草苅伸也

研究テーマ

ALS/FTD原因因子CHCHD10とFTD原因因子Progranulinの遺伝子変異による細胞死メカニズムの解明に取り組んでいます。培養細胞を用いた解析だけでなく、遺伝子改変マウスを用いた行動解析など個体レベルでの解析を行っています。Wetの世界にどっぷりとつかっていますが、修士課程までは情報工学科でコンピュータシミュレーションによる信号解析を行っていましたので、工学的手法も取り入れた解析も今後は取り入れていきたいと考えています。

原著論文

1. Shinya Kusakari, Mikiro Nawa, Yuichi Hashimoto, Masaaki Matsuoka CLSPCOL rescues Alzheimer’s disease mouse models Translational Neuroscience 13(1):11-19, 2022
2. Daiki Jingu, Mika Iino, Joji Kawasaki, Eriko Urano, Shinya Kusakari, Yuriko Hayashi, Takashi Matozaki, Hiroshi Ohnishi Protein tyrosine phosphatase Shp2 positively regulates cold stress-induced tyrosine phosphorylation of SIRPα in neurons Biochemical and Biophysical Research Communications 569, 72-78, 2021
3. Yuichi Hashimoto, Shinya Kusakari, Mikiro Nawa, Koich Okamoto, Yuka Toyama, Masaaki Matsuoka Restoration of the reduced CLSP activity alleviates memory impairment in an Alzheimer disease Translational Psychiatry 11, 44, 2021
4. Ichie Hara, Hiroaki Suzuki, Shinya Kusakari, Masaaki Matsuoka. Practical training of pharmacokinetics with an web-based simulation application Nihon Yakurigaku Zasshi 155, 51-55, 2020
5. Shinya Kusakari, Mikiro Nawa, Katsuko Sudo, Masaaki Matsuoka Calmodulin-like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease Journal of Neurochemistry 144, 218-233, 2018
6. Yuichi Hashimoto, Yuka Toyama, Shinya Kusakari, Mikiro Nawa, Masaaki Matsuoka An Alzheimer disease-linked rare mutation potentiates netrin receptor uncoordinated-5C-induced signaling that merges with amyloid b precursor protein signaling The Journal of Biological Chemistry 291, 12282-12293, 2016
7. Edwin Widyanto Daniwijaya, Yoji Murata, Takenori Kotani, Yasuaki Kitamura, Kemala Isnainisih Mantilidewi, Shinya Kusakari, Hiroshi Ohnishi, Hideki Okazawa, Takashi Matozaki Tyrosine phosphorylation of carcinoembryonic antigen-related cell adhesion molecule 20 and its functional role The Kobe journal of medical sciences 59, 172-183, 2016
8. Shinya Kusakari, Fumihito Saitow, Yukio Ago, Koji Shibasaki, Miho Sato-Hashimoto, Yasunori Matsuzaki, Takenori Kotani, Yoji Murata, Hirokazu Hirai, Toshio Matsuda, Hidenori Suzuki, Takashi Matozaki, Hiroshi Ohnishi Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice Molecular and Cellular Biology 35, 1557-1572, 2015
9. Yoji Murata, Takenori Kotani, Yana Supriatna, Yasuaki Kitamura, Shinya Imada, Kohichi Kawahara, Miki Nishio, Edwin Widyanto Daniwijaya, Hisanobu Sadakata, Shinya Kusakari, Munemasa Mori, Yoshitake Kanazawa, Yasuyuki Saito, Katsuya Okawa, Mariko Takeda-Morishita, Hideki Okazawa, Hiroshi Ohnishi, Takeshi Azuma, Akira Suzuki, Takashi Matozaki Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium” Proceedings of the National Academy of Sciences of the United States of America 112, E4264-4271, 2015
10. Ichie Hara, Hiroaki Suzuki, Shinya Kusakari, Masaaki Matsuoka. The effect of self-training in advance using an e-learning system on pharmacological practice　薬理学実習における事前学習の効果～e-learningシステムを利用して～ Nihon Yakurigaku Zasshi 145, 80-84, 2015
11. Kemala Isnainiasih Mantilidewi, Yoji Murata, Munemasa Mori, Chihiro Otsubo, Takenori Kotani, Shinya Kusakari, Hiroshi Ohnishi and Takashi Matozaki Shear stress-induced redistribution of vascular endothelial-protein-tyrosine phosphatase (VE-PTP) in endothelial cells and its role in cell elongation The Journal of Biological Chemistry 289, 6451-6461, 2014
12. Yuriko Hayashi, Shinya Kusakari, Miho Sato-Hashimoto, Eriko Urano, Masahiro Shigeno, Tsuneo Sekijima, Takenori Kotani, Yoji Murata, Hirokazu Murakami, Takashi Matozaki, Hiroshi Ohnishi Hypothermia-dependent and -independent effects of forced swim on the phosphorylation states of signaling molecules in mouse hippocampus Biochemical and Biophysical Research Communications 428, 475-481, 2012
