-specific P450 (Cyp2d-9) genen in mouse liver. Mol. Cell. Biol., 15, 4158-4166, 1995.
93   Shiroya, T., Hatakeyama, M., Fujimoto, K., Watanabe, H., Wada, T., Imai, T., Kawaguchi, H. and Handa, H. Purification of transcription factor IIA using yeast TATA-binding protein affinity latex particles. Internl. J. Bio-Chromatog., 1, 191-198, 1995.
92   Inomata, Y., Kasuya, Y., Fujimoto, K., Handa, H. and Kawaguchi, H. Purification of membrane receptors with peptide-carrying affinity latex beads. Colloids and Surfaces B: Biointerfaces, 4, 231-241, 1995.
91   Wada, T., Watanabe, H., Kawaguchi, H. and Handa, H. DNA affinity chromatography. Methods Enzymol., 254, 595-604, 1995.
90   Tashiro, S., Takemoto, Y., Handa H. and Ishii, S. Cell type specific trans-activation by the B-myb gene product: requirement of the putative cofactor binding to  the C-terminal conserved domain. Oncogene, 10, 1699-1707, 1995.
89   Matsumoto, K., Okuwaki, K., Kawase, H., Handa, H., Hanaoka, F. and Nagata, K. Stimulation of DNA transcription by the replication factor from the adenovirus genome in a chromatin-like structure. J. Biol. Chem., 270, 9645-9650, 1995.
88   Aizawa, S., Iwase, O., Yaguchi, M., Kuriyama, Y., Toyama, K., Tohyama, K., Nakamura, T., Kaidoh, A. and Handa, H. A lack of hematopoietic supportive function of bone-marrow stromal cells in the patients with myelodysplastic syndrome. Exp.Hematol., 23, 903-903, 1995.
87   Kawasaki, Y., Hayashi, A., Ohji, M., Handa, H. and Tano, Y. Immortalization of retinal-pigment epithelial-cells of royal-college of surgeons (rcs) rats. Invest.Ophthalmol. Visual.Sci., 36, S550-S550, 1995.
86    Ikuno, Y., Hayashi, A., Ohji, M., Handa, H. and Tano, Y. Establishment of a cell-line from rat retinal-pigment epithelium. Invest.Ophthalmol.Visual.Sci., 36, S767-S767, 1995.
85   Zhang, Y., Araki-Sasaki, K., Handa, H. and Akhtar, R.A. Effect of carbachol on phospholipase C-mediated phosphatidylinositol 4,5-bisphosphate hydrolysis, and its modulation by isoproterenol in rabbit corneal epithelial cells. Curr. Eye Res., 14, 563-571, 1995.
84   Araki-Sasaki, K., Ohashi, Y., Sasabe, T., Hayashi, K., Watanabe, H., Tano, Y. and Handa, H. An SV40-immortalized human corneal epithelial cell line and its characterization. Invest. Ophthalmol. Vis. Sci., 36, 614-621, 1995.
83   Inomata, Y., Wada, T., Handa, H., Fujimoto, K. and Kawaguchi, H. Preparation of DNA-carrying affinity latex and purification of transcription factor with the latex. In Polymer Biomaterials in solution, as interfaces and as solids. (eds. Cooper.S.L, Bamford.C.H and Tsuruta.T) Utrecht, 635-644, 1995.
82   Nagata, K., Kawase, H., Handa, H., Yano, K., Yamasaki, M., Ishimi, Y., Okuda, A., Kikuchi, A. and Matsumoto, K. Replication factor encoded by putative oncogene, set, associated with myeloid leukemogenesis. Proc. Natl. Acad. Sci. USA., 92, 4279-4283, 1995.
81   Mach, V., Takiya, S., Ohno, K., Handa, H., Imai, T. and Suzuki, Y. Silk gland factor-1 involved in the regulation of bombyx sericin-1 gene contains fork head motif. J. Biol. Chem., 270, 9340-9346, 1995.
80   Inokuchi, S., Handa, H., Imai, T., Makuuchi, H., Kidokoro, M., Tohya, H., Aizawa, S., Shimamura, K., Ueyama, Y., Mitomi, T. and Sawada, Y. Immortalization of human esophageal epithelial cells by a recombinant SV40-adenovirus vector. Br. J. Cancer., 71, 819-825, 1995.
