Research Achievement


Shumpei Fujie, Natsuki Hasegawa, Naoki Horii, Masataka Uchida, Kiyoshi Sanada, Takafumi Hamaoka, Jaume Padilla, Luis A. Martinez-Lemus, Seiji Maeda, Motoyuk i Iemitsu.
Aerobic exercise restores aging-associated reductions in arterial adropin leve ls and improves adropin-induced nitric oxide-dependent vasorelaxation. J Am He art Assoc, accepted, 2021 (IF: 4.605).[Paper Request]

SHIMOMURA, KAJIMOTO, FUJIE, SANADA, HAMAOKA, IEMITSU. Relationship between plasma asymmetric dimethylarginine and nitric oxide levels affected aerobic exercise training-induced reduction of arterial stiffness in middle-aged and older adults. Physical Activity and Nutrition, 2021, accepted.[Paper Request]


Tasuki Endo, Ryotaro Kime, Sayuri Fuse, Norio Murase, Yuko Kurosawa, Takafumi Hamaoka.Changes in optical path length reveal significant potential errors of muscle o xygenation evaluation during exercise in humans. Med. Sci. Sports Exerc.[Link]

Sayuri Fuse, Tasuki Endo, Riki Tanaka, Miyuki Kuroiwa, Akira Ando, Ayami Kume, Akiko Yamamoto, Kanna Kuribayashi, Shinji Somekawa, Masamichi Takeshita, Masaki Hashimoto, Ryotaro Kime, Yuko Kurosawa, Takafumi Hamaoka.Effects of capsinoid intake on brown adipose tissue vascular density and resting energy expenditure in healthy, middle-aged adults: A randomized, double-blind, placebo-controlled study. nutrients, in press.[Link]

Riki Tanaka, Sayuri Fuse, Miyuki Kuroiwa, Shiho Amagasa, Tasuki Endo, Akira Ando, Ryotaro Kime, Yuko Kurosawa, Takafumi Hamaoka. Vigorous-intensity physical activities are associated with high brown adipose tissue density in humans. International Journal of Environmental Research and Public Health, accepted.[Full text]

Takafumi Hamaoka , Shinsuke Nirengi, Sayuri Fuse, Shiho Amagasa, Ryotaro Kime, Miyuki Kuroiwa, Tasuki Endo, Naoki Sakane, Mami Matsushita, Masayuki Saito, Takeshi Yoneshiro and Yuko Kurosawa. Near-infrared time-resolved spectroscopy for assessing brown adipose tissue density in humans: a reviewFront. Endocrinol. accepted.[Full text]

Ryotaro Kime, Tasuki Endo,Riki Tanaka, Sayuri Fuse, Miyuki Kuroiwa, Yuko Kurosawa, Takafumi Hamaoka. Limited muscle oxygen diffusive transport during exercise in humans. Proc. SPIE, 2020.[Paper Request]

Kanako Hamaguchi, Toshiyuki Kurihara, Masahiro Fujimoto, Koji Sato, Motoyuki I emitsu, Takafumi Hamaoka, Kiyoshi Sanada. Associations among bone mineral dens ity, physical activity and nutritional intake in middle-aged women with high l evels of arterial stiffness. International Journal of Environmental Research a nd Public Health, in press. [Full text]

Naoki Horii, Natsuki Hasegawa, Shumpei Fujie, Keiko Iemitsu, Masataka Uchida, Takafumi Hamaoka, Motoyuki Iemitsu. Effects of Dioscorea esculenta intake with resistance training on muscle hypertrophy and strength in sprint athletes. J Clin Biochem Nutr, in press.[Paper Request]

Sayuri Fuse, Takafumi Hamaoka, Miyuki Kuroiwa, Ryotaro Kime, Tasuki Endo, Riki Tanaka, Shiho Amagasa, Yuko Kurosawa. Identification of human brown/beige adipose tiss ue using near-infrared time-resolved spectroscopy, proc. SPIE, in press.[Full text]

Tanaka, Daichi ; Suga, Tadashi; Kido, Kohei; Honjo, Toyoyuki; Hamaoka, Takafum i; Isaka, Tadao. Acute remote ischemic preconditioning has no effect on quadri ceps muscle endurance.Translational Sports Medicine, accepted.[Paper Request]

Sayuri Fuse, Masahiro Sugimoto, Yuko Kurosawa, Miyuki Kuroiwa, Yasuko Aita, Atsumi Tomita, Eri Yamaguchi, Riki Tanaka, Tasuki Endo, Ryotaro Kime, and Takafumi Hamaoka. Relationships between plasma lipidomic profiles and brown adipose tissue density in humans. Int J Obes, accepted.[Full text]


1.Goto M, Maeda C, Hirayama T, Terada S, Nirengi S, Kurosawa Y, Nagano A, Hamaoka T. Partial Range of Motion Exercise Is Effective for Facilitating Muscle Hypertrophy and Function Through Sustained Intramuscular Hypoxia in Young Trained Men. J Strength Cond Res. 2019 May;33(5):1286-1294. doi: 10.1519/JSC.0000000000002051.[PubMed]

2.Misato Kinoshita, Yuko Kurosawa, Sayuri Fuse, Riki Tanaka, Nobuko Tano, Ryota Kobayashi, Ryotaro Kime and Takafumi Hamaoka. Compression Stockings Suppressed Reduced Muscle Blood Volume and Oxygenation Levels Induced by Persistent Sitting. Appl. Sci. 2019, 9(9), 1800;[Full text]

3.Shinsuke Nirengi, Sayuri Fuse, Shiho Amagasa, Toshiyuki Homma,Ryotaro Kime, Miyuki Kuroiwa, Tasuki Endo, Naoki Sakane, Mami Matsushita,Masayuki Saito, Yuko Kurosawa, Takafumi Hamaoka. Applicability of supraclavicular oxygenated and total hemoglobin evaluated by near-infrared time-resolved spectroscopy as indicators of brown adipose tissue density in humans. int J Mol Sci. 2019, in press.[Full text]

