Shinya Kusakari

Shinya Kusakari

Research theme

I investigate the molecular mechanism of neuronal cell death caused by genetic mutations in CHCHD10, a causative factor of ALS/FTD, and Progranulin, a causative factor of FTD, using cultured cells and genetically modified mouse such as transgenic mouse. I would like to incorporate engineering methods into my analysis in the future.

Publications

  1. Shinya Kusakari, Mikiro Nawa, Yuichi Hashimoto, Masaaki Matsuoka CLSPCOL rescues Alzheimer’s disease mouse models Translational Neuroscience 13(1):11-19, 2022
  2. Daiki Jingu, Mika Iino, Joji Kawasaki, Eriko Urano, Shinya Kusakari, Yuriko Hayashi, Takashi Matozaki, Hiroshi Ohnishi Protein tyrosine phosphatase Shp2 positively regulates cold stress-induced tyrosine phosphorylation of SIRPα in neurons Biochemical and Biophysical Research Communications 569, 72-78, 2021
  3. Yuichi Hashimoto, Shinya Kusakari, Mikiro Nawa, Koich Okamoto, Yuka Toyama, Masaaki Matsuoka Restoration of the reduced CLSP activity alleviates memory impairment in an Alzheimer disease Translational Psychiatry 11, 44, 2021
  4. Ichie Hara, Hiroaki Suzuki, Shinya Kusakari, Masaaki Matsuoka. Practical training of pharmacokinetics with an web-based simulation application Nihon Yakurigaku Zasshi 155, 51-55, 2020
  5. Shinya Kusakari, Mikiro Nawa, Katsuko Sudo, Masaaki Matsuoka Calmodulin-like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease Journal of Neurochemistry 144, 218-233, 2018
  6. Yuichi Hashimoto, Yuka Toyama, Shinya Kusakari, Mikiro Nawa, Masaaki Matsuoka An Alzheimer disease-linked rare mutation potentiates netrin receptor uncoordinated-5C-induced signaling that merges with amyloid b precursor protein signaling The Journal of Biological Chemistry 291, 12282-12293, 2016
  7. Edwin Widyanto Daniwijaya, Yoji Murata, Takenori Kotani, Yasuaki Kitamura, Kemala Isnainisih Mantilidewi, Shinya Kusakari, Hiroshi Ohnishi, Hideki Okazawa, Takashi Matozaki Tyrosine phosphorylation of carcinoembryonic antigen-related cell adhesion molecule 20 and its functional role The Kobe journal of medical sciences 59, 172-183, 2016
  8. Shinya Kusakari, Fumihito Saitow, Yukio Ago, Koji Shibasaki, Miho Sato-Hashimoto, Yasunori Matsuzaki, Takenori Kotani, Yoji Murata, Hirokazu Hirai, Toshio Matsuda, Hidenori Suzuki, Takashi Matozaki, Hiroshi Ohnishi Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice Molecular and Cellular Biology 35, 1557-1572, 2015
  9. Yoji Murata, Takenori Kotani, Yana Supriatna, Yasuaki Kitamura, Shinya Imada, Kohichi Kawahara, Miki Nishio, Edwin Widyanto Daniwijaya, Hisanobu Sadakata, Shinya Kusakari, Munemasa Mori, Yoshitake Kanazawa, Yasuyuki Saito, Katsuya Okawa, Mariko Takeda-Morishita, Hideki Okazawa, Hiroshi Ohnishi, Takeshi Azuma, Akira Suzuki, Takashi Matozaki Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium” Proceedings of the National Academy of Sciences of the United States of America 112, E4264-4271, 2015
  10. Ichie Hara, Hiroaki Suzuki, Shinya Kusakari, Masaaki Matsuoka. The effect of self-training in advance using an e-learning system on pharmacological practice Nihon Yakurigaku Zasshi 145, 80-84, 20
  11. Kemala Isnainiasih Mantilidewi, Yoji Murata, Munemasa Mori, Chihiro Otsubo, Takenori Kotani, Shinya Kusakari, Hiroshi Ohnishi and Takashi Matozaki Shear stress-induced redistribution of vascular endothelial-protein-tyrosine phosphatase (VE-PTP) in endothelial cells and its role in cell elongation The Journal of Biological Chemistry 289, 6451-6461, 2014
  12. Yuriko Hayashi, Shinya Kusakari, Miho Sato-Hashimoto, Eriko Urano, Masahiro Shigeno, Tsuneo Sekijima, Takenori Kotani, Yoji Murata, Hirokazu Murakami, Takashi Matozaki, Hiroshi Ohnishi Hypothermia-dependent and -independent effects of forced swim on the phosphorylation states of signaling molecules in mouse hippocampus Biochemical and Biophysical Research Communications 428, 475-481, 2012