79    Sawada, J-I., Goto, M., Watanabe, H., Handa, H. and Yoshida, M.C. Regional mapping of two subunits of transcription factor E4TF1 to human chromosome. Jpn. J. Can. Res., 86, 10-12, 1995.
 1994年
78   Takemoto, Y., Tashiro, S., Handa, H. and Ishii, S. Multiple nuclear localization signals of the B-myb gene product. FEBS Lett., 350, 55-60, 1994.
77   Aizawa, S., Yaguchi, M., Nagasu, M., Handa, H. and Toyama, K. Effects of hepatocyte growth-factor on hematopoietic-cells in human long term bone-marrow culture. Exp.hematol., 22, 814-814, 1994.
76   Sakurai, M., Higashida, S., Sugano, M., Handa, H., Komai, T., Yagi, R., Nishigaki, T. and Yabe, Y. Studies of human-immunodeficiency-virus type-1(HIV-1) protease inhibitors. 3. structure-activity relationship of HIV-1 protease inhibitors containing. Chem.Pharm.Bull.Tokyo., 42, 534-540, 1994.
75   Shimizu, K., Handa, H., Nakada, S. and Nagata, K. Regulation of influenza virus RNA polymerase activity by cellular and viral factors. Nucleic Acids Res., 22, 5047-5053, 1994.
74   Sanda, F., Nakamura, M., Endo, T., Tanaka, T. and Handa, H. Synthesis of novel optically active polymethacrylamide having L-leucine structure in the side chain. Macromolecules, 27, 7928-7929, 1994.
73   Hojo, H., Aizawa, S., Nagasu, M., Yamaguchi, M., Harigaya, K., Handa, H. and Toyama, K. Specific interaction between T cells and a novel established human thymic stromal cell line (R-3-4) in vitro. Hematol. Path., 8, 177-185, 1994.
72   Savoysky, E., Mizuno, T., Sowa, Y. Watanabe, H., Sawada, J-I., Nomura, H., Ohsugi, Y., Handa, H. and Sakai, T. The retinoblastoma binding factor 1 (RBF-1) site in RB gene promoter binds preferentially E4TF1, a member of the Ets transcription factors family. Oncogene, 9, 1839-1846, 1994.
71   Sawada, J-I., Goto, M., Sawa, C., Watanabe, H. and Handa, H. Transcriptional activation through the tetrameric complex formation of E4TF1 subunits. EMBO J., 13, 1396-1402, 1994.
70    Nakamura, T., Araki, K., Araki, K., Ohji, M., Takahashi, Y., Kiritoshi, A., Sasabe, T., Ohashi, Y. and Handa H. Cell Biological behavior of an SV40-immortalized rabbit conjunctival epithelial-cell line investigative ophthalmology & visual science. Invest.Ophthalmol.Visual.Sci., 35, 1794-1794, 1994.
69   Araki, K., Ohashi, Y., Sasabe, T., Hayashi, K. and Handa, H. SV40-immortalized human corneal epithelial-cell expressing aldehyde dehydrogenase-activity. Invest.Ophthalmol.Visual.Sci., 35, 1939-1939, 1994.
68  Aizawa, S., Yaguchi, M., Nagasu, M., Toyama K. and Handa, H. Interaction of human bone-marrow stromal cells and HL-60 in-vitro. Exp.Hematol., 21, 1052-1052, 1993.
67   Aizawa, S., Yaguchi, M., Nakano, M., Toyama, K., Inokuchi, S., Imai, T., Yasuda, M., Nabeshima, R. and Handa, H. Hematopoietic supportive function of human bone marrow stromal cell lines established by a recombinant SV40-adenovirus vector. Exp. Hematol., 22, 482-487, 1994.
66   Sumi, Y., Shiroya, T., Fujimoto, K., Wada, T., Handa, H. and Kawaguchi, H. Application of cationic latex particles for protein separation. Colloids and Surfaces B: Biointerfaces, 2, 419-427, 1994.
65   Inomata, Y., Wada, T., Handa, H., Fujimoto, K. and Kawaguchi, H. Preparation of DNA-carrying affinity latex and putification of transcription factors with the latex. J. Biomater. Sci. Polymer Edn., 5, 293-302, 1994.