4.Miyuki KUROIWA, Sayuri FUSE, Shiho AMAGASA, Ryotaro KIME, Tasuki ENDO, Yuko KUROSAWA, Takafumi HAMAOKA. Relationship of total hemoglobin in subcutaneous adipose tissue with whole-body and visceral adiposity in humans: Appl. Sci. 2019[Full text]

5.Natsuki Hasegawa, Shumpei Fujie, Naoki Horii, Masataka Uchida, Yuta Toyama, Kenichiro Inoue, Kiyoshi Sanada, Takafumi Hamaoka, Motoyuki Iemitsu. Aging-induced elevation in circulating complement C1q level is associated with arterial stiffness. Experimental Gerontology.accepted.[Pub Med]

6.Goto M, Kumada H, Maeda C, Yamashina Y, Yamato Y, Honda H, and Hamaoka T. Temporal increase in muscle cross-sectional area as an acute effect of resistance exercise in resistance-trained and untrained individuals.Journal of Human Sport & Exercise, accepted.[Paper Request]

7.Higashionna A, Nagayama H, Hamaoka T, Matsumoto T, Yoshida G, Yoshitake Y.Comparison of accelerometer-measured physical activity between the young-old and old-old in Japanese.2019, Meio Daigaku Sougou Kenkyu 28:59-67[Paper Request]

8.T. Hamaoka, K. McCully.Review of early development of near-infrared spectroscopy and recent advancement of studies on muscle oxygenation and oxidative metabolism.The Journal of Physiological Sciences, accepted[Paper Request]

9. Yuko Kurosawa, Miyuki Kuroiwa, Mikiko Nagata, Ayaka Kime, Sayuri Fuse, Ryotaro Kime, Takafumi Hamaoka. A Single‒dose of Oral Nattokinase Activates Natural Killer Cells in Healthy Individuals -A Randomized, Double‒blind, Placebo‒controlled Cross‒over Study-  Jpn Pharmacol Ther vol. 47 no. 9 2019[Paper Request]

10.Tasuki Endo, Ryotaro Kime, Sayuri Fuse, Norio Murase, Yuko Kurosawa and Takafumi Hamaoka. Reduced Scattering Coefficient During Incremental Exercise is Constant Without Being Affected by Changes in Muscle Oxygenation or Hemodynamics Advances in Experimental Medicine and Biology, in press[Paper Request]

11.Tsubasa Watanabe, Norio Murase, Ryotaro Kime, Yuko Kurosawa, Sayuri Fuse and Takafumi Hamaoka. Effects of Exercise Training on Cardiac and Skeletal Muscle Functions in Patients with Chronic Heart Failure Advances in Experimental Medicine and Biology, in press[Paper Request]

12.Inoue, Kenichiro; Fujie, Shumpei; Hasegawa, Natsuki; Horii, Naoki; Uchida, Mas ataka; Iemitsu, Keiko; Sanada, Kiyoshi; Hamaoka, Takafumi; Iemitsu, Motoyuki. Aerobic exercise training-induced irisin secretion is associated with the redu ction of arterial stiffness via nitric oxide production in adults with obesity . Applied Physiology, Nutrition, and Metabolism, in press.[Paper Request]

13.Shumpei Fujie, Natsuki Hasegawa, Kiyoshi Sanada, Takafumi Hamaoka, Seiji Maeda , Jaume Padilla, Luis A. Martinez-Lemus, Motoyuki Iemitsu. Increased serum sal usin-α by aerobic exercise training correlates with improvements in arterial stiffness in middle-aged and older adults. aging in press.[Paper Request]



1.Hasegawa N, Fujie S, Horii N, Miyamoto-Mikami E, Tsuji K, Uchida M, Hamaoka T, Tabata I, and Iemitsu M. Effects of Different Exercise Modes on Arterial Stiffness and Nitric Oxide Synthesis. Medicine & Science in Sports & Exercise Accepted for Publication: 22 January 2018[PubMed][Paper Request]

2.Nirengi S, Sakane N, Amagasa S, Wakui S, Homma T, Kurosawa Y, Hamaoka T. Seasonal differences in brown adipose tissue density and pulse rate variability in a thermoneutral environment. Accepted on Feb. 6, 2018 for publication in Journal of Physiological Anthropology[PubMed][Full text]

3.Tasuki Endo, Ryotaro Kime, Sayuri Fuse, Norio Murase, Yuko Kurosawa and Takafumi Hamaoka. Evaluation of functional hyperemia using NIRTRS without the influence of fat layer thickness. Advances in Experimental Medicine and Biology, in press[Paper Request]

4.Sayuri Fuse,Shinsuke Nirengi,Shiho Amagasa, Toshiyuki Homma, Ryotaro Kime,Tasuki Endo,Naoki Sakane,Mami Matsushita,Masayuki Saito,Takeshi Yoneshiro,Yuko Kurosawa, Takafumi Hamaoka Brown adipose tissue density measured by near-infrared time-resolved spectroscopy in Japanese, across a wide age range.Journal of Biomedical Optics[Full text]

5.Daichi Tanaka, Hayato Tsukamoto, Tadashi Suga, Saki Takenaka,Takafumi Hamaoka, Takeshi Hashimoto, Tadao Isaka, Self-selected music-induced reduction of perceived exertion during moderate-intensity exercise does not interfere with post-exercise improvements in inhibitory control.Physiology & Behavior[PubMed][Paper Request]

6.Chung S, Nelson MD, Hamaoka T, Jacobs RA, Pearson J, Subudhi AW, Jenkins NT, Bartlett MF, Fitzgerald LF, Miehm JD, Kent JA, Lucero AA, Rowlands DS, Stoner L, McCully KK, Call J, Rodriguez-Miguelez P, Harris RA, Porcelli S, Rasica L, Marzorati M, Quaresima V, Ryan TE, Vernillo G, Millet GP, Malatesta D, Millet GY, Zuo L, Chuang C,Commentaries on Viewpoint: Principles, insights, and potential pitfalls of the noninvasive determination of muscle oxidative capacity by near-infrared spectroscopy. J Appl Physiol (1985). 2018 Jan 1;124(1):249-255. doi: 10.1152/japplphysiol.00857.2017.[PubMed][Paper Request]

