原著論文


374 Kabe, Y., Koike, I., Yamamoto, T., Hirai, M., Kanai, A., Furuhata, R., Tsugawa, H., Harada, E., Sugase, K., Hanadate, K., Yoshikawa, N., Hayashi, H., Noda, M., Uchiyama, S., Yamazaki, H., Tanaka, H., Kobayashi, T., Handa, H. and Suematsu, M. Glycyrrhizin derivatives suppress cancer chemoresistance by inhibiting progesterone receptor membrane component 1. Cancers, 13, 3265, 2021. DOI:10.3390/cancers13133265
373 Miyahara, K., Takano, N., Yamada, Y., Kazama, H., Tokuhisa, M., Hirotsugu Hino, H., Koji Fujita, K., Barroga, E., Hiramoto, M., Handa, H., Kuroda, M., Ishikawa, T. and Miyazawa, K. BRCA1 degradation in response to mitochondrial damage in breast cancer cells. Sci. Rep., 11, 8735, 2021.
DOI: 10.1038/s41598-021-87698-7
372 Ishibashi, M., Yamamoto, J., Ito, T., Handa, H., Sunakawa, M., Inokuchi, K, Morita, R. and Tamura, H. Durvalumab combined with immunomodulatory drugs (IMiD) overcomes suppression of antitumor responses due to IMiD-induced PD-L1 upregulation on myeloma cells. Mol. Cancer Ther., 2021.
DOI: 10.1158/1535-7163.MCT-20-0246
371 Hirano, M., Imai, Y., Kaito, Y., Murayama, T., Sato, K., Ishida, T., Yamamoto, J., Ito, T., Futami, M., Ri, M., Yasui, H., Denda, T., Tanaka, Y., Ota, Y., Nojima, M., Kamikubo, Y., Gotoh, N., Iida, S., Handa, H. and Tojo, A. Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma. J. Exp. Clin. Cancer Res., 40, 110, 2021.
DOI: 10.1186/s13046-021-01909-7
370 Tsukahara, T., Sahara, Y., Ribeiro, N., Tsukahara, R., Gotoh, M., Sakamoto, S., Handa, H. and Murakami-Murofushi, K. Adenine nucleotide translocase 2, a putative target protein for 2-carba cyclic phosphatidic acid in microglial cells. Cell. Signal., 82, 109951, 2021. DOI: 10.1016/j.cellsig.2021.109951
369 Hirose, Y., Kitazono, T., Sezaki, M., Abe, M., Sakimura, K., Funato, H., Handa, H., Vogt, K. E. and Yanagisawa, M. Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway. Proc. Natl. Acad. Sci. USA, 117, 23106-23112, 2020. DOI: 10.1073/pnas.1917701117
368 Cho, J., Horikawa, Y., Enya, M., Takeda, J., Imai, Y., Imai, Y., Handa, H. and Imai, T. L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells. Commun. Biol., 3, 497, 2020.   DOI: 10.1038/s42003-020-01226-3
367 Yamamoto, J., Suwa, T., Murase, Y., Tateno, S., Mizutome, H., Asatsuma-Okumura, T., Shimizu, N., Kishi, T., Momose, S., Kizaki, M., Ito, T., Yamaguchi, Y. and Handa, H. ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells. Nat. Chem. Biol., 16, 1208-1217, 2020.  DOI: 10.1038/s41589-020-0645-3
366 Cho, J., Hiramoto, M., Masaike, Y., Sakamoto, S., Imai, Y., Imai, Y., Handa, H. and Imai, T. UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner. Biochem. Biophys. Res. Commun., 527, 668-675, 2020. DOI: 10.1016/j.bbrc.2020.04.158
365 Yokose, T., Kabe, Y., Matsuda, A., Kitago, M., Matsuda, S., Hirai, M., Nakagawa, T., Masugi, Y., Hishiki, T., Nakamura, Y., Shinoda, M., Yagi, H., Abe, Y., Oshima, G., Hori, S., Nakano, Y., Honda, K., Kashiro, A., Morizane, C., Nara, S., Kikuchi, S., Shibahara, T., Itonaga, M., Ono, M., Minegishi, N., Koshiba, S., Yamamoto, M., Kuno, A., Handa, H., Sakamoto, M., Suematsu, M. and Kitagawa, Y. O-Glycan-altered extracellular vesicles: a specific serum marker elevated in pancreatic cance. Cancers, 12, 2469, 2020. DOI: 10.3390/cancers12092469 
364 Tsugawa, H., Kabe, Y., Kanai, A., Sugiura, Y., Hida, S., Taniguchi, S., Takahashi, T., Matsui, H., Yasukawa, Z., Itou, H., Takubo, K., Suzuki, H., Honda, K., Handa, H. and Suematsu, M. Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection. PLoS Biol., 18, e3000813, 2020. DOI: 10.1371/journal.pbio.3000813
363 Saika, K., Kato, M., Sanada, H., Matsushita, S., Matsui, M., Handa, H. and Kawano, M. Induction of adaptive immune responses against antigens incorporated within the capsid of simian virus 40. J. Gen. Virol., 101, 853-862, 2020. DOI: 10.1099/jgv.0.001445
362 Tochigi, T., Miyamoto, T., Hatakeyama, K., Sakoda, T., Ishihara, D., Irifune, H., Shima, T., Kato, K., Maeda, T., Ito, T., Handa, H., Akashi, K. and Kikushige, Y. Aromatase is a novel neosubstrate of cereblon responsible for immunomodulatory drugs-induced thrombocytopenia. Blood, 135, 2146-2158, 2020. DOI: 10.1182/blood.2019003749
361 Tateno, S., Iida, M., Fujii, S., Suwa, T., Katayama, M., Tokuyama, H., Yamamoto, J., Ito, T., Sakamoto, S., Handa, H. and Yamaguchi, Y. Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide. Sci. Rep., 10, 4012, 2020.
DOI: 10.1038/s41598-020-61027-w
360 Asakawa, K., Handa, H. and Kawakami, K. Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons. Nat. Commun., 11, 1004, 2020. DOI: 10.1038/s41467-020-14815-x
359 Kabe, Y., Takemoto, D., Kanai, A., Hirai, M., Ono, Y., Akazawa, S., Horikawa, M., Kitagawa, Y., Handa, H., Rogi, T., Shibata, H. and Suematsu, M. Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites. NPJ Sci. Food, 4, 4, 2020.  DOI: 10.1038/s41538-020-0064-6
358 Sekino, M., Kuwahata, A., Yoshibe, A., Imai, K., Kaneko, M., Chikaki, S., Saito, I., Tsuruma, A., Sakamoto, S., Handa, H., Matsuda, S. and Kusakabe, M. Development of an automatic magnetic immunostaining system for rapid intraoperative diagnosis of cancer metastasis. AIP Adv., 10, 015106, 2020. DOI:10.1063/1.5130478
357 Asatsuma-Okumura, T., Ando, H., Simone, M. D., Yamamoto, J., Sato, T., Shimizu, N., Asakawa, K., Yamaguchi, Y., Ito, T., Guerrini, L. and Handa, H. p63 is a cereblon substrate involved in thalidomide teratogenicity. Nat. Chem. Biol., 15, 1077-1084, 2019. DOI: 10.1038/s41589-019-0366-7
356 Tsugawa, Y., Natori, M., Handa, H. and Imai, T. Estradiol accelerates liver regeneration through estrogen receptor α. Clin. Exp. Gastroenterol., 12, 331–336, 2019. DOI: 10.2147/CEG.S214196 
355 Tsugawa, Y., Handa, H. and Imai, T. Arginine induces IGF-1 secretion from the endoplasmic reticulum. Biochem. Biophys. Res. Commun., 514, 1128-1132, 2019. DOI: 10.1016/j.bbrc.2019.05.044
354 Ando, H., Sato, T., Ito, T., Yamamoto, J., Sakamoto, S., Nitta, N., Asatsuma-Okumura, T., Shimizu, N., Mizushima, R., Aoki, I., Imai, T., Yamaguchi, Y., Berk, A. J. and Handa, H. Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation. iScience, 15, 95-108, 2019. DOI: 10.1016/j.isci.2019.04.007
353 Onishi, T., Matsuda, S., Nakamura, Y., Kuramoto, J., Tsuruma, A., Sakamoto, S., Suzuki, S., Fuchimoto, D., Onishi, A., Chikaki, S., Kaneko, M., Kuwahata, A., Sekino, M., Yasuno, H., Hanyu, N., Kurita, T., Takei, H., Sakatani, T., Taruno, K., Nakamura, S., Hayashida, T., Jinno, H., Kusakabe, M., Handa, H., Kameyama, K. and Kitagawa, Y.  Magnetically promoted rapid immunofluorescence staining for frozen tissue sections. J. Histochem. Cytochem., 67, 575-587, 2019. DOI: 10.1369/0022155419841023 
352 Sharma, J., Ono, T., Yukino, R., Miyashita, H., Hanyu, N., Handa, H. and Sandhu, A. Smartphone based platform for real-time sharing of medical diagnostics information by optical detection of functionalized fluorescent magnetic nanoparticles. Biomed. Phys. Eng. Express, 5, 035014, 2019.
DOI: 10.1016/j.sbsr.2020.100347 
351 Kabe, Y., Suematsu, M., Sakamoto, S., Hirai, M., Koike, I., Hishiki, T., Matsuda, A., Hasegawa, Y., Tsujita, K., Ono, M., Minegishi, N., Hozawa, A., Murakami, Y., Kubo, M., Itonaga, M. and Handa, H. Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera. Clin. Chem., 64, 1463-1473, 2018. DOI: 10.1373/clinchem.2018.291963
350 Kimura, A., Kitajima, M., Nishida, K., Serada, S., Fujimoto, M., Naka, T., Fujii-Kuriyama, Y., Sakamato, S., Ito, T., Handa, H., Tanaka, T., Yoshimura, A. and Suzuki, H. NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation. J. Exp. Med., 215, 2197-2209, 2018.
DOI: 10.1084/jem.20172024
349 Mori, T., Ito, T., Liu, S., Ando, H., Sakamoto, S., Yamaguchi, Y., Tokunaga, E., Shibata, N., Handa, H. and Hakoshima, T. Structural basis of thalidomide enantiomer binding to cereblon. Sci. Rep., 8, 1294, 2018.
DOI: 10.1038/s41598-018-19202-7
348 Boccitto, M., Lee, N., Sakamoto, S., Spruce, L., Handa, H., Clardy, J., Seeholzer, S. and Kalb, R. The neuroprotective marine compound psammaplysene A binds the RNA- binding protein HNRNPK. Mar. Drugs, 15, 246, 2017. DOI: 10.3390/md15080246
347 Sharma, J., Ishizawa, S., Yukino, R., Takamura, T., Hanyu, N., Yasuno, H., Handa, H. and Sandhu, A. Fast and sensitive medical diagnostic protocol based on integrating circular current lines for magnetic washing and optical detection of fluorescent magnetic nanobeads. Sens. Bio-Sensing Res., 9, 7-12, 2016. DOI: 10.1016/j.sbsr.2016.05.002
346 Matyskiela, M. E., Lu, G., Ito, T., Pagarigan, B., Lu, C-C., Miller, K., Fang, W., Wang, N-Y., Nguyen, D., Houston, J., Carmel, G., Tran, T., Riley, M., Nosaka, L., Lander, G. C., Gaidarova, S., Xu, S., Ruchelman, A. L., Handa, H., Carmichael, J., Daniel, T. O., Cathers, B. E., Lopez-Girona, A. and Chamberlain, P. P. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature, 535, 252-257, 2016. DOI: 10.1038/nature18611 
345 Nguyen, T. V., Lee, J. E., Sweredoski, M. J., Yang, S. J., Jeon, S. J., Harrison, J. S., Yim, J. H., Lee, S. G., Handa, H., Kuhlman, B., Jeong, J. S., Reitsma, J. M., Park, C. S., Hess, S. and Deshaies, R. J. Glutamine triggers acetylation-dependent degradation of glutamine synthetase via the thalidomide receptor cereblon. Mol. Cell, 61, 809-820, 2016.
DOI: 10.1016/j.molcel.2016.02.032
344 Klaeger, S., Gohlke, B., Perrin, J., Gupta, V., Heinzlmeir, S., Helm, D., Qiao, H., Bergamini, G., Handa, H., Savitski, M. M., Bantscheff, M., Medard, G., Preissner, R. and Kuster, B. Chemical proteomics reveals ferrochelatase as a common off-target of kinase inhibitors. ACS Chem. Biol., 11, 1245-1254, 2016.
DOI: 10.1021/acschembio.5b01063  
343 Kabe, Y., Nakane, T., Koike, I., Yamamoto, T., Sugiura, Y., Harada, E., Sugase, K., Shimamura, T., Ohmura, M., Muraoka, K., Yamamoto, A., Uchida, T., Iwata, S., Yamaguchi, Y., Krayukhina, E., Noda, M., Handa, H., Ishimori, K., Uchiyama, S., Kobayashi, T. and Suematsu, M. Haem-dependent dimerization of PGRMC1/sigma-2 receptor facilitates cancer proliferation and chemoresistance. Nat. Commun., 7, 11030, 2016. DOI: 10.1038/ncomms11030
342 Mukai, S., Moriya, S., Hiramoto, M., Kazama, H., Kokuba, H., Che, X-F., Yokoyama, T., Sakamoto, S., Sugawara, A., Sunazuka, T., Ōmura, S., Handa, H., Itoi, T. and Miyazawa, K. Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines. Int. J. Oncol., 48, 45-54, 2015. DOI: 10.3892/ijo.2015.3237
341 Laitem, C., Zaborowska, J., Tellier, M., Yamaguchi, Y., Qingfu, C., Egloff, S., Handa, H. and Murphy, S. CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription. Transcription, 6, 79-90, 2015.
DOI: 10.1080/21541264.2015.1095269
340 Cao, Q-F., Yamamoto, J., Isobe, T., Tateno, S., Murase, Y., Chen, Y., Handa, H. and Yamaguchi, Y. Characterization of the human transcription elongation factor Rtf1: evidence for nonoverlapping functions of Rtf1 and the Paf1 complex. Mol. Cell. Biol., 35, 3459-3470, 2015. DOI: 10.1128/MCB.00601-15
339 Ito, T. and Handa, H. Another action of a thalidomide derivative.(News and Views) Nature, 523, 167-168, 2015. DOI: 10.1038/nature14628
338 Kawano, M., Doi, K., Fukuda, H., Kita, Y., Imai, K., Inoue, T., Enomoto, T., Matsui, M., Hatakeyama, M., Yamaguchi, Y. and Handa, H. SV40 VP1 major capsid protein in its self-assembled form allows VP1 pentamers to coat various types of artificial beads in vitro regardless of their sizes and shapes. Biotechnol. Rep., 5, 105-111, 2015. DOI: 10.1016/j.btre.2014.12.008
337 Chamberlain, P. P., Lopez-Girona, A., Miller, K., Carmel, G., Pagarigan, B., Chie-Leon, B., Rychak, E., Corral, L. G., Ren, Y. J., Wang, M., Riley, M., Delker, S. L., Ito, T., Ando, H., Mori, T., Hirano, Y., Handa, H., Hakoshima, T., Daniel, T. O. and Cathers, B. E. Structure of the human cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nat. Struct. Mol. Biol., 21, 803-809, 2014. DOI: 10.1038/nsmb.2874
336 Pérez-Perarnau, A., Preciado, S., Palmeri, C. M., Moncunill-Massaguer, C., Iglesias-Serret, D., González-Gironès, D. M., Miguel, M., Karasawa, S., Sakamoto, S., Cosialls, A. M., Rubio-Patiño, C., Saura-Esteller, J., Ramón, R., Caja, L., Fabregat, I., Pons, G., Handa, H., Albericio, F., Gil, J. and Lavilla, R. A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins. Angew. Chem. Int. Ed., 53, 10150-10154, 2014. DOI: 10.1002/anie.201405758
335 Yamamoto, J., Hagiwara, Y., Chiba, K., Isobe, T., Narita, T., Handa, H. and Yamaguchi, Y. DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes. Nat. Commun., 5, 4263, 2014.