 1993年
64   Nakamura, T., Araki, K., Kiritoshi, A., Sasabe, T., Ohashi, Y. and Handa, H. Establishment of a rabbit conjunctival epithelial-cell line immortalized by a SV40/adeno recombinant virus. Invest.Ophthalmol.visual.Sci., 34, 1473-1473, 1993.
63   Ma, D., Watanabe, H., Mermelstein, F., Admon, A., Oguri, K., Sun, X., Wada, T., Imai, T., Shiroya, T., Reinberg, D. and Handa, H. Isolation of cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription. Genes Dev., 7, 2246-2257, 1993.
62   Sakurai M., Higashida, S., Sugano, M., Nishi, T., Saito F., Ohata, Y., Handa, H., Komai, T., Yagi, R., Nishigaki, T. and Yabe, Y. Studies of HIV-1 protease inhibitors. II. Incorporation of four types of hydroxyethylene dipeptide isosteres at the scissile site of substrate sequences. Chem. Pharm. Bull., 41, 1378-1386, 1993.
61   Sakurai, M., Sugano, M., Handa, H., Konami, K., Yagi, R., Nishigaki, T. and Yabe, Y.  Studies of HIV-1 protease inhibitors. I. Incorporation of a reduced peptide, simple aminoalcohol, and statine analog at the scissile site of substrate sequences. Chem. Pharm. Bull., 41, 1369-1377, 1993.
60   Araki, K., Ohashi, Y., Sasabe, T., Kinoshita, S., Hayashi, K., Yang X.H., Hosaka, Y., Aizawa, S. and Handa, H.. Immortalization of rabbit corneal epithelial cells by recombinant SV40-adenovirus vector. Invest. Ophthalmol. Vis. Sci., 34, 2665-2671, 1993. 
59   Tabuchi, H., Handa, H. and Hirose, S. Underwinding of DNA on binding of yeast TFIID to the TATA element. Biochem. Biophys. Res. Commun., 192, 1432-1438, 1993.
58   Watanabe, H., Sawada J-I., Yano, Y., Yamaguchi, K., Goto, M. and Handa, H. cDNA cloning of transcription factor E4TF1 subunits with ETS and NOTCH motifs. Mol. Cell. Biol., 13, 1385-1391, 1993.
■   1992年
57   Sogawa, K., Handa, H., Fujisawa-Sehara, A., Hiromasa, T., Yamane, M. and Fujii-Kuriyama, Y. Repression of cytochrome P450c gene expression by cotransfection with adenovirus E1a DNA. In Molecular Biology of chytichrome P-450 (ed. Omura.T) (Book) Kyushu University Press, 97-102, 1992.
56   Sakurai, M., Sugano, M., Higashida, S., Kasuya, A., Miyamoto, S., Handa, H., Komai, T., Yagi, R., Nishigaki, T. and Yabe, Y. Synthesis of HIV-1 protease inhibitors. In Peptide Chemistry 1992. (ed. Yanaihara.N) (Book) ESCOM, 532-534, 1992.
55   Hirose, F., Yamaguchi, M., Handa, H., Inomata, Y. and Matsukage, A. Novel 8-bp sequence (DRE) and specific binding factor (DREF) involved in the expression of Drosophila genes for DNA polymeraseαand proliferating cell nuclear antigen. J. Biol. Chem., 268, 2092-2099, 1992.
54   Hashimoto, T., Morohashi, K-I., Takayama, T., Honda., S-I., Wada, T., Handa, H. and Omura, T. Cooperative transcription activation between Ad1, a CREB-like element, and other elements in the CYPB gene promoter. J. Biochem., 112, 573-575, 1992.
53   Zu, Y-L., Takamatsu, Y., Zhao, M-J., Maekawa, T., Handa, H. and Ishii, S. Transcriptional regulation by a point mutant of adenovirus type-2 E1a product lacking DNA binding activity. J. Biol. Chem., 267, 20181-20187, 1992.
52   Morohashi, K-I., Inomata, Y., Handa, H. and Omura, T. A common trans-acting factor to the promoters of sterogenic P-450s. J. Biol. Chem., 267, 17913-17919, 1992.