7.Acosta FM, Berchem J, Martinez-Tellez B, Sanchez-Delgado G, Alcantara JMA, Ortiz-Alvarez L, Hamaoka T, Ruiz JR.Near-Infrared Spatially Resolved Spectroscopy as an Indirect Technique to Assess Brown Adipose Tissue in Young Women.Mol Imaging Biol. 2018 Jun 28. doi: 10.1007/s11307-018-1244-5. [PubMed][Paper Request]

8.Kohei Kido, Tadashi Suga, Daichi Tanaka, Toyoyuki Honjo, Satoshi Fujita, Takafumi Hamaoka, Tadao Isaka. Remote ischemic preconditioning accelerates systemic O2 dynamics and enhances endurance during work-to-work cycling exercise.Translational Sports Medicine[Paper Request]

9.Eri Miyamoto-Mikami, Katsunori Tsuji, Naoki Horii, Natsuki Hasegawa, Shumpei Fujie, Toshiyuki Homma, Masataka Uchida, Takafumi Hamaoka, Hiroaki Kanehisa, Izumi Tabata, and Motoyuki Iemitsu. Gene expression profile of muscle adaptation to high-intensity intermittent exercise training in young men.Scientific Reports[Paper #SREP-18-14364B],[Paper Request]

10.Tasuki Endo, Ryotaro Kime, Tsubasa Watanabe, Sayuri Fuse, Norio Murase, Yuko Kurosawa and Takafumi Hamaoka. Reduced Optical Path Length in the Vastus Lateralis during Ramp Cycling Exercise. Adv Exp Med Biol, in press.[Paper Request]


1. Konishi K, Kimura T, Yuhaku A, Kurihara T, Fujimoto M, Hamaoka T, Sanada K. Effect of sustained high-intensity exercise on executive function. J Phys Fitness Sports Med. 2017. 6 (2): 111-117.[Full text]

2. Tsukamoto H, Takenaka S, Suga T, Tanaka D, Takeuchi T, Hamaoka T, Isaka T, Hashimoto T. Effect of Exercise Intensity and Duration on Postexercise Executive Function. Med Sci Sports Exerc. 2017 Apr;49(4):774-784.[PubMed][Paper Request]

3. Hamaguchi K, Kurihara T, Fujimoto M, Iemitsu M, Sato K, Hamaoka T, Sanada K. The effects of low-repetition and light-load power training on bone mineral density in postmenopausal women with sarcopenia: a pilot study. BMC Geriatrics. 2017. 17:102.[PubMed][Full text]

4. Matsuo K, Sato K, Suemoto K, Miyamoto-Mikami E, Noriyuki Fuku N, Higashida K, Tsuji K, Xu Y, Liu X, Iemitsu M, Hamaoka T, Tabata I. A Mechanism Underlying Preventive Effect of High-Intensity Training on Colon Cancer. Medicine & Science in Sports & Exercise. 2017[PubMed][Paper Request]

5.Goto M, Hamaoka T, Maeda C, Hirayama T, Nirengi S, Kurosawa Y, Nagano A, Terada S. Partial range of motion exercise is effective for facilitating muscle hypertrophy and function via sustained intramuscular hypoxia in young trained men. The Journal of Strength and Conditioning Research · June 2017[Paper Request]

6.Kurosawa Y, Hamaoka T. Creatine in the brain. J Phys Fitness Sports Med. 2017. 6 (4): 215-217[Full text]

7.Tsukamoto H, Suga T, Takenaka S, Takeuchi T, Tanaka D, Hamaoka T, Hashimoto T, Isaka T. An acute bout of localized resistance exercise can rapidly improve inhibitory control. PLoS One. 2017 Sep 6;12(9)[PubMed][Full text]

8.Ueda K, Sanbongi C, Yamaguchi M, Ikegami S, Hamaoka T, Fujita S. The effects of phenylalanine on exercise-induced fat oxidation: a preliminary, double-blind, placebo-controlled, crossover trial. J Int Soc Sports Nutr Sep. 2017. 12;14:34[PubMed][Full text]

9.Tsukamoto H, Suga T, Ishibashi A, Takenaka S, Tanaka D, Hirano Y, Hamaoka T. Goto K, Ebi K, Isaka T, Hashimoto T. Flavanol-rich cocoa consumption enhances exercise-induced executive function improvements in humans. Nutrition 28 September 2017[PubMed][Paper Request]

10.Hasegawa N, Fujie S, Horii N, Uchida M, Kurihara T, Sanada K, Hamaoka T, Iemitsu M. Aerobic exercise training-induced changes in serum C1q/TNF-related protein levels are associated with reduced arterial stiffness in middle-aged and older adults. Am J Physiol Regul Integr Comp Physiol. 2017 Oct[PubMed][Paper Request]

11.Konishi K, Kimura T, Yuhaku A, Kurihara T, Fujimoto M, Hamaoka T, Sanada K. Mouth rinsing with a carbohydrate solution attenuates exercise-induced decline in executive function. Journal of the International Society of Sports Nutrition 2017 14:45[PubMed][Full text]

12.Yoshii N, Sato K, Ogasawara R, Kurihara T, Hamaoka T, Fujita S. Relationship between Dietary Protein or Essential Amino Acid Intake and Training-Induced Muscle Hypertrophy among Older Individuals. J Nutr Sci Vitaminol (Tokyo). 2017 63(6):379-388[PubMed][Full text]


1.Tanaka D,Suga T,Tanaka T,Hamaoka T,:Ischemic Preconditioning Enhances Muscle Endurance during Sustained Isometric Exercise. Int J Sports Med Int J Sports Med. 2016 Jul;37(8):614-8. doi:10.1055/s-0035-1565141. Epub 2016 May 13.[PubMed][Full text]