DOI: 10.1038/ncomms5263
334 Sakamoto, S., Omagari, K., Kita, Y., Mochizuki, Y., Naito, Y., Kawata, S., Matsuda, S., Itano, O., Jinno, H., Takeuchi, H., Yamaguchi, Y., Kitagawa, Y. and Handa, H. Magnetically promoted rapid immunoreactions using functionalized fluorescent magnetic beads: a proof of principle. Clin. Chem., 60, 610-620, 2014. DOI: 10.1373/clinchem.2013.211433
333 Gandhi, A. K., Kang, J., Havens, C. G., Conklin, T., Ning, Y., Wu, L., Ito, T., Ando, H., Waldman, M. F., Thankurta, A., Klippel, A., Handa, H., Daniel, T. O., Schafer, P. H. and Chopra, R. Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN. Br. J. Haematol., 164, 811-821, 2014. DOI: 10.1111/bjh.12708
332 Takemoto, M., Kawamura, Y., Hirohama, M., Yamaguchi, Y., Handa, H., Saitoh, H., Nakao, Y., Kawada, M., Khalid, K., Koshino, H., Kimura, K., Ito, A. and Yoshida, M. Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata. J. Antibiot., 67, 335-338, 2014. DOI: 10.1038/ja.2013.142
331 Kawano, M., Morikawa, K., Suda, T., Ohno, N., Matsushita, S., Akatsuka, T., Handa, H. and Matsui, M. Chimeric SV40 virus-like particles induce specific cytotoxicity and protective immunity against influenza A virus without the need of adjuvants. Virology, 448, 159-167, 2014. DOI: 10.1016/j.virol.2013.10.010
330 Terada, K., Tanaka, T., Hanyu, N., Honda, T. and Handa, H. Rapid and sensitive detection of alpha-fetoprotein by a magnetically promoted shake-free immunoassay employing fluorescent magnetic nanobeads. Int. J. Anal. Bio-Sci., 2, 101-107. 2014. Pdf : https://plaza.umin.ac.jp/~e-jabs/2/2.101.pdf 
329 Ohno, K., Sawada, J., Takiya, S., Kimoto, M., Matsumoto, A., Tsubota, T., Uchimo, K., Hui, C., Sezutsu, H., Handa, H. and Suzuki, Y. Silk gland factor-2, involved in fibroin gene transcription, consists of LIM homeodomain, LIM-interacting, and single-stranded DNA-binding proteins. J. Biol. Chem., 288, 31581-31591, 2013. DOI: 10.1074/jbc.M113.514471
328 Gupta, V., Liu, S., Ando, H., Ishii, R., Tateno, S., Kaneko, Y., Yugami, M., Sakamoto, S., Yamaguchi, Y., Nureki, O. and Handa, H. Salicycle acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesisi activity. Mol. Pharmacol., 84, 824-833, 2013. DOI: 10.1124/mol.113.087940 
327 Miyazaki, H., Higashimoto, K., Yada, Y., Endo, T. A., Sharif, J., Komori, T., Matsuda, M., Koseki, Y., Nakayama, M., Soejima, H., Handa, H., Koseki, H., Hirose, S. and Nishioka, K. Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract Polycomb silencing. PLoS Genet., 9, e1003897, 2013. DOI: 10.1371/journal.pgen.1003897
326 Iida, S., Imai, K., Matsuda, S., Itano, O., Hatakeyama, M., Sakamoto, S., Kokuryo, D., Okabayashi, K., Endo, T., Ishii, Y., Hasegawa, H., Aoki, I., Handa, H. and Kitagawa, Y. In Vivo identification of sentinel lymph nodes using MRI and size-controlled and monodispersed magnetite nanoparticles. J. Magn. Reson. Imaging, 38, 1346-1355,2013. DOI: 10.1002/jmri.24108
325 Enomoto, T., Kawano, M., Fukuda, H., Sawada, W., Inoue, T., Haw, K. C., Kita, Y., Sakamoto, S., Yamaguchi, Y., Imai, T., Hatakeyama, M., Saito, S., Sandhu, A., Matsui, M., Aoki, I. and Handa, H. Viral protein-coating of magnetic nanoparticles using simian virus 40 VP1. J. Biotechnol., 167, 8-15, 2013.
DOI: 10.1016/j.jbiotec.2013.06.005
324 Kang, J., Shen, Z., Lim, J-M., Handa, H., Wells, L. and Tantin, D. Regulation of Oct1/Pou2f1 transcription activity by O-GlcNAcylation. FASEB J., 27, 2807-2817, 2013. DOI: 10.1096/fj.12-220897
323 Hotta, K., Nashimoto, A., Yasumura, E., Suzuki, M., Azuma, M., Iizumi, Y., Shima, D., Nabeshima, R., Hiramoto, M., Okada, A., Sakata-Sogawa, K., Tokunaga, M., Ito, T., Ando, H., Sakamoto, S., Kabe, Y., Aizawa, S., Imai, T., Yamaguchi, Y., Watanabe, H. and Handa, H. Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein. Mol. Pharmacol., 83, 930-938, 2013. DOI: 10.1124/mol.112.081935
322 Kershaw, J., Leuze, C., Aoki, I., Obata, T., Kanno, I., Ito, H., Yamaguchi, Y. and Handa, H. Systematic changes to the apparent diffusion tensor of in vivo rat brain measured with an oscillating-gradient spin-echo sequence. NeuroImage, 70, 10-20. 2013. DOI: 10.1016/j.neuroimage.2012.12.036
321 Karasawa, S., Azuma, M., Kasama, T., Sakamoto, S., Kabe, Y., Imai, T., Yamaguchi, Y., Miyazawa, K. and Handa, H. Vitamin K2 covalently binds to Bak and induces Bak-mediated apoptosis. Mol. Pharmacol., 83, 613-620. 2013. DOI: 10.1124/mol.112.082602
320 Uebi, T., Umeda, M., Maekawa, N., Karasawa, S., Handa, H. and Imai, T. Prohibitins, novel vitamin K2 target factors in osteoblast. J. Biosci. Med., 1, 1-4, 2013. DOI: 10.4236/jbm.2013.13001
319 Umeda, M., Uebi, T., Maekawa, N., Masaike, Y., Handa, H. and Imai, T. Effective cofactor complex purification using nanobeads. J. Biosci. Med., 1, 5-10, 2013. DOI: 10.4236/jbm.2013.13002
318 Ito, Y., Ito, T., Karasawa, S., Enomoto, T., Nashimoto, A., Hase, Y., Sakamoto, S., Mimori, T., Matsumoto, Y., Yamaguchi, Y. and Handa, H. Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of Bisphenol A. PLOS One, 7.e50481, 2012. DOI: 10.1371/journal.pone.0050481
317 Diamant, G., Amir-Zilberstein, L., Yamaguchi, Y., Handa, H. and Dikstein, R. DSIF restricts NF-kB signaling by coordinating elongation with mRNA Processing of negative feedback genes. Cell Rep., 2, 722-731, 2012.
DOI: 10.1016/j.celrep.2012.08.041
316 Wada,T., Hara, M., Taneda, T., Qingfu, C., Takata, R., Moro, K., Takeda, K., Kishimoto, T. and Handa, H. Antisense morpholino targeting just upstream from a poly(A) tail junction of maternal mRNA removes the tail and inhibits translation. Nucleic Acids Res., 40, e173, 2012. DOI: 10.1093/nar/gks765
315 Lopez-Girona, A., Mendy, D., Ito, T., Miller, K., Gandhi, A. K., Kang, J., Karasawa, S., Carmel, G., Jackson, P., Abbasian, M., Mahmoudi, A., Cathers, B., Rychak, E., Gaidarova, S., Chen, R., Schafer, P. H., Handa, H., Daniel, T. O., Evans, J. F. and Chopra, R. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia, 26, 2326-2335, 2012. DOI: 10.1038/leu.2012.119
314 Okuda-Ashitaka, E., Minami, T., Tsubouchi, S., Kiyonari, H., Iwamatsu, A., Noda, T., Handa, H. and Ito, S. Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission. J. Biol. Chem., 287, 10403-10413, 2012. DOI: 10.1074/jbc.M111.271866
313 Kawano, A., Hayashi, Y., Noguchi, S., Handa, H., Horikoshi, M. and Yamaguchi, Y. Global analysis for functional residues of histone variant Htz1 using the comprehensive point mutant library. Genes Cells, 16, 590-607, 2011.
DOI: 10.1111/j.1365-2443.2011.01512.x
312 Enomoto, T., Kukimoto, I., Kawano, M., Yamaguchi, Y., Berk, A. J. and Handa, H. In vitro reconstitution of SV40 particles that are composed of VP1/2/3 capsid proteins and nucleosomal DNA and direct efficient gene transfer. Virology, 420, 1-9, 2011.  DOI: 10.1016/j.virol.2011.08.014
311 Kitai, Y., Fukuda, H., Enomoto, T., Asakawa, Y., Suzuki, T., Inouye, S. and Handa, H. Cell selective targeting of a simian virus 40 virus-like particle conjugated to epidermal growth factor. J. Biotechnol., 155, 251-256, 2011. DOI: 10.1016/j.jbiotec.2011.06.030
310 Yasuma, A., Ochiai, T., Azuma, M., Nishiyama, H., Kikuchi, K., Kondo, M. and Handa, H. Exogenous coproporphyrin III production by Corynebacterium aurimucosum and Microbacterium oxydans in erythrasma lesions. J. Med. Microbiol., 60, 1038-1042, 2011. DOI: 10.1099/jmm.0.027276-0
309 Hatakeyama, M., Kishi, H., Kita, Y., Imai, K., Nishio, K., Karasawa, S., Masaike, Y., Sakamoto, S., Sandhu, A., Tanimoto, A., Gomi, T., Kohda, E., Abe, M. and Handa, H. A two-step ligand exchange reaction generates highly water-dispersed magnetic nanoparticles for biomedical applications. J. Mater. Chem., 21, 5959-5966, 2011. DOI: 10.1039/C0JM04381H
308 Aizawa, M., Abe, Y., Ito, T., Handa, H. and Nawa, H. mRNA distribution of the thalidomide binding protein cereblon in adult mouse brain. Neurosci. Res., 69, 343-347, 2011. DOI: 10.1016/j.neures.2010.12.019
307 Taneda, T., Zhu, W., Cao, Q., Watanabe, H., Yamaguchi, Y., Handa, H. and Wada, T. Erythropoiesis is regulated by the transcription elongation factor Foggy/Spt5 through gata1 gene regulation. Genes Cells, 16, 231-242, 2011. DOI: 10.1111/j.1365-2443.2010.01481.x
306 Maekawa, N., Hiramoto, M., Sakamoto, S., Azuma, M., Ito, T., Ikeda, M., Naitou, M., Acharya, H. P., Kobayashi, Y., Suematsu, M., Handa, H. and Imai, T. High-performance affinity purification for identification of 15-deoxy-Δ12,14-PGJ2 interacting factors using magnetic nanobeads. Biomed. Chromatogr., 25, 466-471, 2011. ODI: 10.1002/bmc.1469
305 Morimoto, Y., Takamura, T., Park, S. Y., Sakamoto, S., Kawata, S., Handa, H. and Sandhu, A. Detection of 8 nm diameter superparamagnetic beads by magnetically-induced manipulation of micrometer-sized magnetic beads: A novel protocol for magnetically-labeled biosensing. Jpn. J. Appl. Phys., 49, 04DL07, 2010. DOI: 10.1143/JJAP.49.04DL07
304 Kim, S., Yamamoto, J., Chen, Y., Aida, M., Wada, T., Handa, H. and Yamaguchi, Y. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. Genes Cells, 15, 1003-1013, 2010.
DOI: 10.1111/j.1365-2443.2010.01436.x
303 Park, S. Y., Ko, P. J., Handa, H. and Sandhu, A. Exploring magneto-optical properties of biofunctionalized magnetic chains for developing label-free immunoassays. J. Appl. Phys., 107, 09B324, 2010. DOI: 10.1063/1.3355896
302 Kume, K., Iizumi, Y., Shimada, M., Ito, Y., Kishi, T., Yamaguchi, Y. and Handa, H. Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. Genes Cells, 15, 339-349, 2010.
DOI: 10.1111/j.1365-2443.2010.01385.x
301 Ito, T., Ando, H., Suzuki, T., Ogura, T., Hotta, K., Imamura, Y., Yamaguchi, Y. and Handa, H. Identification of a primary target of thalidomide teratogenicity. Science, 327, 1345-1350, 2010. DOI: 10.1126/science.1177319
300 Park, S. Y., Handa, H. and Sandhu, A. Magneto-optical biosensing platform based on light scattering from self-assembled chains of functionalized rotating magnetic beads. Nano Lett.,10, 446-451, 2010. DOI: 10.1021/nl9030488
299 Tominaga, A., Sugawara, H., Futagawa, T., Inoue, K., Sasaki, K., Minamino, N., Hatakeyama, M., Handa, H. and Miyata, A. Characterization of the testis-specific promoter region in the human pituitary adenylate cyclase-activating polypeptide (PACAP) gene. Genes Cells, 15, 595-606, 2010.
DOI: 10.1111/j.1365-2443.2010.01403.x
298 Masaike, Y., Takagi, T., Hirota, M., Yamada, J., Ishihara, S., Yung, T. M. C., Inoue, T., Sawa, C., Sagara, H., Sakamoto, S., Kabe, Y., Takahashi, Y., Yamaguchi, Y. and Handa, H. Identification of dynamin-2-mediated endocytosis as a new target of osteoporosis drugs, bisphosphonates. Mol. Pharmacol., 77, 262-269, 2010. DOI: 10.1124/mol.109.059006
297 Hiramoto, M., Maekawa, N., Kuge, T., Ayabe, F., Watanabe, A., Masaike, Y., Hatakeyama, M., Handa, H. and Imai, T. High-performance affinity chromatography method for identification of L-arginine interacting factors using magnetic nanobeads. Biomed. Chromatogr., 24, 606-612, 2010.
DOI: 10.1002/bmc.1334
296 Park, S. Y., Handa, H. and Sandhu, A. Determination of Inter-Molecular Forces by Magneto-Optical Transmittance of Molecule-Covered Superparamagnetic Particles in Solution. IEEE Trans. Magn., 46, 1409-1411, 2010.
DOI: 10.1109/TMAG.2010.2048747
295 Oda, T., Lee, J. S., Sato, Y., Kabe, Y., Sakamoto, S., Handa, H., Mangindaan, R.E.P. and Namikoshi, M. Inhibitory effect of N,N-didesmethylgrossularine-1 on inflammatory cytokine production in lipopolysaccharide-stimulated RAW 264.7 cells. Mar. Drugs, 7, 589-599, 2009. DOI: 10.3390/md7040589
294 Chen, H., Contreras, X., Yamaguchi, Y., Handa, H., Peterlin, B. M., and Guo, S. Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5. Plos ONE, 4, e6918, 2009.
DOI: 10.1371/journal.pone.0006918
293 Kawano, M., Xing, L., Tsukamoto, H., Inoue, T., Hand, H. and Cheng, R. H. Calcium bridge triggers capsid disassembly in the cell entry process of simian virus 40. J. Biol. Chem., 284, 34703-34712, 2009.
DOI: 10.1074/jbc.M109.015107
292 Chen, Y., Yamaguichi, Y., Tsugeno, Y., Yamamoto, J., Yamada, T., Nakamura, M., Hisatake, K. and Handa, H. DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation. Genes Dev., 23, 2765-2777, 2009. DOI: 10.1101/gad.1834709
291 Tanaka, T., Shimazu, R., Nagai, H., Tada, M., Nakagawa, T., Sandhu, A., Handa, H. and Abe, M. Preparation of spherical and uniform-sized ferrite nanoparticles with diameters between 50 and 150 nm for biomedical applications. J. Magn. Magn. Mater., 321, 1417-1420, 2009.
DOI: 10.1016/j.jmmm.2009.02.054
290 Suzuki, E., Ogura, H., Kato, K., Takei, I., Kabe, Y., Handa, H. and Umezawa, K. Preparation of conophylline affinity nano-beads and identification of a target preotein. Bioorg. Med. Chem., 17, 6188-6195, 2009.