51   Inomata, Y., Kawaguchi, H., Hiramoto, M., Wada, T. and Handa, H. Direct purification of multiple polypeptides of the ATF/E4TF3 family from HeLa cell crude nuclear extracts with DNA affinity latex particles. Anal. Biochem., 206, 109-114, 1992.
50   Hosaka, Y., Kitamoto, A., Shimojo, M., Nakajima, K., Imai, Y., Handa, H. and Kohsaka, S. Generation of microglia cell lines by transfection with simian virus 40 large T gene. Neursci. Lett., 141, 139-142, 1992.
49  Aizawa, S., Yaguchi, M., Nagasu, M., Toyama, K. and Handa, H. Hematopoietic supportive functions of cloned human bone-invitro. Exp.Hematol., 20, 811-811, 1992.
48   Araki, K., Ohashi, Y., Sasabe, T., Kinoshita, S., Hayashi, K. and Handa, H. Characterization of newly established rabbit corneal epithelial-cell line. Invest. Ophthalmol. Visual. Sci., 33, 1240-1240, 1992.
 1991年
47   Kawaguchi, H., Asai, A., Ohtsuka, Y., Watanabe, H., Wada, T. and Handa, H. Purification of DNA-binding transcription factors by their selective adsorption on the affinity latex particles. In Transcription Regulation Mechanisms in Eukaryotic Genes. (ed. Muramatsu.M) (Book)Nakanishi Printing Co., Ltd. 18-36, 1991.
46   Inokuchi, S., Ueda, M., Hashimoto, K., Handa, H. and Mitomi, T. Calcium induced differentiation of SV40 immortalized human epidermal keratinocytes cultured in defined medium.(Research Report.)Tokai J. Exp. Clin. Med., 16, 223-229, 1991.
45   Inokuchi, S., Ueda, M., Hashimoto, K., Handa, H. and Mitomi, T. Immortalization of human epidermal keratinocytes by the recombinant SV40-adenovirus vector. In Vitro Cell. Dev. Biol (Letteer) ., 27, 827-828, 1991. 
44   Hibi, T., Fujisawa, T., Kanai, T., Akatsuka, A., Habu, S., Handa, H. and Tsuchiya, M. Establishment of epithelial cell lines from human and mouse thymus immortalized by the 12S adenovirus E1A gene product. Thymus, 18, 155-167, 1991.
43   Satoh, M.S., Moriyama, C., Asai, A., Handa, H., Rajewsky, M.F., Kuroki, T. and Huh, M. Monoclonal antibody-mediated solid-phase assay of mammalian O6-alkylguanine DNA alkyltransferase activity. Anal. Biochem., 196, 403-409, 1991.
42   Aizawa, S., Yaguchi, M., Nakano, M., Toyama, K. and Handa, H. Establishment of a variety of human bone-marrow stromal cell-lines by the recombinant SV40-adenovirous vector. Exp.Hematol., 19, 535-535, 1991.
41   Kawaguchi, H., Inamoto, Y. and Handa, H. Affinity latex for the purification of sequence-specific DNA-Binding proteins. (Research Report.) Abstr.Pap.Amer.Chem.Soc., 201, 334-Coll , 1991.
40   Usuda, Y., Kubota, A., Berk, A.J. and Handa, H. Affinity-purification of transcription factor IIA from HeLa cell nuclear extracts. EMBO J., 10, 2305-2310, 1991.
39   Aizawa, S., Yaguchi, N., Nakano, M., Inokuchi, S., Handa, H. and Toyama, K. Establishment of a variety bone marrow stromal cell lines by the recombinant SV40-adenovirus vector. J. Cell. Physiol., 148, 245-251, 1991.
38   Mizutani, M., Ohta, T., Watanabe, H., Handa, H. and Hirose, S. Negative supercoiling of DNA facilitates an interaction between transcription factor II and fibroin gene promoter. Proc. Natl. Acad. Sci. USA, 88, 718-722, 1991.
37   Wada, T., Watanabe, H., Usuda, Y. and Handa, H. Different biological activities of the hetero- and homo-dimers formed by the 47 kd and 43 kd proteins of transcription factor ATF/E4TF3. J. Virol., 65, 557-564, 1991.
