Members of Publicly Offered Research (2019-2020)
▼A01: Functional analysis of neo-self ▼A02: Structural analysis of neo-self
A01: Functional analysis of neo-self
| Requirement of neoself antigens for the lineage decision of natural killer T cells in the thymus | ||
|---|---|---|
| Principal Investigator | Motoko Y. Kimura | Associate Professor Chiba University, Graduate School of Medicine |
| Elucidating the mechanisms by which regulatory T cells establish and maintain tissue-specific self-tolerance | ||
| Principal Investigator | Shohei Hori | Professor Laboratory of Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo |
| Regulation of T cell repertoire by thymic neo-self antigens | ||
| Principal Investigator | Takeshi Nitta | Associate professor Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo |
| Role of denatured self-antigens in autoantibody produciton to nuclear self-antigens | ||
| Principal Investigator | Takeshi Tsubata | Professor Medical Research Institute, Tokyo Medical and Dental University |
| Elucidation of novel pathways for lipopeptide antigen presentation | ||
| Principal Investigator | Masahiko Sugita | Professor Kyoto University |
| Cancer immunotherapy targeting neo-self antigens in splicing factor mutated cells | ||
| Principal Investigator | Akinori Yoda | Program-Specific Associate Professor Kyoto University |
| Establishment of autoimmune disease model using human immune cells and regenerated tissues | ||
| Principal Investigator | Hiroshi Kawamoto | Professor Institute for Frontier Life nd Medical Sciences, Kyoto University |
| Immune regulation by neo-self peptides | ||
| Principal Investigator | Hisashi Arase | Profesoor Research Institute for Microbial Diseases, Osaka University |
| Elucidation of mechanisms for maintenance of neo-self and neo-nonself on intacellular cellular membranes and pathogenesis of the disruption | ||
| Principal Investigator | Masahiro Yamamoto | Professor RIMD, Osaka University |
| CAR T cell therapy targeting neo-self | ||
| Principal Investigator | Naoki Hosen | Associate Professor Department of Cancer Stem Cell Biology |
| Investigating a new function of neo-self specific regulatory T cells induced by ultraviolet and treatment strategies | ||
| Principal Investigator | Sayuri Yamazaki | Professor and Deparment Chair, Department of Immunology Nagoya City Univeristy Graduate School of Medicine |
| Co-investigator | Akimichi Morita | Professor and Chairman, Department of Geriatric and Environmental Dermatology Nagoya City Univeristy Graduate School of Medicine |
| Functions and their dysregulation of immune proteasomes in neo-self generation | ||
| Principal Investigator | Tsuneyasu Kaisho | Professor Department of Immunology, Institute of Advanced Medicine, Wakayama Medical University |
| Compound library of neo-self lipid antigens and its immunomodulatory functions | ||
| Principal Investigator | Yukari Fujimoto | Professor Keio University |
| Co-investigator | Takanori Matsumaru | Assistant Professor Keio University |
| Generation of neo-self antigens through chromatin misregulation | ||
| Principal Investigator | Shunsuke Chikuma | Lecturer Keio University |
| The recognition of neoselfs by regulatory T cells in brain inflammation | ||
| Principal Investigator | Minako Ito | Lecturer Department of Microbiology and Immunology, Keio University School of Medicine |
| Identification of neoself antigens that tumor-infiltrating B cells present | ||
| Principal Investigator | Daisuke Kitamura | Professor Research Institute for Biomedical Sciences, Tokyo University of Science |
| Co-investigator | Tetsuya Nakatsura | Professor Exploratory Oncology Research and Clinical Trial Center, National Cancer Center |
| The role of pathogenic microorganisms as neo-self antigens in the oral infections. | ||
| Principal Investigator | Yoshihiko Tanaka | Professor Fukuoka Dental College |
| Molecular mechanisms that integrate neo-self antigen recognition into T cell differentiation | ||
| Principal Investigator | Ichiro Taniuchi | Team Leader Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences |
| Identification of a novel transcription factor essential for the induction of thymic self-tolerance | ||
| Principal Investigator | Nobuko Akiyama | Senior Research Scientist RIKEN Center for Integrative Medical Sciences, Laboratory for Immunogenetics |
| Influence of immune reactions against "neoself" antigens on the "self" reactivities | ||
| Principal Investigator | Takashi Sekiya | Chief Department of Immune Regulation, National Center for Global Health and Medicine |
A02: Structural analysis of neo-self
| Understanding the mechanism by which PDI family regulates MHC folding in the endoplasmic reticulum | ||
|---|---|---|
| Principal Investigator | Masaki Okumura | Assistant Professor Frontier Research Institute for Interdisciplinary Sciences, Tohoku University |
| Co-investigator | Kenji Inaba | Professor Institute of Multidisciplinary Research for Advanced Materials, Tohoku University |
| Co-investigator | Katsumi Maenaka | Professor Faculty of Pharmaceutical Sciences, Hokkaido University |
| Co-investigator | Misaki Kinoshita | Postdoctoral fellow Frontier Research Institute for Interdisciplinary Sciences, Tohoku University |
| Mechanism of allogeneic immune response in hematopoietic stem cell transplantation | ||
| Principal Investigator | Satoko Morishima | Associate Professor Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Medicine), Graduate School of Medicine, University of the Ryukyus |
| Co-investigator | Yasuo Morishima | Visiting Professor Aichi Medical University |
| Single-cell transcriptome analysis of cell-cell interactions by a new optical labeling technology | ||
| Principal Investigator | Takahiro Kuchimaru | Assistant professor Jichi Medical University |