DOI: 10.1016/j.bmc.2009.07.062
289 Kamiya, H., Suzuki, A., Yamaguchi, Y., Handa, H. and Harashima, H. Incorporation of 8-hydroxyguanosine 5’-triphosphate (8-oxo-7,8-dihydroguanosine) 5’-triphosphate by bacterial and human RNA polymerases. Free. Radic. Biol. Med., 46, 1703-1707, 2009.
DOI: 10.1016/j.freeradbiomed.2009.04.005
288 Yung, T.M.C., Narita, T., Komori, T., Yamaguchi, Y. and Handa, H. Cellular dynamics of the negative transcription elongation factor NELF. Exp. Cell Res., 315, 1693-1705, 2009. DOI: 10.1016/j.yexcr.2009.02.013
287 Abe, M., Nishio, N., Hatakeyama. M., Hanyu, N., Tanaka, T., Tada, M., Nakagawa, T., Sandhu, A. and Handa, H. Preparation and medical application of magnetic beads conjugated with bioactive molecules. J. Magn. Magn. Mater., 321, 645-649, 2009. DOI: 10.1016/j.jmmm.2008.11.086
286 Hanyu, N., Nishio, K., Hatakeyama, M., Yasuno, H., Tanaka, T., Tada, M., Nakagawa, T., Sandhu, A., abe, M. and Handa, H. High-throughput bioscreening system utilizing high-performance affinity magnetic carriers exhibiting minimal non-specific protein binding. J. Magn. Magn. Mater., 321, 1625-1627, 2009. DOI: 10.1016/j.jmmm.2009.02.100
285 Tada, M., Kanemaru, T., Hara, T., Nakagawa, T., Handa, H. and Abe, M. Synthesis of hollow ferrite nanospheres for biomedical applications. J. Magn. Magn. Mater., 321, 1414-1416, 2009. DOI: 10.1016/j.jmmm.2009.02.053
284 Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T., Soga, T., Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanabe, H., Kataoka, K., Suematsu, M. and Handa, H. Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis. Toxicological Sciences, 109, 143-151, 2009. DOI: 10.1093/toxsci/kfp041
283 Zou, G-M., Karikari, C., Kabe, Y., Handa, H. Anders, R. A. and Maitra, A. The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: Therapeutic implications in tumor angiogenesis. J. Cell. Physiol., 219, 209-218, 2009. DOI: 10.1002/jcp.21666
282 Park, S.Y., Handa, H. and Sandhu, A. High speed magneto-optical valve: Rapid control of the optical transmittance of aqueous solutions by magnetically induced self-assembly of superparamagnetic particle chains. J. Appl. Phys., 105, 07B526, 2009. DOI: 10.1063/1.3072762
281 Bando, M., Ohashi, T., Dede, M., Akram, R., Oral, A., Park, S.Y., Shibasaki, I., Handa, H. and Sandhu, A. High sensitivity and multifunctional micro-Hall sensors fabricated using InAlSb/InAsSb/InAlSb heterostructures. J. Appl. Phys., 105, 07E909, 2009. DOI:  10.1063/1.3074513
280 Morimoto, Y., Abe, M., Hatakeyama, M., Handa, H. and Sandhu, A. Detection of Magnetic Nanobeads by Self-Assembly of Superparamagnetic Microbeads for Biosensing. IEEE Trans. Magn., 45, 2871-2874, 2009.
DOI: 10.1109/TMAG.2009.2018861
279 Kuramori, C., Azuma, M., Kume, K., Kaneko, Y., Inoue, A., Yamaguchi, Y., Kabe, Y., Hosoya, T., Kizaki, M., Suematsu, M. and Handa, H., Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nuclus. Biochem. Biophys. Res. Commun., 379, 519-525, 2009. DOI: 10.1016/j.bbrc.2008.12.103
278 Hatakeyama, M., Mochizuki, Y., Kita, Y., Kishi, H., Nishio, K., Sakamoto, S., Abe, M. and Handa, H. Characterization of a magnetic carrier encapsulating europium and ferrite nanoparticles for biomolecular recognition and imaging. J. Magn. Magn. Mater., 321, 1364-1367, 2009. DOI: 10.1016/j.jmmm.2009.02.039
277 Komori, T., Inukai, N., Yamada, T., Yamaguchi, Y. and Handa, H., Role of human transcription elongation factor DSIF in the suppression of senescence and apoptosis. Genes Cells., 14, 343-354, 2009.
DOI: 10.1111/j.1365-2443.2008.01273.x
276 Nagasaki, S., Suzuki, T., Miki, Y., Akahira, J-I., Kitada, K., Ishida, T., Handa, H., Ohuchi, N. and Sasano, H. 17β-hydroxysteeroid dehydrogenase type 12 in human breast carcinoma: a prognostic factor via potential regulation of fatty acids synthesis. Cancer Res., 69, 1392-1399, 2009.
DOI: 10.1158/0008-5472.CAN-08-0821
275 Kang, J., Gemberling, M., Nakamura, M., Whitby, F. G., Handa, H., Fairbrother, W. G. and Tantin, D. A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Genes Dev., 23, 208-222, 2009. DOI: 10.1101/gad.1750709
274 Tanaka, T., Nagai, H., Tada, M., Nakagawa, T., Sandhu, A., Tamaura, Y., Handa, H. and Abe, M. Wide range (20-200 nm) size control of spherical ferrite particles grown on seed crystals in aqueous solution added with sucrose. J. Mater. Res., 24, 2051-2055, 2009. DOI: 10.1557/jmr.2009.0253
273 Nakanishi, A., Chapellie, B., Maekawa, N., Hiramoto, M., Kuge, T., Takahashi, R. Handa, H. and Imai, T. SV40 vectors carrying minimal sequence of viral origin with exchangeable capsids. Virology., 379, 110-117, 2008. DOI: 10.1016/j.virol.2008.06.032
272 Takahashi, R., Kanesashi, S., Inoue, T., Enomoto, T., Kawano, M., Tsukamoto, H., Takeshita, F., Imai, T., Ochiya, T., Kataoka, K., Yamaguchi, Y. and Handa, H. Presentation of functional foreign peptides on the surface of SV40 virus-like particles. J. Biotechnol., 135, 385-392, 2008. DOI: 10.1016/j.jbiotec.2008.05.012
271 Azuma, M., Kabe, Y., Kuramori, C., Kondo, M., Yamaguchi, Y. and Handa, H. Adenine nucleotide translocator transports haem precursors into mitochondria. Plos ONE, 3, e3070, 2008. DOI: 10.1371/journal.pone.0003070
270 Shimizu, N., Yoshikawa, N., Wada, T., Handa, H., Sano, M., Fukuda, K., Suematsu, M., Sawai, T., Morimoto, C. and Tanaka, H. Tissu- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by Hexamethylene Bisacetamide-Inducible Protein 1. Mol. Endocrinol., 22, 2609-2623, 2008. DOI: 10.1210/me.2008-0101
269 Ando, K., Hirao, S., Kabe, Y., Ogura, Y., Sato, I., Yamaguchi, Y., Wada, T. and Handa, H. A new APE1/Ref-1-dependent pathway leading to reduction of NF-κB and AP-1, and activation of their DNA-binding activity. Nucleic Acids Res., 36, 4327-4336, 2008. DOI: 10.1093/nar/gkn416
268 Suzuki, M., Furukawa, S., Kuramori, C., Sawa, C., Kabe, Y., Nakamura, M., Sawada, J., Yamaguchi, Y., Sakamoto, S., Inoue, S. and Handa, H. Development of a chemical screening system using aqueorin-fused protein. Biochem. Biophys. Res. Commun., 368, 600-605, 2008. DOI: 10.1016/j.bbrc.2008.01.107
 267 Hase, Y., Tatsuno, M., Nishi, T., Kataoka, K., Kabe, Y., Yamaguchi, Y., Ozawa, N., Natori, M., Handa, H. and Watanabe, H. Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm. Biochem. Biophys. Res. Commun., 366, 66-72, 2008. DOI: 10.1016/j.bbrc.2007.11.107
266 Nishio, K., Masaike, Y., Ikeda, M., Narimatsu, H., Gokon, N., Tsubouchi, S., Hatakeyama, M., Sakamoto, S., Hanyu, N., Sandhu, A., Kawaguchi, H., Abe, M. and Handa, H. Development of novel magnetic nano-carriers for high-performance affinity purification. Colloids Surf. B, 64, 162-169, 2008. DOI: 10.1016/j.colsurfb.2008.01.013
265 Yoshida, M., Kabe, Y., Wada, T., Asai, A. and Handa, H. A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Mol. Pharmacol., 73, 987-994, 2008. DOI: 10.1124/mol.107.043307
264 Inoue, T., Kawano, M., Takahashi, R., Tsukamoto, H., Enomoto, T., Imai, T., Kataoka, K. and Handa, H. Engineering of SV40-based nano-capsules for delivery of heterologous proteins as fusions with minor capsid proteins VP2/3. J. Biotechnol., 134, 181-192, 2008. DOI: 10.1016/j.jbiotec.2007.12.006
263 Kuraoka, I., Ito, S., Wada, T., Hayashida, M., Lee, L., Saijo, M., Nakatsu, Y., Matsumoto, M.., Matsunaga, T., Handa, H., Qin, J., Nakatani, Y. and Tanaka, K. Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair. J. Biol. Chem., 283, 940-950, 2008. DOI: 10.1074/jbc.M706647200
262 Matsushita, N., Nakagawa, K., Taniguchi, T., Handa. H., Tada, M., Abe, M. and Yoshimura, M. Hundred-nanometer sized biomagnetic beads with large magnetization using ferrite nanoparticles grown by hydrothermal process. J. Appl. Phys., 103, 07A317, 2008. DOI: 10.1063/1.2838015
261 Kumagai, Y., Imai, Y., Abe, M., Sakamoto, S., Handa, H. and Sandhu, A. Sensitivity dependence of Hall biosensor arrays with the position of superparamagnetic beads on their active regions. J. Appl. Phys., 103, 07A309, 2008. DOI: 10.1063/1.2833306
260 Saito, Y., Imazeki, H., Miura, S., Yoshimura, T., Okutsu, H., Harada, Y., Ohwaki, T., Nagao, O., Kamiya, S., Hayashi, R., Kodama, H., Handa, H., Yoshida, T. and Fukai, F. A peptide derived from tenascin-C induces β1 integrin activation through syndecan-4. J. Biol. Chem., 282, 34929-34937, 2007. DOI: 10.1074/jbc.M705608200
259 Agawa, Y., Sarhan, M., Kageyama, Y., Akagi, K., Takai, M., Hashiyama, K., Wada, T., Handa, H., Iwamatsu, A., Hirose, S. and Ueda, H. Drosophila Blimp-1 is a transient transcriptional respressor that controls timing of the ecdysone-induced developmenatal pathway. Mol. Cell. Biol., 27, 8739-8747, 2007. DOI: 10.1128/MCB.01304-07
258 Iizumi, Y., Sagara, H., Kabe, Y., Azuma, M., Kume, K., Ogawa, M., Nagai, T., Gillespie, P. G., Sasakawa, C. and Handa, H. The Enteropathogenic E.coli effector EspB facilitates microvillus effacing and antiphagocytosis by inhibiting myosin function. Cell Host Microbe, 2, 383-392, 2007. DOI: 10.1016/j.chom.2007.09.012
257 Tsukamoto, H., Kawano, M., Inoue, T., Enomoto, T., Takahashi, R., Yokoyama, N., Yamamoto, N., Imai, T., Kataoka, K., Yamaguchi, Y. and Handa, H. Evidence that SV40 VP1-DNA interactions contribute to the assembly of 40-nm spherical viral particles. Genes Cells, 12, 1267-1279, 2007. DOI: 10.1111/j.1365-2443.2007.01134.x
256 Yamaguchi, Y., Mura, T., Chanarat, S., Okamoto, S. and Handa, H. Hepatitis delta antigen binds to the clamp of RNA polymerase II and affects transcriptional fidelity. Genes Cells, 12,863-875,2007. DOI: 10.1111/j.1365-2443.2007.01094.x
255 Zhu, W., Wada, T., Okabe, S., Taneda, T., Yamaguchi, Y. and Handa, H. DSIF contributes to transcriptional activation by DNA-binding activators by preventing pausing during transcription elongation. Nucleic Acids Res., 35, 4064-4075, 2007. DOI: 10.1093/nar/gkm430
254 Amir-Zilberstein, L., Ainbinder, E., Toube, L., Yamaguchi, Y., Handa, H. and Dikstein, R. Differential regulation of NF-κB by elongation factors is determined by core promoter type. Mol. Cell. Biol., 27, 5246-5259, 2007. DOI: 10.1128/MCB.00586-07
253 Kuraoka, I., Suzuki, K., Ito, S., Hayashida, M., Kwei, J.S.M., Ikegami, T., Handa, H., Nakabeppu, Y. and Tanaka, K. RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS. DNA Repair, 6, 841-851, 2007.DOI: 10.1016/j.dnarep.2007.01.014
252 Narita, T., Yung, T. M. C., Yamamoto, J., Tsuboi, Y., Tanabe, H., Tanaka, K., Yamaguchi, Y. and Handa, H. NELF interacts with CBC and participates in 3’end processing of replication-dependent histone mRNAs. Mol. Cell, 26, 349-365, 2007.  DOI: 10.1016/j.molcel.2007.04.011
251 Sandhu, A., Kumagai, Y., Lapicki, A., Sakamoto, S., Abe, M. and Handa, H. High efficiency Hall effect micro-biosensor platform for detection of magnetically labeled biomolecules. Biosens. Bioelectron., 22, 2115-2120, 2007. DOI: 10.1016/j.bios.2006.09.021
250 Yokoyama, N., Kawano, M., Tsukamoto, H., Enomoto, T., Inoue, T., Takahashi, R., Nakanishi, A., Imai, T., Wada, T. and Handa, H. Mutational analysis of the carboxyl-terminal region of the SV40 major capsid protein VP1. J. Biochem., 141, 279-286, 2007.  DOI: 10.1093/jb/mvm038
249 Nakanishi, A., Itoh, N., Li, P. P., Handa, H., Liddington, R. C. and Kasamatsu, H. Minor capsid proteins of Simian Virus 40 are dispensable for nucleocapsid assembly and cell entry but are required for nuclear entry of the viral genome. J. Virol., 81, 3778-3785, 2007. DOI: 10.1128/JVI.02664-06
248 Nishio, K., Ikeda, M., Gokon, N., Tsubouchi, S., Narimatsu, H., Mochizuki, Y., Sakamoto, S., Snadhu, A., Abe, M. and Handa, H. Preparation of size controlled (30-100 nm) magnetite nanoparticles for biomedical applications. J. Magn. Magn. Mater., 310, 2408-2410, 2007.  DOI: 10.1016/j.jmmm.2006.10.795
247 Nishio, K., Gokon, N., Hasegawa, M., Ogura, Y., Ikeda, M., Narimatsu, H., Tada, M., Yamaguchi, Y., Sakamoto, S., Abe, M. and Handa, H. Identification of a chemical substructure that is immobilized to ferrite nanoparticles (FP). Colloids Surf. B, 54, 249-253, 2007. DOI: 10.1016/j.colsurfb.2006.10.039
246 Yamamoto, N., Suzuki, M., Kawano, M., Inoue, T., Takahashi, R., Tsukamoto, H., Enomoto, T., Yamaguchi, Y., Wada, T. and Handa, H. Adeno-associated virus site-specific integration is regulated by TRP-185. J. Virol., 81, 1990-2001, 2007. DOI: 10.1128/JVI.02014-06
245 Yugami, M., Kabe, Y., Yamaguchi, Y., Wada, T. and Handa, H. hnRNP-U enhances the expression of specific genes by stabilizing mRNA. FEBS Lett., 581, 1-7, 2007.  DOI: 10.1016/j.febslet.2006.11.062
