Mikiro Nawa

Career

【Work Experiences】

【Education】

Academic Societies

The Japanese Pharmacological Society, Society for Neuroscience

Licenses

2002.04 Pharmacist

Awards

Research Theme

Analysis of the mechanism(s) of neuronal cell death in amyotrophic lateral sclerosis and/or frontotemporal dementia.

Publications

1. Kusakari S, Nawa M (equally contributed), Hashimoto Y, Matsuoka M CLSPCOL rescues Alzheimer’s disease mouse models. Transl. Neurosci., 13(1): pp11-19, 2022 doi:10.1515/tnsci-2022-0209. eCollection 2022 Jan 1.
2. Hashimoto Y, Kusakari S, Nawa M, Okamoto K, Toyama Y, Matsuoka M Restoration of the reduced CLSP activity alleviates memory impairment in Alzheimer disease. Transl. Psychiatry, 11(1):44, 2021 doi: 10.1038/s41398-020-01168-8
3. Takahara Y, Miyachi N, Nawa M, Matsuoka M Calmodulin-like skin protein suppresses the increase in senescence-associated β-galactosidase induced by hydrogen peroxide or ultraviolet irradiation in keratinocytes. Cell Biol. Int., 43(7):pp 835-843, 2019 doi: 10.1002/cbin.11159.
4. Kusakari S, Nawa M, Sudo K, Matsuoka M Calmodulin-like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease. J. Neurochem., 144(2): pp218-233, 2018 doi: 10.1111/jnc.14258
5. Hashimoto Y, Toyama Y, Kusakari S, Nawa M, Matsuoka M An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling. J Biol. Chem., 291(23): pp12282-12293, 2016 doi: 10.1074/jbc.M115.698092.
6. Nawa M, Matsuoka M KCTD20, a relative of BTBD10, is a positive regulator of Akt. BMC Biochem., 14:27. doi:10.1186/1471-2091-14-27, 2013
7. Takeshita Y, Hashimoto Y, Nawa M, Uchino H, Matsuoka M SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase. J. Biol. Chem., 288(34):pp 24691-24704, 2013
8. Hashimoto Y, Nawa M, Kurita M, Tokizawa M, Iwamatsu A, Matsuoka M. Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer’s disease models via the heterotrimeric Humanin receptor. Cell Death Dis., 4:e555, 2013
9. Nawa M and Matsuoka M The Method of the Body Bending Assay Using Caenorhabditis elegans. Bio-protocol, Vol2, Iss 17, 9/5/2012. Doi: 10.21769/BioProtoc.253
10. Nawa M, Kage-Nakadai E, Aiso S, Okamoto K, Mitani S, Matsuoka M Reduced expression of BTBD10, an Akt activator, leads to motor neuron death. Cell Death Differ., 19(8):pp 1398-1407, 2012
11. Noguchi A, Nawa M, Chiba T, Okamoto K, Aiso S, Matsuoka M Transforming growth factor β2 level is elevated in neurons of Alzheimer’s disease’s brains. Int. J. Neurosci., 120(3): pp 168-175, 2010
12. Tachi N, Hashimoto Y, Nawa M, Matsuoka M TAG-1 is an inhibitor of TGFβ2-induced neuronal death via amyloid b precursor protein. Biochem. Biophys. Res. Commun., 394(1): pp 119-125, 2010
13. Nakahara J, Kanekura K, Nawa M, Aiso S, Suzuki N Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis. J. Clin. Invest., 119(1): pp 169-181, 2009
14. Nawa M, Kanekura K, Hashimoto Y, Aiso S, and Matsuoka M A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Cell. Signal., 20(3): pp 493-505, 2008
15. Hashimoto Y, Nawa M (equally contributed), Chiba T, Aiso S, Nishimoto I, Matsuoka M Transforming growth factor β2 autocrinally mediates neuronal cell death induced by amyloid-β. J. Neurosci. Res., 83(6): pp 1039-1047, 2006
16. Hashimoto Y, Chiba T, Yamada M, Nawa M, Kanekura K, Suzuki H, Terashita K, Aiso S, Nishimoto I, Matsuoka M Transforming growth factor β2 is a neuronal death-inducing ligand for amyloid-β precursor protein. Mol. Cell. Biol., 25(21): pp 9304-9317, 2005
17. Yamada M, Chiba T, Sasabe J, Nawa M, Tajima H, Niikura T, Terashita K, Aiso S, Kita Y, Matsuoka M, Nishimoto I Implanted cannula-mediated repetitive administration of Aβ 25-35 into the mouse cerebral ventricle effectively impairs spatial working memory. Behav. Brain. Res., 164(2): pp 139-146, 2005
18. Tajima H, Kawasumi M, Chiba T, Yamada M, Yamashita K, Nawa M, Kita Y, Kouyama K, Aiso S, Matsuoka M, Niikura T, Nishimoto I A Humanin derivative, S14G-HN, prevents amyloid-β-induced memory impairment in mice. J. Neurosci. Res., 79(5): pp 714-723, 2005
19. Kawahara Y, Tanonaka K, Daicho T, Nawa M, Oikawa R, Nasa Y, Takeo S Preferable anesthetic conditions for echocardiographic determination of murine cardiac function. J Pharmacol. Sci., 99(1): pp 95-104, 2005
20. Terashita K, Hashimoto Y, Niikura T, Tajima H, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Nawa M, Kita Y, Aiso S, Nishimoto I Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization. J. Neurochem., 85(6) : pp 1521-1538, 2003
21. Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M, Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol. J. Neurosci., 23(24) : pp 8513-8525, 2003
22. Hashimoto Y, Niikura T, Chiba T, Tsukamoto E, Kadowaki H, Nishitoh H, Yamagishi Y, Ishizaka M, Yamada M, Nawa M, Terashita K, Aiso S, Ichijo H, Nishimoto I The cytoplasmic domain of Alzheimer's amyloid-β protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization. J. Pharmacol. Exp. Ther., 306(3): pp 889-902, 2003
23. Niikura T, Hashimoto Y, Tajima H, Ishizaka M, Yamagishi Y, Kawasumi M, Nawa M, Terashita K, Aiso S, Nishimoto I A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer’s disease-relevant insults. Eur. J. Neurosci., 17(6): pp 1150-1158, 2003

Hobby

puzzle, playing instruments