2.Hasegawa N,Fujie S, Kurihara T, Hamaoka T,: Effects of habitual aerobic exercise on the relationship between intramyocellular or extramyocellular lipid content and arterial stiffness. J Hum Hypertens 2016 Oct;30(10):606-12. doi: 10.1038/jhh.2016.28. Epub 2016 May 12.[PubMed][Full text]

3.Nirengi S,Homma T,Inoue N,Hamaoka T,: Assessment of human brown adipose tissue density during daily ingestion of thermogenic capsinoids using near-infrared time-resolved spectroscopy. J Biomed Opt 2016 Sep;21(9):091305. doi: 10.1117/1.JBO.21.9.091305.[PubMed]

4.Yamato Y,Hasegawa N,Sato K,Hamaoka T,: Acute Effect of Static Stretching Exercise on Arterial Stiffness in Healthy Young Adults. Am J Phys Med Rehabil.95(10):764-770[PubMed][Full text]

5.Tsukamoto H,Suga T,Takenaka S,Hamaoka T,: Repeated high-intensity interval exercise shortens the positive effect on executive function during post-exercise recovery in healthy young males. Physiol Behav. 2016 160:26-34.[PubMed][Full text]

6.Ogasawara R,Akimoto T,Umeno T,Hamaoka T,: MicroRNA expression profiling in skeletal muscle reveals different regulatory patterns in high and low responders to resistance training. Physiol Genomics.48(4):320-4.[PubMed][Full text]

7.Toda Y,Kimura T,Taki C,Hamaoka T,: New ultrasonography-based method for predicting total skeletal muscle mass in male athletes .J. Phys. Ther. Sci.28(5):[PubMed][Full text]

8.Nirengi S,Amagasa S,Homma T,Hamaoka T,: Daily ingestion of catechin-rich beverage increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women. Send to
Springerplus. 2016 Aug 18;5(1):1363. doi: 10.1186/s40064-016-3029-0. eCollection 2016.[PubMed][Full text]

9.Goto M,Nirengi S,Kurosawa Y,Hamaoka T,: Effects of the Drop-set and Reverse Drop-set Methods on the Muscle Activity and Intramuscular Oxygenation of the Triceps Brachii among Trained and Un-trained Individuals . Journal of Sports Science and Medicine (2016) 15, 562-568[Paper Request]

11.Fujie S,Hasegawa N,Kurihara T,Hamaoka T,: Association between aerobic exercise training effects of serum adropin level, arterial stiffness, and adiposity in obese elderly adults.Appl Physiol Nutr Metab. 2017 Jan;42(1):8-14. doi: 10.1139/apnm-2016-0310. Epub 2016 Sep[PubMed][Full text]

12.Tsukamoto H,Suga T,Takenaka S,Tanaka D, Takeuchi T, Hamaoka T, Isaka T, Hashimoto T.:Greater impact of acute high-intensity interval exercise on post-exercise executive function compared to moderate-intensity continuous exercise,Physiol Behav. 2016 Mar 1;155:224-30. doi: 10.1016/j.physbeh.2015.12.021. Epub 2015 Dec 23.[PubMed][Full text]

14.Nirengi S,Yoneshiro T,Saiki T,Aita S, Matsushita M, Sugie H, Saito M, Hamaoka T.:Evaluation of Brown Adipose Tissue Using Near-Infrared Time-Resolved Spectroscopy,Adv Exp Med Biol. 2016;876:371-6. doi:10.1007/978-1-4939-3023-4_46[PubMed][Full text]

15.Takagi S, Kime R, Murase N, Niwayama M, Osada T, and Katsumura T. :Effects of low volume aerobic training on muscle desaturation during exercise in elderly subjects. Advances in Experimental Medicine and Biology 876:63-70, 2016.[PubMed][Full text]

16.Takagi S, Kime R, Niwayama M, Osada T, Murase N, Sakamoto S, Katsumura T. :Sex-related differences in muscle deoxygenation response between aerobic capacity-matched elderly men and women. Advances in Experimental Medicine and Biology 876:55-62, 2016.[PubMed][Full text]

17.Fuse S, Kime R, Osada T, Murase N, and Katsumura T. :The effects of passive cycling exercise for twenty minutes on cardiorespiratory dynamics in healthy men.Adv Exp Med Biol. 2016;923:263-268. doi: 10.1007/978-3-319-38810-6_35. [PubMed][Full text]

18.Kime R, Niwayama M, Kaneko Y, Takagi S,Fuse S, Osada T, Murase N, Katsumura T.: Muscle deoxygenation and its heterogeneity changes after endurance training. Adv Exp Med Biol. 2016;923:275-281. doi: 10.1007/978-3-319-38810-6_37.[PubMed][Full text]

19.Kaneko Y, Kime R, Hongo Y, Ohno Y, Sakamoto A, Katsumura T. :Regional differences of metabolic response during dynamic incremental exercise by 31P- CSI. Adv Exp Med Biol. 2016;923:269-274. doi: 10.1007/978-3-319-38810-6_36.[PubMed][Full text]

20.Kaneko Y, Kime R, Furuya E, Sakamoto A, Katsumura T. :The effect of acupuncture stimulation on muscle tissue oxygenation in different points. Adv Exp Med Biol, in press.[Paper Request]

21.Takagi S, Murase N, Kime R, Niwayama M, Osada T, Katsumura T. :Muscle oxygen dynamics during cycling exercise in angina pectoris patients. Adv Exp Med Biol, in press[Paper Request]

22.Takagi S, Murase N, Kime R, Niwayama M, Osada T, Katsumura T. :Low volume aerobic training heightens muscle deoxygenation in early post-angina pectoris patients. Adv Exp Med Biol. 2016;923:255-261. doi: 10.1007/978-3-319-38810-6_34.[PubMed]

