Members of Publicly Offered Research (2017-2018)

▼A01: Functional analysis of neo-self   ▼A02: Structural analysis of neo-self

A01: Functional analysis of neo-self

Regulation of antigen presentation by TRIM family proteins
Principal investigator Shigetsugu Hatakeyama Professor
Department of Biochemistry, Faculty of Medicine, Hokkaido University
Co-investigator Hidehisa Takahashi  Lecturer
Department of Biochemistry, Faculty of Medicine, Hokkaido University
Co-investigator Masashi Watanabe Assistant Professor
Department of Biochemistry, Faculty of Medicine, Hokkaido University
Identification of peptides related to wheat allergy due to percutaneous sensitization by HLA-peptide bindng assay
Principal investigator Emiko Noguchi Professor
Department of Medical Genetics, Faculty of Medicine, University of Tsukuba
Co-investigator Takatsugu Hirokawa Leader
National Institute of Advanced Industrial Science and Technology, Molecular Profiling Research Center for Drug Discovery
Co-investigator Hiroko Miyadera Assistant Professor
Department of Medical Genetics, Faculty of Medicine, University of Tsukuba
Co-investigator Kayoko Matsunaga Professor
Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine
Co-investigator Masashi Nakamura Visiting associate professor
Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine
Requirement of neoself antigens for unconventional T cell differentiation and function in the thymus.
Principal investigator Motoko Y. Kimura Associate Professor
Chiba University, Graduate School of Medicine
Regulation of T cell repertoire by thymic neo-self antigens
Principal investigator Takeshi Nitta Associate professor
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
Co-investigator Hiroshi Takayanagi Professor
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
Elucidating the mechanisms by which regulatory T cells establish and maintain tissue-specific self-tolerance
Principal investigator Shohei Hori Professor
Laboratory of Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Co-investigator Katsuyuki Shiroguchi Unit leader
Laboratory for Integrative Omics, RIKEN Quantitative Biology Center
Study on immune responses to neo-self generated by endocytosis
Principal investigator Takeshi Tsubata Professor
Medical Research Institute, Tokyo Medical and Dental University
Architecture of the lipopeptide antigen repertoire
Principal investigator Masahiko Sugita Professor
Institute for Frontier Life and Medical Sciences, Kyoto University
Assessment of frequency and evaluation of potency of CTL clones specific for neoantigen in tumor infiltrating lymphocytes
Principal investigator Hiroshi Kawamoto Professor
Institute for Life nd Medical Sciences, Kyoto University
Immune regulation by neo-self peptides
Principal investigator Hisashi Arase Professor
Research Institute for Microbial Diseases, Osaka University
Co-investigator Kazuki Kishida SA Researcher
Research Institute for Microbial Diseases, Osaka University
Generation of neo-self by cellular senescence
Principal investigator Masakatsu Yamashita Professor
Graduate School of Medicine, Ehime University
Co-investigator Makoto Kuwahara Assistant Professor
Graduate School of Medicine, Ehime University
Co-investigator Junpei Suzuki Assistant Professor
Graduate School of Medicine, Ehime University
Developing a new therapy for autoimmnue dieseases using regulatory T cell and neo-self induced by ultraviolet 
Principal investigator Sayuri Yamazaki Professor and Department Chair
Department of Immunology, Nagoya City University Graduate School of Medicine
Co-investigator Akimichi Morita Professor and Chairman
Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medicine
Functions of immune proteasomes as neo-self generaters
Principal investigator Tsuneyasu Kaisho Professor
Department of Immunology, Institute of Advanced Medicine, Wakayama Medical University
Co-investigator Nobuo Kanazawa Resarch Associate Professor
Department of Dermatology, Wakayama Medical University
Lipid antigens as "neo-self" molecules: Synthesis and Functional analysis
Principal investigator Yukari Fujimoto Professor
Department of Chemistry, Faculty of Science and Technology, Keio University
Co-investigator Inuki Shinsuke Assistant Professor
Department of Chemistry, Faculty of Science and Technology, Keio University
Generation and function of neo-self antigens due to defective gene silencing
Principal investigator Shunsuke Chikuma Lecturer
Department of Microbiology and Immunology, School of Medicine, Keio University
The significance of Notch signaling at Peyer's patch for the regulation of T cell-mediated IgA production.
Principal investigator Katsuto Hozumi Professor
Tokai University School of Medicine
Identification of neoself antigens that tumor-infiltrating B cells present
Principal investigator Daisuke Kitamura Professor
Research Institute for Biomedical Sciences, Tokyo University of Science
Co-investigator Nguyen Tien Dat Post-doctral fellow
Research Institute for Biomedical Sciences, Tokyo University of Science
Co-investigator Tetsuya Nakatsura Professor
Exploratory Oncology Research and Clinical Trial Center, National Cancer Center
Characterization of pathological state caused by neo-self commensal microbes.
Principal investigator Yoshihiko Tanaka Professor
Department of Functional Bioscience, Division of Biomedical Sciences, Fukuoka Dental College
Co-investigator Jun-ichi Nagao Lecturer
Department of Functional Bioscience, Division of Biomedical Sciences, Fukuoka Dental College
Co-investigator Yuka Narita Assistant Professor
Department of Functional Bioscience, Division of Biomedical Sciences, Fukuoka Dental College
Co-investigator Ken-ichi Arita Assistant Professor
Department of Functional Bioscience, Division of Biomedical Sciences, Fukuoka Dental College
Understnding of mechanisms that integrate neo-self antigenrecognition into cell differentiation 
Principal investigator Ichiro Taniuchi Group Director
Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences
Regulation of T cell activation by self-recognition
Principal investigator Takashi Saito Group Director
Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences

A02: Structural analysis of neo-self

Quantitative phosphoproteomic analysis for the T cell receptor signaling during thymic selection of the T cell development
Principal investigator Kanae Yumimoto Research Assistant Professor
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Co-investigator Keiichi I. Nakayama Professor
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Mechanism of allogeneic immune response in hematopoietic stem cell transplantation
Principal investigator Satoko Morishima Associate Professor
Faculty of Medicine, University of the Ryukyu
Co-investigator Yasuo Morishima Visiting Professor
Aichi Medical University