原著論文・英文総説     著書・和文総説

 Selected Publications


1 Matyskiela, M. E., Lu, G., Ito, T., Pagarigan, B., Lu, C-C., Miller, K., Fang, W., Wang, N-Y., Nguyen, D., Houston, J., Carmel, G., Tran, T., Riley, M., Nosaka, L., Lander, G. C., Gaidarova, S., Xu, S., Ruchelman, A. L., Handa, H., Carmichael, J., Daniel, T. O., Cathers, B. E., Lopez-Girona, A., and Chamberlain, P. P. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature, 535, 252-257, 2016.
2  Thang Van Nguyen, J. Eugene Lee, Michael J. Sweredoski, Seung-Joo Yang, Seung-Je Jeon, Joseph S. Harrison, Jung-Hyuk Yim, Sang Ghil Lee, Handa H., Brian Kuhlman, Ji-Seon Jeong, Justin M. Reitsma, Chul-Seung Park, Sonja Hess, and Raymond J. Deshaies.Glutamine triggers acetylation-dependent degradation of glutamine synthetase via the thalidomide receptor cereblonMol.Cell, 61, 6, 809-820, 2016.
3  Kabe, Y., Nakane, T., Koike, I., Yamamoto, T., Sugiura, Y., Harada, E., Sugase, K., Shimamura, T., Ohmura, M., Muraoka, K., Yamamoto, A., Uchida, T., Iwata, S., Yamaguchi,Y., Krayukhina, E., Noda, M., Handa, H., Ishimori, K., Uchiyama, S., Kobayashi, T. and Suematsu, M. Haem-dependent dimerization of PGRMC1/sigma-2 receptor facilitates cancer proliferation and chemoresistance. Nat. Commun., 7, 2016.
4 Ito, T. and Handa, H. Myeloid desease:Another action of a thalidomide derivative.(NEWS&VIEWS) Nature, 523, 167-168, 2015.
5
Chamberlain, P., Lopez-Girona, A., Miller, K., Carmel, G., Pagarigan, B., Chie-Leon, B., Rychak, E., Corral, L., Ren, Y., Wang, M., Riley, M., Delker, S., Ito, T., Ando, H., Mori, T., Hirano, Y., Handa, H., Hakoshima, T., Daniel, T. and Cathers, B. Structure of the human cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nat. Struct. Mol. Biol., 21, 803-809, 2014.
6 Pérez-Perarnau, A., Preciado, S., Palmeri, C. M., Moncunill-Massaguer, C., Iglesias-Serret, D., González- Gironès, D. M., Miguel, M., Karasawa, S., Sakamoto, S., Cosialls, A. M., Rubio-Patiño, C., Saura-Esteller, J., Ramón, R., Caja, L., Fabregat, I., Pons, G., Handa, H., Albericio, F., Gil, J. and Lavilla, R. Novel trifluorinated thiazoline scaffold leading to proapoptotic agents targeting prohibitins. Angew. Chem. Int. Ed., 53, 10150-10154, 2014.
 7 Yamamoto, J., Hagiwara, Y., Chiba, K., Isobe, T., Narita, T., Handa, H., and Yamaguchi, Y. DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes. Nat. Commun., 5, 4263, 2014.
8 Miyazaki, H., Higashimoto, K., Yada, Y., Endo, T. A., Sharif, J., Komori, T., Matsuda, M., Koseki, Y., Nakayama, M., Soejima, H., Handa, H., Koseki, H., Hirose, S. and Nishioka, K. Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract Polycomf silencing. Plos Genetics, 9,e1003897, 2013.
9 Ito, T., Ando, H., Suzuki, T., Ogura, T., Hotta, K., Imamura, Y., Yamaguchi, Y. and Handa, H. Identification of a primary target of thalidomide teratogenicity. Science, 327, 1345-1350, 2010.
10 Chen, Y., Yamaguichi, Y., Tsugeno, Y., Yamamoto, J., Yamada, t., Nakamura, M., Hisatake, K. and Handa,H. DSIF, the Paf1 complex, and Tat-SF1 have non-redundant, cooperative roles in RNA polymerase II elongation. Genes Dev., 23, 2765-2777, 2009.
11 Kang, J., Gemberling, M., Nakamura, M., Whitby, F. G., Handa, H., Fairbrother, W. and Tantin, D. A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Genes Dev., 23, 208-222, 2009.
12 Iizumi, Y., Sagara, H., Kabe, Y., Azuma, M., Kume, K., Ogawa, M., Nagai, T., Gillespie, P. G., Sasakawa, C. and Handa, H. The Enteropathogenic E.coli effector EspB facilitates microvillus effacing and -antiphagocytosis by inhibiting myosin function. Cell Host & Microbe, 2, 383-392, 2007.
13 Narita, T., Yung, T. M. C., Yamamoto, J., Tsuboi, Y., Tanabe, H., Tanaka, K., Yamaguchi, Y. and Handa, H. NELF interacts with CBC and participates in 3’-end processing of replication-dependent histone mRNAs. Mol.Cell, 26, 349-365, 2007.
14  Yamada, T., Yamaguchi, Y., Inukai, N., Kamijo, S., Mura, T. and Handa, H. P-TEFb-mediated
phosphorylation of the hSpt5 C-terminal repeats is critical to processive transcription elongation.
Mol. Cell, 21, 227-237, 2006.
15 Shimizu, N., Ouchida, R., Yoshikawa, N., Hisada, T., Watanabe, H., Okamoto, K., Kusuhara, M., Handa, H., Morimoto, C and Tanaka, H. HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b. Proc. Natl. Acad. Sci. USA, 102, 8555-8560, 2005.
16  Jennings, B.H., Shah, S., Yamaguchi, Y., Seki, M., Phillips, R.G., Handa, H. and Ish-Horowicz, D. Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila. Curr. Biol., 14, 1680-1684, 2004.
