研究成果

▼原著論文   ▼総説   ▼著書

原著論文

  • Okada M, Chikuma S, Kondo T, Hibino S, Machiyama H, Yokosuka T, Nakano M, Yoshimura A. Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells. Cell Rep. 2017 Aug 1;20(5):1017-1028. doi: 10.1016/j.celrep.2017.07.027.
  • Hayatsu N, Miyao T, Tachibana M, Murakami R, Kimura A, Kato T, Kawakami E, Endo TA, Setoguchi R, Watarai H, Nishikawa T, Yasuda T, Yoshida H, Hori S. Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells. Immunity. 2017 Aug 15;47(2):268-283.e9. doi: 10.1016/j.immuni.2017.07.008. Epub 2017 Aug 1.
  • Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J. Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells. Oncotarget. 2017 May 30;8(22):35542-35557. doi: 10.18632/oncotarget.16221.
  • Maceiras AR, Almeida SCP, Mariotti-Ferrandiz E, Chaara W, Jebbawi F, Six A, Hori S, Klatzmann D, Faro J, Graca L. T follicular helper and T follicular regulatory cells have different TCR specificity. Nat Commun. 2017 Apr 21;8:15067. doi: 10.1038/ncomms15067.
  • Irie A, Imamura T, Michibata Y, Kubo T, Takeda N, Shibuya I, Sogo S, Araki K, and Nishimura Y. Accumulation of HLA-DR4 in colonic epithelial cells causes severe colitis in homozygous HLA-DR4 transgenic mice. Inflamm Bowel Dis. 2017 Aug 7(Accepted)
  • Nitta T, Kochi Y, Muro R, Tomofuji, Y, Okamura T, Murata S, Suzuki H, Sumida T, Yamamoto K, Takayanagi H. Human thymoproteasome variations influence CD8 T cell selection. Sci Immunol. 2017 June 2; 2, eaan5165.doi: 10.1126/sciimmunol.aan5165
  • Ito K, Nakajima A, Fukushima Y, Suzuki K, Sakamoto K, Hamazaki Y, Ogasawara K, Minato N, Hattori M The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine. PLoS One. 2017 Mar 15;12(3):e0173629. doi: 10.1371/journal.pone.0173629
  • Kawakami T, Ito K, Matsuda Y, Noda M, Sakurada A, Hoshikawa Y, Okada Y, Ogasawara K. Cytotoxicity of natural killer cells activated through NKG2D contributes to the development of bronchiolitis obliterans in a murine heterotopic tracheal transplant model. Am J Transplant. 2017 Mar 1. doi: 10.1111/ajt.14257. [Epub ahead of print]
  • Takeda K, Nakayama M, Hayakawa Y, Kojima Y, Ikeda H, Imai N, Ogasawara K, Okumura K, Thomas DM, Smyth MJ IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting. Nat Commun. 2017 Feb 24;8:14607. doi: 10.1038/ncomms14607.
  • Kanzawa-Kiriyama H, Kryukov K, Jinam TA, Hosomichi K, Saso A, Suwa G, Ueda S, Yoneda M, Tajima A, Shinoda KI, Inoue I, Saitou N. A partial nuclear genome of the Jomons who lived 3000 years ago in Fukushima, Japan. J Hum Genet. 2017 Feb;62(2):213-221. doi: 10.1038/jhg.2016.110.
  • Mori T, Hosomichi K, Chiga M, Mandai S, Nakaoka H, Sohara E, Okado T, Rai T, Sasaki S, Inoue I, Uchida S. Comprehensive genetic testing approach for major inherited kidney diseases, using next-generation sequencing with a custom panel. Clin Exp Nephrol. 2017 Feb;21(1):63-75. doi: 10.1007/s10157-016-1252-1.
  • Zaimoku Y, Takamatsu H, Hosomichi K, Ozawa T, Nakagawa N, Imi T, Maruyama H, Katagiri T, Kishi H, Tajima A, Muraguchi A, Kashiwase K, Nakao S. Identification of an HLA class I allele closely involved in the auto-antigen presentation in acquired aplastic anemia. Blood. 2017 Feb 23. pii: blood-2016-11-752378. doi: 10.1182/blood-2016-11-752378. [Epub ahead of print]
  • Yamaguchi T, Hosomichi K, Yano K, Kim Y, Nakaoka H, Kimura R, Otsuka H, Nonaka N, Haga S, Takahashi M, Shirota T, Kikkawa Y, Yamada A, Kamijo R, Park SB, Nakamura M, Maki K, Inoue I. Comprehensive genetic exploration of selective tooth agenesis of mandibular incisors by exome sequencing. Hum Genome Var. 2017 Feb 23;4:17005. doi:10.1038/hgv.2017.5.
