Members of Publicly Offered Research (2017-2018)
▼A01: Functional analysis of neo-self ▼A02: Structural analysis of neo-self
A01: Functional analysis of neo-self
Regulation of antigen presentation by TRIM family proteins | ||
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Principal investigator | Shigetsugu Hatakeyama | Professor Department of Biochemistry, Faculty of Medicine, Hokkaido University |
Co-investigator | Hidehisa Takahashi | Lecturer Department of Biochemistry, Faculty of Medicine, Hokkaido University |
Co-investigator | Masashi Watanabe | Assistant Professor Department of Biochemistry, Faculty of Medicine, Hokkaido University |
Identification of peptides related to wheat allergy due to percutaneous sensitization by HLA-peptide bindng assay | ||
Principal investigator | Emiko Noguchi | Professor Department of Medical Genetics, Faculty of Medicine, University of Tsukuba |
Co-investigator | Takatsugu Hirokawa | Leader National Institute of Advanced Industrial Science and Technology, Molecular Profiling Research Center for Drug Discovery |
Co-investigator | Hiroko Miyadera | Assistant Professor Department of Medical Genetics, Faculty of Medicine, University of Tsukuba |
Co-investigator | Kayoko Matsunaga | Professor Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine |
Co-investigator | Masashi Nakamura | Visiting associate professor Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine |
Requirement of neoself antigens for unconventional T cell differentiation and function in the thymus. | ||
Principal investigator | Motoko Y. Kimura | Associate Professor Chiba University, Graduate School of Medicine |
Regulation of T cell repertoire by thymic neo-self antigens | ||
Principal investigator | Takeshi Nitta | Associate professor Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo |
Co-investigator | Hiroshi Takayanagi | Professor Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo |
Elucidating the mechanisms by which regulatory T cells establish and maintain tissue-specific self-tolerance | ||
Principal investigator | Shohei Hori | Professor Laboratory of Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo |
Co-investigator | Katsuyuki Shiroguchi | Unit leader Laboratory for Integrative Omics, RIKEN Quantitative Biology Center |
Study on immune responses to neo-self generated by endocytosis | ||
Principal investigator | Takeshi Tsubata | Professor Medical Research Institute, Tokyo Medical and Dental University |
Architecture of the lipopeptide antigen repertoire | ||
Principal investigator | Masahiko Sugita | Professor Institute for Frontier Life and Medical Sciences, Kyoto University |
Assessment of frequency and evaluation of potency of CTL clones specific for neoantigen in tumor infiltrating lymphocytes | ||
Principal investigator | Hiroshi Kawamoto | Professor Institute for Life nd Medical Sciences, Kyoto University |
Immune regulation by neo-self peptides | ||
Principal investigator | Hisashi Arase | Professor Research Institute for Microbial Diseases, Osaka University |
Co-investigator | Kazuki Kishida | SA Researcher Research Institute for Microbial Diseases, Osaka University |
Generation of neo-self by cellular senescence | ||
Principal investigator | Masakatsu Yamashita | Professor Graduate School of Medicine, Ehime University |
Co-investigator | Makoto Kuwahara | Assistant Professor Graduate School of Medicine, Ehime University |
Co-investigator | Junpei Suzuki | Assistant Professor Graduate School of Medicine, Ehime University |
Developing a new therapy for autoimmnue dieseases using regulatory T cell and neo-self induced by ultraviolet | ||
Principal investigator | Sayuri Yamazaki | Professor and Department Chair Department of Immunology, Nagoya City University Graduate School of Medicine |
Co-investigator | Akimichi Morita | Professor and Chairman Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medicine |
Functions of immune proteasomes as neo-self generaters | ||
Principal investigator | Tsuneyasu Kaisho | Professor Department of Immunology, Institute of Advanced Medicine, Wakayama Medical University |
Co-investigator | Nobuo Kanazawa | Resarch Associate Professor Department of Dermatology, Wakayama Medical University |
Lipid antigens as "neo-self" molecules: Synthesis and Functional analysis | ||
Principal investigator | Yukari Fujimoto | Professor Department of Chemistry, Faculty of Science and Technology, Keio University |
Co-investigator | Inuki Shinsuke | Assistant Professor Department of Chemistry, Faculty of Science and Technology, Keio University |
Generation and function of neo-self antigens due to defective gene silencing | ||
Principal investigator | Shunsuke Chikuma | Lecturer Department of Microbiology and Immunology, School of Medicine, Keio University |
The significance of Notch signaling at Peyer's patch for the regulation of T cell-mediated IgA production. | ||
Principal investigator | Katsuto Hozumi | Professor Tokai University School of Medicine |
Identification of neoself antigens that tumor-infiltrating B cells present | ||
Principal investigator | Daisuke Kitamura | Professor Research Institute for Biomedical Sciences, Tokyo University of Science |
Co-investigator | Nguyen Tien Dat | Post-doctral fellow Research Institute for Biomedical Sciences, Tokyo University of Science |
Co-investigator | Tetsuya Nakatsura | Professor Exploratory Oncology Research and Clinical Trial Center, National Cancer Center |
Characterization of pathological state caused by neo-self commensal microbes. | ||
Principal investigator | Yoshihiko Tanaka | Professor Department of Functional Bioscience, Division of Biomedical Sciences, Fukuoka Dental College |
Co-investigator | Jun-ichi Nagao | Lecturer Department of Functional Bioscience, Division of Biomedical Sciences, Fukuoka Dental College |
Co-investigator | Yuka Narita | Assistant Professor Department of Functional Bioscience, Division of Biomedical Sciences, Fukuoka Dental College |
Co-investigator | Ken-ichi Arita | Assistant Professor Department of Functional Bioscience, Division of Biomedical Sciences, Fukuoka Dental College |
Understnding of mechanisms that integrate neo-self antigenrecognition into cell differentiation | ||
Principal investigator | Ichiro Taniuchi | Group Director Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences |
Regulation of T cell activation by self-recognition | ||
Principal investigator | Takashi Saito | Group Director Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences |
A02: Structural analysis of neo-self
Quantitative phosphoproteomic analysis for the T cell receptor signaling during thymic selection of the T cell development | ||
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Principal investigator | Kanae Yumimoto | Research Assistant Professor Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University |
Co-investigator | Keiichi I. Nakayama | Professor Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University |
Mechanism of allogeneic immune response in hematopoietic stem cell transplantation | ||
Principal investigator | Satoko Morishima | Associate Professor Faculty of Medicine, University of the Ryukyu |
Co-investigator | Yasuo Morishima | Visiting Professor Aichi Medical University |