244 Kusunoki, N., Ito, T., Sakurai, N., Handa, H. and Kawai S. A Celecoxib Derivative Potently Inhibits Proliferation of Colon Adenocarcinoma Cells by Induction of Apoptosis. Anticancer Res., 26: 3229-3236, 2006.  PDF: http://ar.iiarjournals.org/content/26/5A/3229.long  (DOI不明)
243 Kubo, T., Wada, T., Yamaguchi, Y., Shimizu, A. and Handa, H. Knock-down of 25-kDa subunit of cleavage factor Im in HeLa cells alters alternative polyadenylation within 3’ -UTRs. Nucleic Acids Res.,34, 6264-6271, 2006. DOI: 10.1093/nar/gkl794
242 Uga, H., Kuramori, C., Ohta, A., Tsuboi, Y., Tanaka, H., Hatakeyama, M., Yamaguchi, Y., Takahashi, T., Kizaki, M. and Handa, H. A new mechanism of methotrxate action revealed by target screening with affinity beads. Mol. Pharmacol., 70, 1832-1839, 2006. DOI: 10.1124/mol.106.025866
241 Kabe, Y., Ohmori, M., Shinouchi, K., Tsuboi, Y., Hirano, S., Azuma, M., Watanabe, H., Okura, I. and Handa, H. Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier. J. Biol. Chem., 281, 31729-31735, 2006. DOI: 10.1074/jbc.M604729200
240 Nishio, K., Gokon, N., Tsubouchi, S., Ikeda, M., Narimatsu, H., Sakamoto, S., Izumi, Y., Abe, M. and Handa, H. Direct Detection of Redox Reactions of Sulfur-containing Compounds on Ferrite Nanoparticle (FP) Surface. Chem. Lett., 35, 974-975, 2006. DOI: /10.1246/cl.2006.974
239 Aida, M., Chen, Y., Nakajima, K., Yamaguchi, Y., Wada, T. and Handa, H. Transcriptional Pausing Caused by NELF Plays a Dual Role in Regulating Immediate-Early Expression of the junB Gene. Mol. Cell. Biol., 26, 6094-6104, 2006. DOI: 10.1128/MCB.02366-05
238 Sakurai, N., Miki, Y., Suzuki, T, Watanabe, K., Narita, T., Ando, K., Young, T.M.C., Aoki, D., Sasano, H. and Handa, H. Systemic distribution and tissue localizations of human 17beta-hydroxysteroid dehydrogenase type 12. J. Steroid Biochem. Mol. Biol., 99, 174-181, 2006. DOI: 10.1016/j.jsbmb.2006.01.010
237 Kawano, M., Inoue, T., Tsukamoto, H., Takaya, T., Enomoto, T., Takahashi, R., Yokoyama, N., Yamamoto, N., Nakanishi, A., Imai, T., Wada, T., Kataoka, K. and Handa, H. The VP2/VP3 minor capsid protein of Simian Virus 40 promotes the in vitro assembly of the major capsid protein VP1 into particles. J. Biol. Chem., 281, 10164-10173, 2006. DOI: 10.1074/jbc.M511261200
236 Okawa, K., Sekine, M., Maeda, M., Tada, M., Abe, M., Matsushita, N., Nishio, K. and Handa, H. Heating ability of magnetite nanobeads with various sizes for magnetic hyperthermia at 120kHz, a noninvasive frequency. J. Appl. Phys., 99, 08H102, 2006. DOI:10.1063/1.2173208
235 Maeda, M., Kuroda, C.S., Shimura, T., Tada, M., Abe, M., Yamamuro, S., Sumiyama, K. and Handa, H. Magnetic carriers of iron nanoparticles coated with a functional polymer for high thoughput bio-screening. J. Appl. Phys., 99, 08H103, 2006. DOI: 10.1063/1.2165127 
234 Ogura, Y., Azuma, M., Tsuboi, Y., Kabe, Y., Yamaguchi, Y., Wada, T., Watanabe, H. and Handa, H. TFII-I douwnregulates a subset of estrogen-responsive genes through its interaction with an initiator element and estrogen receptor α. Genes Cells, 11, 373-381, 2006. DOI: 10.1111/j.1365-2443.2006.00952.x
233 Yamada, T., Yamaguchi, Y., Inukai, N., Okamoto, S., Mura, T. and Handa, H. P-TEFb-mediated phosphorylation of the hSpt5 C-terminal repeats is critical for processive transcription elongation. Mol. Cell, 21, 227-237, 2006. DOI: 10.1016/j.molcel.2005.11.024
232 Togawa, K., Sanbonsugi, H., Sandhu, A., Abe, M., Narimatsu, H., Nishio, K. and Handa, H. Detection of magnetically labeled DNA using pseudomorphic AlGaAs/InGaAs/GaAs heterostructure micro-Hall biosensors. J. Appl. Phys., 99, 08P103, 2006. DOI:  10.1063/1.2162041
231 Yamagata, M., Abe, M., Handa, H. and Kawaguchi, H. Magnetite/Polymer Composite Particles Prepared by Molecular Assembling Followed by In-Situ Magnetite Formation. Macromol. Symp., 245-246, 363-370, 2006. DOI:  10.1002/masy.200651350
230 Kuroda, C. S., Shimura, T., Maeda, M., Tada, M., Handa, H., Sandhu, A. and Abe, M. “Ferrite Route” Preparation of Iron Nanoparticles and Their Encapsulation in Styrene-GMA Co-Polymer for Biomedical Applications. IEEE Trans. Magn., 42, 3569-3571, 2006. DOI: 10.1109/TMAG.2006.879622
229 Shimazu, R., Tada, M., Matsushita, N., Handa, H. and Abe, M. Expediting Magnetic Separation Using Ni Wires, Applicable for Robot-Manipulated Bio-Screening Systems. IEEE Trans. Magn., 41, 4143-4145, 2005. DOI: 10.1109/TMAG.2005.855342
228 Funabashi, H., Tanaka, Y., Imamura, Y., Mie, M., Manabe, T., Tanaka, H., Takahashi, T., Handa, H., Aizawa, M. and Kobatake, E. Glucose oxidase assisted homogeneous electrochemical receptor binding assay for drug screening. Biosens. Bioelectron., 21, 1675-1683, 2005. DOI: 10.1016/j.bios.2005.08.002
227 Lapicki, A., Sanbonsugi, H., Yamamura, T., Matsuhita, N., Abe, M., Narimatsu, H., Handa, H., and Sandhu, A. Functionalization of micro-Hall effect sensors for biomedical applications utilizing superparamagnetic beads. IEEE Trans. Magn., 41, 4134-4136, 2005. DOI: 10.1109/TMAG.2005.855341
226 Sandhu, A. and Handa, H. Practical Hall sensors for biomedical instrumentation. IEEE Trans. Magn., 41, 4123-4127, 2005. DOI: 10.1109/TMAG.2005.855339
225 Kuroda, C. S., Maeda, M., Nishibiraki, H., Matsushita, N., Handa, H. and Abe, M. Styrene-coated iron nanobeads for medical use. IEEE Trans. Magn., 41, 4117-4119, 2005. DOI: 10.1109/TMAG.2005.855336
224 Togawa, K., Sanbonsugi, H., Lapicki, A., Abe, M., Handa, H., and Sandhu, A. High sensitivity InSb thin-film micro-Hall sensor arrays for simultaneous multiple detection of magnetic beads for biomedical applications. IEEE Trans. Magn., 41, 3661-3663, 2005. DOI: 10.1109/TMAG.2005.854789
223 Hasegawa, M., Ohno, H., Tanaka, H., Hatakeyama, M., Kawaguchi, H., Takahashi, T. and Handa, H. Affinity Identification of δ-Opioid Receptors Using Latex Nanoparticles. Bioorg. Med. Chem. Lett., 16, 158-161, 2005. DOI: 10.1016/j.bmcl.2005.09.028
222 Azuma, N., Tadokoro, K., Asaka, A., Yamada, M., Yamaguchi, Y., Handa, H., Matsushima, S., Watanabe, T., Kida, Y., Ogura, T., Torii, M., Shimamura, K. and Nakafuku, M. Transdifferntiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor. Hum. Mol. Genet., 14, 1059-1068, 2005. DOI: 10.1093/hmg/ddi098
221 Urano, A., Endoh, M., Wada, T., Morikawa, Y., Itoh, M., Kataoka, Y., Taki, T., Akazawa, H., Nakajima, H., Komuro, I., Yoshida, N., Hayashi, Y., Handa, H., Kitamura, T. and Nosaka, T. Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia. Mol. Cell. Biol., 25, 6834-6845, 2005. DOI: 10.1128/MCB.25.15.6834-6845.2005
220 Kusunoki, N., Ito, T., Sakurai, N., Suguro, T., Handa, H. and Kawai, S. A novel celecoxib derivative potently induces apoptosis of human synovial fibroblasts. J. Pharmcol. Exp. Ther., 314, 796-803, 2005. DOI: 10.1124/jpet.105.086116
219 Azuma, N., Tadokoro, K., Asaka, A., Yamada, M., Yamaguchi,Y., Handa, H., Matsushima, S., Watanabe, T., Kohsaka, S., Kida, Y., Shiraishi, T., Ogura, T., Shimamura, K. and Nakafuku, M. The Pax6 isoform bearing an alternative spliced exon promotes the development of the neural retinal structure. Hum. Mol. Genet., 14, 735-745, 2005. DOI: 10.1093/hmg/ddi069
218 Delehouzee, S., Yoshikawa, T., Sawa, C., Sawada, J., Ito, T., Omori, M., Wada, T, Yamaguchi, Y., Kabe, Y. and Handa, H. GABP, HCF-1 and YY1 are involved in Rb gene expression during myogenesis. Genes Cells, 10, 717-731, 2005. DOI: 10.1111/j.1365-2443.2005.00873.x
217 Shimizu, N., Ouchida, R., Yoshikawa, N., Hisada, T., Watanabe, H., Okamoto, K., Kusuhara, M., Handa, H., Morimoto, C and Tanaka, H. HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b. Proc. Natl. Acad. Sci. USA, 102, 8555-8560, 2005. DOI: 10.1073/pnas.0409863102
216 Oba, S., Hatakeyama, M., Handa, H. and Kawaguchi, H. Development of polymer latex particles for selctive cleavage of mismatched DNA and their application for DNA diagnosis. Bioconjugate Chemistry, 16, 551-558, 2005. DOI: 10.1021/bc049728l
215 Wu, C-H., Lee, C., Fan, R., Smith, M. J., Yamaguchi, Y., Handa, H. and Gilmour, D.S. Molecular characterization of Drosophila NELF. Nucleic Acids Res., 33, 1269-1279, 2005. DOI: 10.1093/nar/gki274
214 Wang, G., Balamotis, M.A., Stevens, J.L., Yamaguchi, Y., Handa, H. and Berk, A.J. Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Mol. Cell, 5, 683-694, 2005.  DOI: 10.1016/j.molcel.2005.02.010
213 Parent, M., Young, T.M.C., Rancourt, A., Ho, E.L.Y., Vispe, S., Suzuki-Matsuda, F., Uehara, A., Wada, T., Handa, H. and Satoh, M. Poly(ADP-ribose) polymerase-1 is a negative regulator of HIV-1 transcription through competitive binding to TAR RNA with Tat·Positive transcription elongation factor b (p-TEFb) complex. J. Biol. Chem., 280, 448-457, 2005. DOI: 10.1074/jbc.M408435200
212 Ohtsu, Y., Ohba, R., Imamura, Y., Kobayashi, M., Hatori, H., Zenkoh, T., Hatakeyama, M., Manabe, T., Hino, M., Yamaguchi, Y., Kataoka, K., Kawaguchi, H., Watanabe, H. and Handa, H. Selective ligand purification using high-performance affinity beads. Anal. Biochem., 338, 245-252, 2005. DOI: 10.1016/j.ab.2004.10.006
211 Kabe, Y., Yamada, J., Uga, H., Yamaguchi, Y., Wada, T. and Handa, H. NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes. Mol. Cell. Biol., 25, 512-522, 2005. DOI: 10.1128/MCB.25.1.512-522.2005
210 Kabe, Y., Ando, K. Hirao, S., Yoshida, M., and Handa, H. Redox Regulation of NF-κB activation : distinct redox regulation between the cytoplasm and the nucleus. Antioxid. Redox. Signal., 7, 393-403, 2005. DOI: 10.1089/ars.2005.7.395
209 Nishibiraki, H., Kuroda, C.S., Maeda, M., Matsushita, N., Abe, M. and Handa, H. Preparation of medical magnetic nanobeads with ferrite particles encapsulated in a polyglycidyl methacrylate (GMA) for bioscreening. J. Appl. Phys., 97, 10Q919, 2005. DOI: 10.1063/1.1861272
208 Togawa, K., Sanbonsugi, H., Sandhu, A., Abe, M., Narimatsu, H., Nishio, K. and Handa, H.   High Sensitivity InSb Hall Effect Biosensor Platform for DNA Detection and Biomolecular Recognition Using Functionalized Magnetic Nanobeads. Jpn. J. Appl. Phys., 44, 46-49, 2005. DOI:10.1143/JJAP.44.L1494
207 Watanabe, H., Suzuki, A., Goto, M., Ohsako, S., Tohyoma, C., Handa, H. and Iguchi, T. Comparative uterine gene expression analisis after dioxin and estradiol administration. J. Mol. Endocr., 33, 763-771, 2004. DOI: 10.1677/jme.1.01529
206 Jennings, B.H., Shah, S., Yamaguchi, Y., Seki, M., Phillips, R.G., Handa, H. and Ish-Horowicz, D. Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila. Curr. Biol., 14, 1680-1684, 2004. DOI: 10.1016/j.cub.2004.08.066
205 Imamura, Y., Ohtsu, Y., Tanaka, H., Hatakeyama, M., Manabe, T., Kawaguchi, H., Handa, H. and Takahashi, T. Synthesis of affinity nanoparticles coupled to FR901464 derivatives. Heterocycles, 64, 51-56, 2004.    https://iss.ndl.go.jp/books/R000000004-I7224795-00 (DOI不明)別刷り有
204 Hiramoto, M., Kawakami, Y., Nabeshima, R., Shima, D., Handa, H. and Aizawa, S. Identification of differentiation-inducing activity produced by human bone marrow stromal cell line LP101. Int. J. Mol. Med., 14, 867-872, 2004. DOI:10.3892/ijmm.14.5.867 
203 Kwei, J.S.M., Kuraoka, I., Horibata, K., Ubukata, M., Kobatake, E., Iwai, S., Handa, H and Tanaka, K. Blockage of RNA polymerase II at a cyclobutane pyrimidine dimer and 6-4 photoproduct. Biochem. Biophys. Res. Commun., 320, 1133-1138, 2004. DOI: 10.1016/j.bbrc.2004.06.066  
 202 Nishio, K., Hasegawa, M., Ikeda, M., Narimatsu, H., Hase, Y., Ogura, Y., Gokon, N.,Tsubouchi, S., Hatakeyama, M., Abe, M. and Handa, H. Synthesis of monodisperse ferrite nanoparticles coated with polyacrylic acid (PAA). Trans. Mater. Res. Soc. Jpn., 29, 1659-1662, 2004. 別刷り有
201 Aiyar, S.E., Sun, J-L., Blair, A.L., Moskaluk, C.A., Lu, Y.Z., Ye, Q-N., Yamaguchi, Y., Mukherjee, A., Ren, D-M., Handa, H. and Li, R. Attenuation of estrogen receptor α-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev., 18, 2134-2146, 2004.  DOI: 10.1101/gad.1214104
200 Hatori, H., Zenkoh, T., Kobayashi, M., Ohtsu, Y., Shigematsu, N., Setoi, H., Hino, M. and Handa, H. FR-225659-binding proteins: identification as serine/threonine protein phosphatase PP1 and PP2A using high-performance affinity beads. J. Antibiotics, 57, 456-461, 2004. DOI: 10.7164/antibiotics.57.456
199 Zenkoh, T., Hatori, H., Tanaka, H., Hasegawa, M., Hatakeyama, M., Kabe, Y., Setoi, H., Kawaguchi, H., Handa, H. and Takahashi, T. Design and synthesis of a solid-supported FR225659 derivative for its receptor screening. Org. Lett., 6, 2477-2480, 2004. DOI:10.1021/ol049100q  
198 Sandhu, A., Sanbonsugi, H., Shibasaki, I., Abe, M. and Handa, H. High sensitivity InSb ultra-thin film micro-Hall sensors for bioscreening applications. Jpn. J. Appl. Phys., 43, 868-870, 2004. DOI:10.1143/JJAP.43.L868  