13. Toshi Maruyama*, Shinya Kusakari*, Miho Sato-Hashimoto, Yuriko Hayashi, Takenori Kotani, Yoji Murata, Hideki Okazawa, Per-Arne Oldenborg, Shoji Kishi, Takashi Matozaki, Hiroshi Ohnishi (*Contributed equally to this work) Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain Journal of Neurochemistry 121, 891-902, 2012
14. Tetsuya Kaneko, Yasuyuki Saito, Takenori Kotani, Hideki Okazawa, Hiroko Iwamura, Miho Sato-Hashimoto, Yoshitake Kanazawa, Satoshi Takahashi., Keiju Hiromura, Shinya Kusakari, Yoriaki Kaneko, Yoji Murata, Hiroshi Ohnishi, Yoshihisa Nojima, Keiji Takagishi, Takashi Matozaki Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity Journal of Immunology 188, 5397-5407, 2012
15. Miho Sato-Hashimoto, Yasuyuki Saito, Hiroshi Ohnishi, Hiroko Iwamura, Yoshitake Kanazawa, Tetsuya Kaneko, Shinya Kusakari, Takenori Kotani, Munemasa Mori, Yoji Murata, Hideki Okazawa, Carl F. Ware, Per-Arne Oldenborg, Yoshihisa Nojima, Takashi Matozaki Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen Journal of Immunology 187, 291-297, 2011
16. Hiroko Iwamura, Yasuyuki Saito, Miho Sato-Hashimoto, Hiroshi Ohnishi, Yoji Murata, Hideki Okazawa, Yoshitake Kanazawa, Tetsuya Kaneko, Shinya Kusakari, Takenori Kotani, Yoshihisa Nojima, Takashi Matozaki Essential roles of SIRPα in homeostatic regulation of skin dendritic cells Immunology Letters 135, 100-107, 2011
17. Naoko Morimoto, Yoji Murata, Sei-ichiro Motegi, Kazutomo Suzue, Yasuyuki Saito, Hideki Okazawa, Hiroshi Ohnishi, Takenori Kotani, Shinya Kusakari, Osamu Ishikawa, Takashi Matozaki. Requirement of SIRPa for protective immunity against Leishmania major Biochemical and Biophysical Research Communications 401, 385-389, 2010
18. Hiroshi Ohnishi*, Takaaki Murata*, Shinya Kusakari*, Yuriko Hayashi, Keizo Takao, Toshi Maruyama, Yukio Ago, Ken Koda, Feng-Jie Jin, Katsuya Okawa, Per-Arne Oldenborg, Hideki Okazawa, Yoji Murata, Nobuhiko Furuya, Toshio Matsuda, Tsuyoshi Miyakawa, Takashi Matozaki (*Contributed equally to this work) Stress-evoked tyrosine phosphorylation of Signal regulatory protein a regulates behavioral immobility in the forced swim test The Journal of Neuroscience 30, 10472-10483, 2010
19. Yoji Murata, Munemasa Mori, Takenori Kotani, Yana Supriatna, Hideki Okazawa, Shinya Kusakari, Yasuyuki Saito, Hiroshi Ohnishi, Takashi Matozaki Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn Genes to Cells 15, 513-524, 2010
20. Munemasa Mori, Yoji Murata, Takenori Kotani, Shinya Kusakari, Hiroshi Ohnishi, Yasuyuki Saito, Hideki Okazawa, Tamotsu Ishizuka, Masatomo Mori, Takashi Matozaki Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrins Journal of Cellular Physiology 224, 195-204, 2010
21. Takenori Kotani, Yoji Murata, Hiroshi Ohnishi, Munemasa Mori, Shinya Kusakari, Yasuyuki Saito, Hideki Okazawa, John L. Bixby, Takashi Matozaki Expression of PTPRO in the interneurons of adult mouse olfactory bulb The Journal of Comparative Neurology 518, 119–136, 2010
22. Hisanobu Sadakata, Hideki Okazawa, Takashi Sato, Yana Supriatna, Hiroshi Ohnishi, Shinya Kusakari, Yoji Murata, Uichi Nishiyama, Takashi Minegishi, Akihiho Harada, Takashi Matozaki SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis Genes to Cells 14, 295–308, 2009
23. Shinya Kusakari, Hiroshi Ohnishi, Feng-Jie Jin, Yuka Kaneko, Takaaki Murata, Yoji Murata, Hideki Okazawa, Takashi Matozaki Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system Journal of Cell Science 121, 1213-1223, 2008
24. Takaaki Murata, Hihoshi Ohnishi, Hideki Okazawa, Yoji Murata, Shinya Kusakari, Yuriko Hayashi, Motoaki Miyashita, Hiroshi Itoh, Per-Arne Oldenborg, Nobuhiko Furuya, Takashi Matozaki CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42 The Journal of Neuroscience 26, 12397-12407, 2006
25. 草苅伸也、松本浩樹、大谷信男、古川利博 尖度を用いたブラインド信号源分離手法の一考察 Journal of Signal Processing 9(5): 397-408, 2005

