Kohsuke Kanekura

Professor Kohsuke Kanekura, M.D., Ph.D

e-mail: kanekura(at)tokyo-med.ac.jp

Profiles

1996 Graduated from Kaseda high school
2002 Graduated from KEIO University School of Medicine
2003 Research fellow (DC1), Japan Society for the Promotion of Science
2005 Graduated from Keio University, Graduate School of Medicine, Doctoral Program
2006 Research fellow (PD), Japan Society for the Promotion of Science
2007 Medical intern, Department of Neurology, Keio University Hospital
2008 Medical intern, Department of Internal Medicine, Keio University Hospital
2003 Research fellow (DC1), Japan Society for the Promotion of Science
2005 Keio University, Graduate School of Medicine, Doctoral Program, Early Entrance to Doctoral Program (Medicine)
2005 Japan Society for the Promotion of Science Special Researcher PDへChange of status
2006: Special Researcher PD of the Japan Society for the Promotion of Science
2007 Medical intern, Department of Neurology, Keio University Hospital
2008 Keio University Hospital Internal Research Fellowship
2010 Overseas research fellow, Japan Society for the Promotion of Science (Univ. Massachusetts Medical School)
2012 Senior Scientist, Washington Univ. St. Louis
2015 Lecturer, Department of Molecular Pathology, Tokyo Medical University
2022 Associate professor, Department of Molecular Pathology, Tokyo Medical University
2023 Professor, Department of Pharmacology, Tokyo Medical University

Profession

Pharmacology, Neurology, Molecular biology

Academic Affiliations

The Japanese Pharmacological Society, The Japanese Biochemical Society, Japan Society for Dementia Research, Society for Neuroscience

Grants received

17.JSPS Grant in Aid for Scientific Research (B). (FY2024-2026)
16. Daiwa Securities Foundation Research Grant (FY2023)
15. Sumitomo Foundation Basic Science Research Projects (FY2023)
14. Japan ALS Foundation Research Grant (FY2023)
13. Naito Foundation Research Grant (FY2023)
12. Mochida for Medical and Pharmaceutical Research (FY2023)
11. Astellas Foundation Research Grant (FY2022)
10. Takeda Science Foundation Medical Research Continuous Grants (FY2022)
9. Takeda Science Foundation Medical Research Grants (FY2020)
8. JSPS Grant in Aid for Scientific Research (B). (FY2020-2022)
7. The Ichiro Kanehara foundation (FY2017)
6. Tokyo Biochemistry Research Foundation (FY2016)
5. Japan Intractable Diseases Research Foundation Research Grant (FY2016)
4. Takeda Science Foundation Medical Research Grants (FY2016)
3. JSPS Grant in Aid for Young Scientists (A). (FY2016-2019)
2. Uehara Memorial Foundation Postdoctoral Fellowship (total ¥3,600,000) (FY2012)
1. Japanese Society for Promotion of Science (JSPS) Overseas Research Fellowship (FY2010-2012)

Selected articles

1. Miyagi T, Ueda K, Sugimoto M, Yagi T, Ito D, Yamazaki R, Narumi S, Hayamizu Y, Uji-i H, Kuroda M, Kanekura K. Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges. iScience 2023 May 25;26(6):106957. doi: 10.1016/j.isci.2023.106957. eCollection 2023 Jun 16.
2. Miyagi T, Yamazaki R, Ueda K, Narumi S, Hayamizu Y, Uji-I H, Kuroda M, Kanekura K. The Patterning and Proportion of Charged Residues in the Arginine- Rich Mixed-Charge Domain Determine the Membrane-Less Organelle Targeted by the Protein. Int J Mol Sci. 2022; 23(14):7658.
3. Miyagi T, Yamanaka Y, Harada Y, Narumi S, Hayamizu Y, Kuroda M, Kanekura K. An improved macromolecular crowding sensor CRONOS for detection of crowding changes in membrane-less organelles under stressed conditions. Biochem Biophys Res Commun. 2021; 583:29-34.
4. Chen C, Yamanaka Y, Ueda K, Li P, Miyagi T, Harada Y, Tezuka S, Narumi S, Sugimoto M, Kuroda M, Hayamizu Y, Kanekura K. Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine. J Cell Biol. 2021; 220(11):e202103160. doi: 10.1083/jcb.202103160.
5. Yamanaka Y, Miyagi T, Harada Y, Kuroda M, Kanekura K. Establishment of chemically oligomerizable TAR DNA-binding protein-43 which mimics amyotrophic lateral sclerosis pathology in mammalian cells. Lab Invest. 2021;101(10):1331-1340.
6. Kanekura K, Harada Y, Fujimoto M, Yagi T, Hayamizu Y, Nagaoka K, Kuroda M. Characterization of membrane penetration and cytotoxicity of C9orf72-encoding arginine-rich dipeptides. Sci Rep. 2018; 8:12740.
7. Kanekura K, Yagi T, Cammack AJ, Mahadevan J, Kuroda M, Harms MB, Miller TM, Urano F. Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation. Hum Mol Genet. 2016; 25:1803-13.
8. Kanekura K, Ma X, Murphy JT, Zhu LJ, Diwan A, Urano F. IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions. Sci Signal. 2015;8:ra62.
9. Kanekura K, Ishigaki S, Merksamer PI, Papa FR, Urano F. Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells. Lab Invest. 2013;93:1254-8.
10. Kanekura K, Nishimoto I, Aiso S, Matsuoka M. Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein- associated protein B (VAPB/ALS8). J Biol Chem. 2006; 281:30223-33.