197 Oshima. S., Nakamura. T., Namiki. S., Okada. E., Tsuchiya. K., Okamaoto. R., Yamazaki. M., Yokota. T., Aida. M., Yamaguchi. Y., Kanai. T., Handa, H. and Watanabe, M. Interferon Regulatory Factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol. Cell. Biol., 24, 6298-6310, 2004. DOI: 10.1128/MCB.24.14.6298-6310.2004
196 Watanabe, H., Suzuki, M., Goto, M., Lubahn, D. B., Handa, H. and Iguchi, T. Tissue-specific estrogenic and non-estrogenic effects of a xenoestrogen, nonylphenol. J. Mol. Endocr., 33, 243-252, 2004. DOI: 10.1677/jme.0.0330243
195 Sawa, C., Nedea, E., Krogan, N., Wada, T., Handa, H., Greenblatt, J. and Buratowski, S. Bromodomai factor 1 (Bdf1) is phosphorylated by protein kinase CK2. Mol. Cell. Biol., 24, 4734-4742, 2004. DOI: 10.1128/MCB.24.11.4734-4742.2004
194 Mandal. S.S, Chu, C., Wada, T., Handa, H., Shatkin, A.J. and Reinberg, D. Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II. Proc. Natl. Acad. Sci. USA, 101, 7572-7577, 2004. DOI: 10.1073/pnas.0401493101
193 Endo, M., Zhu, W., Hasegawa, J., Watanabe, H., Kim, D-K., Aida, M., Inukai, N., Narita, T., Yamada, T., Furuya, A., Sato, H., Yamaguchi, Y., Mandal, S.S., Reinberg, D., Wada, T. and Handa, H. Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. Mol. Cell. Biol., 24, 3324-3336, 2004. DOI: 10.1128/MCB.24.8.3324-3336.2004
192 Ainbinder, E., Amir-Zilberstein, L., Yamaguchi, Y., Handa, H. and Dikstein, R. Elongation inhibition by DRB sensitivity-inducing factor is regulated by the A20 promoter via a novel negative element and NF-κB. Mol. Cell. Biol., 24, 2444-2454, 2004. DOI: 10.1128/mcb.24.6.2444-2454.2004
191 Inukai, N., Yamaguchi, Y., Kuraoka, I., Yamada, T., Kamijo, S., Kato, J., Tanaka, K. and Handa, H. A novel hydrogen peroxide-induced phosphorylation and ubiqutination pathway leading to RNA polymerase II proteolysis. J. Biol. Chem., 279, 8190-8195, 2004. DOI: 10.1074/jbc.M311412200
190 Han, S-I., Kawano, M., Ishizu, K-I., Watanabe, H., Hasegawa, M., Kanesashi, S-N., Kim, Y-S., Nakanishi, A., Kataoka, K. and Handa, H. Rep68 protein of adeno-associated virus type 2 interacts with 14-3-3 proteins depending on phosphorylation at serine 535. Virology, 320, 144-155, 2004. DOI: 10.1016/j.virol.2003.11.024
189 Miyazawa, S., Suzuki, A., Katsu, Y., Kobayashi, M., Goto, M., Handa, H., Watanabe, H. and Iguchi, T. Persistent gene expression in mouse vagina exposed neonatally to diethylstilbesterol. J. Mol. Endocr., 32, 663-677, 2004. DOI: 10.1677/jme.0.0320663
188 Nakadai, T., Shimada, M., Shima, D., Handa, H. and Tamura, T. Specific interaction with transcription factor IIA and localization of the mammalian TATA-binding protein-like protein (TLP/TRF2/TLF). J. Biol. Chem., 279, 7477-7455, 2004. DOI: 10.1074/jbc.M305412200
187 Kataoka, K., Shioda, S., Ando, K., Sakagami, K., Handa, H. and Yasuda, K. Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet α- and β-cells. J. Mol. Endocrinol., 32, 9-20, 2004. DOI: 10.1677/jme.0.0320009
186 Nedialkov, Y.A., Gong, X.Q., Yamaguchi, Y., Handa, H. and Burton, Z.F. Assay of transient state kinetics of RNA polymerase II elongation. Methods Enzymol., 371, 252-264, 2003. DOI: 10.1016/S0076-6879(03)71018-0
185 Shirai, T., Maehara, A., Kiritooshi, N., Matsuzaki, F., Handa, H. and Nakagoshi, H. Differential requirement of EGFR signaling for the expression of defective proventriculus gene in the Drosophila endoderm and ectoderm. Biochem. Biophy. Res. Commun., 311, 473-477, 2003. DOI: 10.1016/j.bbrc.2003.10.017
184 Watanabe, H., Suzuki, A., Kobayashi, M,, Lubahn, D.B., Handa, H. and Iguchi, T. Similarities and differences in uterine gene expression patterns caused by treatment with physiological and non-physiological estrogens. J. Mol. Endocrinol., 31, 487-497, 2003. DOI: 10.1677/jme.0.0310487
183 Hatanaka, S., Matsushita, N., Abe, M., Nishimura, K., Hasegawa, M. and Handa, H. Direct immobilization of fluorescent dyes onto ferrite nanoparticles during their synthesis from aqueous solution. J. Appl. Phys., 93, 7569, 2003. DOI: 10.1063/1.1558677
182 Ando, K., Shioda, S., Handa, H. and Kataoka, K. Isolation and characterization of an alternatively spliced variant of transcription factor Islet-1. J. Mol. Endocrinol., 31, 419-425, 2003. DOI: 10.1677/jme.0.0310419
181 Imaki, H., Nakayama, K., Delehouzee, S., Handa, H., Kitagawa, M., Kamura, T. and Nakayama, K.I. Cell Cycle-dependent regulation of the Skp2 promoter by GA-binding protein. Cancer Res., 63, 4607-4613, 2003. Pubmed:12907639  (DOI不明)
180 Shimojima, T., Okada, M., Nakayama, T., Ueda, H., Okawa, K., Iwamatsu, A., Handa, H. and Hirose, S. Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor. Genes Dev., 17, 1605-1616, 2003. DOI: 10.1101/gad.1086803
179 Wu, C-H., Yamaguchi, Y., Benjamin, L.R., Horvat-Gordon, M., Washinski, J., Enerly, E., Larsson, J., Lambertsson, A., Handa, H. and Gilmour, D. NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. Genes Dev., 17, 1402-1414, 2003. DOI: 10.1101/gad.1091403
178 Nedialkov, Y.A., Gong, X.Q., Hovde, S.L., Yamaguchi, Y., Handa, H., Geiger, J.H., Yan, H. and Burton, Z.F. NTP-driven translocation by human RNA polymerase II. J. Biol. Chem., 278, 18303-18312, 2003. DOI: 10.1074/jbc.M301103200
177 Azuma, N., Yamaguchi, Y., Handa, H., Tadokoro, K., Asuka, A., Kawase, E., and Yamada, M. Mutations of the PAX6 gene detected in patients with a variety of optic-nerve malformations. Am. J. Hum. Genet., 72, 1565-1570, 2003. DOI: 10.1086/375555
176 Kanesashi, S., Ishizu, K., Kawano, M., Han, S-I., Tomita, S., Watanabe, H., Kataoka, K. and Handa, H. Simian virus 40 VP1 capsid protein forms polymorphic assembles in vitro. J. Gen. Virol., 84, 1899-1905, 2003. DOI: 10.1099/vir.0.19067-0
175 Watanabe, H., Suzuki, A., Kobayashi, M., Takahashi, E., Itamoto, M., Lubahn, D.B., Handa, H. and Iguchi, T. Analysisi of temporal changes in the expression of estrogen-regulated genes in the uterus. J. Mol. Endocrinol., 30, 347-358, 2003. DOI: 10.1677/jme.0.0300347
174 Li, P.P., Nakanishi, A., Tran, M.A., Ishizu, K-I., Kawano, M., Phillips, M., Handa, H., Liddington, R.C. and Kasamatsu, H. Important of Vp1 calucium-binding residues in assembly, cell entry, and nuclear entry of Simian Virus 40. J. Virol., 77, 7527-7538, 2003. DOI: 10.1128/jvi.77.13.7527-7538.2003
173 Narita, T., Yamaguchi, Y., Yano, K., Sugimoto, S., Chanarat, S.,Wada, T., Kim, D-K., Hasegawa, J., Omori, M., Inukai, N., Endoh, M., Yamada, T., and Handa, H. Human transcription elongation factor NELF: Identification of novel subunits and reconstitution of the functionally active complex. Mol. Cell. Biol., 23, 1863-1873, 2003. DOI: 10.1128/MCB.23.6.1863-1873.2003
172 Kim, D-K., Inukai, N., Yamada, T., Furuya, A., Sato, H., Yamaguchi, Y., Wada, T. and Handa, H. Structure–function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex. Genes Cells, 8, 371-378, 2003. DOI: 10.1046/j.1365-2443.2003.00638.x
171 Shima, D., Yugami, M., Tatsuno, M., Wada, T., Yamaguchi, Y. and Handa, H. Mechanism of H-8 inhibition of Cyclin-dependent kinase 9: study using inhibitor-immobilized matrices. Genes Cells, 8, 215-223, 2003. DOI: 10.1046/j.1365-2443.2003.00627.x 
170 Ouchida, R., Kusuhara, M., Shimizu, N., Hisada, T., Makino, Y., Morimoto, C., Handa, H., Ohsuzu, F. and Tanaka, H. Suppression of NF-κB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells. Genes Cells, 8, 95-107, 2003. DOI: 10.1046/j.1365-2443.2003.00618.x
169 Hasegawa, J., Endou, M., Narita, T., Yamada, T., Yamaguchi, Y., Wada, T. and Handa, H. A rapid purification method for human RNA polymerase II by two-step affinity chromatography. J. Biochem., 133, 133-138, 2003. DOI: 10.1093/jb/mvg013
168 Kuraoka, I., Endou, M., Yamaguchi, Y., Wada, T., Handa, H. and Tanaka, K. Effects of endogeneous DNA base lesions on transcription elongation by mammalian RNA polymerase II: implications for transcription-coupled DNA repair and transcriptional mutagenesis. J. Biol. Chem., 278, 7294-7299, 2003. DOI: 10.1074/jbc.M208102200
167 Bando, M., Hasegawa, M., Tsuboi, Y., Miyake, Y., Shiina, M., Ito, M., Handa, H., Nagai, K. and Kataoka, T. The mycotoxin penicillic acid inhibits Fas ligand-induced apotosis by blocking self-processing of caspase-8 in death-inducing signaling complex. J. Biol. Chem., 278, 5786-5793, 2003. DOI: 10.1074/jbc.M204178200
166 Oda, T., So, Y., Sato, Y., Shimizu, N., Handa, H., Yasukochi, Y. and Kasahara, T. Inhibition by (+/-)-indenesterol A of interferon gamma-stimulated nitric oxide formation in murine macrophage RAW 264.7 cells. Mutat Res., 534, 187-195, 2003. DOI: 10.1016/s1383-5718(02)00275-9
165 Hasegawa, M., Uga, H., Ohba, R., Tsuboi, Y., Sato, I., Tang, J., Kabe, Y. and Handa, H. Development of affinity-purification technology for identification of drug receptors. Recent Res. Devel. Biophys. Biochem., 3, 445-456, 2003.  (DOI不明) 別刷り有
164 Kataoka, K., Han, S-I., Shioda, S., Hirai, M., Nishizawa, M. and Handa, H. MafA is a glucose-regulated and pancreatic β-cell-specific transcriptional activator for the insulin gene. J. Biol. Chem., 277, 49903-49910, 2002. DOI: 10.1074/jbc.M206796200
163 Nishi, T., Shimizu, N., Hiramoto, M., Sato. I., Yamaguchi, Y., Hasegawa, M., Aizawa, S., Tanaka, H., Kataoka, K., Watanabe, H. and Handa, H. Spatial redox regulation of a critical cysteine residue of NF-κB in vivo. J. Biol. Chem., 277, 44548-44556, 2002. DOI: 10.1074/jbc.M202970200 
162 Oda, T., Ueda, A., Shimizu, N., Handa, H. and Kasahara, T. Suppression of monocyte chemoattractant protein 1, but not IL-8, by alprazolam: effect of alprazolam on c-Rel/p65 and c-Rel/p50 binding to the monocyte chemoattractant protein 1 promoter region. J. Immunol., 169, 3329-3335, 2002. DOI: 10.4049/jimmunol.169.6.3329
161 Sawa, C., Yoshikawa, T., Matsuda-Suzuki, F., Deléhouzée, S., Goto, M., Watanabe, H., Sawada, J., Kataoka, K., and Handa, H. YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors. J. Biol. Chem., 277, 22484-22490, 2002. DOI:10.1074/jbc.M203060200
160 Tomohiro, T., Sawada, J., Sawa, C., Nakura, H., Yoshida, S., Kodaka, M., Hatakeyama, M., Kawaguchi, H., Handa, H. and Okuno, H. Total analysis and purification of cellular proteins brinding to cisplatin-damaged DNA using submicron beads. Bioconjug. Chem., 13, 163-166, 2002. DOI: 10.1021/bc015560h  
159 Nishimura, K., Hasegawa. M., Ogura, Y., Nishi, T., Kataoka, K., Handa, H. and Abe, M. 4 °C preparation of ferrite nanoparticles having protein molecules immobilized on their surfaces. J. Appl. Phys., 91, 8555-8556, 2002. DOI:10.1063/1.1452207  
158 Hiramoto, M., Shimizu, N., Nishi, T., Shima, D., Aizawa, S., Tanaka, H., Hatakeyama, M., Kawaguchi, H. and Handa, H. [8] - High-performance affinity beads for identifying anti-NF-κB drug receptors. Methods Enzymol., 353, 81-88, 2002. DOI: 10.1016/s0076-6879(02)53038-x  
157 Watanabe, H., Suzuki, A., Mizutani, T., Khono, S., Lubahn, D.B., Handa, H. and Iguchi, T. Genome-wide analysis of changes in early gene expression induced by oestrogen. Genes Cells, 7, 497-507, 2002. DOI: 10.1046/j.1365-2443.2002.00535.x
156 Yamaguchi, Y., Inukai, N., Narita, T., Wada, T. and Handa, H. Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. Mol. Cell Biol., 22, 2918-2927, 2002. DOI:10.1128/MCB.22.9.2918-2927.2002
155 Yoshimatsu, T., Saitoh, A., Ryu, J.N.S., Shima, D., Handa, H., Hiramoto, M., Kawakami, Y., and Aizawa, S. Characterization of immortalized human chondrocytes originated from osteoarthritis cartilage. Int. J. Mol. Med., 8, 345-351, 2001. DOI: 10.3892/ijmm.8.4.345
154 Renner, D.B., Yamaguchi, Y., Wada, T., Handa, H. and Price, D.H. A highly purified RNA polymerase II elongation control system. J. Biol. Chem., 276, 42601-42609, 2001. DOI: 10.1074/jbc.M104967200
153 Lavoie, S.B., Albert, A.L., Handa, H., Vincent, M. and Bensaude, O. The Peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9. J. Mol Biol., 312, 675-685, 2001. DOI: 10.1006/jmbi.2001.4991
152 Kataoka, K., Shioda, S., Yoshitomo-Nakagawa, K., Handa, H. and Nishizawa, M.. Maf and Jun nuclear oncoproteins share downstream target genes for inducing cell transformation. J. Biol. Chem., 276, 36849-36856, 2001. DOI: 10.1074/jbc.M102234200
151 Kataoka, K., Handa, H., and Nishizawa, M. Induction of cellular antioxidative stress genes through heterodimeric transcription factor Nrf2/small Maf by antirheumatic gold(I) compounds. J. Biol. Chem., 276, 34074-34081, 2001. DOI: 10.1074/jbc.M105383200
150 Yamaguchi, Y., Filipovska, J., Yano, K., Furuya, A., Inukai, N., Narita, T., Wada, T., Sugimoto, S., Konarska, M.M. and Handa, H. Stimulation of RNA polymerase II elongation by hepatitis delta antigen. Science, 293, 124-127, 2001. DOI: 10.1126/science.1057925 