36   Imai, T., Kawaguchi, H., Wada, T. and Handa, H. E1A gene products stimulate in vitro transciption from the adenovirus early region 4 promoter by enhancingstable preinitiation complex. Virus Genes, 5, 47-55, 1991.
 ■  1990年
35   Wada, T., Nogi, Y., Handa, H. and Fukasawa, T. Strain-specific lethal effect of adenovirus E1a protein of Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun., 170, 470-476, 1990.
34   Watanabe, H., Wada, T. and Handa, H. Transcription factor E4TF1 contains two subunits with different functions. EMBO J., 9, 841-847, 1990.
 1980年代
33   Kawaguchi, H., Asai, A., Ohtsuka, Y., Watanabe, H., Wada, T. and Handa, H. Purification of DNA-binding transcription factor by their selective adsorption of the affinity latex particles. Nucleic Acids Res., 17, 6229-6240, 1989.
32   Handa, H., Watanabe, H., Suzuki, Y. and Hirose, S. Effect of DNA supercoiling on transcription from the adenovirus early region 4. FEBS Lett., 249, 17-20, 1989.
31   Ooyama, S., Imai, T., Hanaka, S. and Handa, H. Transcription in the reverse orientation at either terminus of the adenovirus type 5 genome. EMBO J., 8, 863-868, 1989.
30  Sogawa, K., Handa, H., Fujisawa-Sehara, A., Hiromasa, T., Yamane, M. and Fujii-Kuriyama, Y. Repression of cytochrome P-450c gene expression by the adenovirus E1A gene products. Eur. J. Biochem., 181, 539-544, 1989.
29   Akahori, Y., Handa, H., Imai, K., Abe, M., Kameyama, K., Hibiya, M., Yasui, H., Okamura, K., Naito, M., Matsuoka, H. and Kurosawa, Y. Sigma region located between Cμand Cδ genes of human immunoglobulin heavy chain: Possible involvement of tRNA-like structure in RNA splicing. Nucleic Acids Res., 16, 9497-9511, 1988.
28   Abe, A., Wada, T., Handa, H., Nogi, Y. and Fukasawa, T. Efficient usage of galactose-inducible expression vector in production of heterologus protein in yeast. Agric. Biol. Chem., 52, 2035-2041, 1988. 
27   Kohama, T., Handa, H. and Harigaya, K. A burst-promoting activity derived from the human bone marrow stromal cell line KM102 is identical to the granulocyte-macrophage colony-stimulating factor. Exp. Hematol., 16, 603-608, 1988.
26   Watanabe, H., Imai, T., Sharp, P.A. and Handa, H. Identification of two transcription factors that bind to specific elements in the promoter of the adenovirus early-region 4. Mol. Cell. Biol., 8, 1290-1300, 1988.
25   Nishigaki, T., Hanaka, S., Kingston, R.E. and Handa, H. A specific domain of the adenovirus EIV promoter is necessary to maintain susceptibility of the integrated promoter to E1A transactivation. Mol. Cell. Biol., 8, 353-360, 1988.
24   Handa, H., Toda, T., Tajima, M., Wada, T., Iida, H. and Fukasawa, T. Expression of the human adenovirus E1A product in yeast. Gene, 58, 127-136, 1987.
23   Hanaka, S., Nishigaki, T., Sharp, P.A. and Handa, H. Regulation of in vitro and in vivo transcription of early region IV of adenovirus type 5 by multiple cis-acting elements. Mol. Cell. Biol., 7, 2578-2587, 1987.
22   Oda, K., Masuda-Murata. M., Shiroki, K. and Handa, H. Mitogenic activity of the adenovirus type 12 E1A gene induced by hormones in rat cells. J. Virol., 58, 125-133, 1986.
21   Harigaya, K. and Handa, H. Generation of functional clonal cell lines from human bone marrow stroma. Proc. Natl. Acad. Sci. USA., 82, 3477-3480, 1985.
20   Handa, H., Mizumoto, K., Oda, K., Okamoto, H. and Fukasawa, T. Transcription of the human adenovirus E1A gene in Saccharimyces cerevisiae. Gene, 33, 159-168, 1985.
