Hiroaki Suzuki

Career
- 2003 B.S., School of Pharmacy, Kitasato University
- 2009 Ph.D., Graduate School of Medicine, Keio University School of Medicine
- 2012 Assistant prof., Department of Pharmacology, Tokyo Medical University
- 2018 Lecturer, Department of Pharmacology, Tokyo Medical University
Academic society
The Japanese Pharmacological Society、The Japan Neuroscience Society
Research theme
Elucidation of mechanisms underlying Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementia (FTD)
Selected publications
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鈴木 宏昌, 金蔵孝介(2024)
神経変性疾患と細胞死, 実験医学別冊 もっとよくわかる!シリーズ もっとよくわかる!細胞死 (羊土社), 206-215頁 -
Suzuki H(2022)
Physiological and pathological roles of TMEM106B: a novel component of amyloid fibrils identified by cryo-EM analysis, Journal of clinical and experimental medicine, vol. 283, no. 13, pp1138-1143 -
Suzuki H (Corresponding author), Matsuoka M. (2021)
Proline-arginine poly-dipeptide encoded by the C9orf72 repeat expansion inhibits adenosine deaminase acting on RNA. Journal of Neurochemistry, vol. 158, pp753-765 -
Suzuki H, Shibagaki Y, Hattori S, Matsuoka M. (2019)
C9-ALS/FTD-linked proline-arginine dipeptide repeat protein associates with paraspeckle components and increases paraspeckle formation. Cell Death & Disease, 10:746 -
Suzuki H, Shibagaki Y, Hattori S, Matsuoka M. (2018)
The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis. Cell Death & Disease, 9:975 -
Suzuki H, Matsuoka M. (2017)
hnRNPA1 autoregulates its own mRNA expression to remain non-cytotoxic. Molecular and Cellular Biochemistry, vol. 427, pp123-131 -
Suzuki H, Matsuoka M. (2016)
The lysosomal trafficking transmembrane protein 106B is linked to cell death. Journal of Biological Chemistry, vol. 291, pp21448-21460 -
Suzuki H, Shibagaki Y, Hattori S, Matsuoka M. (2015)
Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs. Human Molecular Genetics, vol. 24, pp1513-1527 -
Suzuki H, Matsuoka M. (2015)
Overexpression of nuclear FUS induces neuronal cell death. Neuroscience, vol. 287, pp113-124 -
Suzuki H, Matsuoka M. (2013)
The JNK/c-Jun signaling axis contributes to the TDP-43-induced cell death. Molecular and Cellular Biochemistry, vol. 372, pp241-248 -
Suzuki H, Matsuoka M. (2012)
TDP-43 toxicity is mediated by the unfolded protein response-unrelated induction of C/EBP homologous protein expression. Journal of Neuroscience Research, vol. 90, pp641-647 -
Lee K, Suzuki H (Co-first author), Aiso S, Matsuoka M. (2012)
Overexpression of TDP-43 causes partially p53-dependent G2/M arrest and p53-independent cell death in HeLa cells. Neuroscience Letters, vol. 506, pp271-276 -
Suzuki H, Matsuoka M. (2011)
Amyotrophic lateral sclerosis-linked mutant VAPB enhances TDP-43-induced motor neuronal toxicity. Journal of Neurochemistry, vol. 119, pp1099-1107 -
Suzuki H, Lee K, Matsuoka M. (2011)
TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage. Journal of Biological Chemistry, vol. 286, pp13171-13183 -
Suzuki H, Kanekura K, Levine TP, Kohno K, Olkkonen VM, Aiso S, Matsuoka M. (2009)
ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB. Journal of Neurochemistry, vol. 108, pp973-985 -
Suzuki H, Kurita M, Mizumoto K, Moriyama M, Aiso S, Nishimoto I, Matsuoka M. (2005)
The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression. Biochemical and Biophysical Research Communications, vol. 326, pp242-248 -
Suzuki H, Kurita M, Mizumoto K, Nishimoto I, Ogata E, Matsuoka M. (2003)
p19ARF-induced p53-independent apoptosis largely occurs through BAX. Biochemical and Biophysical Research Communications, vol. 312, pp1273-1277