  • Nakagawa H, Mizukoshi E, Kobayashi E, Tamai T, Hamana H, Ozawa T, Kishi H, Kitahara M, Yamashita T, Arai K, Terashima T, Iida N, Fushimi K, Muraguchi A, Kaneko S. Association Between High-avidity T-cell Receptors, Induced by Alpha Fetoprotein-derived Peptides, and Anti-tumor Effects in Patients with Hepatocellular Carcinoma. Gastroenterology. 2017 Feb 7. pii: S0016-5085(17)30132-4. doi: 10.1053/j.gastro.2017.02.001. [Epub ahead of print]
  • Toda K, Kawada K, Iwamoto M, Inamoto S, Sasazuki T, Shirasawa S, Hasegawa S, Sakai Y. Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase. Neoplasia. 2016 Nov;18(11):654-665. doi: 10.1016/j.neo.2016.09.004
  • Ando A, Shigenari A, Kojima-Shibata C, Nakajoh M, Suzuki K, Kitagawa H, Shiina T, Inoko H, Uenishi H. Association of swine leukocyte antigen class II haplotypes and immune-related traits in a swine line selected for resistance to mycoplasmal pneumonia. Comp Immunol Microbiol Infect Dis. 2016 Oct;48:33-40. doi: 10.1016/j.cimid.2016.07.004.
  • Sonofuchi K, Hagiwara Y, Koizumi Y, Chiba A, Kawano M, Nakayama M, Ogasawara K, Yabe Y, Itoi E. Quantitative in vivo biocompatibility of new ultralow-nickel cobalt-chromium-molybdenum alloys. J Orthop Res. 2016 Sep;34(9):1505-13. doi: 10.1002/jor.23150.
  • Hashimoto-Tane A, Sakuma M, Ike H, Yokosuka T, Kimura Y, Ohara O, Saito T. Micro-adhesion rings surrounding TCR microclusters are essential for T cell activation. J Exp Med. 2016 Jul 25;213(8):1609-25. doi: 10.1084/jem.20151088.
  • Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM, Kobayashi Y, Inoue J, Akiyama T. Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. J Exp Med. 2016 Jul 25;213(8):1441-58. doi: 10.1084/jem.20151780.
  • Hamana H, Shitaoka K, Kishi H, Ozawa T, Muraguchi A. A novel, rapid and efficient method of cloning functional antigen-specific T-cell receptors from single human and mouse T-cells. Biochem Biophys Res Commun. 2016 Jun 10;474(4):709-14. doi: 10.1016/j.bbrc.2016.05.015.
  • Takeuchi A, Eto M, Tatsugami K, Shiota M, Yamada H, Kamiryo Y, Dejima T, Kashiwagi E, Kiyoshima K, Inokuchi J, Takahashi R, Yokomizo A, Ohara N, Yoshikai Y. Antitumor activity of recombinant Bacille Calmette-Guerin secreting interleukin-15-Ag85B fusion protein against bladder cancer. Int Immunopharmacol. 2016 Jun 35:327-31. doi: 10.1016/j.intimp.2016.03.007.
  • Hao Z, Han X, Sun X, Shen M, Huang J, Li Y, Ozawa T, Pang D, Jin S, Kishi H, Muraguchi A, Jin A. Fully human monoclonal antibodies to TRAIL-R1 enhance TRAIL-induced apoptosis via activation of caspase-8 pathway. Biochem Biophys Res Commun. 2016 Jun 24;475(2):238-44. doi: 10.1016/j.bbrc.2016.05.089.
  • Piao X, Ozawa T, Hamana H, Shitaoka K, Jin A, Kishi H, Muraguchi A. TRAIL-receptor 1 IgM antibodies strongly induce apoptosis in human cancer cells in vitro and in vivo. Oncoimmunology. 2016 May 4;5(5):e1131380. doi: 10.1080/2162402X.2015.1131380.
  • Ohnaga T, Shimada Y, Takata K, Obata T, Okumura T, Nagata T, Kishi H, Muraguchi A, Tsukada K. Capture of esophageal and breast cancer cells with polymeric microfluidic devices for CTC isolation. Mol Clin Oncol. 2016 Apr;4(4):599-602.