23.Kime R, Kaneko Y, Hongo Y, Ohno Y, Sakamoto A, Katsumura T. :Regional differences in muscle energy metabolism in human muscle by 31P-chemical shift imaging. Adv Exp Med Biol,876, 49-54, 2016[Paper Request]

24.Takagi S, Murase N, Kime R, Niwayama M, Osada T, Katsumura T. :Aerobic training enhances muscle deoxygenation in early post-myocardial infarction. Eur J Appl Physiol. 2016[PubMed][Full text]

25.Takagi S, Murase N, Kime R, Niwayama M, Osada T, Katsumura T.: Muscle Oxygen Dynamics during Cycling Exercise in Angina Pectoris Patients.Adv Exp Med Biol. 2016;923:291-297. doi:10.1007/978-3-319-38810-6_39.[PubMed]

26. Takagi S.:Enhancement of muscle deoxygenation in ischemic heart disease (FeatureArticle, BREAKTHROUGHS IN BIOSCIENCE)Scientia招待有り106p.49 - 52 2016年-[Paper Request]

27.Takagi S,:Effects of 8 weeks’ training on systemic and muscle oxygen dynamics in university rugby players.Adv Exp Med Biol. 2017;977:43-49. doi: 10.1007/978-3-319-55231-6_7. [PubMed]

28. Takagi S、:Multi-site measurements of muscle O2 dynamics during cycling exercisein early post-myocardial infarction. [Paper Request]

29.Takagi S、:Skeletal muscle oxygen dynamics and peak aerobic capacityThe Journal of Physical Fitness and Sports Medicine (review) 5(5)p.379- 383 2016年-[Paper Request]

30. H. Tsukamoto, S. Takenaka, T. Suga, T. Hamaoka.: Impact of ExerciseIntensity and Duration on Postexercise Executive Function. Medicine &Science in Sports & Exercise ・ November[Paper Request]

31. S. Haga, T. Sakurai, T. Hamaoka.: Cerebral Artery Blood Flow and Oxygenationin the Frontal Lobe Region in Response to a Judo Chokehold (Shimewaza).Journal of Exercise, Sports & Orthopedics 3(1):1-8[Paper Request]

32. Lu A, Kurosawa Y, Clark J, Tomsick T. Variable MR and Pathologic Patterns of Hemorrhage after Iodinated Contrast Infusion in MCA Occlusion/Reperfusion Model. Journal of NeuroInterventional Surgery 2016.11.[PubMed][Full text]


1.T. Ijichi,Y. Hasegawa,T. Morishima ,T. Hamaoka,:Effect of sprint training: Training once daily versus twice every second day, Eur. J. Sports Sci. 15(2):143-50,2015[PubMed][Paper Request]

2.S. Fujie,K. Sato,E. Miyamoto-Mikami,T. Hamaoka,:Reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults,PLoS One 9(4):e93545 ,2015[PubMed][Full text]

3.Y. Hasegawa ,T. Ijichi,Y. Kurosawa,T. Hamaoka,:Planned overreaching and subsequent short-term detraining enhance cycle sprint performance, Int. J. Sports Med. in press 2015 Jul;36(8):666-71[PubMed][Paper Request]

4.S. Watanabe,K. Sato ,N. Hasegawa,T. Hamaoka,:Serum C1q as a novel biomarker of sarcopenia in older adults,FASEB J. 29(3):1003-1010,2015[PubMed][Paper Request]

5.T. Homma,T. Hamaoka ,T. Osada,:Once-weekly musc le endurance and strength training prevents deterioration of muscle oxidative function and attenuates the degree of strength decline during 3-week forearm immobilization, Eur. J. Appl. Physiol. 115(3):555-63,2015[PubMed][Paper Request]

6.S. Nirengi,T. Yoneshiro,T. Saiki,T. Hamaoka,:Evaluation of brown adipose tissue using near-infrared time-resolved spectroscopyAdv Exp Med Biol. 2016;876:371-376. doi: 10.1007/978-1-4939-3023-4_46.[PubMed][Paper Request]

7.N Hasegawa,T Kurihara,K Sato,T. Hamaoka,:Intramyocellular and Extramyocellular Lipids Are Associated With Arterial Stiffness,Send to
Am J Hypertens. 2015 Dec;28(12):1473-9. doi: 10.1093/ajh/hpv041. Epub 2015 Apr 24. [PubMed][Paper Request]

8.E. Miyamoto-Mikami,K Sato,T Kurihara,T. Hamaoka,:Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults,PLoS One 10(3):e0120354,2015[PubMed][Full text]

9.S. Nirengi,T. Yoneshiro,H. Sugie,T. Hamaoka,: Human brown adipose tissue assessed by simple noninvasive near-infrared time-resolved spectroscopy, Obesity 23(5): 973-980,2015[PubMed][Paper Request]

10.K. Kido,T. Suga,D. Tanaka,T. Hamaoka,: Ischemic preconditioning accelerates muscle deoxygenation dynamics and enhances exercise endurance during the work-to-work test,Physiol. Rep. 3 (5):e12395,201[PubMed][Full text]

11.Y. Kurosawa,S. Nirengi,T. Homma,T. Hamaoka,:A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles,Scientific Reports in press 2015 Jun 25;5:11601.[PubMed][Full text]

12.Fujie S, Hasegawa N, Sato K, Fujita S, Sanada K, Hamaoka T, Iemitsu M.: Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults., Am J Physiol Heart Circ Physiol. 2015 Sep 14:ajpheart.00338.2015.[PubMed][Paper Request]

13.Karin Umeda, Daichi Takagaki,Shinya Watanabe, Kanako Hamaguchi, Taishi Furushima,Koji Sato, Toshiyuki Kurihara, Motoyuki Iemitsu, Takafumi Hamaoka1), Kiyoshi Sanada, :Interaction between Sleep Duration and Age on Metabolic SyndromeRisk Factors in Japanese Women, 睡眠と環境(J.Sleep and Environments),11(1)-12(1),2015[Paper Request]

