英文総説
| 24 | Ito, T., Yamaguchi, Y., Handa、H. Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology. Cell Chem. Biol., 28, 987-999, 2021. DOI:10.1016/j.chembiol.2021.04.012 |
| 23 | Asakawa, K., Handa, H. and Kawakami, K. Multi-phaseted problems of TDP-43 in selective neuronal vulnerability in ALS. Cell. Mol. Life Sci., 78, 4453-4465, 2021. DOI: 10.1007/s00018-021-03792-z |
| 22 | Tomomi Sato, T., Ito, T. and Handa, H. Cereblon-based small-molecule compounds to control neural stem cell proliferation in regenerative medicine. Front. Cell Dev. Biol., 9, 629326, 2021. DOI:10.3389/fcell.2021.629326 |
| 21 | Asakawa, K., Handa, H. and Kawakami, K. Don't curse the darkness of the spinal cord - light TDP-43. Neural Regen Res, 16, 986-987, 2021. DOI：10.4103/1673-5374.297073 |
| 20 | Asatsuma-Okumura, T., Ito, T. and Handa, H. Molecular mechanisms of the teratogenic effects of thalidomide. Pharmaceuticals, 13, 95, 2020. DOI:10.3390/ph13050095 |
| 19 | Ito, T. and Handa, H. Molecular mechanisms of thalidomide and its derivatives. Proc. Jpn. Acad. Ser. b, 96, 189-203, 2020. DOI:10.2183/pjab.96.016 |
| 18 | Asatsuma-Okumura, T., Ito, T. and Handa, H. Molecular mechanisms of cereblon-based drugs. Pharmacol. Ther., 202,132-139, 2019. DOI: 10.1016/j.pharmthera.2019.06.004 |
| 17 | Kabe, Y., Sakamoto, S., Hatakeyama, M., Yamaguchi, Y., Suematsu, M., Itonaga, M., Handa, H. Application of high-performance magnetic nanobeads to biological sensing devices. Anal. Bioanal. Chem., 411, 1825-1837, 2019. DOI: 10.1007/s00216-018-1548-y |
| 16 | Kabe, Y., Handa, H., Suematsu, M. Function and structural regulation of the carbon monoxide (CO)-responsive membrane protein PGRMC1. J Clin Biochem Nutr, 63, 12-17, 2018. DOI: 10.3164/jcbn.17-132 |
| 15 | Ito, T. and Handa, H. Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs. Int. J. Hematol., 104, 293-299, 2016. DOI: 10.1007/s12185-016-2073-4 |
| 14 | Kabe, Y., Yamamoto, T., Kajimura, M., Sugiura, Y., Koike, I., Ohmura, M., Nakamura, T., Tokumoto, Y., Tsugawa, H., Handa, H., Kobayashi, T. and Suematsu, M. Cystathionine β-synthase and PGRMC1 as CO sensors. Free Radic. Biol. Med., 99, 333-344, 2016. DOI: 10.1016/j.freeradbiomed.2016.08.025 |
| 13 | Kawano, M., Matsui, M. and Handa, H. SV40 virus-like particles as an effective delivery system and a vaccine platform. Expert Rev. Vaccines, 86-100，2014. DOI: 10.1586/erv.12.149 |
| 12 | Kawano, M., Matsui, M. and Handa, H. SV40 virus-like particles as an effective delivery system and its application to a vaccine carrier. Expert Rev. Vaccines, 12, 199-210, 2013. DOI: 10.1586/erv.12.149 |
| 11 | Yamaguchi, Y., Shibata H. and Handa, H. Transcription elongation factors DSIF and NELF: Promoter-proximal pausing and beyond. Biochim. Biophs. Acta, 1829, 98-104, 2013. DOI: 10.1016/j.bbagrm.2012.11.007 |
| 10 | Ito, T. and Handa, H. Deciphering the mystery of thalidomide teratogenicity.
Congenital Anomalies, 52, 1-7, 2012. DOI: 10.1111/j.1741-4520.2011.00351.x |
| 9 | Sakamoto, S., Hatakeyama, M., Ito, T. and Handa, H. Tools and methodologies capable of isolating and identifying a target molecule for a bioactive compound. Bioorg. Med. Chem., 20, 1990-2001, 2012. DOI: 10.1016/j.bmc.2011.12.022 |
| 8 | Ito, T., Ando, H. and Handa, H. Teratogenic effects of thalidomide: molecular
mechanisms. Cell. Mol. Life Sci., 68, 1569-1579, 2011. DOI: 10.1007/s00018-010-0619-9 |
| 7 | Chiba, K., Yamamoto, J., Yamaguchi, Y. and Handa, H. Promoter-proximal pausing and its release molecular mechanisms and physiological functions. Exp. Cell Res., 316, 2723-2730, 2010. DOI: 10.1016/j.yexcr.2010.05.036 |
| 6 | Sandhu, A., Handa, H. and Abe, M. Synthesis and applications of magnetic
nanoparticles for biorecognition and point of care medical diagnostics.
Nanotechnology, 21, 442001-442022, 2010. DOI: 10.1088/0957-4484/21/44/442001 |
| 5 | Sakamoto, S., Kabe, Y., Hatakeyama, M., Yamaguchi, Y. and Handa, H. Development
of application of high-performance affinity beads: toward chemical biology
and drug discovery. Chem. Rec., 9, 66-85, 2009. DOI: https://doi.org/10.1002/tcr.20170 |
| 4 | Yamaguchi, Y., Delehouzee, S. and Handa, H. HIV and hepatitis delta virus:
evolution takes different paths to relieve blocks in transcriptional elongation.
Microbes Infect., 4, 1169-1175, 2002. DOI: 10.1016/s1286-4579(02)01641-6 |
| 3 | Kim, D-K., Yamaguchi, Y., Wada, T. and Handa, H. The regulation of elongation by eukaryotic RNA polymerase II: A recent view. Mol. Cells, 11, 267-274, 2001. PMID: 11459214 |
| 2 | Yamaguchi, Y., Narita, T., Inukai, N., Wada, T. and Handa, H. SPT genes: key players in the regulation of transcription, chromatin structure and other cellular processes. J. Biochem., 129, 185-191, 2001. DOI: 10.1093/oxfordjournals.jbchem.a002842 |
| 1 | Yamaguchi, Y., Wada, T. and Handa, H. Drawing a new view of DRB: Interplay between positive and negative elongation factors. Genes Cells, 3, 9-15, 1998. DOI: 10.1046/j.1365-2443.1998.00162.x |