149 Morii, E., Ogihara, H., Oboki, K., Sawa, C., Sakuma, T., Nomura, S., Esko, J.D., Handa, H. and Kitamura, Y. Inhibitory effect of the mi transcription factor encoded by the mutant mi allele on GA binding protein-mediated transcript expression in mouse mast cells. Blood, 97, 3032-3039, 2001. DOI: 10.1182/blood.v97.10.3032
148 Shiba, K., Hamaguchi, T., Kataoka, K., Yamaguchi, Y., Handa, H. and Adachi, K. Cloning of the hamster androgen receptor gene. J. Dermatol. Sci., 26, 163-168, 2001. DOI: 10.1016/s0923-1811(00)00172-9
147 Ishizu, K-I., Watanabe, H., Han, S-I., Kanesashi, S-N., Hoque, M., Yajima, H., Kataoka, K. and Handa, H. Roles of disulfide linkage and calcium ion-mediated interactions in assembly and disassembly by virus-like particles composed of simian virus 40 VP1 capsid protein. J. Virol., 75, 61-72, 2001. DOI: 10.1128/JVI.75.1.61-72.2001
146 Guo, S., Yamaguchi, Y., Schilbach, S., Wada, T., Lee, J., Goddard, A., French, D., Handa, H. and Rosenthal, A. A regulator of transcriptional elongation controls vertebrate neuronal development. Nature, 408, 366-369, 2000. DOI: 10.1038/35042590
145 Yoshida, N., Yoshida, S., Araie, M., Handa, H. and Nabeshima, Y-I. Ets family transcription factor ESE-1 is expressed in corneal epithelial cells and is involved in their differentiation. Mech. Dev., 97, 27-34, 2000. DOI: 10.1016/s0925-4773(00)00419-6
144 Aizawa, S., Hiramoto, M., Hoshi, H., Shima, D., Handa, H. and Toyama, K. Induction of apoptotic change of hematopoietic cells by cloned stromal cells from MDS patient via direct cellular interactions. Exp. Hematol., 28, 69, 2000. DOI: 10.1016/S0301-472X(00)00304-0
143 Aizawa, S., Shimizu, N., Handa, H., Hiramoto, M., Hoshi, H., Nagasu, M., Kanno, H., Nagasu, Y. and Imanishi, Y. Effects of cyclic polylactate (CPL) on the growth of cloned leukemic cells in vitro. Hematol. Oncol., 18, 51-60, 2000. DOI: 10.1002/1099-1069(200006)18:2<51::aid-hon656>3.0.co;2-p
142 Shimizu, N., Sugimoto, K., Tang, J., Nishi, T., Sato, I., Hiramoto, M., Aizawa, S., Hatakeyama, M., Ohba, R., Hatori, H., Yoshikawa, T., Suzuki, F., Oomori, A., Tanaka, H., Kawaguchi, H., Watanabe, H. and Handa, H. High-performance affinity beads for identifying drug receptors. Nature. Biotechnol., 18, 877-881, 2000. DOI: 10.1038/78496
141 Wada, T., Orphanides, G., Hasegawa, J., Kim, D-K., Shima, D., Yamaguchi, Y., Fukuda, A., Hisatake, K., Oh, S., Reinberg, D. and Handa, H. FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. Mol. Cell, 5, 1067-1072, 2000. DOI: 10.1016/s1097-2765(00)80272-5
140 Satoh, S., Hirota, M., Noguchi, T., Hijikata, M., Handa, H. and Shimotohno, K. Cleavage of hepatitis C virus nonstructural protein 5A by a caspase-like protease(s) in mammalian cells. Virology, 270, 476-487, 2000. DOI: 10.1006/viro.2000.0287
139 Araki-Sasaki, K., Aizawa, S., Hiramoto, M., Nakamura, M., Iwase, O., Nakata, K., Sasaki, Y., Mano, T., Handa, H. and Tano, Y. Substance P-induced cadherin expression and its signal transduction in a cloned human corneal epithelial cell line. J. Cell Physiol., 182, 189-195, 2000. DOI: 10.1002/(SICI)1097-4652(200002)182:2<189::AID-JCP7>3.0.CO;2-9
138 Aizawa, S., Hiramoto, M., Hoshi, H., Toyama., K., Shima, D. and Handa, H. Establishment of stromal cell line from an MDS RA patient which induced an apoptopic change in hematopoietic and leukemic cells in vitro. Exp. Hematol., 28, 148-155, 2000. DOI: 10.1016/s0301-472x(99)00142-3
137 Takayama, M., Kim, E., Kidokoro, M., Shimamura, K., Shiroki, K., Yajima, H., Kosukegawa, A., Handa, H. and Inokuchi, S. Transfer of SV40 temperature-sensitive early gene into human epidermal keratinocytes by the recombinant adenovirus vector. In Vitro Cell. Dev. Biol., 36, 110-116, 2000. DOI: 10.1290/1071-2690(2000)036<0110:tostse>2.0.co;2
136 Mishima, M., Ozaki, J., Ikegami, T., Kabe, Y., Goto, M., Ueda, H., Hirose, S., Handa, H. and Shirakawa, M. Resonance assignments, secondary structure and 15N relaxation data of the human transcriptional coactivator hMBF1(57-148). J. Biomol. NMR., 14, 373-376, 1999. DOI: 10.1023/a:1008347729176
135 Hoque, M., Shimizu, N., Ishizu, K-I., Yajima, H., Arisaka, F., Suzuki, K., Watanabe, H., and Handa, H. Chimeric virus-like particle formation of adeno-associated virus. Biochem. Biophys. Res. Commun., 266, 371-376, 1999. DOI: 10.1006/bbrc.1999.1831
134 Kabe, Y., Goto, M., Shima, D., Imai, T., Wada, T., Morohashi, K-I., Shirakawa, M., Hirose, S. and Handa, H. The role of human MBF1 as a transcriptional coactivator. J. Biol. Chem., 274, 34196-34202, 1999. DOI: 10.1074/jbc.274.48.34196
133 Sawada, J-I., Shimizu, N., Suzuki, F., Sawa, C., Goto, M., Hasegawa, M., Imai, T., Watanabe, H. and Handa, H. Synergistic transcriptional activation of hGABP and select members of the activation transcription Factor/cAMP response element-binding protein family. J. Biol. Chem., 274, 35475-35482, 1999. DOI: 10.1074/jbc.274.50.35475
132 Tsutsui, H., Geltinger, C., Murata, T., Itakura, K., Wada, T., Handa, H. and Yokoyama, K.K. The DNA-binding and transcriptional activities of MAZ, a myc-associated zinc finger protein, are regulated by casein kinase II. Biochem. Biophys. Res. Commun., 262, 198-205, 1999. DOI: 10.1006/bbrc.1999.1130
131 Kim, J.B., Yamaguchi, Y., Wada, T., Handa, H. and Sharp, P.A. Tat-SF1 Protein associates with RAP30 and Human SPT5 Proteins. Mol. Cell. Biol., 19, 5960-5968, 1999. DOI: 10.1128/mcb.19.9.5960
130 Hoque, M., Ishizu, K-I., Matsumoto, A., Han, S-I., Arisaka, F., Takayama, M., Suzuki, K., Kato, K., Kanda, T., Watanabe, H. and Handa, H. Nuclear transport of the major capsid protein is essential for Adeno-Associated Virus Capsid Formation. J. Virol., 73, 7912-7915, 1999. DOI:10.1128/JVI.73.9.7912-7915.1999
129 Aizawa, S., Nakano, M., Iwase, O., Yaguchi, M., Hiramoto, M., Hoshi. H., Nabeshima, R., Shima, D., Handa, H. and Toyama, K. Bone marrow stroma from refractory anemia of myelodysplastic syndrome is defective in its ability to support normal CD34-positive cell proliferation and differentiation in vitro. Leuk. Res., 23, 239-246, 1999. DOI: 10.1016/s0145-2126(98)00163-5 
128 Ozaki, J., Takemaru, K-I., Ikegami, T., Mishima, M., Ueda, H., Hirose, S., Kabe, Y., Handa, H., and Shirakawa, M. Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1. Genes Cells, 4, 415-424, 1999. DOI: 10.1046/j.1365-2443.1999.00267.x
127 Azuma, N., Yamaguchi, Y., Handa, H. Hayakawa, M., Kanai, A. and Yamada, M. Missense mutation in the alternative splice region of the PAX6 gene in eye anomalies. Am. J. Hum. Genet., 65, 656-663, 1999. DOI:10.1086/302529
126 Hashimoto, M., Chayama, K., Kobayashi, M., Tsubota, A., Arase, Y., Saitoh, S., Suzuki, Y., Ikeda, K., Matsuda, M., Koike, H., Kobayashi, M., Handa, H. and Kumada, H. Fluctuations of hepatitis C virus load are not related to amino acid substitutions in hypervariable region 1 and interferon sensitivity determining region. J. Med. Virol., 58, 247-255, 1999. DOI: 10.1002/(sici)1096-9071(199907)58:3<247::aid-jmv10>3.0.co;2-3  
125 Satoh, S., Hijikata, M., Handa, H. and Shimotohno, K. Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha. Biochem. J., 342, 65-70, 1999. PMID: 10432301 (DOI不明)
124 Nishina, S., Kohsaka, S., Yamaguchi, Y., Handa, H., Kawakami, A., Fujisawa, H. and Azuma, N. PAX6 expression in the developing human eye. Br. J. Ophthal., 83, 723-727, 1999.  DOI: 10.1136/bjo.83.6.723
123 Sanda, F., Kamatani, J., Handa, H. and Endo, T. Radical polymerization behavior of a proline-substituted acrylamide. Effect of s-cis-s-trans isomerization on the polymerization. Macromolecules, 32, 2490-2494, 1999. DOI:10.1021/ma9814090
122 Yamaguchi, Y., Wada, T., Watanabe, D., Takagi, T., Hasegawa, J. and Handa, H. Structure and function of the human transcription elongation factor DSIF. J. Biol. Chem., 274, 8085-8092, 1999. DOI: 10.1074/jbc.274.12.8085
121 Yamaguchi, Y., Takagi, T., Wada, T., Yano, K., Furuya, A., Sugimoto, S., Hasegawa, J. and Handa, H. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA plymerase II elongation. Cell, 97, 41-51, 1999. DOI: 10.1016/s0092-8674(00)80713-8
120 Aizawa, S., Nakano, M., Iwase, O., Yaguchi, M., Hiramoto, M., Hoshi, H., Nabeshima, R., Shima, D., Handa, H. and Toyama, K. Bone marrow stroma from refractory anemia of myelodysplastic syndrome is defective in its ability to support normal CD34-positive cell proliferation and differentiation in vitro. Leuk. Res., 23, 239-246, 1999. DOI: 10.1016/s0145-2126(98)00163-5
119 van Dijk, T.B., Baltus, B., Caldenhoven, E., Handa, H., Raaijmakers, J.A.M., Lammers, J-W.J., Koenderman, L. and de Groot, R.P. Cloning and characterization of the human interleukin-3 (IL-3)/IL-5/granulocyte-macrophage colony-stimulating factor receptor βc gene: Regulation by Ets family members. Blood, 92, 3636-3646, 1998. DOI: 10.1182/blood.V92.10.3636
118 Toyoda, M., Gotoh, N., Handa, H. and Shibuya, M. Involvement of MAP kinase-independent protein kinase C signaling pathway in the EGF-induced p21(WAF1/Cip1) expression and growth inhibition of A431 cells. Biochem. Biophys. Res. Commun., 250, 430-435,1998. DOI: 10.1006/bbrc.1998.9332
117 Wada, T., Takagi, T., Yamaguchi, Y., Watanabe, D. and Handa, H. Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro. EMBO J., 17, 7395-7403, 1998. DOI: 10.1093/emboj/17.24.7395
116 Suzuki, F., Goto, M., Sawa, C., Ito, S., Watanabe, H., Sawada, J-I. and Handa, H. Functional interactions of transcription factor human GA-binding protein subunits. J. Biol. Chem., 273, 29302-29308, 1998. DOI: 10.1074/jbc.273.45.29302
115 Yamaguchi, Y., Wada, T., Suzuki, F., Takagi, T., Hasegawa, J. and Handa, H. Casein kinase II interacts with the bZIP domains of several transcription factors. Nucleic Acids Res., 26, 3854-3861, 1998. DOI: 10.1093/nar/26.16.3854
114 Hatakeyama, M., Nakamura, K., Iwato, S., Handa, H., Fujimoto, K. and Kawaguchi, H. DNA-carrying latex particles for DNA diagnosis. 2. Distinction of normal and point mutant DNA using S1 nuclease. Colloids Surf. B, 10, 171-178, 1998. DOI:10.1016/S0927-7765(97)00058-1
113 Hatakeyama, M., Iwato, S., Fujimoto, K., Handa, H. and Kawaguchi, H. DNA-carrying latex particles for DNA diagnosis. 1. Separation of normal and point mutant DNAs according to the difference in hybridization efficiency. Colloids Surf. B, 10, 161-169, 1998. DOI:10.1016/S0927-7765(97)00059-3
112 Vassias, I., Hazan, U., Michel, Y., Sawa, C., Handa, H., Gouya, L. and Morinet, F. Regulation of human B19 parvovirus promoter expression by hGABP (E4TF1) transcription factor. J. Biol. Chem., 273, 8287-8293, 1998. DOI: 10.1074/jbc.273.14.8287
111 Hirano, F., Tanaka, H., Hirano, Y., Hiramoto, M., Handa, H., Makino, I. and Scheidereit, C. Functional interference of sp1 and NF-κB through the same DNA binding site. Mol. Cell. Biol., 18, 1266-1274, 1998. DOI: 10.1128/mcb.18.3.1266
110 Hartzog, G.A., Wada, T., Handa, H. and Winston, F. Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae. Genes Dev., 12, 357-369, 1998. DOI: 10.1101/gad.12.3.357
109 Wada, T., Takagi, T., Yamaguchi, Y., Ferdous, A., Imai, T., Hirose, S., Sugimoto, S., Yano, K., Hartzog, G.A., Winston, F., Buratowski, S. and Handa, H. DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. Genes Dev., 12, 343-356, 1998. DOI: 10.1101/gad.12.3.343
108 Hiramoto, M., Aizawa, S., Iwase, O., Nakano, M., Toyama, K., Hoque, M., Nabeshima, R., Kaidow, A., Imai, T., Hoshi, H. and Handa, H. Stimulatory effects of substance P on CD34 positive cell proliferation and differentiation in vitro are mediated by the modulation of stromal cell function. Int. J. Mol. Med., 1, 347- 401, 1998. DOI: 10.3892/ijmm.1.2.347
107 Hiramoto, M., Shimizu, N., Sugimoto, K., Tang, J., Kawakami, Y., Ito, M., Aizawa, S., Tanaka, H. Makino, I. and Handa, H. Nuclear targetted suppression of NF-kB activity by the novel quinone derivative E3330. J. Immunol., 160, 810-819, 1998. PMID: 9551916 (DOI不明)
106 Nakade, K., Handa, H. and Nagata, K. Promoter structure of the MxA gene that confers resistance to influenza virus. FEBS Lett., 418, 315-318, 1997.  DOI: 10.1016/s0014-5793(97)01372-0
105 Hatakeyama, M., Ogura, Y., Sawada, J., Fujimoto, K., Handa, H. and Kawaguchi, H. Preparation of dimerized polypeptide-carrying microspheres and purification of specific proteins bound to these microspheres. Colloids Surf. B , 10, 41-49, 1997. DOI: 10.1016/S0927-7765(97)00042-8  
104 Sowa, Y., Shiio, Y., Fujita, T., Matsumoto, T., Okuyama, Y., Kato, D., Inoue, J-I., Sawada, J-I., Goto, M., Watanabe, H., Handa, H. and Sakai, T. Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1. Cancer Res., 57, 3145-3148, 1997. 