14.Zempo-Miyaki A,Fujie S,Sato K,Hasegawa N, Sanada K, Maeda S, Hamaoka T, Iemitsu M.:Elevated pentraxin 3 level at the early stage of exercise training is associated with reduction of arterial stiffness in middle-aged and older adults,J Hum Hypertens. 2015 Oct 15. doi: 10.1038/jhh.2015.105. [PubMed][Paper Request]

15.Ido A,Nakayama Y,Ishii K,Iemitsu M, Sato K, Fujimoto M, Kurihara T, Hamaoka T, Satoh-Asahara N, Sanada K.:Ultrasound-Derived Abdominal Muscle Thickness Better Detects Metabolic Syndrome Risk in Obese Patients than Skeletal Muscle Index Measured by Dual-Energy X-Ray Absorptiometry,PLoS One. 2015 Dec 23;10(12):e0143858. doi: 10.1371/journal.pone.0143858. eCollection 2015.[PubMed][Full text]

16.Konishi M, Midorikawa T, Takagi S, Torii S, Sakamoto S. Gender difference in maximal fat oxidation relative to fat free mass by dual energy X-ray absorptiometry in prepubertal children. The journal of Japanese Society of Clinical Sports Medicine 23(3):503-510, 2015[Paper Request]

17.Takagi S, Sakamoto S, Katsumura T. Effect of peak oxygen uptake on maximal fat oxidation in prepubertal children. Journal of Physical Fitness, Nutrition and Immunology, 25(1):3-9, 2015[Paper Request]

18.Ogasawara R, Akimoto T, Umeno T, Sawada S, Hamaoka T, Fujita S.:MicroRNA expression profiling in skeletal muscle reveals different regulatory patterns in high and low responders to resistance training: a pilot study. Physiol Genomics. 2016 Feb 5:physiolgenomics.00124.2015. doi: 10.1152/physiolgenomics.00124.2015. [PubMed][Paper Request]


1.T. Morishima, Y. Hasegawa, H. Sasaki, T. Hamaoka: "Effects of different periods of hypoxic training on glucose metabolism and insulin sensitivity, Clin. Physiol. Funct. Imaging 35(2):104-9 ,2014[PubMed][Paper Request]

2.K. Sato,M. Iemitsu,K. Matsutani,T. Hamaoka:Resistance training restores muscle sex steroid hormone steroidogenesis in older men,FASEB J. (ア) 28: 1891-1897,2014[PubMed][Paper Request]

3.Osada T.,Murase N , Kime R , Katsumura T , Radegran G*,:Blood flow dynamics in the limb conduit artery during dynamic knee extensor exercise assessed by continuous Doppler ultrasound measurements ,Journal of Physical Fitness and Sports Medicine 3(4):409-421, 2014[Paper Request]

4.Takagi S.,Murase N , Kime R , Niwayama M* , Osada T , Katsumura T :Skeletal muscle deoxygenation abnormalities in early post myocardial infarction,Medicine & Science in Sports & Exercise 46(11): 2062-2069, 2014[PubMed][Paper Request]

5.Takagi S.,Kime R , Midorikawa T , Niwayama M* , Sakamoto S* , Katsumura T,:Skeletal Muscle Deoxygenation Responses during Treadmill Exercise in Children,Advances in Experimental Medicine and Biology 812: 341-346, 2014[PubMed][Paper Request]

6.Takagi S.,Sakamoto S* , Midorikawa T* , Konishi M* , Katsumura T,:Determination of the exercise intensity that elicits maximal fat oxidation in short-time testing,Journal of Sports Sciences 32(2):175-182, 2014[PubMed][Paper Request]


1.T. Hamaoka,:Muscle oxygenation monitoring using near-infrared spectroscopy,J. Phys. Fitness Sports Med.2: 203-207,2013[Paper Request]

2.T. Morishima ,T. Kurihara,T. Hamaoka,:Whole body, regional fat accumulation, and appetite-related hormonal response after hypoxic training,Clin. Physiol. Funct. Imaging 34: 90-97,2013[PubMed][Paper Request]

3.K. Endo,K. Matsukawa,N. Liang,T. Hamaoka,:Dynamic exercise improves cognitive function in association with increased prefrontal oxygenation, J.Physiol. Sci.63: 287-298,2013[PubMed][Paper Request]

4.F. Aida,S. Haga,S. Sato,T. Hamaoka,:Effects of resistance exercise on intramuscular oxygenation and muscle fiber composition,Sports Medicine & Doping Studies 3:3,2013[Paper Request]

5.Takagi S.,Kime R , Murase N , Watanabe T , Osada T , Niwayama M* , Katsumura T: Aging affects spatial distribution of leg muscle oxygen saturation during ramp cycling exercise , Advances in Experimental Medicine and Biology 789: 157-162, 2013[PubMed][Paper Request]

6.Takagi S, Kime R, Niwayama M, Murase N, Katsumura T,:Muscle oxygen saturation heterogeneity among leg muscles during rampexercise.Advances in Experimental Medicine and Biology査読有り765p.273 - 278 2013年-[PubMed][Paper Request]


1.K. Miyamoto,M. Nishimuta,T. Hamaoka,:Equilibrium Energy Intake Estimated by Dietary Energy Intake and Body Weight C hanges in Japanese Young Females,J Nutri Sci Vitaminol 58(6): 431-437,2012[PubMed][Full text]

2.T. Kawamura, T. Okubo, K. Sato, T. Hamaoka,:Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults, Nutrition 28: 1122-1126,2012[PubMed][Paper Request]

3.Sakamoto S* .,Konishi M* , Kim HK* , Endoh N* , Takahashi M* , Takagi S , Midorikawa T* :Exercise prescription for fat metabolism disorder - From the viewpoint of fat oxidation rate, The Journal of Physical Fitness and Sports Medicine 1(3): 499-504, 2012[Full text]

4.Osada T. ,Iwane H , Katsumura T , Murase N , Higuchi H* , Sakamoto A* , Hamaoka T , Shimomitsu T.:Relationship between reduced lower abdominal blood flows and heart rate in recovery following cycling exercise, Acta Physiologica 204(3): 344-353, 2012[PubMed][Paper Request]

