Organization
▼Greetings ▼Administrative Group ▼International Group ▼Planned Research ▼Co-Investigator
▼Research Friends ▼Evaluation Committee ▼Publicly Offered Research
Greetings from the head investigator
We are pleased to announce that a new research project “Production, function and structure of neo-self” has just launched starting from this summer (FY2016-2020). My name is Mitsuru Matsumoto from Institute for Enzyme Research, Tokushima University. First of all, I would like to appreciate all the people who had contributed to the start of this project.
Our aim of this research project is to elucidate the pathogenesis of autoimmune disease and allergic reaction from a novel viewpoint and concept of “neo-self”. We are also hoping that this novel concept of “neo-self” might help us to develop novel approaches toward a cancer immunotherapy. Then, most obvious and immediate question would be what the “neo-self” is.
Recent studies of our research members have suggested that there might be a novel mode of antigen presentation by major histocompatibility complex (MHC). The studies have suggested that this previously unrecognized mode of antigen presentation is playing an important role in the immune reactions. Indeed, we recently found that an abnormality in such an antigen presentation pathway could become a cause of some types of autoimmune disease. With this novel concept, we are also hoping that we might be able to solve a longstanding question of the relationship between particular types of MHC and susceptibility to many autoimmune diseases and/or allergic reactions.
We are expecting that many researchers, even outside the immunology field, would join us in order to successfully accomplish this research project. Your great understanding and support for our research project is highly appreciated. Now, let’s work together to achieve a sustainable science in this fascinating research field!
Sincerely yours,
Mitsuru Matsumoto, M.D., Ph.D.
Head investigator of “neo-self”
Administrative Group
| Principal Investigator | Mitsuru Matsumoto | Professor, Institute for Enzyme Research, Tokushima University |
| Co-Investigator (buntan) | Tadashi Yokosuka | Professor, Department of Immunology, Tokyo Medical University |
| Co-Investigator (renkei) | Yasunobu Yoshikai | Academic Researcher, Professor Emeritus, Division of Host Defense, Medical Institute of Bioregulation, Kyushu University |
| Kouetsu Ogasawara | Professor, Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University | |
| Keiko Udaka | Professor, Department of Immunology, School of Medicine, Kochi University | |
| Yasuharu Nishimura | Academic Researcher, Professor Emeritus, Department of Immunology, Graduate School of Medical Sciences, Kumamoto University | |
| Hiroyuki Kishi | Associate Professor, Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences (Medicine), University of Toyama | |
| Shigeyuki Yokoyama | Distinguished Senior Scientist, RIKEN Structural Biology Laboratory | |
| Takehiko Sasazuki | University Professor, Kyushu University Institute for Advanced Study | |
| Tadahiro Suenaga | Associate Professor, Fukushima Medical University | |
| Takashi Shiina | Professor, Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine | |
| Kazuyoshi Hosomichi | Associate Professor, Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University |
International Group
| Principal Investigator | Mitsuru Matsumoto | Professor, Institute for Enzyme Research, Tokushima University |
| Co-Investigator (buntan) | Tadashi Yokosuka | Professor, Department of Immunology, Tokyo Medical University |
| Co-Investigator (renkei) | Yasunobu Yoshikai | Academic Researcher, Professor Emeritus, Division of Host Defense, Medical Institute of Bioregulation, Kyushu University |
| Kouetsu Ogasawara | Professor, Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University | |
| Keiko Udaka | Professor, Department of Immunology, School of Medicine, Kochi University | |
| Yasuharu Nishimura | Academic Researcher, Professor Emeritus, Department of Immunology, Graduate School of Medical Sciences, Kumamoto University | |
| Hiroyuki Kishi | Associate Professor, Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences (Medicine), University of Toyama | |
| Shigeyuki Yokoyama | Distinguished Senior Scientist, RIKEN Structural Biology Laboratory | |
| Takehiko Sasazuki | University Professor, Kyushu University Institute for Advanced Study | |
| Tadahiro Suenaga | Associate Professor, Fukushima Medical University | |
| Takashi Shiina | Professor, Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine | |
| Kazuyoshi Hosomichi | Associate Professor, Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University |
Planned Research
Research A01: Functional analysis of neo-self
| Mechanisms for the creation of neo-self in the thymus | ||
|---|---|---|
| Principal Investigator | Mitsuru Matsumoto | Professor, Institute for Enzyme Research, Tokushima University |
| Co-Investigator (buntan) | Yasunobu Yoshikai | Academic Researcher, Professor Emeritus, Division of Host Defense, Medical Institute of Bioregulation, Kyushu University |
| Generation mechanisms of neo-self by metal or medicine | ||
| Principal Investigator | Kouetsu Ogasawara | Professor, Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University |
| Generation of neo-self antigens in the tumor microenvironment | ||
| Principal Investigator | Keiko Udaka | Professor, Department of Immunology, School of Medicine, Kochi University |
| Co-Investigator (buntan) | Yasuharu Nishimura | Academic Researcher, Professor Emeritus, Department of Immunology, Graduate School of Medical Sciences, Kumamoto University |
| Repertoire analysis of neo-self-recognizing receptors | ||
| Principal Investigator | Hiroyuki Kishi | Associate Professor, Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences (Medicine), University of Toyama |
Planned research A02: Structural analysis of neo-self
| Structural analysis of neo-self | ||
|---|---|---|
| Principal Investigator | Shigeyuki Yokoyama | Distinguished Senior Scientist, RIKEN Structural Biology Laboratory |
| Co-Investigator (buntan) | Takehiko Sasazuki | University Professor, Kyushu University Institute for Advanced Study |
| Analysis for neo-self in MHC-misfolded protein complex | ||
| Principal Investigator | Tadashi Yokosuka | Professor, Department of Immunology, Tokyo Medical University |
| Co-Investigator (buntan) | Tadahiro Suenaga | Associate Professor, Fukushima Medical University |
| Genetic analysis of neo-self | ||
| Principal Investigator | Takashi Shiina | Professor, Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine |
| Co-Investigator (buntan) | Kazuyoshi Hosomichi | Associate Professor, Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University |
Co-Investigator (renkei-kenkyusha)
| Matsumoto group | Shigeo Murata | Professor, Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Science, The University of Tokyo |
| Udaka group | Hiroyoshi Nishikawa | Director, Division of cancer Immunology, Exploratory Oncology Research and Clinical Trial Center, Research Institute, National Cancer Center Professor, Department of Immunology, Nagoya University Graduate School of Medicine |
| Kishi group | Hiroshi Hamana | Assistant Professor, Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences (Medicine), University of Toyama |
| Tatsuhiko Ozawa | Assistant Professor, Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences (Medicine), University of Toyama | |
| Yokoyama group | Ken Yamamoto | Professor, Department of Medical Biochemistry, Kurume University School of Medicine |
| Yokosuka group | Hisashi Arase | Professor, Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University |
| Shiina group | Akira Oka | Lecturer, The Institute of Medical Science, Tokai University |
Research Friends
Evaluation Committee
| Kazuo Sugamura | Head, Division of Molecular and Cellular Oncology, Miyagi Prefectural Cancer Institute |
| Junichi Takagi | Professor, Institute for Protein Research, Osaka University |
| Katsushi Tokunaga | Professor, Department of Human Genetics, Graduate School of Medicine, The University of Tokyo |