  • Ahmadloo S, Nakaoka H, Hayano T, Hosomichi K, You H, Utsuno E, Sangai T, Nishimura M, Matsushita K, Hata A, Nomura F, Inoue I. Rapid and cost-effective high-throughput sequencing for identification of germline mutations of BRCA1 and BRCA2. J Hum Genet. 2017 Feb 9. doi: 10.1038/jhg.2017.5. [Epub ahead of print]
  • Takahashi M, Hosomichi K, Yamaguchi T, Yano K, Funatsu T, Adel M, Haga S, Maki K, Tajima A. Whole-exome sequencing analysis of supernumerary teeth occurrence in Japanese individuals. Hum Genome Var. 2017 Jan 26;4:16046. doi: 10.1038/hgv.2016.46.
  • Romero V, Hosomichi K, Nakaoka H, Shibata H, Inoue I. Structure and evolution of the filaggrin gene repeated region in primates. BMC Evol Biol. 2017 Jan 11;17(1):10. doi: 10.1186/s12862-016-0851-5.
  • Hayano T, Matsui H, Nakaoka H, Ohtake N, Hosomichi K, Suzuki K, Inoue I. Germline Variants of Prostate Cancer in Japanese Families. PLoS One. 2016 Oct 4;11(10):e0164233. doi: 10.1371/journal.pone.0164233.
  • Watanabe H, Goto S, Mori H, Higashi K, Hosomichi K, Aizawa N, Takahashi N, Tsuchida M, Suzuki Y, Yamada T, Horii A, Inoue I, Kurokawa K, Narita I. Comprehensive microbiome analysis of tonsillar crypts in IgA nephropathy. Nephrol Dial Transplant. 2016 Sep 28. pii: gfw343. [Epub ahead of print]
  • Tsukamoto H*, Fujieda K*, Hirayama M, Ikeda T, Yuno A, Matsumura K, Fukuma D, Araki K, Mizuta H, Nakayama H, Senju S, Nishimura Y. (*equal contribution) Soluble IL-6R expressed by myeloid cells reduces tumor-specific Th1 differentiation and drives tumor progression. Cancer Res. 2017 Feb 24. pii: canres.2446.2016. doi: 10.1158/0008-5472.CAN-16-2446.
  • Sakisaka M, Haruta M, Komohara Y, Umemoto S, Matsumura K, Ikeda T, Takeya M, Inomata Y, Nishimura Y, Senju S. Therapy of primary and metastatic liver cancer by human iPS cell-derived myeloid cells producing interferon-β. Journal of Hepato-Biliary-Pancreatic Sciences. 2017 Feb;24(2):109-119. doi: 10.1002/jhbp.422.
  • Murakami T, Hatano S, Yamada H, Iwakura Y, Yoshikai Y. Two Types of Interleukin 17A-Producing γδ T Cells in Protection Against Pulmonary Infection With Klebsiella pneumoniae. J Infect Dis. 2016 Dec 1;214(11):1752-1761.doi: https://doi.org/10.1093/infdis/jiw443
  • Toyonaga K, Torigoe S, Motomura Y, Kamichi T, Hayashi JM, Morita YS, Noguchi N, Chuma Y, Kiyohara H, Matsuo K, Tanaka H, Nakagawa Y, Sakuma T, Ohmuraya M, Yamamoto T, Umemura M, Matsuzaki G, Yoshikai Y, Yano I, Miyamoto T, Yamasaki S. C-Type Lectin Receptor DCAR Recognizes Mycobacterial Phosphatidyl-Inositol Mannosides to Promote a Th1 Response during Infection. Immunity. 2016 Dec 20; 45(6):1245-1257. doi:10.1016/j.immuni.2016.10.012.
  • Ohnuki Y, Suzuki S, Shiina T, Uruha A, Watanabe Y, Suzuki S, Izumi S, Nakahara J, Hamanaka K, Takayama K, Suzuki N, Nishino I. HLA-DRB1 alleles in immune-mediated necrotizing myopathy. Neurology. 2016 Nov 1;87(18):1954-1955.
  • Obara H, Kisu I, Kato Y, Yamada Y, Matsubara K, Emoto K, Adachi M, Matoba Y, Umene K, Nogami Y, Banno K, Tsuchiya H, Itagaki I, Kawamoto I, Nakagawa T, Ishigaki H, Itoh Y, Ogasawara K, Saiki Y, Sato SI, Nakagawa K, Shiina T, Aoki D, Kitagawa Y. Surgical technique for allogeneic uterus transplantation in macaques. Sci Rep. 2016 Oct 27;6:35989. doi: 10.1038/srep35989.