19   Handa, H. and Sharp, P.A. Requirement for distal upstream sequences for maximal transcription in vitro of early region IV of adenovirus. Mol. Cell. Biol., 4, 791-798, 1984.
18   Notake, M., Kurosaki, T., Yamamoto, T., Handa, H., Mishina, M. and Numa, S. Sequence requirement for in vitro transcription of the human corticotropin/β-Lipotropin precursor gene. Eur. J. Biochem., 133, 599-605, 1983.
17   Handa, H., Kingston, R.E. and Sharp, P.A. Inhibition of adenovirus early region IV transcription in vitro by purified viral 72,000 DNA binding protein. Nature, 302, 545-547, 1983.
16   Saito, I., Sato, J., Handa, H., Shiroki, K. and Shimojo, H. Mapping of RNAs transcribed from adenovirus type 12 early VA RNA regions. Virology, 114, 379-398, 1981.
15   Cepko, C.L., Hansen, U., Handa, H. and Sharp, P.A. Sequential transcription-translation of SV40 using mammalian cell extracts. Mol. Cell. Biol., 1, 919-931, 1981.
14   Handa, H., Kaufman, R.J., Manley, J.L., Gefter, M.L. and Sharp, P.A. Transcription of SV40 DNA using mammalian cell extracts. J. Biol. Chem., 256, 478-482, 1981.
13   Manley, J.L., Handa, H., Huang, S-Y., Gefter, M.L. and Sharp, P.A. Transcription of animal virus genes in vitro. In Mobilization and Reassembly of Genetic Information. (eds. Acott, W.A. et al) (Book) Academic Press, Inc. 361-378, 1980.
12   Handa, H. and Sharp, P.A. Expression of early and late SV40 transcripts in the absence of protein synthesis. J. Virol., 34, 592-597, 1980.
 ■  1970年代
11  Handa, H. and Carter, B.J. Adeno-associated virus DNA replication complexes in herpes simplex virus or adenovirus-infected cells. J. Biol. Chem., 254, 6603-6610, 1979.
10   Hashimoto, K., Handa, H., Umehara, K. and Sasaki, S. Germfree mice reared on an antigen-free diet. Lab. Anim.Sci., 28, 38-45, 1978.
9 Handa, H., Shiroki, K. and Shimojo, H. In Parvovirus: Replication and Biological Propeties. (eds. D.C.Ward and P.Tattersall) Cold Spring Harbor, New York, 99-108, 1978.
8  Handa, H., Shiroki, K. and Shimojo, H. Isolation and characterization of KB cell lines latently infected with adeno-associated virus type 1. In Parvovirus:Replication and Biological Properties. (eds. Ward, D.C. and Tattersall.P.)(Book) Cold Spring Harbor, New York, 77-86, 1978.
7  Handa, H. and Shimojo, H. Isolation of the viral DNA replication complex from adeno-associated virus type 1-infected cells. J. Virol., 24, 444-450, 1977.
 Shiroki, K., Handa, H., Shimojo, H., Yano, S., Ojima, S. and Fujinaga, K. Establishment and characterization of rat cell lines transformed by restriction endonuclease fragment of adenovirus 12 DNA. Virology, 82, 462-471, 1977.
 Handa, H., Shiroki, K. and Shimojo, H. A helper function(s) for growth of adeno-associated virus in cells transformed by adenovirus 12. Proc. Natl. Acad. Sci. USA, 74, 4508-4510, 1977.
4  Handa, H., Shiroki, K. and Shimojo, H. Establishment and characterization of KB cell lines latently infected with adeno-associated virus type 1. Virology, 82, 84-92, 1977.
3  Handa, H. and Shimojo, H. Viral DNA sysnthesis in vitro with nuclei isolated from adeno-associated virus type 1-infected cells. Virology, 77, 424-428, 1977.
2  Handa, H., Shimojo, H. and Yamaguchi, H. Multiplication of adeno-associated virus type 1 in cells coinfected with a temperature-sensitive mutant of human adeno-virus type 31. Virology, 74, 1-15, 1976.
 Handa, H., Shiroki, K. and Shimojo, H. Complementation of adeno-associated virus growth with temperature-sensitive mutants of human adenovirus types 12 and 5. J. Gen. Virol., 29, 239-242, 1975.