  13. Toshi Maruyama*, Shinya Kusakari*, Miho Sato-Hashimoto, Yuriko Hayashi, Takenori Kotani, Yoji Murata, Hideki Okazawa, Per-Arne Oldenborg, Shoji Kishi, Takashi Matozaki, Hiroshi Ohnishi (*Contributed equally to this work) Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain Journal of Neurochemistry 121, 891-902, 2012
  14. Tetsuya Kaneko, Yasuyuki Saito, Takenori Kotani, Hideki Okazawa, Hiroko Iwamura, Miho Sato-Hashimoto, Yoshitake Kanazawa, Satoshi Takahashi., Keiju Hiromura, Shinya Kusakari, Yoriaki Kaneko, Yoji Murata, Hiroshi Ohnishi, Yoshihisa Nojima, Keiji Takagishi, Takashi Matozaki Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity Journal of Immunology 188, 5397-5407, 2012
  15. Miho Sato-Hashimoto, Yasuyuki Saito, Hiroshi Ohnishi, Hiroko Iwamura, Yoshitake Kanazawa, Tetsuya Kaneko, Shinya Kusakari, Takenori Kotani, Munemasa Mori, Yoji Murata, Hideki Okazawa, Carl F. Ware, Per-Arne Oldenborg, Yoshihisa Nojima, Takashi Matozaki Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen Journal of Immunology 187, 291-297, 2011
  16. Hiroko Iwamura, Yasuyuki Saito, Miho Sato-Hashimoto, Hiroshi Ohnishi, Yoji Murata, Hideki Okazawa, Yoshitake Kanazawa, Tetsuya Kaneko, Shinya Kusakari, Takenori Kotani, Yoshihisa Nojima, Takashi Matozaki Essential roles of SIRPα in homeostatic regulation of skin dendritic cells Immunology Letters 135, 100-107, 2011
  17. Naoko Morimoto, Yoji Murata, Sei-ichiro Motegi, Kazutomo Suzue, Yasuyuki Saito, Hideki Okazawa, Hiroshi Ohnishi, Takenori Kotani, Shinya Kusakari, Osamu Ishikawa, Takashi Matozaki. Requirement of SIRPa for protective immunity against Leishmania major Biochemical and Biophysical Research Communications 401, 385-389, 2010
  18. Hiroshi Ohnishi*, Takaaki Murata*, Shinya Kusakari*, Yuriko Hayashi, Keizo Takao, Toshi Maruyama, Yukio Ago, Ken Koda, Feng-Jie Jin, Katsuya Okawa, Per-Arne Oldenborg, Hideki Okazawa, Yoji Murata, Nobuhiko Furuya, Toshio Matsuda, Tsuyoshi Miyakawa, Takashi Matozaki (*Contributed equally to this work) Stress-evoked tyrosine phosphorylation of Signal regulatory protein a regulates behavioral immobility in the forced swim test The Journal of Neuroscience 30, 10472-10483, 2010
  19. Yoji Murata, Munemasa Mori, Takenori Kotani, Yana Supriatna, Hideki Okazawa, Shinya Kusakari, Yasuyuki Saito, Hiroshi Ohnishi, Takashi Matozaki Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn Genes to Cells 15, 513-524, 2010
  20. Munemasa Mori, Yoji Murata, Takenori Kotani, Shinya Kusakari, Hiroshi Ohnishi, Yasuyuki Saito, Hideki Okazawa, Tamotsu Ishizuka, Masatomo Mori, Takashi Matozaki Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrins Journal of Cellular Physiology 224, 195-204, 2010
  21. Takenori Kotani, Yoji Murata, Hiroshi Ohnishi, Munemasa Mori, Shinya Kusakari, Yasuyuki Saito, Hideki Okazawa, John L. Bixby, Takashi Matozaki Expression of PTPRO in the interneurons of adult mouse olfactory bulb The Journal of Comparative Neurology 518, 119–136, 2010
  22. Hisanobu Sadakata, Hideki Okazawa, Takashi Sato, Yana Supriatna, Hiroshi Ohnishi, Shinya Kusakari, Yoji Murata, Uichi Nishiyama, Takashi Minegishi, Akihiho Harada, Takashi Matozaki SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis Genes to Cells 14, 295–308, 2009
  23. Shinya Kusakari, Hiroshi Ohnishi, Feng-Jie Jin, Yuka Kaneko, Takaaki Murata, Yoji Murata, Hideki Okazawa, Takashi Matozaki Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system Journal of Cell Science 121, 1213-1223, 2008
  24. Takaaki Murata, Hihoshi Ohnishi, Hideki Okazawa, Yoji Murata, Shinya Kusakari, Yuriko Hayashi, Motoaki Miyashita, Hiroshi Itoh, Per-Arne Oldenborg, Nobuhiko Furuya, Takashi Matozaki CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42 The Journal of Neuroscience 26, 12397-12407, 2006
  25. Shinya Kusakari, Hiroki Matsumoto, Nobuo Otani, Toshihiro Furukawa A consideration on blind signal separation algorithm using kurtosis Journal of Signal Processing 9(5): 397-408, 2005