5.Osada T.:Physiological aspects of the determination of comprehensive arterial inflows in the lower abdomen assessed by Doppler ultrasound, Cardiovascular Ultrasound 10(13): 2012[PubMed][Full text]

6.Osada T.,Saltin B* , Mortensen SP* , Radegran G*.:Measurement of the exercising blood flow during rhythmical muscle contractions assessed by Doppler ultrasound: Methodological considerations , Journal of Biomedical Science and Engineering 5: 779-788, 2012[Paper Request]


1.T. Hamaoka,K. McCully,:Muscle Research Work with Britton Chance from in Vivo Magnetic Resonance Spectroscopy to Near-Infrared Spectroscopy,J.Innovative Optical Health Sciences 4: 1-11 2011[Paper Request]

2.T. Hamaoka,K. McCully,M. Niwayama,:The use of muscle near-infrared spectroscopy in sport, health and medical sciences: recent developments,Phil. Trans. R. Soc. A. 369: 4591-4604 2011[Paper Request]

3.Osawa T*. , Kime R , Hamaoka T , Katsumura T , Yamamoto M.:Attenuation of muscle deoxygenation precedes EMG threshold in normoxia and hypoxia, Med Sci Sports Exerc 43(8): 1406-13, 2011[PubMed][Paper Request]

4.T. Osada, H. Iwane, T. Katsumura, T. Hamaoka, Relationship between reduced lower abdominal blood flows and heart rate in recovery following cycling exercise, Acta Physiol. 204: 344-353,2011[PubMed][Paper Request]


1.Osawa T. , Kime R , Katsumura T , Yamamoto M*:Effects of acute hypoxia on the inflection point of muscle oxygenation, Adv Exp Med Biol 62: 385-390, 2010[PubMed][Paper Request]

2.Fujioka M. , Kime R , Koga R , Osawa T , Shimomura K , Osada T , Murase N , Katsumura T:Comparison of muscle O2 dynamics at different sites of the forearm flexor muscle during incremental handgrip exercise, Adv Exp Med Biol 662: 359-364, 2010[Paper Request]

3.Shiroishi K*. , Kime R , Osada T , Murase N , Shimomura K , Katsumura T:Decreased muscle oxygenation and increased arterial blood flow in the nonexercising limb during leg exercise, Adv Exp Med Biol 662: 379-384, 2010[Paper Request]

4.Kime R. , Niwayama M* , Fujioka M , Shiroishi K* , Osawa T , Shimomura K , Osada T , Murase N , Katsumura T:Unchanged muscle deoxygenation heterogeneity during bicycle exercise after 6 weeks of endurance training, Adv Exp Med Biol 662: 353-358, 2010[PubMed][Paper Request]

5.Ohmori F*. , Hamaoka T , Shiroishi K* , Osada T , Murase N , Kurosawa Y* , Ichimura S* , Homma T* , Esaki K* , Kime R , Katsumura T.:Low-volume strength and endurance training prevent the decrease in exercise hyperemia induced by non-dominant forearm immobilization, Eur J Appl Physiol 110(4): 845-51, 2010[PubMed][Full text][Paper Request]

6.Midorikawa T*. , Sakamoto S* , Ohta M* , Torii S* , Konishi M* , Takagi S , Bemben MG* , Kondo M*:Metabolic profiles and fat distribution in Japanese college Sumo wrestlers, International Journal of Body Composition Research 8(2): 57-60, 2010[PubMed][Paper Request]


1.Inoue S. , Murase N , Shimomitsu T , Ohya Y , Odagiri Y , Takamiya T , Ishii K* , Katsumura T , Sallis JF*:Association of physical activity and neighborhood environment among Japanese adults, Prev Med 48: 321-325, 2009[PubMed][Paper Request]

2.T. Homma, T. Hamaoka, N. Murase,: Low-volume muscle endurance training prevents decrease in muscle oxidative and endurance function during 21-day forearm immobilization, Acta Physiologica 197(4): 313-320, 2009[PubMed][Paper Request]

3.Osada T,Nagata H,Murase N,Shimomura K,Kime R,Shiroishi K*,Nakagawa N,Katsumura T:Hemodynamic relationships among upper-abdominal aorta and femoral arteries: Basis for measurement of arterial blood flow to abdominal-pelvic organs,Med Sci Monit 15(7): CR332-340, 2009[PubMed][Paper Request]

4.Osada T,Radegran G*:Femoral artery blood flow and its relationship to spontaneous fluctuations in rhythmic thigh muscle workload,Clin Physiol Funct Imaging 29: 277-292, 2009[PubMed][Paper Request]

5.Kime R,Im J*,Moser D*,Nioka S*,Katsumura T,Chance B*:Noninvasive determination of exercise-induced vasodilation during bicycle exercise using near infrared spectroscopy,Med Sci Monit 15(3): CR89-94, 2009[PubMed][Paper Request]

6.Shimomura K,Murase N,Osada T,Kime R,Anjo M,Esaki K,Shiroishi K*,Hamaoka T*,Katsumura T:A study of passive weight-bearing lower limb exercise effects on local muscles and whole body oxidative metabolism: a comparison with simulated horse riding, bicycle, and walking exercise,Dyn Med 8(4): 1-8, 2009[PubMed][Full text]

7.Ohkubo M,Hamaoka T*,Niwayama M*,Murase N,Osada T,Kime R,Kurosawa Y*,Sakamoto A*,Katsumura T:Local increase in trapezius muscle oxygenation during and after acupuncture,Dyn Med 8(2): 1-8, 2009[PubMed][Full text]