17 Aiyar, S.E., Sun, J-L., Blair, L.A., Moskaluk, A.C., Lv, Y., Ye, O-N., Yamaguchi., Y, Mukherjee., A, Re., D-M, Handa, H. and Li, R.Attenuation of estrogen receptor α-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev., 18, 2134-2146, 2004.
18 Mandal. S.S, Chu, C., Wada, T., Handa, H., Shatkin, J.A. and Reinberg, D. Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase Ⅱ. Proc. Natl. Acad. Sci. USA., 101, 7572-7577, 2004.
19 Shimojima, T., Okada, M., Nakayama, T., Ueda, H., Okawa, K., Iwamatsu, A., Handa, H. and Hirose, H.Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor. Genes Dev., 17, 1605-1616, 2003.
20 Wu, C-H., Yamaguchi, Y., Benjamin, L., Horvat-Gordon, M., Washinski, J., Enerly, E., Lambertsson, A., Handa, H. and Gilmoury, D. NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. Genes Dev., 17, 1402-1414, 2003.
21 Yamaguchi, Y., Filipovska, J., Yano, K., Furuya, A., Inukai, N., Narita, T., Wada, T., Sugimoto, S., Konarska, M.M. and Handa, H. Stimulation of RNA polymerase II elongation by hepatitis delta antigen. Science, 293, 124-127, 2001.
22 Guo, S., Yamaguchi, Y., Schilbach, S., Wada, T., Lee, J., Goddard, A., French, D., Handa, H. and Rosenthal, A. A regulator of transcriptional elongation controls vertebrate neuronal development. Nature, 408, 366-369,2001.
23 Shimizu, N., Sugimoto, K., Tang, J., Nishi, T., Sato, I., Hiramoto, M., Aizawa, S., Hatakeyama, M., Ohba, R., Hatori, H., Yoshikawa, T., Suzuki, F., Oomori, A., Watanabe, H., Tanaka, H., Kawaguchi, H. and Handa, H.High-performance affinity beads for identifying drug receptors. Nat. Biotechnol., 18, 877-881, 2000.
24 Wada, T., Orphanides, G., Hasegawa, J., Kim, D-K., Shima, D., Yamaguchi, Y., Fukuda, A., Hisatake, K., Oh, S., Reinberg, D. and Handa, H. FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. Mol. Cell, 5, 1067-1072, 2000.
25 Yamaguchi, Y., Takagi, T., Wada, T., Yano, K., Furuya, A., Sugimoto, S., Hasegawa, J. and Handa, H. NELF, a multisubunit Complex Containing RD, Cooperates with DSIF to Repress RNA Polymerase II Elongation. Cell, 97, 41-51, 1999.
26 Wada, T., Takagi, T., Yamaguchi, Y., Watanabe, D. and Handa, H. Evidence that p-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro. EMBO J., 17, 7395-7403, 1998.
27 Hartzog, G.A., Wada, T., Handa, H. and Winston, F. Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae. Genes Dev., 12, 357-369, 1998.
28 Wada, T., Takagi, T., Yamaguchi, Y., Ferdous, A., Imai, T., Hirose, S., Sugimoto, S., Yano, K., Hartzog, G.A., Winston, F., Buratowski, S. and Handa, H. DSIF, a novel negative transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. Genes Dev., 12, 343-356, 1998.
29 Nagata, K., Kawase, H., Handa, H., Yano, K., Yamasaki, M., Ishimi, Y., Okuda, A., Kikuchi, A. and
Matsumoto, K. Replication factor encoded by putative oncogene, set, associated with myeloid
leukemogenesis.
Proc. Natl. Acad. Sci. USA., 92, 4279-4283, 1995.
30 Sawada, J-I., Goto, M., Sawa, C., Watanabe, H. and Handa, H. Transcriptional activation through the tetrameric complex formation of E4TF1 subunits. EMBO J., 13, 1396-1402, 1994.
31 Ma, D., Watanabe, H., Mermelstein, F., Admon, A., Oguri, K., Sun, X., Wada, T., Imai, T., Shiroya, T., Reinberg, D. and Handa, H. Isolation of cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription. Genes Dev., 7, 2246-2257, 1993.
32 Usuda, Y., Kubota, A., Berk, A.J. and Handa, H. Affinity-purification of transcription factor IIA from HeLa cell nuclear extracts. EMBO J., 10, 2305-2310, 1991.
33 Mizutani, M., Ohta, T., Watanabe, H., Handa, H. and Hirose, S. Negative supercoiling of DNA facilitates an interaction between transcription factor IID and the fibroin gene promoter. Proc. Natl. Acad. Sci. USA, 88,718-722, 1991.
34 Watanabe, H., Wada, T. and Handa, H. Transcription factor E4TF1 contains two subunits with different functions. EMBO J., 9, 841-847, 1990.
35 Ooyama, S., Imai, T., Hanaka, S. and Handa, H. Transcription in the reverse orientation at either terminus of the adenovirus type 5 genome. EMBO J., 8, 863-868, 1989.
36 Harigaya, K. and Handa, H. Generation of functional clonal cell lines from human bone marrow stroma. Proc. Natl. Acad. Sci. USA., 82, 3477-3480, 1985.
37 Handa, H., Kingston, R.E. and Sharp, P.A. Inhibition of adenovirus early region IV transcription in vitro by purified viral DNA binding protein. Nature, 302, 545-547, 1983.

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