Grants

  1. 2023.　Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science (JSPS)
  2. 2022.　SENSHIN Medical Research Foundation
  3. 2020.　Takeda Science Foundation
  4. 2019.　Grant-in-Aid for Scientific Research (C) JSPS
  5. 2018.　SENSHIN Medical Research Foundation
  6. 2018.　The Tokyo Medical University Research Grant
  7. 2016.　Grant-in-Aid for Scientific Research(C), JSPS
  8. 2012.　Grant-in-Aid for Young Scientists (B), JSPS
  9. 2009.　Grant-in-Aid for Young Scientists (B), JJSPS
  10. 2009.　The Japan Foundation for Neuroscience and Mental Health

Awards/Honors

  • November, 2019　Encouragement Award, Tokyo Medical University
  • June, 2019　Sasa Award, Tokyo Medical University
  • October, 2016　Research Award, Japanese Association for Protein Phosphatase Research
  • February, 2014　Young Investigator Award on Protein Phosphatase Conference, Japanese Association for Protein Phosphatase Research
  • December, 2012　Koichi Suzuki memorial award, The 85th Annual Meeting of the Japanese Biochemical Society
  • March, 2008　Global COE Young Investigator Encouragement Award, Gunma University
  • January, 2007　Graduate School Dean Award, Gunma University

Education

  • April, 2004 – March, 2008　Graduate School of Medicine, Gunma University, Gunma Japan
  • April, 2002 – March, 2004　Division of Systems Information Technology Maebashi Institute of Technology, Gunma, Japan
  • April, 1998 – March, 2002　Department of Information Technology, Maebashi Institute of Technology, Gunma, Japan
  • April, 1995 – March, 1997　Sagae High School, Yamagata, Japan

A degree and a doctoral dissertation

  • 2008.　Doctor of Philosophy (Medicine), Gunma University
  • 2004.　Master of Engineering, Maebashi Institute of Technology
  • 2002.　Bachelor of Engineering, Maebashi Institute of Technology

Work Experiences

  • December, 2020－Present　Assistant Professor, Department of Pharmacology, Tokyo Medical University
  • April, 2014－December, 2020　Instructor, Department of Pharmacology, Tokyo Medical University
  • April, 2008－March, 2014　Postdoctoral fellow, Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University

東京医科大学

薬理学分野

〒160-8402東京都新宿区新宿6-1-1

Department of Pharmacology

Tokyo Medical University

6-1-1, Shinjuku, Shinjuku-ku, Tokyo 160-8402, JAPAN

Copyright © Department of Pharmacology
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