8.Sallis JF*,Bowles HR*,Bauman A*,Ainsworth BE*,Bull FC*,Craig CL*,Sjostrom M*,Bourdeaudhuij ID*,Lefevre J*,Matsudo V*,Matsudo S*,Macfarlane DJ*,Gomez DLF*,Inoue S*,Murase N,Volbekiene V*,McLean G*,Carr H*,Heggebo LK*,Tomten H*,Bergman P*:Neighborhood Environments and Physical Activity Among Adults in 11 Countries,Am J Prev Med 36(6): 484-490, 2009[PubMed][Paper Request]


1.Matsumura M,Ueda C,Shiroishi K,Esaki K,Ohmori F,Yamaguchi K,Ichimura S,Kurosawa Y,Kime R,Osada T, Murase N,Katsumura T,Hoshika A,Hamaoka T:Low-volume muscular endurance and strength training during 3-week forearm immobilization was effective in preventing functional deterioration,Dyn Med,7(1):1-8, 2008[PubMed][Full text]


1.T. Hamaoka, K. McCully, V. Quaresima,: Near-infrared spectroscopy/imaging for monitoring muscle oxygenation and oxidative metabolism in healthy and diseased humans , J. Biomed.Opt. 12(6): 62105-62120,2007[PubMed][Paper Request]

2.Osada T,Murase N,Kime R,Shiroishi K,Shimomura K,Nagata H,Katsumura T:Arterial blood flow of all abdominal-pelvic organs using Doppler ultrasound: range, variability, and physiological impact,Physiol Meas,28:1303-1316,2007[PubMed][Paper Request]

3.Hoffman J.R,Im J, Kang J,Maresh C.M,Kraemer W.J,French D,Nioka S,Kime R,Rundell K.W,Ratamess N.A,Faigenbaum A.D,Chance B:Comparison of low- and high-intensity resistance exercise on lipid peroxidation: role of muscle oxygenation,J Strength Cond Res,21(1):118-122,2007[PubMed][Paper Request]


1.Murase N,Ichimura S,Mori M,Shiroishi K,Mitsuoka K,Kime R,Osada T,Nagae T,Ishimaru S,Katsumura T:Effects of bicycle ergmeter exercise and PGE1 injection for patients with intermittent claudication,Jpn J Phys Fitness Sports Med,55(Suppl):S119-123,2006[Paper Request]

2.Osada T,Radegran G:Differences in exercising limb blood flow variability between cardiac and muscle contraction cycle related analysis during dynamic knee,J Sports Med Phys Fitness,46:590-597,2006[PubMed][Paper Request]

3.Osada T,Radegran G:Alterations in the blood velocity profile influence the blood flow response during muscle contractions and relaxation,J Physiol Sci,56:195-203,2006[PubMed][Paper Request]

4.Kime R,Osada T,Shiroishi K,Ichimura S,Kurosawa Y,Homma T,Nakagawa N,Miyazaki J,Murase N, Katsumura T:Muscle oxygenation heterogeneity in a single muscle at rest and during bicycle exercise,Jpn J Phys Fitness Sports Med,55(Suppl):S19-22,2006[Full text]

5.Mitsuoka K,Kime R,Osada T,Murase N,Katsumura T:Muscle oxygenation kinetics on isokinetic exercise -comparison with isometric exercise-,Journal of Clinical Welfare,3(1):40-45,2006[Paper Request]

6.Ichimura S,Murase N,Osada T,Kime R,Homma T,Ueda C,Nagasawa T,Motobe M,Hamaoka T,Katsumura T:Effects of physical activity on age-related decline in oxygen delivery to working muscles,Jpn J Phys Fitness Sports Med,55(Suppl):S217-222,2006[Full text]

7.Miyakawa S,Matsumoto N, Chikamoto H,Hatori M,Ito K,Adachi T,Kitame S,Ichimura S,Osada T,Katsumura T,Hamaoka T:Change of forearm muscle oxygen consumption in pediatrie kidney ransplant patients,Jpn J Phys Fitness Sports Med,55(Suppl):S25-28,2006[Paper Request]

8.Matsumoto N,Ichimura S,Hamaoka T,Osada T,Hattori M,Miyakawa S:Impaired muscle oxygen metabolism in uremic children: improved after renal transplantation,American journal of kidney diseases,48(3):473-480,2006[PubMed][Paper Request]

9.Ichimura S,Murase N,Osada T,Kime R,Homma T,Ueda C,Nagasawa T,Motobe M,Hamaoka T,Katsumura T:Age and activity status affect muscle reoxygenaiton time after maximal cycling exercise,medicine and science in sports and exercise,38(7):1277 - 1281,2006[PubMed][Paper Request]

10.Nioka S,Kime R,Sunar U,Im J,Izzetoglu M,Zhang J,Alacam B,Chance B:A novel method to measure regional muscle blood flow continuously using NIRS kinetics information,Dyn Med,16(5):5,2006[PubMed][Full text]

11.Burns SF,Broom DR,Miyashita M,Ueda C,Stensel DJ:Increased postprandial triacylglycerol concentrations following resistance exercise,Med Sci Sports Exerc,3:527-33,2006[PubMed][Paper Request]

12.Kimura N,Hamaoka T,Kurosawa Y,Katumura T:Contribution of intramuscular oxidative metabolism to total ATP production during forearm isometric exercise at varying intensities,Tohoku Journal of Experimental Medicine in press,208(4):307-320,2006[PubMed][Full text]

13.S. Nioka, DJ. Wang, J. Im, T. Hamaoka,: Simulation of Mb/Hb in nirs and oxygen gradient in the human and canine skeletal muscles using H-NMR and NIRS, Adv. Exp. Med. Biol. 578: 223-228, 2006[PubMed][Paper Request]

14.F. Ohmori, S. Shimizu, T. Hamaoka,: Blood flow after contraction of short duration reaches its peak by 3rd cardiac cycle, Jpn. J. Phys. Fitness Sports Med. 55 Supple: S153-S158, 2006[Full text]

15.T. Hamaoka, Y. Kurosawa, T. Osada,: Oxygenation and energetics of the human skeletal muscle during elevated energy demand, J. Exerc. Sci. 16: 13-23, 2006[Paper Request]