Mikiro Nawa

Career
【Work Experiences】
- 2017.03- Lecturer, Tokyo medical university, Department of Pharmacology
- 2011.04-2017.02 Research Associate, Tokyo medical university, Department of Pharmacology
- 2009.04-2011.03 Postdoctoral fellow, Tokyo Medical University, Department of Pharmacology
- 2008.04-2009.03 Postdoctoral fellow, Keio University School of Medicine, Department of Cell Biology and Neuroscience
- 2006.04-2008.03 Research Fellow for Young Scientist (21 Century COE DC2), Japan Society for the Promotion of Science
【Education】
- 2004.04-2008.03 Ph.D. (anatomy), Graduate School of Medicine, Keio University School of Medicine
- 2002.04-2004.03 M.S. (Pharmacology), Graduate School of Medicine, Keio University School of Medicine
- 1998.04-2002.03 B.S. (Pharmacy), Tokyo University of Pharmacy and Life Sciences School of Pharmacy
Academic Societies
The Japanese Pharmacological Society, Society for Neuroscience
Licenses
2002.04 Pharmacist
Awards
- 2024.03 Best Teachers’ Award, Tokyo Medical University
- 2023.03 Best Teachers’ Award, Tokyo Medical University
- 2013.05 Sasa Memorial Award
Research Theme
Analysis of the mechanism(s) of neuronal cell death in amyotrophic lateral sclerosis and/or frontotemporal dementia.
Publications
- Kusakari S, Nawa M (equally contributed), Hashimoto Y, Matsuoka M CLSPCOL rescues Alzheimer’s disease mouse models. Transl. Neurosci., 13(1): pp11-19, 2022 doi:10.1515/tnsci-2022-0209. eCollection 2022 Jan 1.
- Hashimoto Y, Kusakari S, Nawa M, Okamoto K, Toyama Y, Matsuoka M Restoration of the reduced CLSP activity alleviates memory impairment in Alzheimer disease. Transl. Psychiatry, 11(1):44, 2021 doi: 10.1038/s41398-020-01168-8
- Takahara Y, Miyachi N, Nawa M, Matsuoka M Calmodulin-like skin protein suppresses the increase in senescence-associated β-galactosidase induced by hydrogen peroxide or ultraviolet irradiation in keratinocytes. Cell Biol. Int., 43(7):pp 835-843, 2019 doi: 10.1002/cbin.11159.
- Kusakari S, Nawa M, Sudo K, Matsuoka M Calmodulin-like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease. J. Neurochem., 144(2): pp218-233, 2018 doi: 10.1111/jnc.14258
- Hashimoto Y, Toyama Y, Kusakari S, Nawa M, Matsuoka M An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling. J Biol. Chem., 291(23): pp12282-12293, 2016 doi: 10.1074/jbc.M115.698092.
- Nawa M, Matsuoka M KCTD20, a relative of BTBD10, is a positive regulator of Akt. BMC Biochem., 14:27. doi:10.1186/1471-2091-14-27, 2013
- Takeshita Y, Hashimoto Y, Nawa M, Uchino H, Matsuoka M SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase. J. Biol. Chem., 288(34):pp 24691-24704, 2013
- Hashimoto Y, Nawa M, Kurita M, Tokizawa M, Iwamatsu A, Matsuoka M. Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer’s disease models via the heterotrimeric Humanin receptor. Cell Death Dis., 4:e555, 2013
- Nawa M and Matsuoka M The Method of the Body Bending Assay Using Caenorhabditis elegans. Bio-protocol, Vol2, Iss 17, 9/5/2012. Doi: 10.21769/BioProtoc.253
- Nawa M, Kage-Nakadai E, Aiso S, Okamoto K, Mitani S, Matsuoka M Reduced expression of BTBD10, an Akt activator, leads to motor neuron death. Cell Death Differ., 19(8):pp 1398-1407, 2012
- Noguchi A, Nawa M, Chiba T, Okamoto K, Aiso S, Matsuoka M Transforming growth factor β2 level is elevated in neurons of Alzheimer’s disease’s brains. Int. J. Neurosci., 120(3): pp 168-175, 2010
- Tachi N, Hashimoto Y, Nawa M, Matsuoka M TAG-1 is an inhibitor of TGFβ2-induced neuronal death via amyloid b precursor protein. Biochem. Biophys. Res. Commun., 394(1): pp 119-125, 2010
- Nakahara J, Kanekura K, Nawa M, Aiso S, Suzuki N Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis. J. Clin. Invest., 119(1): pp 169-181, 2009
- Nawa M, Kanekura K, Hashimoto Y, Aiso S, and Matsuoka M A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Cell. Signal., 20(3): pp 493-505, 2008
- Hashimoto Y, Nawa M (equally contributed), Chiba T, Aiso S, Nishimoto I, Matsuoka M Transforming growth factor β2 autocrinally mediates neuronal cell death induced by amyloid-β. J. Neurosci. Res., 83(6): pp 1039-1047, 2006
- Hashimoto Y, Chiba T, Yamada M, Nawa M, Kanekura K, Suzuki H, Terashita K, Aiso S, Nishimoto I, Matsuoka M Transforming growth factor β2 is a neuronal death-inducing ligand for amyloid-β precursor protein. Mol. Cell. Biol., 25(21): pp 9304-9317, 2005
- Yamada M, Chiba T, Sasabe J, Nawa M, Tajima H, Niikura T, Terashita K, Aiso S, Kita Y, Matsuoka M, Nishimoto I Implanted cannula-mediated repetitive administration of Aβ 25-35 into the mouse cerebral ventricle effectively impairs spatial working memory. Behav. Brain. Res., 164(2): pp 139-146, 2005
- Tajima H, Kawasumi M, Chiba T, Yamada M, Yamashita K, Nawa M, Kita Y, Kouyama K, Aiso S, Matsuoka M, Niikura T, Nishimoto I A Humanin derivative, S14G-HN, prevents amyloid-β-induced memory impairment in mice. J. Neurosci. Res., 79(5): pp 714-723, 2005
- Kawahara Y, Tanonaka K, Daicho T, Nawa M, Oikawa R, Nasa Y, Takeo S Preferable anesthetic conditions for echocardiographic determination of murine cardiac function. J Pharmacol. Sci., 99(1): pp 95-104, 2005
- Terashita K, Hashimoto Y, Niikura T, Tajima H, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Nawa M, Kita Y, Aiso S, Nishimoto I Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization. J. Neurochem., 85(6) : pp 1521-1538, 2003
- Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M, Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol. J. Neurosci., 23(24) : pp 8513-8525, 2003
- Hashimoto Y, Niikura T, Chiba T, Tsukamoto E, Kadowaki H, Nishitoh H, Yamagishi Y, Ishizaka M, Yamada M, Nawa M, Terashita K, Aiso S, Ichijo H, Nishimoto I The cytoplasmic domain of Alzheimer's amyloid-β protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization. J. Pharmacol. Exp. Ther., 306(3): pp 889-902, 2003
- Niikura T, Hashimoto Y, Tajima H, Ishizaka M, Yamagishi Y, Kawasumi M, Nawa M, Terashita K, Aiso S, Nishimoto I A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer’s disease-relevant insults. Eur. J. Neurosci., 17(6): pp 1150-1158, 2003
Hobby
puzzle, playing instruments