科学研究費補助金

1. 令和5－7年度（2023-2025）　基盤研究（C） 研究代表者 研究課題名：前頭側頭葉変性症原因因子Progranulinによるリソソーム制御と疾患発症との関連解明
2. 平成31-34年度　基盤研究（C） 研究代表者 研究課題名：新仮説に基づく前頭側頭葉変性症の発症メカニズム解明と治療薬開発戦略
3. 平成28-30年度　基盤研究（C） 研究代表者 研究課題名：神経変性疾患原因因子Progranulinの新たな生理機能とそのメカニズムの解明
4. 平成25-26年度　若手研究（B） 研究代表者 研究課題名：チロシンホスファターゼShp2を介した脳高次機能制御機構の解明
5. 平成23-24年度　若手研究（B） 研究代表者 研究課題名：細胞質型チロシンホスファターゼShp2による脳機能制御メカニズムの解明

その他の助成金

1. 公益財団法人薬学研究奨励財団　第44回研究助成金　 研究代表者　 研究課題名：タンパク質異常凝集を標的としたALS治療薬の確立
2. 東京医科大学 令和５年度 学長裁量経費＜研究活性化支援＞　 研究代表者　 研究課題名：筋萎縮性側索硬化症原因遺伝子CHCHD10の遺伝子変異による細胞死メカニズムの解明
3. 公益財団法人 大樹生命厚生財団　医学研究助成　2023年度　 研究代表者　 研究課題名：前頭側頭型認知症原因因子 Progranulinと神経発達障害との関連解明
4. 公益財団法人 先進医薬研究振興財団　精神薬療分野　2022年度　一般研究助成　 研究代表者　 研究課題名：前頭側頭型認知症原因因子CHCHD10の新たな生理機能と認知症発症との関係解明
5. 公益財団法人 武田科学振興財団　2020年度　医学系研究助成　 研究代表者　 研究課題名：ミトコンドリアストレス応答異常とALS/FTD発症との関連解明
6. 公益財団法人 先進医薬研究振興財団　精神薬療分野　2018年度　若手研究者助成　 研究代表者　 研究課題名：CHCHD10遺伝子変異による認知症発症メカニズムの解明と治療薬探索
7. 平成30年度東京医科大学研究助成金　 研究代表者　 研究課題名：筋萎縮性側索硬化症原因遺伝子CHCHD10の遺伝子変異による発症メカニズムの解明
8. 財団法人　精神・神経科学振興財団　調査研究助成　平成23年度　 研究代表者　 研究課題名：蛋白質チロシンリン酸化シグナルによる脳のストレス応答制御メカニズムの解明

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