Organization

▼Greetings   ▼Administrative Group   ▼International Group   ▼Planned Research   ▼Co-Investigator
▼Research Friends   ▼Evaluation Committee   ▼Publicly Offered Research

Greetings from the head investigator

We are pleased to announce that a new research project “Production, function and structure of neo-self” has just launched starting from this summer (FY2016-2020). My name is Mitsuru Matsumoto from Institute for Enzyme Research, Tokushima University. First of all, I would like to appreciate all the people who had contributed to the start of this project.

Our aim of this research project is to elucidate the pathogenesis of autoimmune disease and allergic reaction from a novel viewpoint and concept of “neo-self”. We are also hoping that this novel concept of “neo-self” might help us to develop novel approaches toward a cancer immunotherapy. Then, most obvious and immediate question would be what the “neo-self” is.

Recent studies of our research members have suggested that there might be a novel mode of antigen presentation by major histocompatibility complex (MHC). The studies have suggested that this previously unrecognized mode of antigen presentation is playing an important role in the immune reactions. Indeed, we recently found that an abnormality in such an antigen presentation pathway could become a cause of some types of autoimmune disease. With this novel concept, we are also hoping that we might be able to solve a longstanding question of the relationship between particular types of MHC and susceptibility to many autoimmune diseases and/or allergic reactions.

We are expecting that many researchers, even outside the immunology field, would join us in order to successfully accomplish this research project. Your great understanding and support for our research project is highly appreciated. Now, let’s work together to achieve a sustainable science in this fascinating research field!

Sincerely yours,
Mituru Matumoto
Mitsuru Matsumoto, M.D., Ph.D.
Head investigator of “neo-self”

Administrative Group

Principal Investigator Mitsuru Matsumoto Professor, Institute for Enzyme Research, Tokushima University
Co-Investigator (buntan) Tadashi Yokosuka Professor, Department of Immunology, Tokyo Medical University
Co-Investigator (renkei) Yasunobu Yoshikai Professor, Division of Host Defense, Medical Institute of Bioregulation, Kyushu University
Kouetsu Ogasawara Professor, Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University
Keiko Udaka Professor, Department of Immunology, School of Medicine, Kochi University
Yasuharu Nishimura Senior Professor, Nishimura Project Laboratory, Institute of Resource Development and Analysis, Kumamoto University
Hiroyuki Kishi Associate Professor, Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences (Medicine), University of Toyama
Shigeyuki Yokoyama Distinguished Senior Scientist, RIKEN Structural Biology Laboratory
Takehiko Sasazuki University Professor, Kyushu University Institute for Advanced Study
Tadahiro Suenaga Associate Professor, Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University
Takashi Shiina Associate Professor, Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine
Kazuyoshi Hosomichi Associate Professor, Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University
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All-inclusive activities supporting entire research area

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International Group

Principal Investigator Mitsuru Matsumoto Professor, Institute for Enzyme Research, Tokushima University
Co-Investigator (buntan) Tadashi Yokosuka Professor, Department of Immunology, Tokyo Medical University
Co-Investigator (renkei) Yasunobu Yoshikai Professor, Division of Host Defense, Medical Institute of Bioregulation, Kyushu University
Kouetsu Ogasawara Professor, Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University
Keiko Udaka Professor, Department of Immunology, School of Medicine, Kochi University
Yasuharu Nishimura Senior Professor, Nishimura Project Laboratory, Institute of Resource Development and Analysis, Kumamoto University
Hiroyuki Kishi Associate Professor, Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences (Medicine), University of Toyama
Shigeyuki Yokoyama Distinguished Senior Scientist, RIKEN Structural Biology Laboratory
Takehiko Sasazuki University Professor, Kyushu University Institute for Advanced Study
Tadahiro Suenaga Associate Professor, Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University
Takashi Shiina Associate Professor, Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine
Kazuyoshi Hosomichi Associate Professor, Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University
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International group works to fulfil the sustinable science

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Planned Research

Research A01: Functional analysis of neo-self

Mechanisms for the creation of neo-self in the thymus
Principal Investigator Mitsuru Matsumoto Professor, Institute for Enzyme Research, Tokushima University
Co-Investigator (buntan) Yasunobu Yoshikai Professor, Division of Host Defense, Medical Institute of Bioregulation, Kyushu University
Generation mechanisms of neo-self by metal or medicine
Principal Investigator Kouetsu Ogasawara Professor, Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University
Generation of neo-self antigens in the tumor microenvironment
Principal Investigator Keiko Udaka Professor, Department of Immunology, School of Medicine, Kochi University
Co-Investigator (buntan) Yasuharu Nishimura Senior Professor, Nishimura Project Laboratory, Institute of Resource Development and Analysis, Kumamoto University
Repertoire analysis of neo-self-recognizing receptors
Principal Investigator Hiroyuki Kishi Associate Professor, Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences (Medicine), University of Toyama

Planned research A02: Structural analysis of neo-self

Structural analysis of neo-self
Principal Investigator Shigeyuki Yokoyama Distinguished Senior Scientist, RIKEN Structural Biology Laboratory
Co-Investigator (buntan) Takehiko Sasazuki University Professor, Kyushu University Institute for Advanced Study
Analysis for neo-self in MHC-misfolded protein complex
Principal Investigator Tadashi Yokosuka Professor, Department of Immunology, Tokyo Medical University
Co-Investigator (buntan) Tadahiro Suenaga Associate Professor, Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University
Genetic analysis of neo-self
Principal Investigator Takashi Shiina Associate Professor, Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine
Co-Investigator (buntan) Kazuyoshi Hosomichi Associate Professor, Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University

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Co-Investigator (renkei-kenkyusha)

Matsumoto group Shigeo Murata Professor, Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Science, The University of Tokyo
Udaka group Hiroyoshi Nishikawa Director, Division of cancer Immunology, Exploratory Oncology Research and Clinical Trial Center, Research Institute, National Cancer Center
Professor, Department of Immunology, Nagoya University Graduate School of Medicine
Kishi group Hiroshi Hamana Assistant Professor, Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences (Medicine), University of Toyama
Tatsuhiko Ozawa Assistant Professor, Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences (Medicine), University of Toyama
Yokoyama group Ken Yamamoto Professor, Department of Medical Biochemistry, Kurume University School of Medicine
Yokosuka group Hisashi Arase Professor, Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University
Shiina group Akira Oka Lecturer, The Institute of Medical Science, Tokai University

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Research Friends

   

Evaluation Committee

Kazuo Sugamura Head, Division of Molecular and Cellular Oncology, Miyagi Prefectural Cancer Institute
Junichi Takagi Professor, Institute for Protein Research, Osaka University
Katsushi Tokunaga Professor, Department of Human Genetics, Graduate School of Medicine, The University of Tokyo

Publicly Offered Research

» Members of Publicly Offered Research (2017-2018)