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103 Yamaguchi, Y., Sawada, J-I., Yamada, M., Handa, H. and Azuma, N. Autoregulation of Pax6 transcriptional activation by two distinct DNA-binding subdomains of the paired domain. Genes Cells, 2, 255-261, 1997. DOI: 10.1046/j.1365-2443.1997.1170315.x
102 Li, F.Q., Takemaru, K-I., Goto, M., Ueda, H., Handa, H. and Hirose, S. Transcriptional activation through interaction of MBF2 with TFIIA. Genes Cells, 2, 143-153, 1997. DOI:10.1046/j.1365-2443.1997.1090306.x
101 Aizawa, S., Nakano, M., Yaguchi, M., Kuriyama, Y., Iwase, O., Toyama, K., Tanaka, K., Hoshi, H., Sugimoto, K., Kaido, A., Imai, T., Nabeshima, R. and Handa, H. Possible involvement of bone marrow stromal cells in agranulocytosis caused by vesnarinone treatment. Acta Haematol., 98, 140-146, 1997. DOI: 10.1159/000203608  
100 Aoki, H., Seki, T., Sawada, J-I., Handa, H. and Adachi, K. The promoter of the androgen dependent gene in the hamster flank organ. J. Dermatol. Sci., 15, 36-43, 1997. DOI:10.1016/S0923-1811(97)00597-5  
99 Komai, T., Ishikawa, Y., Yagi, R., Suzuki-Sugawara, H., Nishigaki, T. and Handa, H. Development of HIV-1 protease expression methods using T7 phage promoter system. Appl. Microbiol. Biotechnol., 47, 241-245, 1997. DOI: 10.1007/s002530050920  
98 Komai, T., Yagi, R., Suzuki-Sunagawa, H., Sakurai, M., Higashida, S., Sugano, M., Handa, H., Mohri, H., Yasuoka, A., Oka, S., Yabe, Y., Nishigaki, T., Kimura, S. and Shimada, K. In vitro and ex vivo anti-human immunodeficiency virus(HIV) activities of a new water-soluble HIV protease inhibitor, R-87366, containing (2S,3S)-3-amino-2-hidroxy-4- phenylbutanoic acid. Biol..Pharm.Bull., 20, 175-180, 1997. DOI: 10.1248/bpb.20.175
97 Nabeshima, R., Aizawa, S., Nakano, M., Toyama, K., Sugimoto, K., Kaidow, A., Imai, T. and Handa, H. Effects of vesnarinone on the bone marrow stromal cell-dependent proliferation and differentiation of HL60 cells in vitro. Exp. Hematol., 25, 509-515, 1997. PMID: 9197329 (DOI不明)
96 Murakami, M., Sonobe, M.H., Ui, M., Kabuyama, Y., Watanabe, H., Wada, T., Handa, H., and Iba, H. Phosphorylation and high level expression of Fra-2 in v-src transformed cells: a pathway of activation of endogeneous AP-1. Oncogene, 14, 2435-2444, 1997. DOI: 10.1038/sj.onc.1201077
95 Imai, T., Matsuda, K., Shimojima, T., Hashimoto, T., Masuhiro, Y., Kitamoto, T., Sugita, A., Suzuki, K., Matsumoto, H., Masushige, S., Nogi, Y., Muramatsu, M., Handa, H. and Kato, S. ERC-55, a binding protein for the papilloma virus E6 oncoprotein, specifically interacts with vitamin D receptor among nuclear receptors. Biochem. Biophys. Res. Commun., 233, 765-769, 1997. DOI: 10.1006/bbrc.1997.6531
94 Momose, F., Handa, H. and Nagata, K. Identification of host factors that regulate the influenza virus RNA polymerase activity. Biochimie, 78, 1103-1108, 1996. DOI: 10.1016/s0300-9084(97)86736-3
93 Kamura, T., Handa, H., Hamasaki, N. and Kitajima, S. Characterization of the human thrombopoietin gene promoter : A POSSIBLE ROLE OF AN Ets TRANSCRIPTION FACTOR, E4TF1. J. Biol. Chem., 272, 11361-11368, 1997. DOI: 10.1074/jbc.272.17.11361
92 Komai, T., Yagi, R., Suzuki-Sunagawa, H., Ishikawa, Y., Kasuya, A., Miyamoto, S., Handa, H. and Nishigaki, T. Inhibition of HIV-1 protease by oxim derivatives. Biochem. Biophys. Res. Commun., 230, 557-561, 1997. DOI: 10.1006/bbrc.1996.5907
91 Kawase, H., Okuwaki, M., Miyaji, M., Ohba, R., Handa, H., Ishimi, Y., Fujii-Nakata, T., Kikuchi, A. and Nagata, K. NAP-1 is a functional homologue of TAF-1 that is required for replication and transcription of the adenovirus genome in a chromatin-like structure. Genes Cells, 1, 1045-1056, 1996. DOI: 10.1046/j.1365-2443.1996.d01-223.x
90 Komai, T., Higashida, S., Sakurai, M., Nitta, T., Kasuya, A., Miyamaoto, S., Yagi, R., Ozawa, Y., Handa, H., Mohri, H., Yasuoka, A., Oka, S., Nishigaki, T., Kimura, S., Shimada, K. and Yabe, Y. Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA-II. Modification of pyrrolidine ring at P1’ prolone. Bioorgan. Med. Chem., 4, 1365-1377, 1996. DOI: 10.1016/0968-0896(96)00130-7 
89 Sawa, C., Goto. M., Suzuki, F., Watanabe, H., Sawada. J-I. and Handa, H. Functional domains of transcription factor hGABPβ1/E4TF1-53 required for nuclear localization and transcription activation. Nucleic Acids Res., 24, 4954-4961, 1996. DOI:10.1093/nar/24.24.4954
88 Yajima, H., Kosukegawa, A., Hoque, M.M., Shimojima, T., Ishizu, K-I., Takayama, M., Sasaki, Y., Sakai, H., Otsuka, M., Inokuchi, S. and Handa, H. Construction and characterization of a recombinant adenovirus vector carrying the human preproinsulin gene under the control of the methallothionein gene promoter. Biochem. Biophys. Res. Commun., 229, 778-787, 1996. DOI: 10.1006/bbrc.1996.1880
87 Okazaki, T., Takita, J., Kohno, T., Handa, H. and Yokota, J. Detection of amplified genomic sequences in human small-cell lung carcinoma cells by arbitrarily primed-PCR genomic fingerprinting. Human Genomics, 98, 253-258, 1996. DOI: 10.1007/s004390050203
86 Kosukegawa, A., Arisaka, F., Takayama, M., Yajima, H., Kaidow, A. and Handa, H. Purification and characterization of virus-like particles and pentamers produced by the expression of SV40 capsid proteins in insect cells. Biochim. Biophys. Acta., 1290, 37-45, 1996. DOI:10.1016/0304-4165(95)00184-0
85 Hashimoto, M., Chayama, K., Tsubota, A., Kobayashi M., Saitou, S., Arase, Y., Ikeda, K., Kobayashi, M., Nakano, A., Takagi, K., Koike, H., Okamoto, K., Handa, H. and Kumada, H. Typing six major hepatitis C virus genotypes by polymerase chain reaction using primers derived from nucleotide sequences of the NS5 region. Int. Hepatol. Commun., 4, 263- 267, 1996. DOI:10.1016/0928-4346(96)00257-5
84 Shimada, H., Wada, T., Handa, H., Ohta, H., Mizoguchi, H., Nishimura, K., Masuda, T., Shioi, Y. and Takamiya, K-I. A transcription factor with a leucine-zipper motif involved in light-dependent inhibition of expression of the puf operon in the photosynthetic bacterium Rhodobacter sphaeroides. Plant Cell Physiol., 37, 515-522, 1996. DOI: 10.1093/oxfordjournals.pcp.a028974
83 Shiio, Y., Sawada, J., Handa, H., Yamamoto, T. and Inoue, J. Activation of the retinoblastoma gene expression by Bcl-3: Implication for muscle cell differentiation. Oncogene, 12, 1837-1845, 1996. PMID: 8649843 (DOI不明)
82 Wada, T., Takagi, T., Yamaguchi, Y., Kawase, H., Hiramoto, M., Ferdous, A., Takayama, M., Lee, K.A.W., Hurst, H.C. and Handa, H. Copurification of casein kinase II with transcription factor ATF/E4TF3. Nucleic Acids Res., 24, 876-884, 1996. DOI:10.1093/nar/24.5.876
81 Hirano, F., Tanaka, H., Makino, Y., Okamoto, K., Hiramoto, M., Handa, H. and Makino, I. Induction of the transcription factor AP-1 in cultured human colon adenocarcinoma cells following exposure to bile acids. Carcinogenesis, 17, 427-433, 1996. DOI: 10.1093/carcin/17.3.427
80 Imai, T., Sumi, Y., Hatakeyama M., Fujimoto, K., Kawaguchi, H., Hayashida, N., Shiozaki, K., Terada, K., Yajima, H. and Handa, H. Selective isolation of DNA or RNA using single-stranded DNA affinity latex particles. J. Colloid Interface Sci., 177, 245-249, 1996. DOI: 10.1006/jcis.1996.0027
79 Watanabe, K., Handa, H., Mizumoto, K. and Nagata, K. Mechanism for inhibition of influenza virus RNA polymerase activity by matrix protein. J. Virol., 70, 241-247, 1996. PMID: 8523532 (DOI不明)
78 Goto, M., Shimizu, T., Sawada, J-I., Sawa, C., Watanabe, H., Ichikawa, H., Ohira. M., Ohki, M. and Handa, H. Assignment of the E4TF1-60 gene to human chromosome 21q21.2-q21.3. Gene, 166, 337-338, 1995. DOI: 10.1016/0378-1119(95)00575-7
77 Tanaka, H., Makino, Y., Hiramoto, M., Handa, H. and Makino, I. Potentiation of glucocorticoid-mediated gene expression by the novel benzoquinone derivative (2E)-3-[5-(2,3-dimethoxy-o-methyl-1,4-benzoquinoyl)]-2-nonyl-2-propenoic acid (E3330). Eur. J. Pharm. : Molecular Pharmacology, 291, 121-127, 1995. DOI: 10.1016/0922-4106(95)90133-7  
76 Hayashida, N., Sumi, Y., Wada, T., Handa, H. and Shinozaki, K. Construction of a cDNA library for a specific region of chromosome using a novel cDNA selection method utilizing latex particles. Gene, 165, 155-161, 1995. DOI: 10.1016/0378-1119(95)00473-j  
75 Rosmarin, A.G., Caprio D.G., Kirsch, D.G., Handa, H. and Simkevich, C.P. GABP and PU.1 compete for binding, yet cooperate to increase CD18 (β2 leukocyte integrin) transcription. J. Biol. Chem., 270, 23627-23633, 1995. DOI: 10.1074/jbc.270.40.23627
74 Watanabe, K., Momose, F., Handa, H. and Nagata, K. Interaction between influenza virus proteins and pine cone antitumor substance that inhibits the virus multiplication. Biochem. Biophys. Res. Commun., 214, 318-323, 1995. DOI: 10.1006/bbrc.1995.2290
73 Sueyoshi, T., Kobayashi, R., Nishio, K., Aida, K., Moore, R., Wada, T., Handa, H. and Negishi, M. A nuclear factor (NF2d9) that binds to the male-specific P450 (Cyp2d-9) gene in mouse liver. Mol. Cell. Biol., 15, 4158-4166, 1995. DOI: 10.1128/mcb.15.8.4158
72 Inomata, Y., Kasuya, Y., Fujimoto, K., Handa, H. and Kawaguchi, H. Purification of membrane receptors with peptide-carrying affinity latex particles. Colloids and Surfaces B: Biointerfaces, 4, 231-241, 1995. DOI:10.1016/0927-7765(95)01192-L  
71 Wada, T., Watanabe, H., Kawaguchi, H. and Handa, H. DNA affinity chromatography. Methods Enzymol., 254, 595-604, 1995. DOI: 10.1016/0076-6879(95)54042-3  
70 Tashiro, S., Takemoto, Y., Handa H. and Ishii, S. Cell type-specific trans-activation by the B-myb gene product: requirement of the putative cofactor binding to the C-terminal conserved domain. Oncogene, 10, 1699-1707, 1995. PMID: 7753546  (DOI不明)
69 Matsumoto, K., Okuwaki, M., Kawase, H., Handa, H., Hanaoka, F. and Nagata, K. Stimulation of DNA transcription by the replication factor from the adenovirus genome in a chromatin-like structure. J. Biol. Chem., 270, 9645-9650, 1995. DOI: 10.1074/jbc.270.16.9645
68 Zhang, Y., Araki-Sasaki, K., Handa, H. and Akhtar, R.A. Effect of carbachol on phospholipase C-mediated phosphatidylinositol 4,5-bisphosphate hydrolysis, and its modulation by isoproterenol in rabbit corneal epithelial cells. Curr. Eye Res., 14, 563-571, 1995. DOI:10.3109/02713689508998403
67 Araki-Sasaki, K., Ohashi, Y., Sasabe, T., Hayashi, K., Watanabe, H., Tano, Y. and Handa, H. An SV40-immortalized human corneal epithelial cell line and its characterization. Invest. Ophthalmol. Vis. Sci., 36, 614-621, 1995. PMID: 7534282 (DOI不明) 
66 Nagata, K., Kawase, H., Handa, H., Yano, K., Yamasaki, M., Ishimi, Y., Okuda, A., Kikuchi, A. and Matsumoto, K. Replication factor encoded by putative oncogene, set, associated with myeloid leukemogenesis. Proc. Natl. Acad. Sci. USA, 92, 4279-4283, 1995. DOI: 10.1073/pnas.92.10.4279
65 Mach, V., Takiya, S., Ohno, K., Handa, H., Imai, T. and Suzuki, Y. Silk gland factor-1 involved in the regulation of bombyx sericin-1 gene contains fork head motif. J. Biol. Chem., 270, 9340-9346, 1995. DOI: 10.1074/jbc.270.16.9340
64 Inokuchi, S., Handa, H., Imai, T., Makuuchi, H., Kidokoro, M., Tohya, H., Aizawa, S., Shimamura, K., Ueyama, Y., Mitomi, T. and Sawada, Y. Immortalization of human oesophageal epithelial cells by a recombinant SV40 adenovirus vector. Br. J. Cancer., 71, 819-825, 1995. DOI:10.1038/bjc.1995.158
63 Sawada, J-I., Goto, M., Watanabe, H., Handa, H. and Yoshida, M.C. Regional mapping of two subunits of transcription factor E4TF1 to human chromosome. Jpn. J. Can. Res., 86, 10-12, 1995. DOI: 10.1111/j.1349-7006.1995.tb02981.x
62 Takemoto, Y., Tashiro, S., Handa, H. and Ishii, S. Multiple nuclear localization signals of the B-myb gene product. FEBS Lett., 350, 55-60, 1994. DOI: 10.1016/0014-5793(94)00733-0
61 Sakurai, M., Higashida, S., Sugano, M., Handa, H., Komai, T., Yagi, R., Nishigaki, T. and Yabe, Y. Studies of human-immunodeficiency-virus type-1(HIV-1) protease inhibitors. Ⅲ. Structure-activity relationship of HIV-1 protease inhibitors containing cyclohexylalanylalanine hydroxyethylene dipeptide isostere. Chem. Pharm. Bull., 42, 534-540, 1994. DOI:10.1248/cpb.42.534
60 Shimizu, K., Handa, H., Nakada, S. and Nagata, K. Regulation of influenza virus RNA polymerase activity by cellular and viral factors. Nucleic Acids Res., 22, 5047-5053, 1994. DOI: 10.1093/nar/22.23.5047  
59 Sanda, F., Nakamura, M., Endo, T., Takaka, T. and Handa, H. Synthesis of novel optically active polymethacrylamide having L-leucine structure in the side chain. Macromolecules, 27, 7928-7929, 1994. DOI:10.1021/ma00104a059
58 Hojo, H., Yamaguchi, M., Nagasu, M., Aizawa, S., Nakano, M., Harigaya, K., Handa, H. and Toyama, K. Establishment of a human thymic stromal cell line (R-3-4) and its adhesive capacity with T cells in vitro. Hematol. Path., 8, 177-185, 1994. PMID: 7860435 (DOI不明)
57 Savoysky, E., Mizuno, T., Sowa, Y. Watanabe, H., Sawada, J-I., Nomura, H., Ohsugi, Y., Handa, H. and Sakai, T. The retinoblastoma binding factor 1 (RBF-1) site in RB gene promoter binds preferentially E4TF1, a member of the Ets transcription factors family. Oncogene, 9, 1839-1846, 1994. PMID: 8208529 (DOI不明)
