Members of Publicly Offered Research (2019-2020)

▼A01: Functional analysis of neo-self   ▼A02: Structural analysis of neo-self

A01: Functional analysis of neo-self

Requirement of neoself antigens for the lineage decision of natural killer T cells in the thymus
Principal Investigator Motoko Y. Kimura Associate Professor
Chiba University, Graduate School of Medicine
Elucidating the mechanisms by which regulatory T cells establish and maintain tissue-specific self-tolerance
Principal Investigator Shohei Hori Professor
Laboratory of Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Regulation of T cell repertoire by thymic neo-self antigens
Principal Investigator Takeshi Nitta Associate professor
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
Role of denatured self-antigens in autoantibody produciton to nuclear self-antigens
Principal Investigator Takeshi Tsubata Professor
Medical Research Institute, Tokyo Medical and Dental University
Elucidation of novel pathways for lipopeptide antigen presentation
Principal Investigator Masahiko Sugita Professor
Kyoto University
Cancer immunotherapy targeting neo-self antigens in splicing factor mutated cells
Principal Investigator Akinori Yoda Program-Specific Associate Professor
Kyoto University
Establishment of autoimmune disease model using human immune cells and regenerated tissues
Principal Investigator Hiroshi Kawamoto Professor
Institute for Frontier Life nd Medical Sciences, Kyoto University
Immune regulation by neo-self peptides
Principal Investigator Hisashi Arase Profesoor
Research Institute for Microbial Diseases, Osaka University
Elucidation of mechanisms for maintenance of neo-self and neo-nonself on intacellular cellular membranes and pathogenesis of the disruption
Principal Investigator Masahiro Yamamoto Professor
RIMD, Osaka University
CAR T cell therapy targeting neo-self
Principal Investigator Naoki Hosen Associate Professor
Department of Cancer Stem Cell Biology
Investigating a new function of neo-self specific regulatory T cells induced by ultraviolet and treatment strategies
Principal Investigator Sayuri Yamazaki Professor and Deparment Chair, Department of Immunology
Nagoya City Univeristy Graduate School of Medicine
Co-investigator Akimichi Morita Professor and Chairman, Department of Geriatric and Environmental Dermatology
Nagoya City Univeristy Graduate School of Medicine
Functions and their dysregulation of immune proteasomes in neo-self generation
Principal Investigator Tsuneyasu Kaisho Professor
Department of Immunology, Institute of Advanced Medicine, Wakayama Medical University
Compound library of neo-self lipid antigens and its immunomodulatory functions
Principal Investigator Yukari Fujimoto Professor
Keio University
Co-investigator Takanori Matsumaru Assistant Professor
Keio University
Generation of neo-self antigens through chromatin misregulation
Principal Investigator Shunsuke Chikuma Lecturer
Keio University
The recognition of neoselfs by regulatory T cells in brain inflammation
Principal Investigator Minako Ito Lecturer
Department of Microbiology and Immunology, Keio University School of Medicine
Identification of neoself antigens that tumor-infiltrating B cells present
Principal Investigator Daisuke Kitamura Professor
Research Institute for Biomedical Sciences, Tokyo University of Science
Co-investigator Tetsuya Nakatsura Professor
Exploratory Oncology Research and Clinical Trial Center, National Cancer Center
The role of pathogenic microorganisms as neo-self antigens in the oral infections.
Principal Investigator Yoshihiko Tanaka Professor
Fukuoka Dental College
Molecular mechanisms that integrate neo-self antigen recognition into T cell differentiation
Principal Investigator Ichiro Taniuchi Team Leader
Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences
Identification of a novel transcription factor essential for the induction of thymic self-tolerance
Principal Investigator Nobuko Akiyama Senior Research Scientist
RIKEN Center for Integrative Medical Sciences, Laboratory for Immunogenetics
Influence of immune reactions against "neoself" antigens on the "self" reactivities
Principal Investigator Takashi Sekiya Chief
Department of Immune Regulation, National Center for Global Health and Medicine

A02: Structural analysis of neo-self

Understanding the mechanism by which PDI family regulates MHC folding in the endoplasmic reticulum
Principal Investigator Masaki Okumura Assistant Professor
Frontier Research Institute for Interdisciplinary Sciences, Tohoku University
Co-investigator Kenji Inaba Professor
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
Co-investigator Katsumi Maenaka Professor
Faculty of Pharmaceutical Sciences, Hokkaido University
Co-investigator Misaki Kinoshita Postdoctoral fellow
Frontier Research Institute for Interdisciplinary Sciences, Tohoku University
Mechanism of allogeneic immune response in hematopoietic stem cell transplantation
Principal Investigator Satoko Morishima Associate Professor
Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Medicine), Graduate School of Medicine, University of the Ryukyus
Co-investigator Yasuo Morishima Visiting Professor
Aichi Medical University
Single-cell transcriptome analysis of cell-cell interactions by a new optical labeling technology
Principal Investigator Takahiro Kuchimaru Assistant professor
Jichi Medical University