  • Kametani Y, Ohshima S, Miyamoto A, Shigenari A, Takasu M, Imaeda N, Matsubara T, Tanaka M, Shiina T, Kamiguchi H, Suzuki R, Kitagawa H, Kulski JK, Hirayama N, Inoko H, Ando A. Production of a Locus- and Allele-Specific Monoclonal Antibody for the Characterization of SLA-1*0401 mRNA and Protein Expression Levels in MHC-Defined Microminipigs. PLoS One. 2016 Oct 19;11(10):e0164995. doi: 10.1371/journal.pone.0164995.
  • Sugita S, Iwasaki Y, Makabe K, Kamao H, Mandai M, Shiina T, Ogasawara K, Hirami Y, Kurimoto Y, Takahashi M. Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models. Stem Cell Reports. 2016 Oct 11;7(4):635-648. doi: 10.1016/j.stemcr.2016.08.010.
  • Shiba Y, Gomibuchi T, Seto T, Wada Y, Ichimura H, Tanaka Y, Ogasawara T, Okada K, Shiba N, Sakamoto K, Ido D, Shiina T, Ohkura M, Nakai J, Uno N, Kazuki Y, Oshimura M, Minami I, Ikeda U. Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts. Nature. 2016 Oct 10;538(7625):388-391. doi: 10.1038/nature19815.
  • Hayano T, Matsui H, Nakaoka H, Ohtake N, Hosomichi K, Suzuki K, Inoue I. Germline Variants of Prostate Cancer in Japanese Families. PLoS One. 2016 Oct 4;11(10):e0164233. doi:10.1371/journal.pone.0164233.
  • Maruyama H, Katagiri T, Kashiwase K, Shiina T, Sato-Otsubo A, Zaimoku Y, Maruyama K, Hosokawa K, Ishiyama K, Yamazaki H, Inoko H, Ogawa S, Nakao S. Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia. Exp Hematol. 2016 Oct;44(10):931-939.e3. doi: 10.1016/j.exphem.2016.05.013.
  • Watanabe H, Goto S, Mori H, Higashi K, Hosomichi K, Aizawa N, Takahashi N, Tsuchida M, Suzuki Y, Yamada T, Horii A, Inoue I, Kurokawa K, Narita I. Comprehensive microbiome analysis of tonsillar crypts in IgA nephropathy. Nephrol Dial Transplant. 2016 Sep 28. pii: gfw343. [Epub ahead of print]
  • Yoshizaki Y, Yuba E, Komatsu T, Udaka K, Harada A, Kono K.
    Improvement of Peptide-Based Tumor Immunotherapy Using pH-Sensitive Fusogenic Polymer-Modified Liposomes.
    Molecules. 2016 Sep 26;21(10). doi:10.3390/molecules21101284.
  • Kanzawa-Kiriyama H, Kryukov K, Jinam TA, Hosomichi K, Saso A, Suwa G, Ueda S, Yoneda M, Tajima A, Shinoda KI, Inoue I, Saitou N. A partial nuclear genome of the Jomons who lived 3000 years ago in Fukushima, Japan. J Hum Genet. 2016 Sep 1. doi: 10.1038/jhg.2016.110. [Epub ahead of print]
  • Huang Y, Matsumura Y, Hatano S, Noguchi N, Murakami T, Iwakura Y, Sun X, Ohara N, Yoshikai Y. IL-21 inhibits IL-17A-producing γδ T-cell response after infection with Bacillus Calmette-Guérin via induction of apoptosis. Innate Immun. 2016 Nov; 22:8:588-597. doi: 10.1177/1753425916664125.PMID: 27554052
  • Wang Y, Jiang X, Zhu J, Dan Yue, Zhang X, Wang X, You Y, Wang B, Xu Y, Lu C, Sun X, Yoshikai Y. IL-21/IL-21R signaling suppresses intestinal inflammation induced by DSS through regulation of Th responses in lamina propria in mice. Sci Rep. 2016 Aug 22;6:31881. doi: 10.1038/srep31881.
  • Sakuraba K, Oyamada A, Fujimura K, Spolski R, Iwamoto Y, Leonard WJ, Yoshikai Y, Yamada H. Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice. Arthritis Res Ther. 2016 Aug 17;18:188. doi: 10.1186/s13075-016-1086-y.