56 Sawada, J-I., Goto, M., Sawa, C., Watanabe, H. and Handa, H. Transcriptional activation through the tetrameric complex formation of E4TF1 subunits. EMBO J., 13, 1396-1402, 1994. PMID: 8137823 (DOI不明)
55 Aizawa, S., Yaguchi, M., Nakano, M., Toyama, K., Inokuchi, S., Imai, T., Yasuda, M., Nabeshima, R. and Handa, H. Hematopoietic supportive function of human bone marrow stromal cell lines established by a recombinant SV40-adenovirus vector. Exp. Hematol., 22, 482-487, 1994. PMID: 8187845 (DOI不明)
54 Sumi, Y., Shiroya, T., Fujimoto, K., Wada, T., Handa, H. and Kawaguchi, H. Application of cationic latex particles for protein separation. Colloids and Surfaces B: Biointerfaces, 2, 419-427, 1994. DOI:10.1016/0927-7765(94)80006-5
53 Inomata, Y., Wada, T., Handa, H., Fujimoto, K. and Kawaguchi, H. Preparation of DNA-carrying affinity latex and purtification of transcription factors with the latex. J. Biomater. Sci. Polymer Edn., 5, 293-302, 1994. DOI:10.1163/156856294X00031
52 Ma, D., Watanabe, H., Mermelstein, F., Admon, A., Oguri, K., Sun, X., Wada, T., Imai, T., Shiroya, T., Reinberg, D. and Handa, H. Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription. Genes Dev., 7, 2246-2257, 1993. DOI: 10.1101/gad.7.11.2246
51 Sakurai M., Higashida, S., Sugano, M., Nishi, T., Saito, F., Ohata, Y., Handa, H., Komai, T., Yagi, R., Nishigaki, T. and Yabe, Y. Studies of HIV-1 protease inhibitors. II. Incorporation of four types of hydroxyethylene dipeptide isosteres at the scissile site of substrate sequences. Chem. Pharm. Bull., 41, 1378-1386, 1993. DOI:10.1248/cpb.41.1378 
50 Sakurai, M., Sugano, M., Handa, H., Konami, K., Yagi, R., Nishigaki, T. and Yabe, Y. Studies of HIV-1 protease inhibitors. I. Incorporation of a reduced peptide, simple aminoalcohol, and statine analog at the scissile site of substrate sequences. Chem. Pharm. Bull., 41, 1369-1377, 1993. DOI:10.1248/cpb.41.1369
49 Araki, K., Ohashi, Y., Sasabe, T., Kinoshita, S., Hayashi, K., Yang X.Z., Hosaka, Y., Aizawa, S. and Handa, H. Immortalization of rabbit corneal epithelial cells by a recombinant SV40-adenovirus vector. Invest. Ophthalmol. Vis. Sci., 34, 2665-2671, 1993. PMID: 7688358 (DOI不明)
48 Tabuchi, H., Handa, H. and Hirose, S. Underwinding of DNA on binding of yeast TFIID to the TATA element. Biochem. Biophys. Res. Commun., 192, 1432-1438, 1993. DOI: 10.1006/bbrc.1993.1576  
47 Watanabe, H., Sawada J-I., Yano, K-I., Yamaguchi, K., Goto, M. and Handa, H. cDNA cloning of transcription factor E4TF1 subunits with ets and notch motifs. Mol. Cell. Biol., 13, 1385-1391, 1993. DOI: 10.1128/mcb.13.3.1385
46 Hirose, F., Yamaguchi, M., Handa, H., Inomata, Y. and Matsukage, A. Novel 8-base pair sequence (Drosophila DNA replication-related element) and specific binding factor involved in the expression of Drosophila genes for DNA polymerase α and proliferating cell nuclear antigen. J. Biol. Chem., 268, 2092-2099, 1993. PMID: 8093616 (DOI不明)
45 Hashimoto, T., Morohashi, K-I., Takayama, K., Honda., S-I., Wada, T., Handa, H. and Omura, T. Cooperative transcription activation between Ad1, a CRE-like element, and other elements in the CYP11B gene promoter. J. Biochem., 112, 573-575, 1992. DOI:10.1093/oxfordjournals.jbchem.a123941  
44 Zu, Y-L., Takamatsu, Y., Zhao, M-J., Maekawa, T., Handa, H. and Ishii, S. Transcriptional regulation by a point mutant of adenovirus-2 E1a product lacking DNA binding activity. J. Biol. Chem., 267, 20181-20187, 1992. PMID: 1356975 (DOI不明)
43 Morohashi, K-I., Honda, S-I., Inomata, Y., Handa, H. and Omura, T. A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s. J. Biol. Chem., 267, 17913-17919, 1992. PMID: 1517227 (DOI不明)
42 Inomata, Y., Kawaguchi, H., Hiramoto, M., Wada, T. and Handa, H. Direct purification of multiple ATF/E4TF3 polypeptides from HeLa cell crude nuclear extracts using DNA affinity latex particles. Anal. Biochem., 206, 109-114, 1992. DOI:10.1016/S0003-2697(05)80018-1  
41 Hosaka, Y., Kitamoto, A., Shimojo, M., Nakajima, K., Imai, Y., Handa, H. and Kohsaka, S. Generation of microglia cell lines by transfection with simian virus 40 large T gene. Neursci. Lett., 141, 139-142, 1992. DOI: 10.1016/0304-3940(92)90880-g  
40 Inokuchi, S., Hashimoto, K., Mitomi, T., Ueda, M. and Handa, H. Immortalization of human epidermal keratinocytes by the recombinant SV40 adenovirus vector. In Vitro Cell. Dev. Biol., 27, 827-828, 1991. DOI: 10.1007/BF02630980  
39 Hibi, T., Fujisawa, T., Kanai, T., Akatsuka, A., Habu, S., Handa, H. and Tsuchiya, M. Establishment of epithelial cell lines from human and mouse thymus immortalized by the 12S adenoviral E1a gene product. Thymus, 18, 155-167, 1991.
38 Satoh, M.S., Moriyama, C., Asai, A., Handa, H., Rajewsky, M.F., Kuroki, T. and Huh, N. Monoclonal antibody-mediated solid-phase assay for mammalian O6-alkylguanine DNA alkyltransferase activity. Anal. Biochem., 196, 403-409, 1991. DOI:10.1016/0003-2697(91)90485-C
37 Usuda, Y., Kubota, A., Berk, A.J. and Handa, H. Affinity purification of transcription factor IIA from HeLa cell nuclear extracts. EMBO J., 10, 2305-2310, 1991. PMID: 2065666 (DOI不明)
36 Aizawa, S., Yaguchi, M., Nakano, M., Inokuchi, S., Handa, H. and Toyama, K. Establishment of a variety of human bone marrow stromal cell lines by the recombinant SV40-adenovirus vector. J. Cell. Physiol., 148, 245-251, 1991. DOI: 10.1002/jcp.1041480209  
35 Mizutani, M., Ohta, T., Watanabe, H., Handa, H. and Hirose, S. Negative supercoiling of DNA facilitates an interaction between transcription factor IID and the fibroin gene promoter. Proc. Natl. Acad. Sci. USA, 88, 718-722, 1991. DOI: 10.1073/pnas.88.3.718
34 Wada, T., Watanabe, H., Usuda, Y. and Handa, H. Different biological activities of the hetero- and homodimers formed by the 47- and 43-kilodalton proteins of transcription factor ATF/E4TF3. J. Virol., 65, 557-564, 1991. PMID: 1987369 (DOI不明)
33 Imai, T., Kawaguchi, H., Wada, T. and Handa, H. E1A gene products stimulate in vitro transciption from the adenovirus early region 4 promoter by enhancing a stable preinitiation complex. Virus Genes, 5, 47-55, 1991. DOI: 10.1007/BF00571730   
32 Wada, T., Nogi, Y., Handa, H. and Fukasawa, T. Strain-specific lethal effect of the adenovirus E1a protein on Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun., 170, 470-476, 1990. DOI: 10.1016/0006-291x(90)92115-g   
31 Watanabe, H., Wada, T. and Handa, H. Transcription factor E4TF1 contains two subunits with different functions. EMBO J., 9, 841-847, 1990. PMID: 2311585 (DOI不明)
30 Kawaguchi, H., Asai, A., Ohtsuka, Y., Watanabe, H., Wada, T. and Handa, H. Purification of DNA-binding transcription factors by their selective adsorption on the affinity latex particles. Nucleic Acids Res., 17, 6229-6240, 1989. DOI: 10.1093/nar/17.15.6229  
29 Handa, H., Watanabe, H., Suzuki, Y. and Hirose, S. Effect of DNA supercoiling on in vitro transcription from the adenovirus early region 4. FEBS Lett., 249, 17-20, 1989. DOI: 10.1016/0014-5793(89)80006-7
28 Ooyama, S., Imai, T., Hanaka, S. and Handa, H. Transcription in the reverse orientation at either terminus of the adenovirus type 5 genome. EMBO J., 8, 863-868, 1989. PMID: 2524383 (DOI不明)
27 Sogawa, K., Handa, H., Fujisawa-Sehara, A., Hiromasa, T., Yamane, M. and Fujii-Kuriyama, Y. Repression of cytochrome P-450c gene expression by cotransfection with adenovirus E1a DNA. Eur. J. Biochem., 181, 539-544, 1989. DOI: 10.1111/j.1432-1033.1989.tb14757.x
26 Akahori, Y., Handa, H., Imai, K., Abe, M., Kameyama, K., Hibiya, M., Yasui, H., Okamura, K., Naito, M., Matsuoka, H. and Kurosawa, Y. Sigma region located between Cμ and Cδ genes of human immunoglobulin heavy chain: possible involvement of tRNA-like structure in RNA splicing. Nucleic Acids Res., 16, 9497-9511, 1988. DOI: 10.1093/nar/16.20.9497  
25 Abe, A., Wada, T., Handa, H., Nogi, Y. and Fukasawa, T. Efficient usage of a galactose-inducible expression vector for the production of heterologous protein in yeast. Agric. Biol. Chem., 52, 2035-2041, 1988. DOI:10.1271/bbb1961.52.2035
24 Kohama, T., Handa, H. and Harigaya, K. A burst-promoting activity derived from the human bone marrow stromal cell line KM-102 is identical to the granulocyte-macrophage colony-stimulating factor. Exp. Hematol., 16, 603-608, 1988. PMID: 3134250  (DOI不明)
23 Watanabe, H., Imai, T., Sharp, P.A. and Handa, H. Identification of two transcription factors that bind to specific elements in the promoter of the adenovirus early-region 4. Mol. Cell. Biol., 8, 1290-1300, 1988. DOI: 10.1128/mcb.8.3.1290
22 Nishigaki, T., Hanaka, S., Kingston, R. E. and Handa, H. A specific domain of the adenovirus EIV promoter is necessary to maintain susceptibility of the integrated promoter to EIA transactivation. Mol. Cell. Biol., 8, 353-360, 1988. DOI: 10.1128/mcb.8.1.353
21 Handa, H., Toda, T., Tajima, M., Wada, T., Iida, H. and Fukasawa, T. Expression of the human adenovirus E1a product in yeast. Gene, 58, 127-136, 1987. DOI: 10.1016/0378-1119(87)90035-7   
20 Hanaka, S., Nishigaki, T., Sharp, P. A. and Handa, H. Regulation of in vitro and in vivo transcription of early-region IV of adenovirus type 5 by multiple cis-acting elements. Mol. Cell. Biol., 7, 2578-2587, 1987. DOI: 10.1128/mcb.7.7.2578
19 Oda, K., Masuda-Murata. M., Shiroki, K. and Handa, H. Mitogenic activity of the adenovirus type 12 E1A gene induced by hormones in rat cells. J. Virol., 58, 125-133, 1986. PMID: 2936902 (DOI不明)
18 Harigaya, K. and Handa, H. Generation of functional clonal cell lines from human bone marrow stroma. Proc. Natl. Acad. Sci. USA, 82, 3477-3480, 1985. DOI: 10.1073/pnas.82.10.3477
17 Handa, H., Mizumoto, K., Oda, K., Okamoto, T. and Fukasawa, T. Transcription of the human adenovirus E1a gene in Saccharomyces cerevisiae. Gene, 33, 159-168, 1985. DOI: 10.1016/0378-1119(85)90090-3   
16 Handa, H. and Sharp, P. A. Requirement for distal upstream sequences for maximal transcription in vitro of early region IV of adenovirus. Mol. Cell. Biol., 4, 791-798, 1984. DOI: 10.1128/mcb.4.4.791
15 Notake, M., Kurosaki, T., Yamamoto, T., Handa, H., Mishina, M. and Numa, S. Sequence requirement for transcription in vitro of the human corticotropin/β-lipotropin precursor gene. Eur. J. Biochem., 133, 599-605, 1983. DOI:10.1111/j.1432-1033.1983.tb07504.x
14 Handa, H., Kingston, R.E. and Sharp, P.A. Inhibition of adenovirus early region IV transcription in vitro by a purified viral DNA binding protein. Nature, 302, 545-547, 1983. DOI:10.1038/302545a0   
13 Saito, I., Sato, J-I., Handa, H., Shiroki, K. and Shimojo, H. Mapping of RNAs transcribed from adenovirus type 12 early and VA RNA regions. Virology, 114, 379-398, 1981. DOI:10.1016/0042-6822(81)90219-1  
12 Cepko, C.L., Hansen, U., Handa, H. and Sharp, P.A. Sequential transcription-translation of Simian virus 40 by using mammalian cell extracts. Mol. Cell. Biol., 1, 919-931, 1981. DOI: 10.1128/mcb.1.10.919  
11 Handa, H., Kaufman, R.J., Manley, J., Gefter, M.L. and Sharp, P.A. Transcription of Simian virus 40 DNA in a HeLa whole cell extracts. J. Biol. Chem., 256, 478-482, 1981. PMID: 6256354 (DOI不明)
10 Handa, H. and Sharp, P.A. Expression of early and late Simian virus 40 transcripts in the absence of protein synthesis. J. Virol., 34, 592-597, 1980. PMID: 6247498 (DOI不明)
9 Handa, H. and Carter, B.J. Adeno-associated virus DNA replication complexes in herpes simplex virus or adenovirus-infected cells. J. Biol. Chem., 254, 6603-6610, 1979. PMID: 221504 (DOI不明)
8 Hashimoto, K., Handa, H., Umehara, K. and Sasaki, S. Germfree mice reared on an “antigen-free” diet. Lab. Anim. Sci., 28, 38-45, 1978. PMID: 633838 (DOI不明)
7 Handa, H. and Shimojo, H. Isolation of the viral DNA replication complex from adeno-associated virus type 1-infected cells. J. Virol., 24, 444-450, 1977. PMID: 916024 (DOI不明)
6 Shiroki, K., Handa, H., Shimojo, H., Yano, S., Ojima, S. and Fujinaga, K. Establishment and characterization of rat cell lines transformed by restriction endonuclease fragments of adenovirus 12 DNA. Virology, 82, 462-471, 1977. DOI: 10.1016/0042-6822(77)90019-8  
5 Handa, H., Shiroki, K. and Shimojo, H. Helper factor(s) for growth of adeno-associated virus in cells transformed by adenovirus 12. Proc. Natl. Acad. Sci. USA, 74, 4508-4510, 1977. DOI:10.1073/pnas.74.10.4508
4 Handa, H., Shiroki, K. and Shimojo, H. Establishment and characterization of KB cell lines latently infected with adeno-associated virus type 1. Virology, 82, 84-92, 1977. DOI: 10.1016/0042-6822(77)90034-4  
3 Handa, H. and Shimojo, H. Viral DNA sysnthesis in vitro with nuclei isolated from adeno-associated virus type 1-infected cells. Virology, 77, 424-428, 1977. DOI: 10.1016/0042-6822(77)90441-x
2  Handa, H., Shimojo, H. and Yamaguchi, K. Multiplication of adeno-associated virus type 1 in cells coinfected with A temperature-sensitive mutant of human adenovirus type 31. Virology, 74, 1-15, 1976.
DOI: 10.1016/0042-6822(76)90123-9
1  Handa, H., Shiroki, K. and Shimojo, H. Complementation of adeno-associated virus growth with temperature-sensitive mutants of human adenovirus types 12 and 5. J. Gen. Virol., 29, 239-242, 1975. DOI: 10.1099/0022-1317-29-2-239




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