  • Kawasaki Y, Sakimura A, Park CM, Tomaru R, Tanaka T, Ozawa T, Zhou Y, Narita K, Kishi H, Muraguchi A, Sakurai H. Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain. Sci Rep. 2016 Aug 17;6:31502. doi: 10.1038/srep31502.

総説

  • Chikuma S. CTLA-4, an Essential Immune-Checkpoint for T cell Activation. Curr Top Microbiol Immunol. 2017 [Epub ahead of print] doi: 10.1007/82_2017_61.
  • Hashimoto-Tane A, Yokosuka T, Saito T. Analyzing the Dynamics of Signaling Microclusters. The Immune Synapse. 2017 pp15-64. doi: 10.1007/978-1-4939-6881-7_4.
  • Shiina T, Blancher A, Inoko H, Kulski JK. Comparative genomics of the human, macaque and mouse major histocompatibility complex. Immunology. 2017 Feb;150(2):127-138. doi: 10.1111/imm.12624.
  • Badr MESG, Furuhata M, Toyoda H, Yokosuka T. The multifaced role of PD-1 in health and disease. Chronic inflammation. 2016.p441-457. Springer. doi: 10.1007/978-4-431-56068-5_34
  • Terada T, Kusano S, Matsuda T, Shirouzu M, Yokoyama S. Cell-Free Protein Production for Structural Biology. Advanced Methods in Structural Biology. 2016 Aug 3:83-102. doi: 10.1007/978-4-431-56030-2_5
  • Kimura-Someya T, Hosaka T, Shinoda T, Shimono K, Shirouzu M, Yokoyama S. Cell-Free Synthesis of Membrane Proteins. Advanced Methods in Structural Biology. 2016 Aug 3:123-135. doi: 10.1007/978-4-431-56030-2_7
  • 平山真敏、西村泰治: がん抗原ワクチン療法の現状と展望 実験医学 第34巻12号 増刊「がん免疫療法;腫瘍免疫学の最新知見から治療法のアップデートまで」 pp148-155 2016年8月1日発行
  • 吉開泰信: 次世代アジュバント開発のためのメカニズム解明と安全性評価 アジュバントしてのIL-15 印刷中 2017年 シーエムシー出版
  • 吉開泰信: IL-7とIL17Aγδ型T細胞 医学のあゆみ 印刷中 2017年
  • 永淵正法、勝田 仁、三根敬一朗、吉開泰信: ウイルスによる膵島細胞障害—ウイルス糖尿病予防ワクチンの開発は可能か?— 実験医学 35(2)40-46 2017年1月 羊土社 ISBN9784787822406

著書

  • 横須賀忠、古畑昌枝、豊田博子、秦喜久美、矢那瀬紀子、町山裕亮:「細胞膜脂質成分によるT細胞シグナルソームと活性化の制御機構」臨床免疫・アレルギー科 67(3):321-328 2017年3月
  • 小笠原康悦:「マウスモデルを用いた歯科金属アレルギーの分子機構」炎症と免疫 先端医学社 11-16 Vol.25-2 2017年3月
  • 小笠原康悦:「金属と炎症」炎症と免疫 先端医学社 1-3 Vol.25-2 2017年3月 
  • 宇高恵子: 免疫機構によるがん細胞攻撃の仕組み.日本臨床 75 (2): 170-173 2017年2月
  • 鈴木重明、大貫優子、椎名 隆: 免疫性筋疾患とHLA Annual Review 神経 2017、鈴木則宏ら編、中外医学社 p.237-242 2017年1月
  • 末永忠広荒瀬尚: ネオ・セルフMHCクラスII分子による新たな自己免疫疾患発症機構. 臨床免疫・アレルギー科 66: 234-240 2016年9月
  • 小澤龍彦、岸 裕幸、 村口 篤: TRAIL受容体1-IgM抗体によるがん細胞のアポトーシス誘導. 臨床免疫・アレルギー科 66(3): 215-220 2016年9月
  • 横須賀忠、古畑昌枝、豊田博子、秦喜久美、矢那瀬紀子、町山裕亮:「最先端イメージング技術によるTCRシグナル研究の進歩」臨床免疫・アレルギー科 66(2):169-176 2016年8月
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    笹月健彦監訳 エッセンシャル免疫学第3版 2016年 メディカル・サイエンス・インターナショナル